Functional disruption of the dystrophin gene in rhesus monkey using CRISPR/Cas9
Chen, Yongchang, Zheng, Yinghui, Kang, Yu, Yang, Weili, Niu, Yuyu, Guo, Xiangyu, Tu, Zhuchi, Si, Chenyang, Wang, Hong, Xing, Ruxiao, Pu, Xiuqiong, Yang, Shang-Hsun, Li, Shihua, Ji, Weizhi, Li, Xiao-Jiang
Published in Human molecular genetics (01.07.2015)
Published in Human molecular genetics (01.07.2015)
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Journal Article
Promoting Cas9 degradation reduces mosaic mutations in non-human primate embryos
Tu, Zhuchi, Yang, Weili, Yan, Sen, Yin, An, Gao, Jinquan, Liu, Xudong, Zheng, Yinghui, Zheng, Jiezhao, Li, Zhujun, Yang, Su, Li, Shihua, Guo, Xiangyu, Li, Xiao-Jiang
Published in Scientific reports (03.02.2017)
Published in Scientific reports (03.02.2017)
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Journal Article
CRISPR/Cas9-mediated PINK1 deletion leads to neurodegeneration in rhesus monkeys
Yang, Weili, Liu, Yunbo, Tu, Zhuchi, Xiao, Chong, Yan, Sen, Ma, Xishan, Guo, Xiangyu, Chen, Xiusheng, Yin, Peng, Yang, Zhengyi, Yang, Su, Jiang, Tianzi, Li, Shihua, Qin, Chuan, Li, Xiao-Jiang
Published in Cell research (01.04.2019)
Published in Cell research (01.04.2019)
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Journal Article
CRISPR/Cas9-mediated disruption of SHANK3 in monkey leads to drug-treatable autism-like symptoms
Tu, Zhuchi, Zhao, Hui, Li, Bang, Yan, Sen, Wang, Lu, Tang, Yongjin, Li, Zhujun, Bai, Dazhang, Li, Caijuan, Lin, Yingqi, Li, Yuefeng, Liu, Jianrong, Xu, Hao, Guo, Xiangyu, Jiang, Yong-hui, Zhang, Yong Q, Li, Xiao-Jiang
Published in Human molecular genetics (15.02.2019)
Published in Human molecular genetics (15.02.2019)
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Journal Article
Maternal valproic acid exposure leads to neurogenesis defects and autism-like behaviors in non-human primates
Zhao, Hui, Wang, Qiqi, Yan, Ting, Zhang, Yu, Xu, Hui-juan, Yu, Hao-peng, Tu, Zhuchi, Guo, Xiangyu, Jiang, Yong-hui, Li, Xiao-jiang, Zhou, Huihui, Zhang, Yong Q.
Published in Translational psychiatry (21.10.2019)
Published in Translational psychiatry (21.10.2019)
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Journal Article
PINK1 kinase dysfunction triggers neurodegeneration in the primate brain without impacting mitochondrial homeostasis
Yang, Weili, Guo, Xiangyu, Tu, Zhuchi, Chen, Xiusheng, Han, Rui, Liu, Yanting, Yan, Sen, Wang, Qi, Wang, Zhifu, Zhao, Xianxian, Zhang, Yunpeng, Xiong, Xin, Yang, Huiming, Yin, Peng, Wan, Huida, Chen, Xingxing, Guo, Jifeng, Yan, Xiao-Xin, Liao, Lujian, Li, Shihua, Li, Xiao-Jiang
Published in Protein & cell (01.01.2022)
Published in Protein & cell (01.01.2022)
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Journal Article
Application of CRISPR/Cas9 System in Establishing Large Animal Models
Lin, Yingqi, Li, Jun, Li, Caijuan, Tu, Zhuchi, Li, Shihua, Li, Xiao-Jiang, Yan, Sen
Published in Frontiers in cell and developmental biology (17.05.2022)
Published in Frontiers in cell and developmental biology (17.05.2022)
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Journal Article
A Specific Mini‐Intrabody Mediates Lysosome Degradation of Mutant Huntingtin
Li, Caijuan, Lin, Yingqi, Chen, Yizhi, Song, Xichen, Zheng, Xiao, Li, Jiawei, He, Jun, Chen, Xiusheng, Huang, Chunhui, Wang, Wei, Wu, Jianhao, Wu, Jiaxi, Gao, Jiale, Tu, Zhuchi, Li, Xiao‐Jiang, Yan, Sen, Li, Shihua
Published in Advanced science (01.11.2023)
Published in Advanced science (01.11.2023)
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Journal Article
Tauopathy promotes spinal cord-dependent production of toxic amyloid-beta in transgenic monkeys
Tu, Zhuchi, Yan, Sen, Han, Bofeng, Li, Caijuan, Liang, Weien, Lin, Yingqi, Ding, Yongyan, Wei, Huiyi, Wang, Lu, Xu, Hao, Ye, Jianmeng, Li, Bang, Li, Shihua, Li, Xiao-Jiang
Published in Signal transduction and targeted therapy (22.09.2023)
Published in Signal transduction and targeted therapy (22.09.2023)
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Journal Article
Generation of inactivated IL2RG and RAG1 monkeys with severe combined immunodeficiency using base editing
Zheng, Xiao, Huang, Chunhui, Lin, Yingqi, Han, Bofeng, Chen, Yizhi, Li, Caijuan, Li, Jiawei, Ding, Yongyan, Song, Xichen, Wang, Wei, Liang, Weien, Wu, Jianhao, Wu, Jiaxi, Gao, Jiale, Wei, Chengxi, Zhang, Xudong, Tu, Zhuchi, Yan, Sen
Published in Signal transduction and targeted therapy (04.09.2023)
Published in Signal transduction and targeted therapy (04.09.2023)
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Journal Article
Intravenous AAV9 administration results in safe and widespread distribution of transgene in the brain of mini-pig
Lin, Yingqi, Li, Caijuan, Wang, Wei, Li, Jiawei, Huang, Chunhui, Zheng, Xiao, Liu, Zhaoming, Song, Xichen, Chen, Yizhi, Gao, Jiale, Wu, Jianhao, Wu, Jiaxi, Tu, Zhuchi, Lai, Liangxue, Li, Xiao-Jiang, Li, Shihua, Yan, Sen
Published in Frontiers in cell and developmental biology (24.01.2023)
Published in Frontiers in cell and developmental biology (24.01.2023)
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Journal Article
CHD8 mutations increase gliogenesis to enlarge brain size in the nonhuman primate
Li, Bang, Zhao, Hui, Tu, Zhuchi, Yang, Weili, Han, Rui, Wang, Lu, Luo, Xiaopeng, Pan, Mingtian, Chen, Xiusheng, Zhang, Jiawei, Xu, Huijuan, Guo, Xiangyu, Yan, Sen, Yin, Peng, Zhao, Zhiguang, Liu, Jianrong, Luo, Yafeng, Li, Yuefeng, Yang, Zhengyi, Zhang, Baogui, Tan, Zhiqiang, Xu, Hao, Jiang, Tianzi, Jiang, Yong-hui, Li, Shihua, Zhang, Yong Q., Li, Xiao-Jiang
Published in Cell discovery (07.03.2023)
Published in Cell discovery (07.03.2023)
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Journal Article
A Huntingtin Knockin Pig Model Recapitulates Features of Selective Neurodegeneration in Huntington’s Disease
Yan, Sen, Tu, Zhuchi, Liu, Zhaoming, Fan, Nana, Yang, Huiming, Yang, Su, Yang, Weili, Zhao, Yu, Ouyang, Zhen, Lai, Chengdan, Yang, Huaqiang, Li, Li, Liu, Qishuai, Shi, Hui, Xu, Guangqing, Zhao, Heng, Wei, Hongjiang, Pei, Zhong, Li, Shihua, Lai, Liangxue, Li, Xiao-Jiang
Published in Cell (03.05.2018)
Published in Cell (03.05.2018)
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Journal Article
Use of CRISPR/Cas9 to model brain diseases
Yan, Sen, Tu, Zhuchi, Li, Shihua, Li, Xiao-Jiang
Published in Progress in neuro-psychopharmacology & biological psychiatry (02.02.2018)
Published in Progress in neuro-psychopharmacology & biological psychiatry (02.02.2018)
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Journal Article
Altered neurogenesis and disrupted expression of synaptic proteins in prefrontal cortex of SHANK3-deficient non-human primate
Zhao, Hui, Tu, Zhuchi, Xu, Huijuan, Yan, Sen, Yan, Huanhuan, Zheng, Yinghui, Yang, Weili, Zheng, Jiezhao, Li, Zhujun, Tian, Rui, Lu, Youming, Guo, Xiangyu, Jiang, Yong-hui, Li, Xiao-Jiang, Zhang, Yong Q
Published in Cell research (01.10.2017)
Published in Cell research (01.10.2017)
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Journal Article
TBN improves motor function and prolongs survival in a TDP-43M337V mouse model of ALS
Huang, Chunhui, Li, Jun, Zhang, Guiliang, Lin, Yingqi, Li, Caijuan, Zheng, Xiao, Song, Xichen, Han, Bofeng, Guo, Baojian, Tu, Zhuchi, Zhang, Jun, Sun, Yewei, Wang, Yuqiang, Zhang, Zaijun, Yan, Sen
Published in Human molecular genetics (28.07.2021)
Published in Human molecular genetics (28.07.2021)
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Journal Article
Large animal models for Huntington's disease research
Han, Bofeng, Liang, Weien, Li, Xiao-Jiang, Li, Shihua, Yan, Sen, Tu, Zhuchi
Published in Dōngwùxué yánjiū (18.03.2024)
Published in Dōngwùxué yánjiū (18.03.2024)
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Journal Article
Deficiency of parkin causes neurodegeneration and accumulation of pathological α-synuclein in monkey models
Han, Rui, Wang, Qi, Xiong, Xin, Chen, Xiusheng, Tu, Zhuchi, Li, Bang, Zhang, Fei, Chen, Chunyu, Pan, Mingtian, Xu, Ting, Chen, Laiqiang, Wang, Zhifu, Liu, Yanting, He, Dajian, Guo, Xiangyu, He, Feng, Wu, Peng, Yin, Peng, Liu, Yunbo, Yan, Xiaoxin, Li, Shihua, Li, Xiao-Jiang, Yang, Weili
Published in The Journal of clinical investigation (15.10.2024)
Published in The Journal of clinical investigation (15.10.2024)
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Journal Article
Suppressing UBE2N ameliorates Alzheimer's disease pathology through the clearance of amyloid beta
Zhang, Chen, Jia, Qingqing, Zhu, Longhong, Hou, Junqi, Wang, Xiang, Li, Dandan, Zhang, Jiawei, Zhang, Yiran, Yang, Su, Tu, Zhuchi, Yan, Xiao‐Xin, Yang, Weili, Li, Shihua, Li, Xiao‐Jiang, Yin, Peng
Published in Alzheimer's & dementia (01.09.2024)
Published in Alzheimer's & dementia (01.09.2024)
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