ROCK inhibitors 4: Structure-activity relationship studies of 7-azaindole-based rho kinase (ROCK) inhibitors
Bandarage, Upul K., Court, John, Gao, Huai, Nanthakumar, Suganthini, Come, Jon H., Giroux, Simon, Green, Jeremy
Published in Bioorganic & medicinal chemistry letters (01.02.2021)
Published in Bioorganic & medicinal chemistry letters (01.02.2021)
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Journal Article
Design, Synthesis, and Structure–Activity Relationships of Pyridine-Based Rho Kinase (ROCK) Inhibitors
Green, Jeremy, Cao, Jingrong, Bandarage, Upul K, Gao, Huai, Court, John, Marhefka, Craig, Jacobs, Marc, Taslimi, Paul, Newsome, David, Nakayama, Tomoko, Shah, Sundeep, Rodems, Steve
Published in Journal of medicinal chemistry (25.06.2015)
Published in Journal of medicinal chemistry (25.06.2015)
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Journal Article
ROCK inhibitors 2. Improving potency, selectivity and solubility through the application of rationally designed solubilizing groups
Gao, Huai, Marhefka, Craig, Jacobs, Marc D., Cao, Jingrong, Bandarage, Upul K., Green, Jeremy
Published in Bioorganic & medicinal chemistry letters (15.08.2018)
Published in Bioorganic & medicinal chemistry letters (15.08.2018)
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Journal Article
ROCK inhibitors 3: Design, synthesis and structure-activity relationships of 7-azaindole-based Rho kinase (ROCK) inhibitors
Bandarage, Upul K., Cao, Jingrong, Come, Jon H., Court, John J., Gao, Huai, Jacobs, Marc D., Marhefka, Craig, Nanthakumar, Suganthi, Green, Jeremy
Published in Bioorganic & medicinal chemistry letters (15.08.2018)
Published in Bioorganic & medicinal chemistry letters (15.08.2018)
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Journal Article
Design and Synthesis of a Novel Series of Orally Bioavailable, CNS-Penetrant, Isoform Selective Phosphoinositide 3‑Kinase γ (PI3Kγ) Inhibitors with Potential for the Treatment of Multiple Sclerosis (MS)
Come, Jon H, Collier, Philip N, Henderson, James A, Pierce, Albert C, Davies, Robert J, Le Tiran, Arnaud, O’Dowd, Hardwin, Bandarage, Upul K, Cao, Jingrong, Deininger, David, Grey, Ron, Krueger, Elaine B, Lowe, Derek B, Liang, Jianglin, Liao, Yusheng, Messersmith, David, Nanthakumar, Suganthi, Sizensky, Emmanuelle, Wang, Jian, Xu, Jinwang, Chin, Elaine Y, Damagnez, Veronique, Doran, John D, Dworakowski, Wojciech, Griffith, James P, Jacobs, Marc D, Khare-Pandit, Suvarna, Mahajan, Sudipta, Moody, Cameron S, Aronov, Alex M
Published in Journal of medicinal chemistry (28.06.2018)
Published in Journal of medicinal chemistry (28.06.2018)
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Journal Article
Fragment-Based Discovery of Dual JC Virus and BK Virus Helicase Inhibitors
Bonafoux, Dominique, Nanthakumar, Suganthini, Bandarage, Upul K, Memmott, Christine, Lowe, Derek, Aronov, Alex M, Bhisetti, Govinda Rao, Bonanno, Kenneth C, Coll, Joyce, Leeman, Joshua, Lepre, Christopher A, Lu, Fan, Perola, Emanuele, Rijnbrand, Rene, Taylor, William P, Wilson, Dean, Zhou, Yi, Zwahlen, Jacque, ter Haar, Ernst
Published in Journal of medicinal chemistry (11.08.2016)
Published in Journal of medicinal chemistry (11.08.2016)
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Journal Article
Discovery of Highly Isoform Selective Thiazolopiperidine Inhibitors of Phosphoinositide 3‑Kinase γ
Collier, Philip N., Messersmith, David, Le Tiran, Arnaud, Bandarage, Upul K., Boucher, Christina, Come, Jon, Cottrell, Kevin M., Damagnez, Veronique, Doran, John D., Griffith, James P., Khare-Pandit, Suvarna, Krueger, Elaine B., Ledeboer, Mark W., Ledford, Brian, Liao, Yusheng, Mahajan, Sudipta, Moody, Cameron S., Roday, Setu, Wang, Tiansheng, Xu, Jinwang, Aronov, Alex M.
Published in Journal of medicinal chemistry (23.07.2015)
Published in Journal of medicinal chemistry (23.07.2015)
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Journal Article
Discovery of a Novel Series of Potent and Selective Alkynylthiazole-Derived PI3K gamma Inhibitors
Bandarage, Upul K., Aronov, Alex M., Cao, Jingrong, Come, Jon H., Cottrell, Kevin M., Davies, Robert J., Giroux, Simon, Jacobs, Marc, Mahajan, Sudipta, Messersmith, David, Moody, Cameron S., Swett, Rebecca, Xu, Jinwang
Published in ACS medicinal chemistry letters (14.01.2021)
Published in ACS medicinal chemistry letters (14.01.2021)
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Journal Article
Isosteric replacements of the carboxylic acid of drug candidate VX-787: Effect of charge on antiviral potency and kinase activity of azaindole-based influenza PB2 inhibitors
Boyd, Michael J., Bandarage, Upul K., Bennett, Hamilton, Byrn, Randal R., Davies, Ioana, Gu, Wenxin, Jacobs, Marc, Ledeboer, Mark W., Ledford, Brian, Leeman, Joshua R., Perola, Emanuele, Wang, Tiansheng, Bennani, Youssef, Clark, Michael P., Charifson, Paul S.
Published in Bioorganic & medicinal chemistry letters (01.05.2015)
Published in Bioorganic & medicinal chemistry letters (01.05.2015)
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Journal Article
Novel 2‑Substituted 7‑Azaindole and 7‑Azaindazole Analogues as Potential Antiviral Agents for the Treatment of Influenza
Bandarage, Upul K., Clark, Michael P., Perola, Emanuele, Gao, Huai, Jacobs, Marc D., Tsai, Alice, Gillespie, Jeffery, Kennedy, Joseph M., Maltais, François, Ledeboer, Mark W., Davies, Ioana, Gu, Wenxin, Byrn, Randal A., Nti Addae, Kwame, Bennett, Hamilton, Leeman, Joshua R., Jones, Steven M., O’Brien, Colleen, Memmott, Christine, Bennani, Youssef, Charifson, Paul S.
Published in ACS medicinal chemistry letters (09.02.2017)
Published in ACS medicinal chemistry letters (09.02.2017)
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Journal Article
Discovery of Novel, Orally Bioavailable β‑Amino Acid Azaindole Inhibitors of Influenza PB2
Farmer, Luc J., Clark, Michael P., Boyd, Michael J., Perola, Emanuele, Jones, Steven M., Tsai, Alice, Jacobs, Marc D., Bandarage, Upul K., Ledeboer, Mark W., Wang, Tiansheng, Deng, Hongbo, Ledford, Brian, Gu, Wenxin, Duffy, John P., Bethiel, Randy S., Shannon, Dean, Byrn, Randal A., Leeman, Joshua R., Rijnbrand, Rene, Bennett, Hamilton B., O’Brien, Colleen, Memmott, Christine, Nti-Addae, Kwame, Bennani, Youssef L., Charifson, Paul S.
Published in ACS medicinal chemistry letters (09.02.2017)
Published in ACS medicinal chemistry letters (09.02.2017)
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Journal Article
Synthesis and Selective Cyclooxygenase-2 Inhibitory Activity of a Series of Novel, Nitric Oxide Donor-Containing Pyrazoles
Ranatunge, Ramani R, Augustyniak, Michael, Bandarage, Upul K, Earl, Richard A, Ellis, James L, Garvey, David S, Janero, David R, Letts, L. Gordon, Martino, Allison M, Murty, Madhavi G, Richardson, Stewart K, Schroeder, Joseph D, Shumway, Matthew J, Tam, S. William, Trocha, A. Mark, Young, Delano V
Published in Journal of medicinal chemistry (22.04.2004)
Published in Journal of medicinal chemistry (22.04.2004)
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Journal Article
Novel thiol-based TACE inhibitors: Rational design, synthesis, and SAR of thiol-containing aryl sulfonamides
Govinda Rao, B., Bandarage, Upul K., Wang, Tiansheng, Come, Jon H., Perola, Emanuele, Wei, Yunyi, Tian, Shi-Kai, Saunders, Jeffrey O.
Published in Bioorganic & medicinal chemistry letters (15.04.2007)
Published in Bioorganic & medicinal chemistry letters (15.04.2007)
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Journal Article
Nitrosothiol Esters of Diclofenac: Synthesis and Pharmacological Characterization as Gastrointestinal-Sparing Prodrugs
Bandarage, Upul K, Chen, Liqing, Fang, Xinqin, Garvey, David S, Glavin, Alicia, Janero, David R, Letts, L. Gordon, Mercer, Gregory J, Saha, Joy K, Schroeder, Joseph D, Shumway, Matthew J, Tam, S. William
Published in Journal of medicinal chemistry (19.10.2000)
Published in Journal of medicinal chemistry (19.10.2000)
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Journal Article