First‐in‐Human, Healthy Volunteers Integrated Protocol of ETC‐206, an Oral Mnk 1/2 Kinase Inhibitor Oncology Drug
Teneggi, Vincenzo, Novotny‐Diermayr, Veronica, Lee, Lay Hoon, Yasin, Maryam, Yeo, Pauline, Ethirajulu, Kantharaj, Gan, Sylvia Bong Hwa, Blanchard, Stephanie E., Nellore, Ranjani, Umrani, Dhananjay N., Gomeni, Roberto, Teck, Darren Lim Wan, Li, Greg, Lu, Qing Shu, Cao, Yang, Matter, Alex
Published in Clinical and translational science (01.01.2020)
Published in Clinical and translational science (01.01.2020)
Get full text
Journal Article
Discovery of a potent and selective small molecule hGPR91 antagonist
Bhuniya, Debnath, Umrani, Dhananjay, Dave, Bhavesh, Salunke, Deepak, Kukreja, Gagan, Gundu, Jayasagar, Naykodi, Minakshi, Shaikh, Nadim S., Shitole, Prasad, Kurhade, Santosh, De, Siddhartha, Majumdar, Sreemita, Reddy, Srinivasa B., Tambe, Suhas, Shejul, Yogesh, Chugh, Anita, Palle, Venkata P., Mookhtiar, Kasim A., Cully, Doris, Vacca, Joseph, Chakravarty, Prasun K., Nargund, Ravi P., Wright, Samuel D., Graziano, Michael P., Singh, Sheo B., Roy, Sophie, Cai, Tian-Quan
Published in Bioorganic & medicinal chemistry letters (15.06.2011)
Published in Bioorganic & medicinal chemistry letters (15.06.2011)
Get full text
Journal Article
Effect of chronic treatment with losartan on streptozotocin-induced renal dysfunction
Murali, B, Umrani, Dhananjay N, Goyal, Ramesh K
Published in Molecular and cellular biochemistry (01.07.2003)
Published in Molecular and cellular biochemistry (01.07.2003)
Get full text
Journal Article
Design and synthesis of novel spirocyclic carboxylic acids as potent and orally bioavailable DGAT1 inhibitors and their biological evaluation
Koul, Summon, Kurhade, Suresh, Bhosale, Sandeep, Naik, Keshav, Salunkhe, Videsh, Ravula, Sudhir, Punde, Prasad, Velayutham, Ravikumar, Tiwari, Atul, Ahl, Daniela, Malkapuram, Srividya, Mudagala, Vamsi, Raje, Amol, Umrani, Dhananjay, Tambe, Suhas, Patil, Poonam, Singh, Umesh, Bhuniya, Debnath, Hariharan, Narayanan, Mookhtiar, Kasim
Published in Bioorganic & medicinal chemistry letters (15.04.2022)
Published in Bioorganic & medicinal chemistry letters (15.04.2022)
Get full text
Journal Article
Abstract 609: Pharmacological Inhibition of NLRP3 Inflammasome by Parthenolide Improves Obesity-Induced Insulin Resistance in Diet-Induced Obese Mice
Nandave, Mukesh, Chinta, Pavan K, Tambe, Suhas, Umrani, Dhananjay
Published in Arteriosclerosis, thrombosis, and vascular biology (01.05.2014)
Published in Arteriosclerosis, thrombosis, and vascular biology (01.05.2014)
Get full text
Journal Article
Discovery and pharmacological evaluation of indole derivatives as potent and selective RORγt inverse agonist for multiple autoimmune conditions
Shaikh, Nadim S., Iyer, Jitesh P., Munot, Yogesh S., Mukhopadhyay, Partha P., Raje, Amol A., Nagaraj, Ranganayaki, Jamdar, Vijay, Gavhane, Ravindra, Lohote, Mahendra, Sherkar, Prasad, Bala, Madhu, Petla, Rajkanth, Meru, Ashwinkumar, Umrani, Dhananjay, Rouduri, Sreekanth, Joshi, Sachin, Reddy, Satyanarayan, Kandikere, Vishwottam, Bhuniya, Debnath, Kulkarni, Bheemashankar, Mookhtiar, Kasim A.
Published in Bioorganic & medicinal chemistry letters (15.08.2019)
Published in Bioorganic & medicinal chemistry letters (15.08.2019)
Get full text
Journal Article
Discovery of liver-directed glucokinase activator having anti-hyperglycemic effect without hypoglycemia
Deshpande, Anil M., Bhuniya, Debnath, De, Siddhartha, Dave, Bhavesh, Vyavahare, Vinod P., Kurhade, Santosh H., Kandalkar, Sachin R., Naik, Keshav P., Kobal, Balasaheb S., Kaduskar, Rahul D., Basu, Sujay, Jain, Vaibhav, Patil, Pratima, Chaturvedi Joshi, Sandhya, Bhat, Ganesh, Raje, Amol A., Reddy, Satyanarayana, Gundu, Jayasagar, Madgula, Vamsi, Tambe, Suhas, Shitole, Prasad, Umrani, Dhananjay, Chugh, Anita, Palle, Venkata P., Mookhtiar, Kasim A.
Published in European journal of medicinal chemistry (16.06.2017)
Published in European journal of medicinal chemistry (16.06.2017)
Get full text
Journal Article
Discovery and evaluation of 1H-pyrrolo[2,3-b]pyridine based selective and reversible small molecule BTK inhibitors for the treatment of rheumatoid arthritis
Thakkar, Mahesh, Bhuniya, Debnath, Kaduskar, Rahul, Mengawade, Tanaji, Naik, Keshav, Salunkhe, Videsh, Bhalerao, Amit, Kurhade, Santosh, Mavinahalli, Jagadeesh, Jain, Vaibhav, Petla, Rajkanth, Avaragolla, Satheesh, Ray, Swagatam, Rouduri, Sreekanth, Dhanave, Avinash, De, Siddhartha, Pathade, Vishal, Tambe, Ashwini, Raje, Amol A., Madgula, Vamsi, Joshi, Sachin, Nadeem, Ahmed, bala, Madhu, Umrani, Dhananjay, Hariharan, Narayanan, Kulkarni, Bheemashankar, Mookhtiar, Kasim A.
Published in Bioorganic & medicinal chemistry letters (15.04.2017)
Published in Bioorganic & medicinal chemistry letters (15.04.2017)
Get full text
Journal Article
Discovery and evaluation of 1 H -pyrrolo[2,3- b ]pyridine based selective and reversible small molecule BTK inhibitors for the treatment of rheumatoid arthritis
Thakkar, Mahesh, Bhuniya, Debnath, Kaduskar, Rahul, Mengawade, Tanaji, Naik, Keshav, Salunkhe, Videsh, Bhalerao, Amit, Kurhade, Santosh, Mavinahalli, Jagadeesh, Jain, Vaibhav, Petla, Rajkanth, Avaragolla, Satheesh, Ray, Swagatam, Rouduri, Sreekanth, Dhanave, Avinash, De, Siddhartha, Pathade, Vishal, Tambe, Ashwini, Raje, Amol A., Madgula, Vamsi, Joshi, Sachin, Nadeem, Ahmed, bala, Madhu, Umrani, Dhananjay, Hariharan, Narayanan, Kulkarni, Bheemashankar, Mookhtiar, Kasim A.
Published in Bioorganic & medicinal chemistry letters (01.04.2017)
Published in Bioorganic & medicinal chemistry letters (01.04.2017)
Get full text
Journal Article
Increased Renal Angiotensin II AT 1 Receptor Function in Obese Zucker Rat
Becker, Misti, Umrani, Dhananjay, Lokhandwala, Mustafa F., Hussain, Tahir
Published in Clinical and experimental hypertension (1993) (01.01.2003)
Published in Clinical and experimental hypertension (1993) (01.01.2003)
Get full text
Journal Article
Pharmacodynamic evaluation of AUM001/tinodasertib, an oral inhibitor of mitogen-activated protein kinase (MAPK)-interacting protein kinase 1, 2 (MNK1/2) in preclinical models and tissues from a Phase 1 clinical study
Gan, Bong Hwa, Lee, Lay Hoon, Takeda, Reika, Yasin, Maryam, Teneggi, Vincenzo, Ethirajulu, Kantharaj, Yeo, Pauline, Umrani, Dhananjay, Pendharkar, Vishal, Darren Wen Teck Lim, Li, Greg, Lu, Qingshu, Cao, Yang, Nellore, Ranjani, Blanchard, Stephanie, Hentze, Hannes, Novotny-Diermayr, Veronica
Published in bioRxiv (29.02.2024)
Published in bioRxiv (29.02.2024)
Get full text
Paper