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Freezing the Bioactive Conformation to Boost Potency: The Identification of BAY85-8501, a Selective and Potent Inhibitor of Human Neutrophil Elastase for Pulmonary Diseases

Freezing the Bioactive Conformation to Boost Potency: The Identification of BAY85-8501, a Selective and Potent Inhibitor of Human Neutrophil Elastase for Pulmonary Diseases

by von Nussbaum, Franz, Li, Volkhart M. -J., Allerheiligen, Swen, Anlauf, Sonja, Baerfacker, Lars, Bechem, Martin, Delbeck, Martina, Fitzgerald, Mary F., Gerisch, Michael, Gielen-Haertwig, Heike, Haning, Helmut, Karthaus, Dagmar, Lang, Dieter, Lustig, Klemens, Meibom, Daniel, Mittendorf, Joachim, Rosentreter, Ulrich, Schaefer, Martina, Schaefer, Stefan, Schamberger, Jens, Telan, Leila A., Tersteegen, Adrian
Published in ChemMedChem (01.07.2015)

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Journal Article

Cover Picture: Freezing the Bioactive Conformation to Boost Potency: The Identification of BAY 85-8501, a Selective and Potent Inhibitor of Human Neutrophil Elastase for Pulmonary Diseases (ChemMedChem 7/2015)

Cover Picture: Freezing the Bioactive Conformation to Boost Potency: The Identification of BAY 85-8501, a Selective and Potent Inhibitor of Human Neutrophil Elastase for Pulmonary Diseases (ChemMedChem 7/2015)

by von Nussbaum, Franz, Li, Volkhart M.-J., Allerheiligen, Swen, Anlauf, Sonja, Bärfacker, Lars, Bechem, Martin, Delbeck, Martina, Fitzgerald, Mary F., Gerisch, Michael, Gielen-Haertwig, Heike, Haning, Helmut, Karthaus, Dagmar, Lang, Dieter, Lustig, Klemens, Meibom, Daniel, Mittendorf, Joachim, Rosentreter, Ulrich, Schäfer, Martina, Schäfer, Stefan, Schamberger, Jens, Telan, Leila A., Tersteegen, Adrian
Published in ChemMedChem (01.07.2015)

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Journal Article

Cover Picture: Freezing the Bioactive Conformation to Boost Potency: The Identification of BAY85-8501, a Selective and Potent Inhibitor of Human Neutrophil Elastase for Pulmonary Diseases

Cover Picture: Freezing the Bioactive Conformation to Boost Potency: The Identification of BAY85-8501, a Selective and Potent Inhibitor of Human Neutrophil Elastase for Pulmonary Diseases

by vonNussbaum, Franz, Li, Volkhart M-J, Allerheiligen, Swen, Anlauf, Sonja, Barfacker, Lars, Bechem, Martin, Delbeck, Martina, Fitzgerald, Mary F, Gerisch, Michael, Gielen-Haertwig, Heike, Haning, Helmut, Karthaus, Dagmar, Lang, Dieter, Lustig, Klemens, Meibom, Daniel, Mittendorf, Joachim, Rosentreter, Ulrich, Schafer, Martina, Schafer, Stefan, Schamberger, Jens, Telan, Leila A, Tersteegen, Adrian
Published in ChemMedChem (01.07.2015)

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Journal Article

Freezing the Bioactive Conformation to Boost Potency: The Identification of BAY 85-8501, a Selective and Potent Inhibitor of Human Neutrophil Elastase for Pulmonary Diseases

Freezing the Bioactive Conformation to Boost Potency: The Identification of BAY 85-8501, a Selective and Potent Inhibitor of Human Neutrophil Elastase for Pulmonary Diseases

by von Nussbaum, Franz, Li, Volkhart M.-J., Allerheiligen, Swen, Anlauf, Sonja, Bärfacker, Lars, Bechem, Martin, Delbeck, Martina, Fitzgerald, Mary F., Gerisch, Michael, Gielen-Haertwig, Heike, Haning, Helmut, Karthaus, Dagmar, Lang, Dieter, Lustig, Klemens, Meibom, Daniel, Mittendorf, Joachim, Rosentreter, Ulrich, Schäfer, Martina, Schäfer, Stefan, Schamberger, Jens, Telan, Leila A., Tersteegen, Adrian
Published in ChemMedChem (01.07.2015)

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Journal Article

Heterocyklylamidsubstituerte imidazoler

Heterocyklylamidsubstituerte imidazoler

by Hendrix, Martin, Zimmermann, Holger, Brueckner, David, Keldenich, Joerg, Paulsen, Daniela, Radtke, Martin, Henninger, Keistin, Kern, Armin, Rosentreter, Ulrich, Lang, Dieter
Year of Publication 07.11.2016

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Patent

composto de fórmula (i), método para preparar o composto de fórmula (i) e uso do composto de fórmula (i)

composto de fórmula (i), método para preparar o composto de fórmula (i) e uso do composto de fórmula (i)

by Daniela Paulsen, Armin Kern, Holger Zimmermann, David Brüeckner, Dieter Lang, Jörg Keldenich, Ulrich Rosentreter, Martin Radtke, Kerstin Henninger, Martin Hendrix
Year of Publication 25.05.2021

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Patent

Substituted 2-thio-3,5-dicyano-4-phenyl-6-aminopyridines process for preparing them, pharmaceutical compositions containing them and use thereof

Substituted 2-thio-3,5-dicyano-4-phenyl-6-aminopyridines process for preparing them, pharmaceutical compositions containing them and use thereof

by ROSENTRETER ULRICH, KRAHN THOMAS, SHIMADA MITSUYUKI, WISCHNAT RALF, STASCH JOHANNES-PETER, KRAEMER THOMAS, DIEDRICHS NICOLE, HENNINGER KERSTIN, HUEBSCH WALTER
Year of Publication 29.06.2015

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Patent

Optimal Fraction Collecting in Preparative LC/MS

Optimal Fraction Collecting in Preparative LC/MS

by Rosentreter, Ulrich, Huber, Udo
Published in Journal of combinatorial chemistry (01.03.2004)

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Journal Article

composto de fórmula (i), método para preparar o composto de fórmula (i) e uso do composto de fórmula (i)

composto de fórmula (i), método para preparar o composto de fórmula (i) e uso do composto de fórmula (i)

by Daniela Paulsen, Armin Kern, Holger Zimmermann, David Brüeckner, Dieter Lang, Jörg Keldenich, Ulrich Rosentreter, Martin Radtke, Kerstin Henninger, Martin Hendrix
Year of Publication 16.07.2019

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Patent

Use of Substituted 2-thio-3,5-dicyano-4-phenyl-6-aminopyridines in the treatment of nausea and vomiting

Use of Substituted 2-thio-3,5-dicyano-4-phenyl-6-aminopyridines in the treatment of nausea and vomiting

by ROSENTRETER ULRICH, KRAHN THOMAS, KRAEMER THOMAS, THIELEMANN WOLFGANG, DIEDRICHS NICOLE
Year of Publication 04.05.2010

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Patent

Use of Substituted 2-thio-3,5-dicyano-4-phenyl-6-aminopyridines in the treatment of nausea and vomiting

Use of Substituted 2-thio-3,5-dicyano-4-phenyl-6-aminopyridines in the treatment of nausea and vomiting

by Krahn, Thomas, Thielemann, Wolfgang, Rosentreter, Ulrich, Diedrichs, Nicole, Krämer, Thomas
Year of Publication 04.05.2010

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Patent

SYNTHESIS OF (+)-(3R)-3-(4-FLUOROPHENYLSULFONAMIDO)-1,2,3,4-TETRAHYDRO-9-[5,6,7,8,12,13-U-C-14]CARBAZOLEPROPANOIC ACID, [C-14] BAY-U-3405

SYNTHESIS OF (+)-(3R)-3-(4-FLUOROPHENYLSULFONAMIDO)-1,2,3,4-TETRAHYDRO-9-[5,6,7,8,12,13-U-C-14]CARBAZOLEPROPANOIC ACID, [C-14] BAY-U-3405

by RADTKE, M, BOBERG, M, PLEISS, U, ROSENTRETER, U
Published in Journal of labelled compounds & radiopharmaceuticals (01.12.1994)

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Journal Article

VERWENDUNG VON SUBSTITUIERTEN 2-THIO-3,5-DICYANO- 4-PHENYL-6-AMINOPYRIDINEN BEI DER BEHANDLUNG VON ÜBELKEIT UND ERBRECHEN

VERWENDUNG VON SUBSTITUIERTEN 2-THIO-3,5-DICYANO- 4-PHENYL-6-AMINOPYRIDINEN BEI DER BEHANDLUNG VON ÜBELKEIT UND ERBRECHEN

by KRAEMER, THOMAS, DIEDRICHS, NICOLE, THIELEMANN, WOLFGANG, ROSENTRETER, ULRICH, KRAHN, THOMAS
Year of Publication 15.11.2009

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Patent

USE OF SUBSTITUTED 2-THIO-3,5-DICYANO-4-PHENYL-6-AMINOPYRIDINES IN THE TREATMENT OF NAUSEA AND VOMITING

USE OF SUBSTITUTED 2-THIO-3,5-DICYANO-4-PHENYL-6-AMINOPYRIDINES IN THE TREATMENT OF NAUSEA AND VOMITING

by KRAEMER, THOMAS, DIEDRICHS, NICOLE, THIELEMANN, WOLFGANG, ROSENTRETER, ULRICH, KRAHN, THOMAS
Year of Publication 28.10.2009

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Patent

ANTIVIRAL 4-AMINOCARBONYLAMINO-SUBSTITUTED IMIDAZOLE COMPOUNDS

ANTIVIRAL 4-AMINOCARBONYLAMINO-SUBSTITUTED IMIDAZOLE COMPOUNDS

by HENDRIX, MARTIN, HENNINGER, KERSTIN, BRUECKNER, DAVID, HEIMBACH, DIRK, HEWLETT, GUY, ZIMMERMANN, HOLGER, LANG, DIETER, RADTKE, MARTIN, ROSENTRETER, ULRICH, KELDENICH, JOERG
Year of Publication 28.05.2013

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Patent

Substituted 2, 6-Diamino-3, 5-Dicyano-4-Aryl-Pyridines And Their Use As Adenosine-Receptor-Selective Ligands

Substituted 2, 6-Diamino-3, 5-Dicyano-4-Aryl-Pyridines And Their Use As Adenosine-Receptor-Selective Ligands

by ROSENTRETER ULRICH, VAUPEL ANDREA, KRAHN THOMAS, DEMBOWSKY KLAUS, STASCH JOHANNES-PETER, KRAEMER THOMAS, DIEDRICHS NICOLE, HUEBSCH WALTER
Year of Publication 14.02.2013

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Patent

Substituted phenylaminothiazoles and use thereof

Substituted phenylaminothiazoles and use thereof

by ROSENTRETER ULRICH, HUETTER JOACHIM, KNORR ANDREAS, NELL PETER, DIEDRICHS NICOLE, HENNINGER KERSTIN, ERGUEDEN JENS-KERIM, KARIG GUNTER, ARNDT SABINE, SCHLEMMER KARL-HEINZ, ALBRECHT BARBARA, BROHM DIRK, HUEBSCH WALTER
Year of Publication 08.04.2014

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Patent

HETEROCYCLYLAMIDE-SUBSTITUTED IMIDAZOLES

HETEROCYCLYLAMIDE-SUBSTITUTED IMIDAZOLES

by HENNINGER, KERSTIN, HENDRIX, MARTIN, BRUECKNER, DAVID, ZIMMERMANN, HOLGER, LANG, DIETER, RADTKE, MARTIN, PAULSEN, DANIELA, KERN, ARMIN, ROSENTRETER, ULRICH, KELDENICH, JOERG
Year of Publication 27.11.2012

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Patent

Use of Substituted 2-Thio-3,5-Dicyano-4-Phenyl-6-Aminopyridines In the Treatment of Nausea and Vomiting

Use of Substituted 2-Thio-3,5-Dicyano-4-Phenyl-6-Aminopyridines In the Treatment of Nausea and Vomiting

by ROSENTRETER ULRICH, KRAMER THOMAS, KRAHN THOMAS, THIELEMANN WOLFGANG, DIEDRICHS NICOLE
Year of Publication 09.10.2008

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Patent

Substituted 2, 6-diamino-3, 5-dicyano-4-arylpyridines and their use as adenosine-receptor-selective ligands

Substituted 2, 6-diamino-3, 5-dicyano-4-arylpyridines and their use as adenosine-receptor-selective ligands

by ROSENTRETER ULRICH, KRAMER THOMAS, VAUPEL ANDREA, HUBSCH WALTER, KRAHN THOMAS, DEMBOWSKY KLAUS, STASCH JOHANNES-PETER, DIEDRICHS NICOLE
Year of Publication 14.08.2012

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