Potent, selective, and orally active adenosine A2A receptor antagonists : Arylpiperazine derivatives of pyrazolo[4,3-e]-1,2,4-triazolo[1 ,5-c]pyrimidines
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Published in Bioorganic & medicinal chemistry letters (01.03.2007)
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The Anxiolytic-Like Effects of the Novel, Orally Active Nociceptin Opioid Receptor Agonist 8-[bis(2-Methylphenyl)methyl]-3-phenyl-8-azabicyclo[3.2.1]octan-3-ol (SCH 221510)
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Published in The Journal of pharmacology and experimental therapeutics (01.08.2008)
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6-(2-Furanyl)-9H-purin-2-amine derivatives as A2A adenosine antagonists
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Published in Bioorganic & medicinal chemistry letters (15.04.2005)
Published in Bioorganic & medicinal chemistry letters (15.04.2005)
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Synthesis and SAR development of novel P2X₇ receptor antagonists for the treatment of pain: Part 2
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Published in Bioorganic & medicinal chemistry letters (15.12.2011)
Published in Bioorganic & medicinal chemistry letters (15.12.2011)
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Pharmacological profile of the NOP agonist and cough suppressing agent SCH 486757 (8-[Bis(2-Chlorophenyl)Methyl]-3-(2-Pyrimidinyl)-8-Azabicyclo[3.2.1]Octan-3-Ol) in preclinical models
McLeod, Robbie L., Tulshian, Deen B., Bolser, Donald C., Varty, Geoffrey B., Baptista, Marco, Fernandez, Xiomara, Parra, Leonard E., Zimmer, Jennifer C., Erickson, Christine H., Ho, Ginny D., Jia, Yanlin, Ng, Fay W., Korfmacher, Walter, Xu, Xiaoying, Veals, John, Smith-Torhan, April, Wainhaus, Samuel, Fawzi, Ahmad B., Austin, Theodore M., van Heek, Margaret, Hey, John A.
Published in European journal of pharmacology (25.03.2010)
Published in European journal of pharmacology (25.03.2010)
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The discovery and synthesis of novel adenosine receptor (A 2A) antagonists
Matasi, Julius J., Caldwell, John P., Hao, Jinsong, Neustadt, Bernard, Arik, Leyla, Foster, Carolyn J., Lachowicz, Jean, Tulshian, Deen B.
Published in Bioorganic & medicinal chemistry letters (01.03.2005)
Published in Bioorganic & medicinal chemistry letters (01.03.2005)
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Discovery of Orally Active 3-Pyridinyl-tropane As a Potent Nociceptin Receptor Agonist for the Management of Cough
Yang, Shu-Wei, Ho, Ginny, Tulshian, Deen, Greenlee, William J, Anthes, John, Fernandez, Xiomara, McLeod, Robbie L, Hey, John A, Xu, Xiaoying
Published in Journal of medicinal chemistry (10.09.2009)
Published in Journal of medicinal chemistry (10.09.2009)
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Synthesis and structure–activity relationships of N-substituted spiropiperidines as nociceptin receptor ligands: Part 2
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Published in Bioorganic & medicinal chemistry letters (15.02.2009)
Published in Bioorganic & medicinal chemistry letters (15.02.2009)
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The discovery of tropane derivatives as nociceptin receptor ligands for the management of cough and anxiety
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Published in Bioorganic & medicinal chemistry letters (01.05.2009)
Published in Bioorganic & medicinal chemistry letters (01.05.2009)
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Nociceptin inhibits cough in the guinea‐pig by activation of ORL1 receptors
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Published in British journal of pharmacology (01.03.2001)
Published in British journal of pharmacology (01.03.2001)
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2-(2-Furanyl)-7-phenyl[1,2,4]triazolo[1,5-c]pyrimidin-5-amine analogs: highly potent, orally active, adenosine A2A antagonists. Part 1
Matasi, Julius J, Caldwell, John P, Zhang, Hongtao, Fawzi, Ahmad, Cohen-Williams, Mary E, Varty, Geoffrey B, Tulshian, Deen B
Published in Bioorganic & medicinal chemistry letters (15.08.2005)
Published in Bioorganic & medicinal chemistry letters (15.08.2005)
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3H-[1,2,4] -Triazolo[5,1-i]purin -5 -amine derivatives as adenosine A2A antagonists
SILVERMAN, Lisa S, CALDWELL, John P, ONGINI, Ennio, GREENLEE, William J, KISELGOF, Eugenia, MATASI, Julius J, TULSHIAN, Deen B, ARIK, Leyla, FOSTER, Carolyn, BERTORELLI, Rosalia, MONOPOLI, Angela
Published in Bioorganic & medicinal chemistry letters (15.03.2007)
Published in Bioorganic & medicinal chemistry letters (15.03.2007)
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Antitussive action of nociceptin in the cat
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Published in European journal of pharmacology (26.10.2001)
Published in European journal of pharmacology (26.10.2001)
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SCH-202676: An Allosteric Modulator of Both Agonist and Antagonist Binding to G Protein-Coupled Receptors
Fawzi, A B, Macdonald, D, Benbow, L L, Smith-Torhan, A, Zhang, H, Weig, B C, Ho, G, Tulshian, D, Linder, M E, Graziano, M P
Published in Molecular pharmacology (01.01.2001)
Published in Molecular pharmacology (01.01.2001)
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Effect of a Novel NOP Receptor Agonist (SCH 225288) on Guinea Pig Irritant-Evoked, Feline Mechanically Induced and Canine Infectious Tracheobronchitis Cough
McLeod, Robbie L., Tulshian, Deen B., Ho, Ginny D., Fernandez, Xiomara, Bolser, Donald C., Parra, Leonard E., Zimmer, Jennifer C., Erickson, Christine H., Fawzi, Ahmad B., Jayappa, Huchappa, Lehr, Craig, Erskine, Jason, Smith-Torhan, April, Zhang, Hongtao, Hey, John A.
Published in Pharmacology (01.01.2009)
Published in Pharmacology (01.01.2009)
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2-(2-Furanyl)-7-phenyl[1,2,4]triazolo[1,5-c]pyrimidin-5-amine analogs as adenosine A2A antagonists: the successful reduction of hERG activity. Part 2
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Published in Bioorganic & medicinal chemistry letters (15.08.2005)
Published in Bioorganic & medicinal chemistry letters (15.08.2005)
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Antitussive Effect of Nociceptin/Orphanin FQ in Experimental Cough Models
McLeod, Robbie L., Bolser, Donald C., Jia, Yanlin, Parra, Leonard E., Mutter, Jennifer C., Wang, Xin, Tulshian, Deen B., Egan, Robert W., Hey, John A.
Published in Pulmonary Pharmacology & Therapeutics (01.01.2002)
Published in Pulmonary Pharmacology & Therapeutics (01.01.2002)
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Book Review
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Antitussive Profile of the NOP Agonist Ro-64-6198 in the Guinea Pig
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Published in Pharmacology (01.07.2004)
Published in Pharmacology (01.07.2004)
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