Development of Potent and Selective Inhibitors of Aldo–Keto Reductase 1C3 (Type 5 17β-Hydroxysteroid Dehydrogenase) Based on N-Phenyl-Aminobenzoates and Their Structure–Activity Relationships
Adeniji, Adegoke O, Twenter, Barry M, Byrns, Michael C, Jin, Yi, Chen, Mo, Winkler, Jeffrey D, Penning, Trevor M
Published in Journal of medicinal chemistry (08.03.2012)
Published in Journal of medicinal chemistry (08.03.2012)
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Journal Article
Total Synthesis of (±)‐Phomoidride D
Leung, Joyce C., Bedermann, Aaron A., Njardarson, Jón T., Spiegel, David A., Murphy, Graham K., Hama, Naoto, Twenter, Barry M., Dong, Ping, Shirahata, Tatsuya, McDonald, Ivar M., Inoue, Munenori, Taniguchi, Nobuaki, McMahon, Travis C., Schneider, Christopher M., Tao, Nancy, Stoltz, Brian M., Wood, John L.
Published in Angewandte Chemie International Edition (12.02.2018)
Published in Angewandte Chemie International Edition (12.02.2018)
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A 3-(4-nitronaphthen-1-yl) amino-benzoate analog as a bifunctional AKR1C3 inhibitor and AR antagonist: Head to head comparison with other advanced AKR1C3 targeted therapeutics
Wangtrakuldee, Phumvadee, Adeniji, Adegoke O., Zang, Tianzhu, Duan, Ling, Khatri, Buddha, Twenter, Barry M., Estrada, Michelle A., Higgins, Tyler F., Winkler, Jeffrey D., Penning, Trevor M.
Published in The Journal of steroid biochemistry and molecular biology (01.09.2019)
Published in The Journal of steroid biochemistry and molecular biology (01.09.2019)
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Journal Article
Crystal structures of AKR1C3 containing an N-(aryl)amino-benzoate inhibitor and a bifunctional AKR1C3 inhibitor and androgen receptor antagonist. Therapeutic leads for castrate resistant prostate cancer
Chen, Mo, Adeniji, Adegoke O., Twenter, Barry M., Winkler, Jeffrey D., Christianson, David W., Penning, Trevor M.
Published in Bioorganic & medicinal chemistry letters (15.05.2012)
Published in Bioorganic & medicinal chemistry letters (15.05.2012)
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Journal Article
Discovery of substituted 3-(phenylamino)benzoic acids as potent and selective inhibitors of type 5 17β-hydroxysteroid dehydrogenase (AKR1C3)
Adeniji, Adegoke O., Twenter, Barry M., Byrns, Michael C., Jin, Yi, Winkler, Jeffrey D., Penning, Trevor M.
Published in Bioorganic & medicinal chemistry letters (01.03.2011)
Published in Bioorganic & medicinal chemistry letters (01.03.2011)
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Journal Article
Toward the Synthesis of Phomoidride D
Murphy, Graham K, Shirahata, Tatsuya, Hama, Naoto, Bedermann, Aaron, Dong, Ping, McMahon, Travis C, Twenter, Barry M, Spiegel, David A, McDonald, Ivar M, Taniguchi, Nobuaki, Inoue, Munenori, Wood, John L
Published in Journal of organic chemistry (18.01.2013)
Published in Journal of organic chemistry (18.01.2013)
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Journal Article
Wharton-Fragmentation-Based Approach to the Carbocyclic Core of the Phomoidrides
Murphy, Graham K, Hama, Naoto, Bedermann, Aaron, Dong, Ping, Schneider, Chris M, McMahon, Travis C, Tao, Ran N, Twenter, Barry M, Spiegel, David A, Wood, John L
Published in Organic letters (07.09.2012)
Published in Organic letters (07.09.2012)
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Regiocontrolled synthesis and HIV inhibitory activity of unsymmetrical binaphthoquinone and trimeric naphthoquinone derivatives of conocurvone
Stagliano, Kenneth W., Emadi, Ashkan, Lu, Zhenhai, Malinakova, Helena C., Twenter, Barry, Yu, Min, Holland, Louis E., Rom, Amanda M., Harwood, John S., Amin, Ronak, Johnson, Allison A., Pommier, Yves
Published in Bioorganic & medicinal chemistry (15.08.2006)
Published in Bioorganic & medicinal chemistry (15.08.2006)
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Journal Article
Total Synthesis of (±)‐Phomoidride D
Leung, Joyce C., Bedermann, Aaron A., Njardarson, Jón T., Spiegel, David A., Murphy, Graham K., Hama, Naoto, Twenter, Barry M., Dong, Ping, Shirahata, Tatsuya, McDonald, Ivar M., Inoue, Munenori, Taniguchi, Nobuaki, McMahon, Travis C., Schneider, Christopher M., Tao, Nancy, Stoltz, Brian M., Wood, John L.
Published in Angewandte Chemie (12.02.2018)
Published in Angewandte Chemie (12.02.2018)
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Journal Article
A 3-(4-Nitronaphthen-1-yl) amino-benzoate analog as a Bifunctional AKR1C3 Inhibitor with AR Antagonist Activity: Head to Head Comparison with Other Advanced AKR1C3 Targeted Therapeutics
Wangtrakuldee, Phumvadee, Adeniji, Adegoke O., Zang, Tianzhu, Duan, Ling, Khatri, Buddha, Twenter, Barry M., Estrada, Michelle A., Higgins, Tyler F., Winkler, Jeffrey D., Penning, Trevor M.
Published in The Journal of steroid biochemistry and molecular biology (11.01.2019)
Published in The Journal of steroid biochemistry and molecular biology (11.01.2019)
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Journal Article
Bifunctional AKR1C3 inhibitors/androgen receptor modulators and methods of use thereof
Penning, Trevor M, Twenter, Barry, Adeniji, Adegoke O, Winkler, Jeffrey, Byrns, Michael C
Year of Publication 11.09.2018
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Year of Publication 11.09.2018
Patent
Bifunctional AKR1C3 Inhibitors/Androgen Receptor Modulators and Methods of Use Thereof
ADENIJI ADEGOKE O, BURNS MICHAEL C, TWENTER BARRY, PENNING TREVOR M, WINKLER JEFFREY
Year of Publication 09.06.2016
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Year of Publication 09.06.2016
Patent
Bifunctional AKR1C3 inhibitors/androgen receptor modulators and methods of use thereof
ADENIJI ADEGOKE O, BURNS MICHAEL C, TWENTER BARRY, PENNING TREVOR M, WINKLER JEFFREY
Year of Publication 01.03.2016
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Year of Publication 01.03.2016
Patent
Bifunctional AKR1C3 Inhibitors/Androgen Receptor Modulators and Methods of Use Thereof
ADENIJI ADEGOKE O, BURNS MICHAEL C, TWENTER BARRY, PENNING TREVOR M, WINKLER JEFFREY
Year of Publication 17.04.2014
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Year of Publication 17.04.2014
Patent
BIFUNCTIONAL AKR1C3 INHIBITORS/ANDROGEN RECEPTOR MODULATORS AND METHODS OF USE THEREOF
WINKLER, JEFFREY, BYRNS, MICHAEL, C, TWENTER, BARRY, PENNING, TREVOR, M, ADENIJI, ADEGOKE, O
Year of Publication 18.10.2012
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Year of Publication 18.10.2012
Patent