Inhibition of USP9X induces apoptosis in FLT3-ITD-positive AML cells cooperatively by inhibiting the mutant kinase through aggresomal translocation and inducing oxidative stress
Akiyama, Hiroki, Umezawa, Yoshihiro, Ishida, Shinya, Okada, Keigo, Nogami, Ayako, Miura, Osamu
Published in Cancer letters (01.07.2019)
Published in Cancer letters (01.07.2019)
Get full text
Journal Article
Targeting USP14/UCHL5: A Breakthrough Approach to Overcoming Treatment-Resistant FLT3-ITD-Positive AML
Nogami, Ayako, Amemiya, Hideki Jose, Fujiwara, Hiroki, Umezawa, Yoshihiro, Tohda, Shuji, Nagao, Toshikage
Published in International journal of molecular sciences (01.10.2024)
Published in International journal of molecular sciences (01.10.2024)
Get full text
Journal Article
FLT3-ITD induces expression of Pim kinases through STAT5 to confer resistance to the PI3K/Akt pathway inhibitors on leukemic cells by enhancing the mTORC1/Mcl-1 pathway
Okada, Keigo, Nogami, Ayako, Ishida, Shinya, Akiyama, Hiroki, Chen, Cheng, Umezawa, Yoshihiro, Miura, Osamu
Published in Oncotarget (06.02.2018)
Published in Oncotarget (06.02.2018)
Get full text
Journal Article
FLT3-ITD confers resistance to the PI3K/Akt pathway inhibitors by protecting the mTOR/4EBP1/Mcl-1 pathway through STAT5 activation in acute myeloid leukemia
Nogami, Ayako, Oshikawa, Gaku, Okada, Keigo, Fukutake, Shusaku, Umezawa, Yoshihiro, Nagao, Toshikage, Kurosu, Tetsuya, Miura, Osamu
Published in Oncotarget (20.04.2015)
Published in Oncotarget (20.04.2015)
Get full text
Journal Article
Molecular mechanisms for enhancement of stromal cell-derived factor 1–induced chemotaxis by platelet endothelial cell adhesion molecule 1 (PECAM-1)
Umezawa, Yoshihiro, Akiyama, Hiroki, Okada, Keigo, Ishida, Shinya, Nogami, Ayako, Oshikawa, Gaku, Kurosu, Tetsuya, Miura, Osamu
Published in The Journal of biological chemistry (01.12.2017)
Published in The Journal of biological chemistry (01.12.2017)
Get full text
Journal Article
Mechanisms for mTORC1 activation and synergistic induction of apoptosis by ruxolitinib and BH3 mimetics or autophagy inhibitors in JAK2-V617F-expressing leukemic cells including newly established PVTL-2
Ishida, Shinya, Akiyama, Hiroki, Umezawa, Yoshihiro, Okada, Keigo, Nogami, Ayako, Oshikawa, Gaku, Nagao, Toshikage, Miura, Osamu
Published in Oncotarget (01.06.2018)
Published in Oncotarget (01.06.2018)
Get full text
Journal Article
Inhibition of the STAT5/Pim Kinase Axis Enhances Cytotoxic Effects of Proteasome Inhibitors on FLT3-ITD–Positive AML Cells by Cooperatively Inhibiting the mTORC1/4EBP1/S6K/Mcl-1 Pathway
Nogami, Ayako, Okada, Keigo, Ishida, Shinya, Akiyama, Hiroki, Umezawa, Yoshihiro, Miura, Osamu
Published in Translational oncology (01.02.2019)
Published in Translational oncology (01.02.2019)
Get full text
Journal Article
Proliferation and survival signaling from both Jak2-V617F and Lyn involving GSK3 and mTOR/p70S6K/4EBP1 in PVTL-1 cell line newly established from acute myeloid leukemia transformed from polycythemia vera
Nagao, Toshikage, Kurosu, Tetsuya, Umezawa, Yoshihiro, Nogami, Ayako, Oshikawa, Gaku, Tohda, Shuji, Yamamoto, Masahide, Miura, Osamu
Published in PloS one (03.01.2014)
Published in PloS one (03.01.2014)
Get full text
Journal Article
Successful treatment with bortezomib for refractory fever associated with myelodysplastic syndrome with underlying lymphoplasmacytic lymphoma
Motomura, Yotaro, Umezawa, Yoshihiro, Arimatsu, Tomoyuki, Okada, Keigo, Miura, Osamu, Kumagai, Takashi
Published in Clinical case reports (01.02.2022)
Published in Clinical case reports (01.02.2022)
Get full text
Journal Article
A Rare Case of Radiation-Induced Liver Disease in Treated Abdominal Lymphoma Showing High [ 18 F]FDG Avidity and Low EOB Uptake Proportional to the Irradiation Dose
Usami, Aya, Yokoyama, Kota, Tsuchiya, Junichi, Umezawa, Yoshihiro, Toda, Kazuma, Tateishi, Ukihide, Yoshimura, Ryoichi
Published in Diagnostics (Basel) (16.02.2022)
Published in Diagnostics (Basel) (16.02.2022)
Get full text
Journal Article
Down regulation of Chk1 by p53 plays a role in synergistic induction of apoptosis by chemotherapeutics and inhibitors for Jak2 or BCR/ABL in hematopoietic cells
Umezawa, Yoshihiro, Kurosu, Tetsuya, Akiyama, Hiroki, Wu, Nang, Nogami, Ayako, Nagao, Toshikage, Miura, Osamu
Published in Oncotarget (12.07.2016)
Published in Oncotarget (12.07.2016)
Get full text
Journal Article
Therapy-related Leukemia with Inv(16)(p13.1q22) and Type D CBFB/MYH11 Developing after Exposure to Irinotecan-containing Chemoradiotherapy
Akiyama, Hiroki, Yamamoto, Masahide, Sakashita, Chizuko, Umezawa, Yoshihiro, Kurosu, Tetsuya, Murakami, Naomi, Miura, Osamu
Published in Internal Medicine (01.01.2015)
Published in Internal Medicine (01.01.2015)
Get full text
Journal Article
Acute promyelocytic leukemia with asymptomatic cerebral hemorrhage
Koi, Satoshi, Nogami, Ayako, Fujiwara, Hiroki, Bando, Kana, Saito, Makiko, Osada, Yuki, Tanaka, Keisuke, Sakashita, Chizuko, Yoshifuji, Kota, Okada, Keigo, Umezawa, Yoshihiro, Nagao, Toshikage, Yamamoto, Masahide, Mori, Takehiko
Published in Rinshō ketsueki (2023)
Published in Rinshō ketsueki (2023)
Get more information
Journal Article
Marginal zone lymphoma-like primary bone marrow lymphoma with long-term pancytopenia preceding diagnosis
Nogami, Ayako, Yamamoto, Masahide, Yamamoto, Kohei, Ito, Masafumi, Umezawa, Yoshihiro, Tohda, Shuji, Miura, Osamu, Fukuda, Tetsuya
Published in Rinshō ketsueki (2020)
Published in Rinshō ketsueki (2020)
Get more information
Journal Article
Perioperative management of laparoscopic cholecystectomy in a patient with paroxysmal nocturnal haemoglobinuria undergoing ravulizumab treatment
Kimura, Moyu, Nishiyama, Yu, Ueda, Hiroki, Kitajo, Akiko, Arimatsu, Tomoyuki, Kuboki, Mai, Takahata, Atsushi, Saito, Makiko, Sakashita, Chizuko, Okada, Keigo, Umezawa, Yoshihiro, Nagao, Toshikage, Yamamoto, Masahide, Tohda, Shuji, Tanabe, Minoru, Mori, Takehiko, Nogami, Ayako
Published in Rinshō ketsueki (2022)
Published in Rinshō ketsueki (2022)
Get more information
Journal Article
Manufacturing results of tisagenlecleucel for acute lymphoblastic leukemia: a survey by the CAR-T cell therapy taskforce of the Japan Society of Transfusion Medicine and Cell Therapy
Jo, Tomoyasu, Henzan, Tomoko, Tomizawa, Daisuke, Yoshihara, Satoru, Kahata, Kaoru, Yamada-Fujiwara, Minami, Okuyama, Yoshiki, Shiba, Norio, Fujii, Keiko, Umezawa, Yoshihiro, Yamazaki, Rie, Takeda, Wataru, Hanajiri, Ryo, Fukushima, Kentaro, Mimura, Naoya, Ikemoto, Junko, Iwaki, Keita, Yonetani, Noboru, Fujiwara, Shin-Ichiro, Ri, Masaki, Nagamura-Inoue, Tokiko, Tanosaki, Ryuji, Arai, Yasuyuki
Published in Rinshō ketsueki (2023)
Published in Rinshō ketsueki (2023)
Get more information
Journal Article