Bacterial amyloid curli acts as a carrier for DNA to elicit an autoimmune response via TLR2 and TLR9
Tursi, Sarah A, Lee, Ernest Y, Medeiros, Nicole J, Lee, Michael H, Nicastro, Lauren K, Buttaro, Bettina, Gallucci, Stefania, Wilson, Ronald Paul, Wong, Gerard C L, Tükel, Çagla
Published in PLoS pathogens (14.04.2017)
Published in PLoS pathogens (14.04.2017)
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Journal Article
Salmonella Typhimurium biofilm disruption by a human antibody that binds a pan-amyloid epitope on curli
Tursi, Sarah A, Puligedda, Rama Devudu, Szabo, Paul, Nicastro, Lauren K, Miller, Amanda L, Qiu, Connie, Gallucci, Stefania, Relkin, Norman R, Buttaro, Bettina A, Dessain, Scott K, Tükel, Çagla
Published in Nature communications (21.02.2020)
Published in Nature communications (21.02.2020)
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Journal Article
In vivo synthesis of bacterial amyloid curli contributes to joint inflammation during S. Typhimurium infection
Miller, Amanda L, Pasternak, J. Alex, Medeiros, Nicole J, Nicastro, Lauren K, Tursi, Sarah A, Hansen, Elizabeth G, Krochak, Ryan, Sokaribo, Akosiererem S, MacKenzie, Keith D, Palmer, Melissa B, Herman, Dakoda J, Watson, Nikole L, Zhang, Yi, Wilson, Heather L, Wilson, R. Paul, White, Aaron P, Tükel, Çagla, Knodler, Leigh, Tsolis, Renée M
Published in PLoS pathogens (09.07.2020)
Published in PLoS pathogens (09.07.2020)
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Journal Article
STAT2 dependent Type I Interferon response promotes dysbiosis and luminal expansion of the enteric pathogen Salmonella Typhimurium
Wilson, R Paul, Tursi, Sarah A, Rapsinski, Glenn J, Medeiros, Nicole J, Le, Long S, Kotredes, Kevin P, Patel, Sajan, Liverani, Elisabetta, Sun, Shuang, Zhu, Wenhan, Kilpatrick, Laurie, Winter, Sebastian E, Gamero, Ana M, Tükel, Çagla
Published in PLoS pathogens (01.04.2019)
Published in PLoS pathogens (01.04.2019)
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Journal Article
Phenol-Soluble Modulins From Staphylococcus aureus Biofilms Form Complexes With DNA to Drive Autoimmunity
Grando, Kaitlyn, Nicastro, Lauren K, Tursi, Sarah A, De Anda, Jaime, Lee, Ernest Y, Wong, Gerard C L, Tükel, Çağla
Published in Frontiers in cellular and infection microbiology (11.05.2022)
Published in Frontiers in cellular and infection microbiology (11.05.2022)
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Journal Article
Persistent Bacteriuria and Antibodies Recognizing Curli/eDNA Complexes From Escherichia coli Are Linked to Flares in Systemic Lupus Erythematosus
Pachucki, Ryan J., Corradetti, Chelsea, Kohler, Lynne, Ghadiali, Jay, Gallo, Paul M., Nicastro, Lauren, Tursi, Sarah A., Gallucci, Stefania, Tükel, Çagla, Caricchio, Roberto
Published in Arthritis & rheumatology (Hoboken, N.J.) (01.11.2020)
Published in Arthritis & rheumatology (Hoboken, N.J.) (01.11.2020)
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Journal Article
Cytotoxic Curli Intermediates Form during Salmonella Biofilm Development
Nicastro, Lauren K, Tursi, Sarah A, Le, Long S, Miller, Amanda L, Efimov, Andrey, Buttaro, Bettina, Tam, Vincent, Tükel, Çağla
Published in Journal of bacteriology (15.09.2019)
Published in Journal of bacteriology (15.09.2019)
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Journal Article
Protein kinase C-delta inhibition is organ-protective, enhances pathogen clearance, and improves survival in sepsis
Liverani, Elisabetta, Tursi, Sarah A, Cornwell, William D, Mondrinos, Mark J, Sun, Shuang, Buttaro, Bettina A, Wolfson, Marla R, Rogers, Thomas J, Tükel, Çagla, Kilpatrick, Laurie E
Published in The FASEB journal (01.02.2020)
Published in The FASEB journal (01.02.2020)
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Journal Article
1701 Curli amyloid/DNA complexes from bacterial biofilms break tolerance in murine lupus using T cell-independent and T cell-dependent modalities
Lee, Michael H, Tursi, Sarah A, Nicastro, Lauren K, Green, Benjamin L, Caricchio, Roberto, Tükel, Çagla, Gallucci, Stefania
Published in Lupus science & medicine (04.11.2021)
Published in Lupus science & medicine (04.11.2021)
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Journal Article
Biofilm-associated bacterial amyloids dampen inflammation in the gut: oral treatment with curli fibres reduces the severity of hapten-induced colitis in mice
Oppong, Gertrude O, Rapsinski, Glenn J, Tursi, Sarah A, Biesecker, Steven G, Klein-Szanto, Andres Jp, Goulian, Mark, McCauley, Christine, Healy, Catherine, Wilson, R Paul, Tükel, Cagla
Published in NPJ biofilms and microbiomes (14.10.2015)
Published in NPJ biofilms and microbiomes (14.10.2015)
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Journal Article
Persistent Bacteriuria and Antibodies recognizing Curli/eDNA complexes from E. coli are Linked to Flares in Systemic Lupus Erythematosus
Pachucki, Ryan J., Corradetti, Chelsea, Kohler, Lynne, Ghadiali, Jay, Gallo, Paul M., Nicastro, Lauren, Tursi, Sarah A., Gallucci, Stefania, Tükel, Çagla, Caricchio, Roberto
Published in Arthritis & rheumatology (Hoboken, N.J.) (11.10.2020)
Published in Arthritis & rheumatology (Hoboken, N.J.) (11.10.2020)
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Journal Article
Bacterial amyloids from biofilms break tolerance in lupus
Lee, Michael Hweemoon, Tursi, Sarah A, Green, Benjamin L, Caricchio, Roberto, Tükel, Çagla, Gallucci, Stefania
Published in The Journal of immunology (1950) (01.05.2017)
Published in The Journal of immunology (1950) (01.05.2017)
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Journal Article
AI-27 Bacterial amyloids from biofilms break tolerance in lupus
Lee, Michael H, Tursi, Sarah A, Green, Benjamin L, Pachucki, Ryan J, Caricchio, Roberto, Tukel, Cagla, Gallucci, Stefania
Published in Lupus science & medicine (01.09.2016)
Published in Lupus science & medicine (01.09.2016)
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Journal Article