SARS-CoV-2 variants with mutations at the S1/S2 cleavage site are generated in vitro during propagation in TMPRSS2-deficient cells
Sasaki, Michihito, Uemura, Kentaro, Sato, Akihiko, Toba, Shinsuke, Sanaki, Takao, Maenaka, Katsumi, Hall, William W, Orba, Yasuko, Sawa, Hirofumi
Published in PLoS pathogens (21.01.2021)
Published in PLoS pathogens (21.01.2021)
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MRC5 cells engineered to express ACE2 serve as a model system for the discovery of antivirals targeting SARS-CoV-2
Uemura, Kentaro, Sasaki, Michihito, Sanaki, Takao, Toba, Shinsuke, Takahashi, Yoshimasa, Orba, Yasuko, Hall, William W., Maenaka, Katsumi, Sawa, Hirofumi, Sato, Akihiko
Published in Scientific reports (08.03.2021)
Published in Scientific reports (08.03.2021)
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Journal Article
TMPRSS11D and TMPRSS13 Activate the SARS-CoV-2 Spike Protein
Kishimoto, Mai, Uemura, Kentaro, Sanaki, Takao, Sato, Akihiko, Hall, William W, Kariwa, Hiroaki, Orba, Yasuko, Sawa, Hirofumi, Sasaki, Michihito
Published in Viruses (01.03.2021)
Published in Viruses (01.03.2021)
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Efficacy of ensitrelvir against SARS-CoV-2 in a delayed-treatment mouse model
Nobori, Haruaki, Fukao, Keita, Kuroda, Takayuki, Anan, Naomi, Tashima, Ryoichi, Nakashima, Masaaki, Noda, Sayuri, Tajiri, Minako, Torii, Mikinori, Toba, Shinsuke, Uemura, Kentaro, Sanaki, Takao, Shishido, Takao, Tachibana, Yuki, Kato, Teruhisa
Published in Journal of antimicrobial chemotherapy (28.10.2022)
Published in Journal of antimicrobial chemotherapy (28.10.2022)
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Journal Article
Synthesis and Anti-dengue Virus Activity of 5-Ethynylimidazole-4-carboxamide (EICA) Nucleotide Prodrugs
Nakamura, Motoki, Uemura, Kentaro, Saito-Tarashima, Noriko, Sato, Akihiko, Orba, Yasuko, Sawa, Hirofumi, Matsuda, Akira, Maenaka, Katsumi, Minakawa, Noriaki
Published in Chemical & pharmaceutical bulletin (01.03.2022)
Published in Chemical & pharmaceutical bulletin (01.03.2022)
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Journal Article
SARS-CoV-2 Bearing a Mutation at the S1/S2 Cleavage Site Exhibits Attenuated Virulence and Confers Protective Immunity
Sasaki, Michihito, Toba, Shinsuke, Itakura, Yukari, Chambaro, Herman M, Kishimoto, Mai, Tabata, Koshiro, Intaruck, Kittiya, Uemura, Kentaro, Sanaki, Takao, Sato, Akihiko, Hall, William W, Orba, Yasuko, Sawa, Hirofumi
Published in mBio (31.08.2021)
Published in mBio (31.08.2021)
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Journal Article
Lipoprotein Receptors Redundantly Participate in Entry of Hepatitis C Virus
Yamamoto, Satomi, Fukuhara, Takasuke, Ono, Chikako, Uemura, Kentaro, Kawachi, Yukako, Shiokawa, Mai, Mori, Hiroyuki, Wada, Masami, Shima, Ryoichi, Okamoto, Toru, Hiraga, Nobuhiko, Suzuki, Ryosuke, Chayama, Kazuaki, Wakita, Takaji, Matsuura, Yoshiharu
Published in PLoS pathogens (01.05.2016)
Published in PLoS pathogens (01.05.2016)
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Journal Article
Host serine proteases TMPRSS2 and TMPRSS11D mediate proteolytic activation and trypsin-independent infection in group A rotaviruses
Sasaki, Michihito, Itakura, Yukari, Kishimoto, Mai, Tabata, Koshiro, Uemura, Kentaro, Ito, Naoto, Sugiyama, Makoto, Wastika, Christida E, Orba, Yasuko, Sawa, Hirofumi
Published in Journal of virology (10.05.2021)
Published in Journal of virology (10.05.2021)
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Journal Article
An African tick flavivirus forming an independent clade exhibits unique exoribonuclease-resistant RNA structures in the genomic 3′-untranslated region
Harima, Hayato, Orba, Yasuko, Torii, Shiho, Qiu, Yongjin, Kajihara, Masahiro, Eto, Yoshiki, Matsuta, Naoya, Hang’ombe, Bernard M., Eshita, Yuki, Uemura, Kentaro, Matsuno, Keita, Sasaki, Michihito, Yoshii, Kentaro, Nakao, Ryo, Hall, William W., Takada, Ayato, Abe, Takashi, Wolfinger, Michael T., Simuunza, Martin, Sawa, Hirofumi
Published in Scientific reports (01.03.2021)
Published in Scientific reports (01.03.2021)
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Journal Article
Electrolyzed hypochlorous acid water exhibits potent disinfectant activity against various viruses through irreversible protein aggregation
Dianty, Rahmi, Hirano, Junki, Anzai, Itsuki, Kanai, Yuta, Hayashi, Tsuyoshi, Morimoto, Masae, Kataoka-Nakamura, Chikako, Kobayashi, Sakura, Uemura, Kentaro, Ono, Chikako, Watanabe, Tokiko, Kobayashi, Takeshi, Murakami, Kosuke, Kikuchi, Kenji, Hotta, Kunimoto, Yoshikawa, Toshikazu, Taguwa, Shuhei, Matsuura, Yoshiharu
Published in Frontiers in microbiology (19.10.2023)
Published in Frontiers in microbiology (19.10.2023)
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Journal Article
Suppression of HBV replication by the expression of nickase- and nuclease dead-Cas9
Kurihara, Takeshi, Fukuhara, Takasuke, Ono, Chikako, Yamamoto, Satomi, Uemura, Kentaro, Okamoto, Toru, Sugiyama, Masaya, Motooka, Daisuke, Nakamura, Shota, Ikawa, Masato, Mizokami, Masashi, Maehara, Yoshihiko, Matsuura, Yoshiharu
Published in Scientific reports (21.07.2017)
Published in Scientific reports (21.07.2017)
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Journal Article
Characterization of miR-122-independent propagation of HCV
Ono, Chikako, Fukuhara, Takasuke, Motooka, Daisuke, Nakamura, Shota, Okuzaki, Daisuke, Yamamoto, Satomi, Tamura, Tomokazu, Mori, Hiroyuki, Sato, Asuka, Uemura, Kentaro, Fauzyah, Yuzy, Kurihara, Takeshi, Suda, Takahiro, Nishio, Akira, Hmwe, Su Su, Okamoto, Toru, Tatsumi, Tomohide, Takehara, Tetsuo, Chayama, Kazuaki, Wakita, Takaji, Koike, Kazuhiko, Matsuura, Yoshiharu
Published in PLoS pathogens (11.05.2017)
Published in PLoS pathogens (11.05.2017)
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Inhibitory effect of maple syrup on the cell growth and invasion of human colorectal cancer cells
YAMAMOTO, TETSUSHI, UEMURA, KENTARO, MORIYAMA, KAHO, MITAMURA, KUNIKO, TAGA, ATSUSHI
Published in Oncology reports (01.04.2015)
Published in Oncology reports (01.04.2015)
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Journal Article
Human Cathelicidin Compensates for the Role of Apolipoproteins in Hepatitis C Virus Infectious Particle Formation
Puig-Basagoiti, Francesc, Fukuhara, Takasuke, Tamura, Tomokazu, Ono, Chikako, Uemura, Kentaro, Kawachi, Yukako, Yamamoto, Satomi, Mori, Hiroyuki, Kurihara, Takeshi, Okamoto, Toru, Aizaki, Hideki, Matsuura, Yoshiharu
Published in Journal of virology (01.10.2016)
Published in Journal of virology (01.10.2016)
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Journal Article
Host-derived apolipoproteins play comparable roles with viral secretory proteins Erns and NS1 in the infectious particle formation of Flaviviridae
Fukuhara, Takasuke, Tamura, Tomokazu, Ono, Chikako, Shiokawa, Mai, Mori, Hiroyuki, Uemura, Kentaro, Yamamoto, Satomi, Kurihara, Takeshi, Okamoto, Toru, Suzuki, Ryosuke, Yoshii, Kentaro, Kurosu, Takeshi, Igarashi, Manabu, Aoki, Hiroshi, Sakoda, Yoshihiro, Matsuura, Yoshiharu
Published in PLoS pathogens (01.06.2017)
Published in PLoS pathogens (01.06.2017)
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Journal Article
5-Hydroxymethyltubercidin exhibits potent antiviral activity against flaviviruses and coronaviruses, including SARS-CoV-2
Uemura, Kentaro, Nobori, Haruaki, Sato, Akihiko, Sanaki, Takao, Toba, Shinsuke, Sasaki, Michihito, Murai, Akiho, Saito-Tarashima, Noriko, Minakawa, Noriaki, Orba, Yasuko, Kariwa, Hiroaki, Hall, William W., Sawa, Hirofumi, Matsuda, Akira, Maenaka, Katsumi
Published in iScience (22.10.2021)
Published in iScience (22.10.2021)
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Journal Article
Discovery of S‑217622, a Noncovalent Oral SARS-CoV‑2 3CL Protease Inhibitor Clinical Candidate for Treating COVID-19
Unoh, Yuto, Uehara, Shota, Nakahara, Kenji, Nobori, Haruaki, Yamatsu, Yukiko, Yamamoto, Shiho, Maruyama, Yuki, Taoda, Yoshiyuki, Kasamatsu, Koji, Suto, Takahiro, Kouki, Kensuke, Nakahashi, Atsufumi, Kawashima, Sho, Sanaki, Takao, Toba, Shinsuke, Uemura, Kentaro, Mizutare, Tohru, Ando, Shigeru, Sasaki, Michihito, Orba, Yasuko, Sawa, Hirofumi, Sato, Akihiko, Sato, Takafumi, Kato, Teruhisa, Tachibana, Yuki
Published in Journal of medicinal chemistry (12.05.2022)
Published in Journal of medicinal chemistry (12.05.2022)
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