Multi attribute method implementation using a High Resolution Mass Spectrometry platform: From sample preparation to batch analysis
Carvalho, Sofia B, Gomes, Ricardo A, Pfenninger, Anja, Fischer, Martina, Strotbek, Michaela, Isidro, Inês A, Tugçu, Nihal, Gomes-Alves, Patrícia
Published in PloS one (27.01.2022)
Published in PloS one (27.01.2022)
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Journal Article
Definition and dynamic control of a continuous chromatography process independent of cell culture titer and impurities
Chmielowski, Rebecca A., Mathiasson, Linda, Blom, Hans, Go, Daniel, Ehring, Hanno, Khan, Heera, Li, Hong, Cutler, Collette, Lacki, Karol, Tugcu, Nihal, Roush, David
Published in Journal of Chromatography A (01.12.2017)
Published in Journal of Chromatography A (01.12.2017)
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Journal Article
Accurate and Rapid Protein Concentration Measurement of In‐Process, High Concentration Protein Pools
McKechnie, William S., Tugcu, Nihal, Kandula, Sunitha
Published in Biotechnology progress (01.09.2018)
Published in Biotechnology progress (01.09.2018)
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Journal Article
Impact of Freeze/Thaw Process on Drug Substance Storage of Therapeutics
Rayfield, William J., Kandula, Sunitha, Khan, Heera, Tugcu, Nihal
Published in Journal of pharmaceutical sciences (01.08.2017)
Published in Journal of pharmaceutical sciences (01.08.2017)
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Journal Article
Salting-In and Salting-Out of Hydrophobic Solutes in Aqueous Salt Solutions
Kalra, Amrit, Tugcu, Nihal, Cramer, Steven M, Garde, Shekhar
Published in The journal of physical chemistry. B (12.07.2001)
Published in The journal of physical chemistry. B (12.07.2001)
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Journal Article
Special Issue on “Recovery of Biological Products: Past, Present, Future”
Farid, Suzanne S., Tugcu, Nihal, Staby, Arne
Published in Biotechnology and bioengineering (01.08.2024)
Published in Biotechnology and bioengineering (01.08.2024)
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Journal Article
Pilot‐scale demonstration of an end‐to‐end integrated and continuous biomanufacturing process
Coolbaugh, Michael J., Varner, Chad T., Vetter, Tarl A., Davenport, Emily K., Bouchard, Brad, Fiadeiro, Marcus, Tugcu, Nihal, Walther, Jason, Patil, Rohan, Brower, Kevin
Published in Biotechnology and bioengineering (01.09.2021)
Published in Biotechnology and bioengineering (01.09.2021)
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Journal Article
Cation exchange as a single polishing step for conjugated peptides
Rockwell, Lauren, Bao, Haiying, Insaidoo, Francis, Ikechukwu, Ijeoma, Tugcu, Nihal, Kandula, Sunitha
Published in Biotechnology progress (01.05.2022)
Published in Biotechnology progress (01.05.2022)
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Journal Article
Quantitative assessment of environmental impact of biologics manufacturing using process mass intensity analysis
Madabhushi, Sri R., Gavin, John, Xu, Sen, Cutler, Collette, Chmielowski, Rebecca, Rayfield, William, Tugcu, Nihal, Chen, Hao
Published in Biotechnology progress (01.11.2018)
Published in Biotechnology progress (01.11.2018)
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Journal Article
Multi-angle light scattering as a process analytical technology measuring real-time molecular weight for downstream process control
Patel, Bhumit A., Gospodarek, Adrian, Larkin, Michael, Kenrick, Sophia A., Haverick, Mark A., Tugcu, Nihal, Brower, Mark A., Richardson, Douglas D.
Published in mAbs (03.10.2018)
Published in mAbs (03.10.2018)
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Journal Article
Retrospective assessment of clonality of a legacy cell line by analytical subcloning of the master cell bank
Li, Guanghua (Benson), Pollard, Jennifer, Liu, Ren, Stevens, Richard C., Quiroz, Jorge, Nelson, Michael C., Manahan, Matthew, Murgolo, Nicholas, Ehrick, Robin S., Wallenstein, Eric J., Hughes, Jason, Tsao, Yung‐shyeng, Zhao, Jia, Du, Zhimei, Tugcu, Nihal, Pollard, David
Published in Biotechnology progress (01.01.2022)
Published in Biotechnology progress (01.01.2022)
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Journal Article
Highland games: A benchmarking exercise in predicting biophysical and drug properties of monoclonal antibodies from amino acid sequences
Coffman, Jonathan, Marques, Bruno, Orozco, Raquel, Aswath, Minni, Mohammad, Hasan, Zimmermann, Eike, Khouri, Joelle, Griesbach, Jan, Izadi, Saeed, Williams, Ambrose, Sankar, Kannan, Walters, Benjamin, Lin, Jasper, Hepbildikler, Stefan, Schiel, John, Welsh, John, Ferreira, Gisela, Delmar, Jared, Mody, Neil, Afdahl, Christopher, Cui, Tingting, Khalaf, Rushd, Hanke, Alexander, Pampel, Lars, Parimal, Siddharth, Hong, Xuan, Patil, Ujwal, Pollard, Jennifer, Insaidoo, Francis, Robinson, Julie, Chandra, Divya, Blanco, Marco, Panchal, Jainik, Soundararajan, Soundara, Roush, David, Tugcu, Nihal, Cramer, Steven, Haynes, Charles, Willson, Richard C.
Published in Biotechnology and bioengineering (01.07.2020)
Published in Biotechnology and bioengineering (01.07.2020)
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Journal Article
High throughput chromatography strategies for potential use in the formal process characterization of a monoclonal antibody
Petroff, Matthew G., Bao, Haiying, Welsh, John P., van Beuningen - de Vaan, Miranda, Pollard, Jennifer M., Roush, David J., Kandula, Sunitha, Machielsen, Peter, Tugcu, Nihal, Linden, Thomas O.
Published in Biotechnology and bioengineering (01.06.2016)
Published in Biotechnology and bioengineering (01.06.2016)
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Journal Article
Maximizing productivity of chromatography steps for purification of monoclonal antibodies
Tugcu, Nihal, Roush, David J, Göklen, Kent E
Published in Biotechnology and bioengineering (15.02.2008)
Published in Biotechnology and bioengineering (15.02.2008)
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Journal Article
Proceedings of the 2009 Viral Clearance Symposium
Miesegaes, G, Bailey, M, Willkommen, H, Chen, Q, Roush, D, Blümel, J, Brorson, K
Published in Developments in biologicals (2010)
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Published in Developments in biologicals (2010)
Journal Article
Identification of Chemically Selective Displacers Using Parallel Batch Screening Experiments and Quantitative Structure Efficacy Relationship Models
Tugcu, Nihal, Ladiwala, Asif, Breneman, Curt M, Cramer, Steven M
Published in Analytical chemistry (Washington) (01.11.2003)
Published in Analytical chemistry (Washington) (01.11.2003)
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Journal Article
Prediction of Protein Retention Times in Anion-Exchange Chromatography Systems Using Support Vector Regression
Song, Minghu, Breneman, Curt M, Bi, Jinbo, Sukumar, N, Bennett, Kristin P, Cramer, Steven, Tugcu, Nihal
Published in Journal of Chemical Information and Computer Sciences (01.11.2002)
Published in Journal of Chemical Information and Computer Sciences (01.11.2002)
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Journal Article