Small molecule targeting r(UGGAA)n disrupts RNA foci and alleviates disease phenotype in Drosophila model
Shibata, Tomonori, Nagano, Konami, Ueyama, Morio, Ninomiya, Kensuke, Hirose, Tetsuro, Nagai, Yoshitaka, Ishikawa, Kinya, Kawai, Gota, Nakatani, Kazuhiko
Published in Nature communications (11.01.2021)
Published in Nature communications (11.01.2021)
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Journal Article
Therapeutic reduction of GGGGCC repeat RNA levels by hnRNPA3 suppresses neurodegeneration in Drosophila models of C9orf72-linked ALS/FTD
Taminato, Tomoya, Takeuchi, Toshihide, Ueyama, Morio, Mori, Kohji, Ikeda, Manabu, Mochizuki, Hideki, Nagai, Yoshitaka
Published in Human molecular genetics (05.05.2023)
Published in Human molecular genetics (05.05.2023)
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Journal Article
Regulatory Role of RNA Chaperone TDP-43 for RNA Misfolding and Repeat-Associated Translation in SCA31
Ishiguro, Taro, Sato, Nozomu, Ueyama, Morio, Fujikake, Nobuhiro, Sellier, Chantal, Kanegami, Akemi, Tokuda, Eiichi, Zamiri, Bita, Gall-Duncan, Terence, Mirceta, Mila, Furukawa, Yoshiaki, Yokota, Takanori, Wada, Keiji, Taylor, J. Paul, Pearson, Christopher E., Charlet-Berguerand, Nicolas, Mizusawa, Hidehiro, Nagai, Yoshitaka, Ishikawa, Kinya
Published in Neuron (Cambridge, Mass.) (05.04.2017)
Published in Neuron (Cambridge, Mass.) (05.04.2017)
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Journal Article
FUS regulates RAN translation through modulating the G-quadruplex structure of GGGGCC repeat RNA in C9orf72 -linked ALS/FTD
Fujino, Yuzo, Ueyama, Morio, Ishiguro, Taro, Ozawa, Daisaku, Ito, Hayato, Sugiki, Toshihiko, Murata, Asako, Ishiguro, Akira, Gendron, Tania, Mori, Kohji, Tokuda, Eiichi, Taminato, Tomoya, Konno, Takuya, Koyama, Akihide, Kawabe, Yuya, Takeuchi, Toshihide, Furukawa, Yoshiaki, Fujiwara, Toshimichi, Ikeda, Manabu, Mizuno, Toshiki, Mochizuki, Hideki, Mizusawa, Hidehiro, Wada, Keiji, Ishikawa, Kinya, Onodera, Osamu, Nakatani, Kazuhiko, Petrucelli, Leonard, Taguchi, Hideki, Nagai, Yoshitaka
Published in eLife (18.07.2023)
Published in eLife (18.07.2023)
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Journal Article
Wolbachia-mediated male killing is associated with defective chromatin remodeling
Riparbelli, Maria Giovanna, Giordano, Rosanna, Ueyama, Morio, Callaini, Giuliano
Published in PloS one (23.01.2012)
Published in PloS one (23.01.2012)
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Journal Article
E46K mutant α-synuclein is more degradation resistant and exhibits greater toxic effects than wild-type α-synuclein in Drosophila models of Parkinson's disease
Sakai, Ryusuke, Suzuki, Mari, Ueyama, Morio, Takeuchi, Toshihide, Minakawa, Eiko N, Hayakawa, Hideki, Baba, Kousuke, Mochizuki, Hideki, Nagai, Yoshitaka
Published in PloS one (26.06.2019)
Published in PloS one (26.06.2019)
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Journal Article
p62 Plays a Protective Role in the Autophagic Degradation of Polyglutamine Protein Oligomers in Polyglutamine Disease Model Flies
Saitoh, Yuji, Fujikake, Nobuhiro, Okamoto, Yuma, Popiel, H. Akiko, Hatanaka, Yusuke, Ueyama, Morio, Suzuki, Mari, Gaumer, Sébastien, Murata, Miho, Wada, Keiji, Nagai, Yoshitaka
Published in The Journal of biological chemistry (16.01.2015)
Published in The Journal of biological chemistry (16.01.2015)
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Journal Article
Dysregulation of stress granule dynamics by DCTN1 deficiency exacerbates TDP-43 pathology in Drosophila models of ALS/FTD
Ueda, Tetsuhiro, Takeuchi, Toshihide, Fujikake, Nobuhiro, Suzuki, Mari, Minakawa, Eiko N, Ueyama, Morio, Fujino, Yuzo, Kimura, Nobuyuki, Nagano, Seiichi, Yokoseki, Akio, Onodera, Osamu, Mochizuki, Hideki, Mizuno, Toshiki, Wada, Keiji, Nagai, Yoshitaka
Published in Acta neuropathologica communications (04.02.2024)
Published in Acta neuropathologica communications (04.02.2024)
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Journal Article
Identification of ter94, Drosophila VCP, as a strong modulator of motor neuron degeneration induced by knockdown of Caz, Drosophila FUS
Azuma, Yumiko, Tokuda, Takahiko, Shimamura, Mai, Kyotani, Akane, Sasayama, Hiroshi, Yoshida, Tomokatsu, Mizuta, Ikuko, Mizuno, Toshiki, Nakagawa, Masanori, Fujikake, Nobuhiro, Ueyama, Morio, Nagai, Yoshitaka, Yamaguchi, Masamitsu
Published in Human molecular genetics (01.07.2014)
Published in Human molecular genetics (01.07.2014)
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Journal Article
Hippo, Drosophila MST, is a novel modifier of motor neuron degeneration induced by knockdown of Caz, Drosophila FUS
Azuma, Yumiko, Tokuda, Takahiko, Kushimura, Yukie, Yamamoto, Itaru, Mizuta, Ikuko, Mizuno, Toshiki, Nakagawa, Masanori, Ueyama, Morio, Nagai, Yoshitaka, Iwasaki, Yasushi, Yoshida, Mari, Pan, Duojia, Yoshida, Hideki, Yamaguchi, Masamitsu
Published in Experimental cell research (15.10.2018)
Published in Experimental cell research (15.10.2018)
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Journal Article
NPM-hMLF1 fusion protein suppresses defects of a Drosophila FTLD model expressing the human FUS gene
Yamamoto, Itaru, Azuma, Yumiko, Kushimura, Yukie, Yoshida, Hideki, Mizuta, Ikuko, Mizuno, Toshiki, Ueyama, Morio, Nagai, Yoshitaka, Tokuda, Takahiko, Yamaguchi, Masamitsu
Published in Scientific reports (26.07.2018)
Published in Scientific reports (26.07.2018)
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Journal Article
Increased apoptosis of myoblasts in Drosophila model for the Walker-Warburg syndrome
Ueyama, Morio, Akimoto, Yoshihiro, Ichimiya, Tomomi, Ueda, Ryu, Kawakami, Hayato, Aigaki, Toshiro, Nishihara, Shoko
Published in PloS one (13.07.2010)
Published in PloS one (13.07.2010)
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Journal Article
Parkinson’s disease-linked DNAJC13 mutation aggravates alpha-synuclein-induced neurotoxicity through perturbation of endosomal trafficking
Yoshida, Shun, Hasegawa, Takafumi, Suzuki, Mari, Sugeno, Naoto, Kobayashi, Junpei, Ueyama, Morio, Fukuda, Mitsunori, Ido-Fujibayashi, Akemi, Sekiguchi, Kiyotoshi, Ezura, Michinori, Kikuchi, Akio, Baba, Toru, Takeda, Atsushi, Mochizuki, Hideki, Nagai, Yoshitaka, Aoki, Masashi
Published in Human molecular genetics (01.03.2018)
Published in Human molecular genetics (01.03.2018)
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Journal Article
Mutations in the desat1 gene reduces the production of courtship stimulatory pheromones through a marked effect on fatty acids in Drosophila melanogaster
Ueyama, Morio, Chertemps, Thomas, Labeur, Carole, Wicker-Thomas, Claude
Published in Insect biochemistry and molecular biology (01.08.2005)
Published in Insect biochemistry and molecular biology (01.08.2005)
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Journal Article
Identification and Characterization of a Novel Drosophila 3′-Phosphoadenosine 5′-Phosphosulfate Transporter
Goda, Emi, Kamiyama, Shin, Uno, Takaaki, Yoshida, Hideki, Ueyama, Morio, Kinoshita-Toyoda, Akiko, Toyoda, Hidenao, Ueda, Ryu, Nishihara, Shoko
Published in The Journal of biological chemistry (29.09.2006)
Published in The Journal of biological chemistry (29.09.2006)
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Journal Article
Repeat Expansion Disease Models
Ueyama, Morio, Nagai, Yoshitaka
Published in Advances in experimental medicine and biology (01.01.2018)
Published in Advances in experimental medicine and biology (01.01.2018)
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Journal Article
Enhanced cost of mating in female sterile mutants of Drosophila melanogaster
Ueyama, M. (Tokyo Metropolitan Univ., Hachioji (Japan)), Fuyama, Y
Published in Genes & Genetic Systems (01.02.2003)
Published in Genes & Genetic Systems (01.02.2003)
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