Efficient intraocular penetration of topical anti-TNF-alpha single-chain antibody (ESBA105) to anterior and posterior segment without penetration enhancer
Ottiger, Michael, Thiel, Michael A, Feige, Ulrich, Lichtlen, Peter, Urech, David M
Published in Investigative ophthalmology & visual science (01.02.2009)
Published in Investigative ophthalmology & visual science (01.02.2009)
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Journal Article
Relative contribution of VEGF and TNF-alpha in the cynomolgus laser-induced CNV model: comparing the efficacy of bevacizumab, adalimumab, and ESBA105
Lichtlen, Peter, Lam, Tim T, Nork, T Michael, Streit, Tim, Urech, David M
Published in Investigative ophthalmology & visual science (01.09.2010)
Published in Investigative ophthalmology & visual science (01.09.2010)
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Journal Article
Novel multispecific heterodimeric antibody format allowing modular assembly of variable domain fragments
Egan, Timothy J, Diem, Dania, Weldon, Richard, Neumann, Tessa, Meyer, Sebastian, Urech, David M
Published in mAbs (01.01.2017)
Published in mAbs (01.01.2017)
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Journal Article
Design of antibody variable fragments with reduced reactivity to preexisting anti-drug antibodies
Johansson, Maria U, Weinert, Christopher, Reichardt, Dietrich Alexander, Mahler, Dana, Diem, Dania, Hess, Christian, Feusi, Diana, Carnal, Simon, Tietz, Julia, Giezendanner, Noreen, Spiga, Fabio Mario, Urech, David, Warmuth, Stefan
Published in mAbs (2023)
Published in mAbs (2023)
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Journal Article
An engineered T-cell engager with selectivity for high mesothelin-expressing cells and activity in the presence of soluble mesothelin
Snell, Daniel, Gunde, Tea, Warmuth, Stefan, Chatterjee, Bithi, Brock, Matthias, Hess, Christian, Johansson, Maria, Simonin, Alexandre, Spiga, Fabio Mario, Weinert, Christopher, Kirk, Niels, Bassler, Nicole, Campos Carrascosa, Lucia, Flückiger, Naomi, Heiz, Robin, Wagen, Sandro, Giezendanner, Noreen, Alberti, Alessandra, Yaman, Yasemin, Mahler, Dana, Diem, Dania, Lichtlen, Peter, Urech, David
Published in Oncoimmunology (31.12.2023)
Published in Oncoimmunology (31.12.2023)
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Journal Article
Engineering of a trispecific tumor-targeted immunotherapy incorporating 4-1BB co-stimulation and PD-L1 blockade
Warmuth, Stefan, Gunde, Tea, Snell, Daniel, Brock, Matthias, Weinert, Christopher, Simonin, Alexandre, Hess, Christian, Tietz, Julia, Johansson, Maria, Spiga, Fabio Mario, Heiz, Robin, Flückiger, Naomi, Wagen, Sandro, Zeberer, Julia, Diem, Dania, Mahler, Dana, Wickihalder, Belinda, Muntwiler, Simone, Chatterjee, Bithi, Küttner, Benjamin, Bommer, Bettina, Yaman, Yasemin, Lichtlen, Peter, Urech, David
Published in Oncoimmunology (01.01.2021)
Published in Oncoimmunology (01.01.2021)
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Journal Article
1389 An assessment of ROR1 expression across tumor tissue and the investigation of a ROR1-targeted T cell engager as a therapeutic strategy to target ROR1 positive tumors
Snell, Daniel, Kirk, Niels, Bassler, Nicole, Carrascosa, Lucia Campos, Chrom, Pawel, Lichtlen, Peter, Urech, David
Published in Journal for immunotherapy of cancer (01.11.2023)
Published in Journal for immunotherapy of cancer (01.11.2023)
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Journal Article
Generic Approach for the Generation of Stable Humanized Single-chain Fv Fragments from Rabbit Monoclonal Antibodies
Borras, Leo, Gunde, Tea, Tietz, Julia, Bauer, Ulrich, Hulmann-Cottier, Valérie, Grimshaw, John P.A., Urech, David M.
Published in The Journal of biological chemistry (19.03.2010)
Published in The Journal of biological chemistry (19.03.2010)
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Journal Article
Injectable formulations for an intravitreal sustained-release application of a novel single-chain VEGF antibody fragment
Asmus, Lutz R., Grimshaw, John P.A., Richle, Philipp, Eicher, Barbara, Urech, David M., Gurny, Robert, Möller, Michael
Published in European journal of pharmaceutics and biopharmaceutics (01.09.2015)
Published in European journal of pharmaceutics and biopharmaceutics (01.09.2015)
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Journal Article
Pharmacokinetics and posterior segment biodistribution of ESBA105, an anti-TNF-alpha single-chain antibody, upon topical administration to the rabbit eye
Furrer, Esther, Berdugo, Marianne, Stella, Cinzia, Behar-Cohen, Francine, Gurny, Robert, Feige, Ulrich, Lichtlen, Peter, Urech, David M
Published in Investigative ophthalmology & visual science (01.02.2009)
Published in Investigative ophthalmology & visual science (01.02.2009)
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Journal Article
Intranasal delivery of ESBA105, a TNF-alpha-inhibitory scFv antibody fragment to the brain
Furrer, Esther, Hulmann, Valérie, Urech, David M
Published in Journal of neuroimmunology (30.10.2009)
Published in Journal of neuroimmunology (30.10.2009)
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Journal Article
A Bispecific, Tetravalent Antibody Targeting Inflammatory and Pruritogenic Pathways in Atopic Dermatitis
Tietz, Julia, Gunde, Tea, Warmuth, Stefan, Weinert, Christopher, Brock, Matthias, Simonin, Alexandre, Hess, Christian, Johansson, Maria, Spiga, Fabio, Muntwiler, Simone, Wickihalder, Belinda, Mahler, Dana, Diem, Dania, Zeberer, Julia, Heiz, Robin, Flückiger, Naomi, Shiraishi, Noriko, Miyake, Yoshihide, Takahashi, Nobuaki, Fehrholz, Markus, Bertolini, Marta, Lichtlen, Peter, Urech, David, Snell, Daniel
Published in JID innovations (01.03.2024)
Published in JID innovations (01.03.2024)
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Journal Article
Effects of N-Glycosylation of the human cation channel TRPA1 on agonist-sensitivity
Egan, Timothy James, Acuña, Mario A, Zenobi-Wong, Marcy, Zeilhofer, Hanns Ulrich, Urech, David
Published in Bioscience reports (01.10.2016)
Published in Bioscience reports (01.10.2016)
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Journal Article
844 A trispecific ROR1 x CD3 T cell engager mediates in vitro tumor cell killing and in vivo tumor eradication
Chatterjee, Bithi, Snell, Daniel, Hess, Christian, Brock, Matthias, Spiga, Fabio, Simonin, Alexandre, Gunde, Tea, Warmuth, Stefan, Weinert, Christopher, Bassler, Nicole, Kirk, Niels, Schumacher, Nina, Mahler, Dana, Yaman, Yasemin, Bommer, Bettina, Gambino, Giorgio, Giezendanner, Noreen, Kuettner, Benjamin, Flueckiger, Naomi, Heiz, Robin, Wagen, Sandro, Diem, Dania, Zeberer, Julia, Urech, David
Published in Journal for immunotherapy of cancer (01.11.2021)
Published in Journal for immunotherapy of cancer (01.11.2021)
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Journal Article
684 A low affinity bivalent mesothelin-binding MATCH4 multispecific T cell engager increases cytotoxic selectivity for high mesothelin expressing cells
Chatterjee, Bithi, Simonin, Alexandre, Snell, Daniel, Gunde, Tea, Hess, Christian, Brock, Matthias, Warmuth, Stefan, Weinert, Christopher, Kirk, Niels, Diem, Dania, Flückiger, Naomi, Heiz, Robin, Küttner, Benjamin, Mahler, Dana, Morenzoni, Diego, Wagen, Sandro, Zeberer, Julia, Urech, David
Published in Journal for immunotherapy of cancer (01.11.2020)
Published in Journal for immunotherapy of cancer (01.11.2020)
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Journal Article
Cell growth selection system to detect extracellular and transmembrane protein interactions
Urech, David M., Lichtlen, Peter, Barberis, Alcide
Published in Biochimica et biophysica acta (23.07.2003)
Published in Biochimica et biophysica acta (23.07.2003)
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