Discovery of (1S,2R,3R)-2,3-Dimethyl-2-phenyl-1-sulfamidocyclopropanecarboxylates: Novel and Highly Selective Aggrecanase Inhibitors
Shiozaki, Makoto, Maeda, Katsuya, Miura, Tomoya, Kotoku, Masayuki, Yamasaki, Takayuki, Matsuda, Isamu, Aoki, Kenta, Yasue, Katsutaka, Imai, Hiroto, Ubukata, Minoru, Suma, Akira, Yokota, Masahiro, Hotta, Takahiro, Tanaka, Masahiro, Hase, Yasunori, Haas, Julia, Fryer, Andrew M, Laird, Ellen R, Littmann, Nicole M, Andrews, Steven W, Josey, John A, Mimura, Takayuki, Shinozaki, Yuichi, Yoshiuchi, Hiromi, Inaba, Takashi
Published in Journal of medicinal chemistry (28.04.2011)
Published in Journal of medicinal chemistry (28.04.2011)
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Journal Article
Rhodium-Catalyzed Intermolecular [4+2] Cycloaddition of Unactivated Substrates
Murakami, Masahiro, Ubukata, Minoru, Itami, Kenichiro, Ito, Yoshihiko
Published in Angewandte Chemie International Edition (04.09.1998)
Published in Angewandte Chemie International Edition (04.09.1998)
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Journal Article
Correction to "Optimization Efforts for Identification of Novel Highly Potent Keap1-Nrf2 Protein-Protein Interaction Inhibitors"
Otake, Kazuki, Hara, Yoshinori, Ubukata, Minoru, Inoue, Masafumi, Nagahashi, Noboru, Motoda, Dai, Ogawa, Naoki, Hantani, Yoshiji, Hantani, Rie, Adachi, Tsuyoshi, Nomura, Akihiro, Yamaguchi, Keishi, Maekawa, Mariko, Mamada, Hideaki, Motomura, Takahisa, Sato, Motohide, Harada, Kazuhito
Published in Journal of medicinal chemistry (12.09.2024)
Published in Journal of medicinal chemistry (12.09.2024)
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Journal Article
Fragment-based lead discovery to identify novel inhibitors that target the ATP binding site of pyruvate dehydrogenase kinases
Akaki, Tatsuo, Bessho, Yuki, Ito, Takashi, Fujioka, Shingo, Ubukata, Minoru, Mori, Genki, Yamanaka, Kenji, Orita, Takuya, Doi, Satoki, Iwanaga, Tomoko, Ikegashira, Kazutaka, Hantani, Yoshiji, Nakanishi, Isao, Adachi, Tsuyoshi
Published in Bioorganic & medicinal chemistry (15.08.2021)
Published in Bioorganic & medicinal chemistry (15.08.2021)
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Journal Article
Optimization Efforts for Identification of Novel Highly Potent Keap1-Nrf2 Protein–Protein Interaction Inhibitors
Otake, Kazuki, Hara, Yoshinori, Ubukata, Minoru, Inoue, Masafumi, Nagahashi, Noboru, Motoda, Dai, Ogawa, Naoki, Hantani, Yoshiji, Hantani, Rie, Adachi, Tsuyoshi, Nomura, Akihiro, Yamaguchi, Keishi, Maekawa, Mariko, Mamada, Hideaki, Motomura, Takahisa, Sato, Motohide, Harada, Kazuhito
Published in Journal of medicinal chemistry (14.03.2024)
Published in Journal of medicinal chemistry (14.03.2024)
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Journal Article
Methyl and Fluorine Effects in Novel Orally Bioavailable Keap1–Nrf2 PPI Inhibitor
Otake, Kazuki, Ubukata, Minoru, Nagahashi, Noboru, Ogawa, Naoki, Hantani, Yoshiji, Hantani, Rie, Adachi, Tsuyoshi, Nomura, Akihiro, Yamaguchi, Keishi, Maekawa, Mariko, Mamada, Hideaki, Motomura, Takahisa, Sato, Motohide, Harada, Kazuhito
Published in ACS medicinal chemistry letters (11.05.2023)
Published in ACS medicinal chemistry letters (11.05.2023)
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Journal Article
Lead generation and optimization of novel GPR119 agonists with a spirocyclic cyclohexane structure
Harada, Kazuhito, Mizukami, Jun, Watanabe, Takashi, Mori, Genki, Ubukata, Minoru, Suwa, Katsunori, Fukuda, Sumiaki, Negoro, Tamotsu, Sato, Motohide, Inaba, Takashi
Published in Bioorganic & medicinal chemistry letters (01.02.2019)
Published in Bioorganic & medicinal chemistry letters (01.02.2019)
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Journal Article
Structure-based drug design of novel and highly potent pyruvate dehydrogenase kinase inhibitors
Bessho, Yuki, Akaki, Tatsuo, Hara, Yoshinori, Yamakawa, Maki, Obika, Shingo, Mori, Genki, Ubukata, Minoru, Yasue, Katsutaka, Nakane, Yoshitomi, Terasako, Yasuo, Orita, Takuya, Doi, Satoki, Iwanaga, Tomoko, Fujishima, Ayumi, Adachi, Tsuyoshi, Ueno, Hiroshi, Motomura, Takahisa
Published in Bioorganic & medicinal chemistry (15.12.2021)
Published in Bioorganic & medicinal chemistry (15.12.2021)
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Journal Article
Optimization of oxadiazole derivatives with a spirocyclic cyclohexane structure as novel GPR119 agonists
Harada, Kazuhito, Mizukami, Jun, Watanabe, Takashi, Mori, Genki, Ubukata, Minoru, Suwa, Katsunori, Fukuda, Sumiaki, Negoro, Tamotsu, Sato, Motohide, Inaba, Takashi
Published in Bioorganic & medicinal chemistry letters (15.08.2019)
Published in Bioorganic & medicinal chemistry letters (15.08.2019)
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Journal Article
Discovery of potent liver-selective stearoyl-CoA desaturase-1 (SCD1) inhibitors, thiazole-4-acetic acid derivatives, for the treatment of diabetes, hepatic steatosis, and obesity
Iida, Tetsuya, Ubukata, Minoru, Mitani, Ikuo, Nakagawa, Yuichi, Maeda, Katsuya, Imai, Hiroto, Ogoshi, Yosuke, Hotta, Takahiro, Sakata, Shohei, Sano, Ryuhei, Morinaga, Hisayo, Negoro, Tamotsu, Oshida, Shinichi, Tanaka, Masahiro, Inaba, Takashi
Published in European journal of medicinal chemistry (05.10.2018)
Published in European journal of medicinal chemistry (05.10.2018)
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Journal Article
One-Step Synthesis of Heteroaromatic-Fused Pyrrolidines via Cyclopropane Ring-Opening Reaction: Application to the PKCβ Inhibitor JTT-010
Tanaka, Masahiro, Ubukata, Minoru, Matsuo, Takafumi, Yasue, Katsutaka, Matsumoto, Katsuya, Kajimoto, Yasuyuki, Ogo, Takashi, Inaba, Takashi
Published in Organic letters (16.08.2007)
Published in Organic letters (16.08.2007)
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