Comparison of the safety and pharmacokinetics of ST-246® after i.v. infusion or oral administration in mice, rabbits and monkeys
Chen, Yali, Amantana, Adams, Tyavanagimatt, Shanthakumar R, Zima, Daniela, Yan, X Steven, Kasi, Gopi, Weeks, Morgan, Stone, Melialani A, Weimers, William C, Samuel, Peter, Tan, Ying, Jones, Kevin F, Lee, Daniel R, Kickner, Shirley S, Saville, Bradley M, Lauzon, Martin, McIntyre, Alan, Honeychurch, Kady M, Jordan, Robert, Hruby, Dennis E, Leeds, Janet M
Published in PloS one (15.08.2011)
Published in PloS one (15.08.2011)
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A potent Lassa virus antiviral targets an arenavirus virulence determinant
Madu, Ikenna G, Files, Megan, Gharaibeh, Dima N, Moore, Amy L, Jung, Kie-Hoon, Gowen, Brian B, Dai, Dongcheng, Jones, Kevin F, Tyavanagimatt, Shanthakumar R, Burgeson, James R, Korth, Marcus J, Bedard, Kristin M, Iadonato, Shawn P, Amberg, Sean M
Published in PLoS pathogens (01.12.2018)
Published in PLoS pathogens (01.12.2018)
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A Novel Inhibitor of Dengue Virus Replication That Targets the Capsid Protein
Byrd, Chelsea M, Dai, Dongcheng, Grosenbach, Douglas W, Berhanu, Aklile, Jones, Kevin F, Cardwell, Kara B, Schneider, Christine, Wineinger, Kristin A, Page, Jessica M, Harver, Chris, Stavale, Eric, Tyavanagimatt, Shanthakumar, Stone, Melialani A, Bartenschlager, Ralf, Scaturro, Pietro, Hruby, Dennis E, Jordan, Robert
Published in Antimicrobial Agents and Chemotherapy (01.01.2013)
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Novel Benzoxazole Inhibitor of Dengue Virus Replication That Targets the NS3 Helicase
BYRD, Chelsea M, GROSENBACH, Douglas W, WINEINGER, Kristin A, PAGE, Jessica, STAVALE, Eric, STONE, Melialani A, FULLER, Kathleen P, LOVEJOY, Candace, LEEDS, Janet M, HRUBY, Dennis E, JORDAN, Robert, BERHANU, Aklile, DONGCHENG DAI, JONES, Kevin F, CARDWELL, Kara B, SCHNEIDER, Christine, GUANG YANG, TYAVANAGIMATT, Shanthakumar, HARVER, Chris
Published in Antimicrobial Agents and Chemotherapy (01.04.2013)
Published in Antimicrobial Agents and Chemotherapy (01.04.2013)
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Safety and Pharmacokinetics of the Anti-Orthopoxvirus Compound ST-246 following a Single Daily Oral Dose for 14 Days in Human Volunteers
CHINSANGARAM, Jarasvech, HONEYCHURCH, Kady M, ROSS, Eric, LICHTENSTEIN, Israel, PICKENS, Margaret, CORRADO, Michael, CLARKE, Jean M, FRIMM, Annie M, HRUBY, Dennis E, TYAVANAGIMATT, Shanthakumar R, LEEDS, Janet M, BOLKEN, Tove' C, JONES, Kevin F, JORDAN, Robert, MARBURY, Thomas, RUCKLE, Jon, MEE-LEE, Denis
Published in Antimicrobial Agents and Chemotherapy (01.09.2012)
Published in Antimicrobial Agents and Chemotherapy (01.09.2012)
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Development of ST-246® for Treatment of Poxvirus Infections
Jordan, Robert, Leeds, Janet M, Tyavanagimatt, Shanthakumar, Hruby, Dennis E
Published in Viruses (01.11.2010)
Published in Viruses (01.11.2010)
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Book Review
Pharmacokinetics and interspecies allometric scaling of ST-246, an oral antiviral therapeutic for treatment of orthopoxvirus infection
Amantana, Adams, Chen, Yali, Tyavanagimatt, Shanthakumar R, Jones, Kevin F, Jordan, Robert, Chinsangaram, Jarasvech, Bolken, Tove C, Leeds, Janet M, Hruby, Dennis E
Published in PloS one (18.04.2013)
Published in PloS one (18.04.2013)
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ST-246 Antiviral Efficacy in a Nonhuman Primate Monkeypox Model: Determination of the Minimal Effective Dose and Human Dose Justification
JORDAN, Robert, GOFF, Arthur, JOHNSON, Wendy, CHAPMAN, Jennifer, TWENHAFEL, Nancy, TYAVANAGIMATT, Shanthakumar, AMANTANA, Adams, CHINSANGARAM, Jarasvech, HRUBY, Dennis E, HUGGINS, John, FRIMM, Annie, CORRADO, Michael L, HENSLEY, Lisa E, BYRD, Chelsea M, MUCKER, Eric, SHAMBLIN, Josh, BOLKEN, Tove C, WLAZLOWSKI, Carly
Published in Antimicrobial Agents and Chemotherapy (01.05.2009)
Published in Antimicrobial Agents and Chemotherapy (01.05.2009)
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Single-Dose Safety and Pharmacokinetics of ST-246, a Novel Orthopoxvirus Egress Inhibitor
JORDAN, Robert, TIEN, Deborah, BOLKEN, Tove C, JONES, Kevin F, TYAVANAGIMATT, Shanthakumar R, STRASSER, Josef, FRIMM, Annie, CORRADO, Michael L, STROME, Phoebe G, HRUBY, Dennis E
Published in Antimicrobial Agents and Chemotherapy (01.05.2008)
Published in Antimicrobial Agents and Chemotherapy (01.05.2008)
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Pharmacokinetic and Pharmacodynamic Modeling To Determine the Dose of ST-246 To Protect against Smallpox in Humans
LEEDS, Janet M, FENNETEAU, Frederique, CHINSANGARAM, Jarasvech, TYAVANAGIMATT, Shanthakumar R, HRUBY, Dennis E, JORDAN, Robert, GOSSELIN, Nathalie H, MOUKSASSI, Mohamad-Samer, KASSIR, Nastya, MARIER, J. F, YALI CHEN, GROSENBACH, Doug, FRIMM, Annie E, HONEYCHURCH, Kady M
Published in Antimicrobial Agents and Chemotherapy (01.03.2013)
Published in Antimicrobial Agents and Chemotherapy (01.03.2013)
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SAR analysis of a series of acylthiourea derivatives possessing broad-spectrum antiviral activity
Burgeson, James R., Moore, Amy L., Boutilier, Jordan K., Cerruti, Natasha R., Gharaibeh, Dima N., Lovejoy, Candace E., Amberg, Sean M., Hruby, Dennis E., Tyavanagimatt, Shanthakumar R., Allen, Robert D., Dai, Dongcheng
Published in Bioorganic & medicinal chemistry letters (01.07.2012)
Published in Bioorganic & medicinal chemistry letters (01.07.2012)
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Safety and Pharmacokinetics of the Antiorthopoxvirus Compound ST-246 following Repeat Oral Dosing in Healthy Adult Subjects
JORDAN, Robert, CHINSANGARAM, Jarasvech, CLARKE, Jean, MARBURY, Thomas C, HRUBY, Dennis E, BOLKEN, Tove' C, TYAVANAGIMATT, Shanthakumar R, TIEN, Deborah, JONES, Kevin F, FRIMM, Annie, CORRADO, Michael L, PICKENS, Margaret, LANDIS, Patrick
Published in Antimicrobial Agents and Chemotherapy (01.06.2010)
Published in Antimicrobial Agents and Chemotherapy (01.06.2010)
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Pharmacokinetic Comparison of a Single Oral Dose of Polymorph Form I versus Form V Capsules of the Antiorthopoxvirus Compound ST-246 in Human Volunteers
CHINSANGARAM, Jarasvech, HONEYCHURCH, Kady M, LANDIS, Patrick, CLARKE, Jean M, FRIMM, Annie M, HRUBY, Dennis E, TYAVANAGIMATT, Shanthakumar R, BOLKEN, Tove' C, JORDAN, Robert, JONES, Kevin F, MARBURY, Thomas, LICHTENSTEIN, Israel, PICKENS, Margaret, CORRADO, Michael
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Pacritinib Is a Potent ACVR1 Inhibitor with Significant Anemia Benefit in Patients with Myelofibrosis
Oh, Stephen T, Mesa, Ruben, Harrison, Claire, Bose, Prithviraj, Gerds, Aaron T., Heaney, Mark L., Gupta, Vikas, Scott, Bart L., Kiladjian, Jean-Jacques, Lucchesi, Alessandro, Buckley, Sarah, Tyavanagimatt, Shanthakumar, Roman-Torres, Karisse, Mascarenhas, John, Verstovsek, Srdan
Published in Blood (15.11.2022)
Published in Blood (15.11.2022)
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MPN-145 Retrospective Analysis of Anemia Benefit of Pacritinib From the PERSIST-2 Trial
Oh, Stephen, Mesa, Ruben, Harrison, Claire, Bose, Prithviraj, Gerds, Aaron, Gupta, Vikas, Swami, Ashwin, Tyavanagimatt, Shanthakumar, Buckley, Sarah, Roman-Torres, Karisse, Verstovsek, Srdan
Published in Clinical lymphoma, myeloma and leukemia (01.10.2022)
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Poster: MPN-145 Retrospective Analysis of Anemia Benefit of Pacritinib From the PERSIST-2 Trial
Oh, Stephen, Mesa, Ruben, Harrison, Claire, Bose, Prithviraj, Gerds, Aaron, Gupta, Vikas, Swami, Ashwin, Tyavanagimatt, Shanthakumar, Buckley, Sarah, Roman-Torres, Karisse, Verstovsek, Srdan
Published in Clinical lymphoma, myeloma and leukemia (01.10.2022)
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Results of PAC203: A Randomized Phase 2 Dose-Finding Study and Determination of the Recommended Dose of Pacritinib
Gerds, Aaron T., Savona, Michael R., Scott, Bart L., Talpaz, Moshe, Egyed, Miklos, Harrison, Claire N, Yacoub, Abdulraheem, Vannucchi, Alessandro M., Mead, Adam J., O'Sullivan, Jennifer, Buckley, Sarah A, Mould, Diane R., Tyavanagimatt, Shanthakumar, Smith, Jennifer A., Mascarenhas, John
Published in Blood (13.11.2019)
Published in Blood (13.11.2019)
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Determining the recommended dose of pacritinib: results from the PAC203 dose-finding trial in advanced myelofibrosis
Gerds, Aaron T., Savona, Michael R., Scott, Bart L., Talpaz, Moshe, Egyed, Miklos, Harrison, Claire N., Yacoub, Abdulraheem, Vannucchi, Alessandro, Mead, Adam J., Kiladjian, Jean-Jacques, O'Sullivan, Jennifer, García-Gutiérrez, Valentin, Bose, Prithviraj, Rampal, Raajit K., Miller, Carole B., Palmer, Jeanne, Oh, Stephen T., Buckley, Sarah A., Mould, Diane R., Ito, Kaori, Tyavanagimatt, Shanthakumar, Smith, Jennifer A., Roman-Torres, Karisse, Devineni, Sri, Craig, Adam R., Mascarenhas, John O.
Published in Blood advances (24.11.2020)
Published in Blood advances (24.11.2020)
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Pacritinib is a potent ACVR1 inhibitor with significant anemia benefit in patients with myelofibrosis
Oh, Stephen T., Mesa, Ruben A., Harrison, Claire N., Bose, Prithviraj, Gerds, Aaron T., Gupta, Vikas, Scott, Bart L., Kiladjian, Jean-Jacques, Lucchesi, Alessandro, Kong, Tim, Buckley, Sarah A., Tyavanagimatt, Shanthakumar, Harder, Bryan G., Roman-Torres, Karisse, Smith, Jennifer, Craig, Adam R., Mascarenhas, John, Verstovsek, Srdan
Published in Blood advances (10.10.2023)
Published in Blood advances (10.10.2023)
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Small Molecule Functional Converter of B‑Cell Lymphoma‑2 (Bcl-2) Suppresses Breast Cancer Lung Metastasis
Kopparapu, Prasad R., Löhr, Christiane V., Pearce, Martin C., Tyavanagimatt, Shanthakumar, Nakshatri, Harikrishna, Kolluri, Siva K.
Published in ACS pharmacology & translational science (10.05.2024)
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