The IGF1R/INSR Inhibitor BI 885578 Selectively Inhibits Growth of IGF2-Overexpressing Colorectal Cancer Tumors and Potentiates the Efficacy of Anti-VEGF Therapy
Sanderson, Michael P, Hofmann, Marco H, Garin-Chesa, Pilar, Schweifer, Norbert, Wernitznig, Andreas, Fischer, Stefan, Jeschko, Astrid, Meyer, Reiner, Moll, Jürgen, Pecina, Thomas, Arnhof, Heribert, Weyer-Czernilofsky, Ulrike, Zahn, Stephan K, Adolf, Günther R, Kraut, Norbert
Published in Molecular cancer therapeutics (01.10.2017)
Published in Molecular cancer therapeutics (01.10.2017)
Get full text
Journal Article
Insulin-Like Growth Factor (IGF) Pathway Targeting in Cancer: Role of the IGF Axis and Opportunities for Future Combination Studies
Simpson, Aaron, Petnga, Wilfride, Macaulay, Valentine M., Weyer-Czernilofsky, Ulrike, Bogenrieder, Thomas
Published in Targeted oncology (01.10.2017)
Published in Targeted oncology (01.10.2017)
Get full text
Journal Article
Chemoresistance in Pancreatic Cancer Is Driven by Stroma-Derived Insulin-Like Growth Factors
Ireland, Lucy, Santos, Almudena, Ahmed, Muhammad S, Rainer, Carolyn, Nielsen, Sebastian R, Quaranta, Valeria, Weyer-Czernilofsky, Ulrike, Engle, Danielle D, Perez-Mancera, Pedro A, Coupland, Sarah E, Taktak, Azzam, Bogenrieder, Thomas, Tuveson, David A, Campbell, Fiona, Schmid, Michael C, Mielgo, Ainhoa
Published in Cancer research (Chicago, Ill.) (01.12.2016)
Published in Cancer research (Chicago, Ill.) (01.12.2016)
Get full text
Journal Article
Blockade of insulin-like growth factors increases efficacy of paclitaxel in metastatic breast cancer
Ireland, Lucy, Santos, Almudena, Campbell, Fiona, Figueiredo, Carlos, Hammond, Dean, Ellies, Lesley G., Weyer-Czernilofsky, Ulrike, Bogenrieder, Thomas, Schmid, Michael, Mielgo, Ainhoa
Published in Oncogene (01.04.2018)
Published in Oncogene (01.04.2018)
Get full text
Journal Article
Nuclear IGF1R Interacts with Regulatory Regions of Chromatin to Promote RNA Polymerase II Recruitment and Gene Expression Associated with Advanced Tumor Stage
Aleksic, Tamara, Gray, Nicki, Wu, Xiaoning, Rieunier, Guillaume, Osher, Eliot, Mills, Jack, Verrill, Clare, Bryant, Richard J, Han, Cheng, Hutchinson, Kathryn, Lambert, Adam G, Kumar, Rajeev, Hamdy, Freddie C, Weyer-Czernilofsky, Ulrike, Sanderson, Michael P, Bogenrieder, Thomas, Taylor, Stephen, Macaulay, Valentine M
Published in Cancer research (Chicago, Ill.) (01.07.2018)
Published in Cancer research (Chicago, Ill.) (01.07.2018)
Get full text
Journal Article
CHK1 inhibition exacerbates replication stress induced by IGF blockade
Wu, Xiaoning, Seraia, Elena, Hatch, Stephanie B., Wan, Xiao, Ebner, Daniel V., Aroldi, Francesca, Jiang, Yanyan, Ryan, Anderson J., Bogenrieder, Thomas, Weyer-Czernilofsky, Ulrike, Rieunier, Guillaume, Macaulay, Valentine M.
Published in Oncogene (21.01.2022)
Published in Oncogene (21.01.2022)
Get full text
Journal Article
Efficacy of the highly selective focal adhesion kinase inhibitor BI 853520 in adenocarcinoma xenograft models is linked to a mesenchymal tumor phenotype
Hirt, Ulrich A., Waizenegger, Irene C., Schweifer, Norbert, Haslinger, Christian, Gerlach, Daniel, Braunger, Jürgen, Weyer-Czernilofsky, Ulrike, Stadtmüller, Heinz, Sapountzis, Ioannis, Bader, Gerd, Zoephel, Andreas, Bister, Bojan, Baum, Anke, Quant, Jens, Kraut, Norbert, Garin-Chesa, Pilar, Adolf, Günther R.
Published in Oncogenesis (New York, NY) (23.02.2018)
Published in Oncogenesis (New York, NY) (23.02.2018)
Get full text
Journal Article
Abstract 3055: Xentuzumab, a humanized IGF-1 and IGF-2 ligand co-neutralizing monoclonal antibody, shows efficacy in a human breast cancer model of bone metastasis
Weyer-Czernilofsky, Ulrike, Krecioch, Izabela, Handschuh, Stephan, Glösmann, Martin, Kuttke, Mario, Jacob, Robin, Obenauf, Anna C.
Published in Cancer research (Chicago, Ill.) (15.08.2020)
Published in Cancer research (Chicago, Ill.) (15.08.2020)
Get full text
Journal Article
Discovery of Novel Spiro[3H‑indole-3,2′-pyrrolidin]-2(1H)‑one Compounds as Chemically Stable and Orally Active Inhibitors of the MDM2–p53 Interaction
Gollner, Andreas, Rudolph, Dorothea, Arnhof, Heribert, Bauer, Markus, Blake, Sophia M, Boehmelt, Guido, Cockroft, Xiao-Ling, Dahmann, Georg, Ettmayer, Peter, Gerstberger, Thomas, Karolyi-Oezguer, Jale, Kessler, Dirk, Kofink, Christiane, Ramharter, Juergen, Rinnenthal, Jörg, Savchenko, Alexander, Schnitzer, Renate, Weinstabl, Harald, Weyer-Czernilofsky, Ulrike, Wunberg, Tobias, McConnell, Darryl B
Published in Journal of medicinal chemistry (23.11.2016)
Published in Journal of medicinal chemistry (23.11.2016)
Get full text
Journal Article
BI-907828, a novel potent MDM2 inhibitor, inhibits glioblastoma brain tumor stem cells in vitro and prolongs survival in orthotopic xenograft mouse models
Hao, Xiaoguang, Bahia, Ravinder K, Cseh, Orsolya, Bozek, Danielle A, Blake, Sophia, Rinnenthal, Jörg, Weyer-Czernilofsky, Ulrike, Rudolph, Dorothea, Artee Luchman, H
Published in Neuro-oncology (Charlottesville, Va.) (04.05.2023)
Published in Neuro-oncology (Charlottesville, Va.) (04.05.2023)
Get full text
Journal Article
Discovery and Characterization of Brigimadlin, a Novel and Highly Potent MDM2-p53 Antagonist Suitable for Intermittent Dose Schedules
Gollner, Andreas, Rudolph, Dorothea, Weyer-Czernilofsky, Ulrike, Baumgartinger, Rosa, Jung, Peter, Weinstabl, Harald, Ramharter, Jürgen, Grempler, Rolf, Quant, Jens, Rinnenthal, Jörg, Pérez Pitarch, Alejandro, Golubovic, Bojana, Gerlach, Daniel, Bader, Gerd, Wetzel, Kristiane, Otto, Sebastian, Mandl, Christian, Boehmelt, Guido, McConnell, Darryl B, Kraut, Norbert, Sini, Patrizia
Published in Molecular cancer therapeutics (11.09.2024)
Published in Molecular cancer therapeutics (11.09.2024)
Get full text
Journal Article
Targeting IGF Perturbs Global Replication through Ribonucleotide Reductase Dysfunction
Rieunier, Guillaume, Wu, Xiaoning, Harris, Letitia E, Mills, Jack V, Nandakumar, Ashwin, Colling, Laura, Seraia, Elena, Hatch, Stephanie B, Ebner, Daniel V, Folkes, Lisa K, Weyer-Czernilofsky, Ulrike, Bogenrieder, Thomas, Ryan, Anderson J, Macaulay, Valentine M
Published in Cancer research (Chicago, Ill.) (15.04.2021)
Published in Cancer research (Chicago, Ill.) (15.04.2021)
Get full text
Journal Article
Antitumor Activity of the IGF-1/IGF-2-Neutralizing Antibody Xentuzumab (BI 836845) in Combination with Enzalutamide in Prostate Cancer Models
Weyer-Czernilofsky, Ulrike, Hofmann, Marco H, Friedbichler, Katrin, Baumgartinger, Rosa, Adam, Paul J, Solca, Flavio, Kraut, Norbert, Nguyen, Holly M, Corey, Eva, Liu, Gang, Sprenger, Cynthia C, Plymate, Stephen R, Bogenrieder, Thomas
Published in Molecular cancer therapeutics (01.04.2020)
Published in Molecular cancer therapeutics (01.04.2020)
Get full text
Journal Article
Abstract 3197: BI-907828, a novel and potent MDM2-p53 antagonist, acts synergistically in a triple combination with anti-PD-1 and anti-LAG-3 antibodies in syngeneic mouse models of cancer
Rudolph, Dorothea, Weyer-Czernilofsky, Ulrike, Reschke, Markus, Sykora, Martina, Rinnenthal, Jörg, Blake, Sophia, Gremel, Gabriela, Wernitznig, Andreas, Gollner, Andreas, Kraut, Norbert, Moll, Jürgen
Published in Cancer research (Chicago, Ill.) (01.07.2019)
Published in Cancer research (Chicago, Ill.) (01.07.2019)
Get full text
Journal Article
Abstract 4190: A promising blood-brain-barrier penetrant MDM2-p53 antagonist, BI-MDM2, increases survival in orthotopic, glioblastoma patient-derived xenograft models
Tuma, Ann C. Mladek, Gupta, Shiv, Talele, Surabhi, Mohammad, Afroz Shareef, Bakken, Katrina K., He, Helen, Hu, Zeng, Connors, Margaret A., Burgenske, Danielle M., Carlson, Brett L., Elmquist, William F., Weyer-Czernilofsky, Ulrike, Sarkaria, Jann N.
Published in Cancer research (Chicago, Ill.) (15.08.2020)
Published in Cancer research (Chicago, Ill.) (15.08.2020)
Get full text
Journal Article
Abstract 20: Xentuzumab, a humanized IGF-1 and IGF-2 ligand neutralizing antibody, improves the antitumor efficacy of enzalutamide in preclinical models of prostate cancer
Weyer-Czernilofsky, Ulrike, Hofmann, Marco H., Adam, Paul J., Solca, Flavio, Friedbichler, Katrin, Kraut, Norbert, Corey, Eva, Bogenrieder, Thomas
Published in Cancer research (Chicago, Ill.) (01.07.2017)
Published in Cancer research (Chicago, Ill.) (01.07.2017)
Get full text
Journal Article
Abstract 1194: Neutralization of IGF-I and -II ligands with the fully humanized bispecific monoclonal antibody xentuzumab inhibits AR-V7-induced enzalutamide resistance in castration-resistant prostate cancer
Liu, Gang, Nguyen, Holly M., Maltzan, Kristine van, Sun, Shihua, Sprenger, Cynthia, Weyer-Czernilofsky, Ulrike, Corey, Eva, Plymate, Stephen R.
Published in Cancer research (Chicago, Ill.) (01.07.2017)
Published in Cancer research (Chicago, Ill.) (01.07.2017)
Get full text
Journal Article
Abstract 4865: BI 907828: A highly potent MDM2 inhibitor with low human dose estimation, designed for high-dose intermittent schedules in the clinic
Rinnenthal, Joerg, Rudolph, Dorothea, Blake, Sophia, Gollner, Andreas, Wernitznig, Andreas, Weyer-Czernilofsky, Ulrike, Haslinger, Christian, Garin-Chesa, Pilar, Moll, Jürgen, Kraut, Norbert, McConnell, Darryl, Quant, Jens
Published in Cancer research (Chicago, Ill.) (01.07.2018)
Published in Cancer research (Chicago, Ill.) (01.07.2018)
Get full text
Journal Article
Abstract 4868: BI 907828: A novel, potent MDM2 inhibitor that is suitable for high-dose intermittent schedules
Rudolph, Dorothea, Gollner, Andreas, Blake, Sophia, Rinnenthal, Jörg, Wernitznig, Andreas, Weyer-Czernilofsky, Ulrike, Haslinger, Christian, Garin-Chesa, Pilar, Quant, Jens, McConnell, Darryl B., Moll, Jürgen, Norbert, Kraut
Published in Cancer research (Chicago, Ill.) (01.07.2018)
Published in Cancer research (Chicago, Ill.) (01.07.2018)
Get full text
Journal Article