Mild Method for Succinimide Hydrolysis on ADCs: Impact on ADC Potency, Stability, Exposure, and Efficacy
Tumey, L. Nathan, Charati, Manoj, He, Tao, Sousa, Eric, Ma, Dangshe, Han, Xiaogang, Clark, Tracey, Casavant, Jeff, Loganzo, Frank, Barletta, Frank, Lucas, Judy, Graziani, Edmund I
Published in Bioconjugate chemistry (15.10.2014)
Published in Bioconjugate chemistry (15.10.2014)
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Journal Article
Visualizing drug-induced lipid accumulation in lysosomes of live cancer cells with stimulated Raman imaging
Yuan, Yuhao, Olawode, Emmanuel O, Tumey, L Nathan, Lu, Fake
Published in Biomedical optics express (01.06.2023)
Published in Biomedical optics express (01.06.2023)
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Journal Article
PF-06804103, A Site-specific Anti-HER2 Antibody–Drug Conjugate for the Treatment of HER2-expressing Breast, Gastric, and Lung Cancers
Graziani, Edmund I., Sung, Matthew, Ma, Dangshe, Narayanan, Bitha, Marquette, Kimberly, Puthenveetil, Sujiet, Tumey, L. Nathan, Bikker, Jack, Casavant, Jeffrey, Bennett, Eric M., Charati, Manoj B., Golas, Jonathon, Hosselet, Christine, Rohde, Cynthia M., Hu, George, Guffroy, Magali, Falahatpisheh, Hadi, Finkelstein, Martin, Clark, Tracey, Barletta, Frank, Tchistiakova, Lioudmila, Lucas, Judy, Rosfjord, Edward, Loganzo, Frank, O'Donnell, Christopher J., Gerber, Hans-Peter, Sapra, Puja
Published in Molecular cancer therapeutics (01.10.2020)
Published in Molecular cancer therapeutics (01.10.2020)
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Journal Article
Evaluation of an ester-linked immunosuppressive payload: A case study in understanding the stability and cleavability of ester-containing ADC linkers
Jackson, Courtney P., Fang, Siteng, Benjamin, Samantha R., Alayi, Tchilabalo, Hathout, Yetrib, Gillen, Sarah M., Handel, Jillian P., Brems, Brittany M., Howe, Justin M., Nathan Tumey, L.
Published in Bioorganic & medicinal chemistry letters (01.11.2022)
Published in Bioorganic & medicinal chemistry letters (01.11.2022)
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Journal Article
Development of Highly Optimized Antibody-Drug Conjugates against CD33 and CD123 for Acute Myeloid Leukemia
Han, Yoon-Chi, Kahler, Jennifer, Piché-Nicholas, Nicole, Hu, Wenyue, Thibault, Stephane, Jiang, Fan, Leal, Mauricio, Katragadda, Madan, Maderna, Andreas, Dushin, Russell, Prashad, Nadira, Charati, Manoj B, Clark, Tracey, Tumey, L Nathan, Tan, Xingzhi, Giannakou, Andreas, Rosfjord, Edward, Gerber, Hans-Peter, Tchistiakova, Lioudmila, Loganzo, Frank, O'Donnell, Christopher J, Sapra, Puja
Published in Clinical cancer research (15.01.2021)
Published in Clinical cancer research (15.01.2021)
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Journal Article
Multivalent peptidic linker enables identification of preferred sites of conjugation for a potent thialanstatin antibody drug conjugate
Puthenveetil, Sujiet, He, Haiyin, Loganzo, Frank, Musto, Sylvia, Teske, Jesse, Green, Michael, Tan, Xingzhi, Hosselet, Christine, Lucas, Judy, Tumey, L Nathan, Sapra, Puja, Subramanyam, Chakrapani, O'Donnell, Christopher J, Graziani, Edmund I
Published in PloS one (30.05.2017)
Published in PloS one (30.05.2017)
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Journal Article
Optimization of Tubulysin Antibody–Drug Conjugates: A Case Study in Addressing ADC Metabolism
Tumey, L. Nathan, Leverett, Carolyn A, Vetelino, Beth, Li, Fengping, Rago, Brian, Han, Xiaogang, Loganzo, Frank, Musto, Sylvia, Bai, Guoyun, Sukuru, Sai Chetan K, Graziani, Edmund I, Puthenveetil, Sujiet, Casavant, Jeffrey, Ratnayake, Anokha, Marquette, Kimberly, Hudson, Sarah, Doppalapudi, Venkata Ramana, Stock, Joseph, Tchistiakova, Lioudmila, Bessire, Andrew J, Clark, Tracey, Lucas, Judy, Hosselet, Christine, O’Donnell, Christopher J, Subramanyam, Chakrapani
Published in ACS medicinal chemistry letters (10.11.2016)
Published in ACS medicinal chemistry letters (10.11.2016)
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Journal Article
Natural Product Bis-Intercalator Depsipeptides as a New Class of Payloads for Antibody–Drug Conjugates
Ratnayake, Anokha S, Chang, Li-ping, Tumey, L. Nathan, Loganzo, Frank, Chemler, Joseph A, Wagenaar, Melissa, Musto, Sylvia, Li, Fengping, Janso, Jeffrey E, Ballard, T. Eric, Rago, Brian, Steele, Greg L, Ding, WeiDong, Feng, Xidong, Hosselet, Christine, Buklan, Vlad, Lucas, Judy, Koehn, Frank E, O’Donnell, Christopher J, Graziani, Edmund I
Published in Bioconjugate chemistry (16.01.2019)
Published in Bioconjugate chemistry (16.01.2019)
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Journal Article
Molecular Validation of LpxC as an Antibacterial Drug Target in Pseudomonas aeruginosa
MDLULI, Khisimuzi E, WITTE, Pamela R, RAETZ, Christian R. H, KENDALL STOVER, C, KLINE, Toni, BARB, Adam W, ERWIN, Alice L, MANSFIELD, Bryce E, MCCLERREN, Amanda L, PIRRUNG, Michael C, NATHAN TUMEY, L, WARRENER, Paul
Published in Antimicrobial Agents and Chemotherapy (01.06.2006)
Published in Antimicrobial Agents and Chemotherapy (01.06.2006)
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Journal Article
Where Did the Linker-Payload Go? A Quantitative Investigation on the Destination of the Released Linker-Payload from an Antibody-Drug Conjugate with a Maleimide Linker in Plasma
Wei, Cong, Zhang, Guodong, Clark, Tracey, Barletta, Frank, Tumey, L. Nathan, Rago, Brian, Hansel, Steven, Han, Xiaogang
Published in Analytical chemistry (Washington) (03.05.2016)
Published in Analytical chemistry (Washington) (03.05.2016)
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Journal Article
High-Throughput Catch-and-Release Synthesis of Oxazoline Hydroxamates. Structure−Activity Relationships in Novel Inhibitors of Escherichia coli LpxC: In Vitro Enzyme Inhibition and Antibacterial Properties
PIRRUNG, Michael C., TUMEY, L. Nathan, MCCLERREN, Amanda L., RAETZ, Christian R. H.
Published in Journal of the American Chemical Society (12.02.2003)
Published in Journal of the American Chemical Society (12.02.2003)
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Journal Article
Enzyme-Agnostic Lysosomal Screen Identifies New Legumain-Cleavable ADC Linkers
Miller, Jared T, Vitro, Caitlin N, Fang, Siteng, Benjamin, Samantha R, Tumey, L. Nathan
Published in Bioconjugate chemistry (21.04.2021)
Published in Bioconjugate chemistry (21.04.2021)
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Journal Article
Inhibition of the Antibacterial Target UDP-(3-O-acyl)-N-acetylglucosamine Deacetylase (LpxC): Isoxazoline Zinc Amidase Inhibitors Bearing Diverse Metal Binding Groups
Pirrung, Michael C, Tumey, L. Nathan, Raetz, Christian R. H, Jackman, Jane E, Snehalatha, Karnem, McClerren, Amanda L, Fierke, Carol A, Gantt, Stephanie L, Rusche, Kristin M
Published in Journal of medicinal chemistry (12.09.2002)
Published in Journal of medicinal chemistry (12.09.2002)
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Journal Article
The identification and optimization of a N-hydroxy urea series of flap endonuclease 1 inhibitors
Tumey, L. Nathan, Bom, David, Huck, Bayard, Gleason, Elizabeth, Wang, Jianmin, Silver, Daniel, Brunden, Kurt, Boozer, Sherry, Rundlett, Stephen, Sherf, Bruce, Murphy, Steven, Dent, Tom, Leventhal, Christina, Bailey, Andrew, Harrington, John, Bennani, Youssef L.
Published in Bioorganic & medicinal chemistry letters (17.01.2005)
Published in Bioorganic & medicinal chemistry letters (17.01.2005)
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Journal Article
Development of Solid-Phase Site-Specific Conjugation and Its Application toward Generation of Dual Labeled Antibody and Fab Drug Conjugates
Puthenveetil, Sujiet, Musto, Sylvia, Loganzo, Frank, Tumey, L. Nathan, O’Donnell, Christopher J, Graziani, Edmund
Published in Bioconjugate chemistry (20.04.2016)
Published in Bioconjugate chemistry (20.04.2016)
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Journal Article