Epigenetics and beyond: targeting writers of protein lysine methylation to treat disease
Bhat, Kamakoti P., Ümit Kaniskan, H., Jin, Jian, Gozani, Or
Published in Nature reviews. Drug discovery (01.04.2021)
Published in Nature reviews. Drug discovery (01.04.2021)
Get full text
Journal Article
TF-PROTACs Enable Targeted Degradation of Transcription Factors
Liu, Jing, Chen, He, Kaniskan, H. Ümit, Xie, Ling, Chen, Xian, Jin, Jian, Wei, Wenyi
Published in Journal of the American Chemical Society (16.06.2021)
Published in Journal of the American Chemical Society (16.06.2021)
Get full text
Journal Article
Advancing targeted protein degradation for cancer therapy
Dale, Brandon, Cheng, Meng, Park, Kwang-Su, Kaniskan, H. Ümit, Xiong, Yue, Jin, Jian
Published in Nature reviews. Cancer (01.10.2021)
Published in Nature reviews. Cancer (01.10.2021)
Get full text
Journal Article
Cancer Selective Target Degradation by Folate-Caged PROTACs
Liu, Jing, Chen, He, Liu, Yi, Shen, Yudao, Meng, Fanye, Kaniskan, H. Ümit, Jin, Jian, Wei, Wenyi
Published in Journal of the American Chemical Society (19.05.2021)
Published in Journal of the American Chemical Society (19.05.2021)
Get full text
Journal Article
Artificial intelligence and machine learning‐aided drug discovery in central nervous system diseases: State‐of‐the‐arts and future directions
Vatansever, Sezen, Schlessinger, Avner, Wacker, Daniel, Kaniskan, H. Ümit, Jin, Jian, Zhou, Ming‐Ming, Zhang, Bin
Published in Medicinal research reviews (01.05.2021)
Published in Medicinal research reviews (01.05.2021)
Get full text
Journal Article
TF-DUBTACs Stabilize Tumor Suppressor Transcription Factors
Liu, Jing, Yu, Xufen, Chen, He, Kaniskan, H. Ümit, Xie, Ling, Chen, Xian, Jin, Jian, Wei, Wenyi
Published in Journal of the American Chemical Society (20.07.2022)
Published in Journal of the American Chemical Society (20.07.2022)
Get full text
Journal Article
An MDM2 degrader for treatment of acute leukemias
Marcellino, Bridget K., Yang, Xiaobao, Ümit Kaniskan, H., Brady, Claudia, Chen, He, Chen, Karie, Qiu, Xing, Clementelli, Cara, Herschbein, Lauren, Li, Zhijun, Elghaity-Beckley, Sebastian, Arandela, Joann, Kelly, Brianna, Hoffman, Ronald, Liu, Jing, Xiong, Yue, Jin, Jian, Shih, Alan H.
Published in Leukemia (01.02.2023)
Published in Leukemia (01.02.2023)
Get full text
Journal Article
Selective Inhibitors of Protein Methyltransferases
Kaniskan, H. Ümit, Konze, Kyle D, Jin, Jian
Published in Journal of medicinal chemistry (26.02.2015)
Published in Journal of medicinal chemistry (26.02.2015)
Get full text
Journal Article
Harnessing the E3 Ligase KEAP1 for Targeted Protein Degradation
Wei, Jieli, Meng, Fanye, Park, Kwang-Su, Yim, Hyerin, Velez, Julia, Kumar, Prashasti, Wang, Li, Xie, Ling, Chen, He, Shen, Yudao, Teichman, Emily, Li, Dongxu, Wang, Gang Greg, Chen, Xian, Kaniskan, H. Ümit, Jin, Jian
Published in Journal of the American Chemical Society (22.09.2021)
Published in Journal of the American Chemical Society (22.09.2021)
Get full text
Journal Article
Telomere Targeting Chimera Enables Targeted Destruction of Telomeric Repeat-Binding Factor Proteins
Wang, Zhen, Liu, Jing, Chen, He, Qiu, Xing, Xie, Ling, Kaniskan, H. Ümit, Chen, Xian, Jin, Jian, Wei, Wenyi
Published in Journal of the American Chemical Society (17.05.2023)
Published in Journal of the American Chemical Society (17.05.2023)
Get full text
Journal Article
Chemically induced degradation of epigenetic targets
Kabir, Md, Yu, Xufen, Kaniskan, H. Ümit, Jin, Jian
Published in Chemical Society reviews (03.07.2023)
Published in Chemical Society reviews (03.07.2023)
Get full text
Journal Article
Recent advances in developing degraders & inhibitors of lysine methyltransferases
Velez, Julia, Kaniskan, H. Ümit, Jin, Jian
Published in Current opinion in chemical biology (01.10.2023)
Published in Current opinion in chemical biology (01.10.2023)
Get full text
Journal Article
Acetylation Targeting Chimera Enables Acetylation of the Tumor Suppressor p53
Kabir, Md, Sun, Ning, Hu, Xiaoping, Martin, Tiphaine C., Yi, Jingjie, Zhong, Yue, Xiong, Yan, Kaniskan, H. Ümit, Gu, Wei, Parsons, Ramon, Jin, Jian
Published in Journal of the American Chemical Society (12.07.2023)
Published in Journal of the American Chemical Society (12.07.2023)
Get full text
Journal Article
Discovery of the First Lactate Dehydrogenase Proteolysis Targeting Chimera Degrader for the Treatment of Pancreatic Cancer
Sun, Ning, Kabir, Md, Lee, Youngeun, Xie, Ling, Hu, Xiaoping, Velez, Julia, Chen, Xian, Kaniskan, H. Ümit, Jin, Jian
Published in Journal of medicinal chemistry (12.01.2023)
Published in Journal of medicinal chemistry (12.01.2023)
Get full text
Journal Article
Light-induced control of protein destruction by opto-PROTAC
Liu, Jing, Chen, He, Ma, Leina, He, Zhixiang, Wang, Dong, Liu, Yi, Lin, Qian, Zhang, Tinghu, Gray, Nathanael, Kaniskan, H Ümit, Jin, Jian, Wei, Wenyi
Published in Science advances (21.02.2020)
Published in Science advances (21.02.2020)
Get full text
Journal Article
Discovery of the First-in-Class G9a/GLP PROTAC Degrader
Velez, Julia, Han, Yulin, Yim, Hyerin, Yang, Peiyi, Deng, Zhijie, Park, Kwang-su, Kabir, Md, Kaniskan, H. Ümit, Xiong, Yan, Jin, Jian
Published in Journal of medicinal chemistry (25.04.2024)
Published in Journal of medicinal chemistry (25.04.2024)
Get full text
Journal Article
Structurally Specific Z‑DNA Proteolysis Targeting Chimera Enables Targeted Degradation of Adenosine Deaminase Acting on RNA 1
Wang, Zhen, Zhang, Dingpeng, Qiu, Xing, Inuzuka, Hiroyuki, Xiong, Yan, Liu, Jing, Chen, Li, Chen, He, Xie, Ling, Kaniskan, H. Ümit, Chen, Xian, Jin, Jian, Wei, Wenyi
Published in Journal of the American Chemical Society (20.03.2024)
Published in Journal of the American Chemical Society (20.03.2024)
Get full text
Journal Article
Structure–Activity Relationship Studies for Enhancer of Zeste Homologue 2 (EZH2) and Enhancer of Zeste Homologue 1 (EZH1) Inhibitors
Yang, Xiaobao, Li, Fengling, Konze, Kyle D, Meslamani, Jamel, Ma, Anqi, Brown, Peter J, Zhou, Ming-Ming, Arrowsmith, Cheryl H, Kaniskan, H. Ümit, Vedadi, Masoud, Jin, Jian
Published in Journal of medicinal chemistry (25.08.2016)
Published in Journal of medicinal chemistry (25.08.2016)
Get full text
Journal Article