Structure of a Janus kinase cytokine receptor complex reveals the basis for dimeric activation
Glassman, Caleb R, Tsutsumi, Naotaka, Saxton, Robert A, Lupardus, Patrick J, Jude, Kevin M, Garcia, K Christopher
Published in Science (American Association for the Advancement of Science) (08.04.2022)
Published in Science (American Association for the Advancement of Science) (08.04.2022)
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Journal Article
Structure-based decoupling of the pro- and anti-inflammatory functions of interleukin-10
Saxton, Robert A, Tsutsumi, Naotaka, Su, Leon L, Abhiraman, Gita C, Mohan, Kritika, Henneberg, Lukas T, Aduri, Nanda G, Gati, Cornelius, Garcia, K Christopher
Published in Science (American Association for the Advancement of Science) (19.03.2021)
Published in Science (American Association for the Advancement of Science) (19.03.2021)
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Journal Article
Structure of human Frizzled5 by fiducial-assisted cryo-EM supports a heterodimeric mechanism of canonical Wnt signaling
Tsutsumi, Naotaka, Mukherjee, Somnath, Waghray, Deepa, Janda, Claudia Y, Jude, Kevin M, Miao, Yi, Burg, John S, Aduri, Nanda Gowtham, Kossiakoff, Anthony A, Gati, Cornelius, Garcia, K Christopher
Published in eLife (07.08.2020)
Published in eLife (07.08.2020)
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Journal Article
Structure of the IL-27 quaternary receptor signaling complex
Caveney, Nathanael A, Glassman, Caleb R, Jude, Kevin M, Tsutsumi, Naotaka, Garcia, K Christopher
Published in eLife (17.05.2022)
Published in eLife (17.05.2022)
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Journal Article
Structural basis for the constitutive activity and immunomodulatory properties of the Epstein-Barr virus-encoded G protein-coupled receptor BILF1
Tsutsumi, Naotaka, Qu, Qianhui, Mavri, Maša, Baggesen, Maibritt S., Maeda, Shoji, Waghray, Deepa, Berg, Christian, Kobilka, Brian K., Rosenkilde, Mette M., Skiniotis, Georgios, Garcia, K. Christopher
Published in Immunity (Cambridge, Mass.) (13.07.2021)
Published in Immunity (Cambridge, Mass.) (13.07.2021)
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Journal Article
Structural basis of Janus kinase trans-activation
Caveney, Nathanael A., Saxton, Robert A., Waghray, Deepa, Glassman, Caleb R., Tsutsumi, Naotaka, Hubbard, Stevan R., Garcia, K. Christopher
Published in Cell reports (Cambridge) (28.03.2023)
Published in Cell reports (Cambridge) (28.03.2023)
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Journal Article
The structural basis for receptor recognition of human interleukin-18
Tsutsumi, Naotaka, Kimura, Takeshi, Arita, Kyohei, Ariyoshi, Mariko, Ohnishi, Hidenori, Yamamoto, Takahiro, Zuo, Xiaobing, Maenaka, Katsumi, Park, Enoch Y, Kondo, Naomi, Shirakawa, Masahiro, Tochio, Hidehito, Kato, Zenichiro
Published in Nature communications (15.12.2014)
Published in Nature communications (15.12.2014)
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Journal Article
Viral GPCR US28 can signal in response to chemokine agonists of nearly unlimited structural degeneracy
Miles, Timothy F, Spiess, Katja, Jude, Kevin M, Tsutsumi, Naotaka, Burg, John S, Ingram, Jessica R, Waghray, Deepa, Hjorto, Gertrud M, Larsen, Olav, Ploegh, Hidde L, Rosenkilde, Mette M, Garcia, K Christopher
Published in eLife (08.06.2018)
Published in eLife (08.06.2018)
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Journal Article
Structure of the Wnt-Frizzled-LRP6 initiation complex reveals the basis for coreceptor discrimination
Tsutsumi, Naotaka, Hwang, Sunhee, Waghray, Deepa, Hansen, Simon, Jude, Kevin M, Wang, Nan, Miao, Yi, Glassman, Caleb R, Caveney, Nathanael A, Janda, Claudia Y, Hannoush, Rami N, Garcia, K Christopher
Published in Proceedings of the National Academy of Sciences - PNAS (14.03.2023)
Published in Proceedings of the National Academy of Sciences - PNAS (14.03.2023)
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Journal Article
Author Correction: Structure and mechanism of oxalate transporter OxlT in an oxalate-degrading bacterium in the gut microbiota
Jaunet-Lahary, Titouan, Shimamura, Tatsuro, Hayashi, Masahiro, Nomura, Norimichi, Hirasawa, Kouta, Shimizu, Tetsuya, Yamashita, Masao, Tsutsumi, Naotaka, Suehiro, Yuta, Kojima, Keiichi, Sudo, Yuki, Tamura, Takashi, Iwanari, Hiroko, Hamakubo, Takao, Iwata, So, Okazaki, Kei-ichi, Hirai, Teruhisa, Yamashita, Atsuko
Published in Nature communications (28.09.2023)
Published in Nature communications (28.09.2023)
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Journal Article
Tuning MPL signaling to influence hematopoietic stem cell differentiation and inhibit essential thrombocythemia progenitors
Cui, Lu, Moraga, Ignacio, Lerbs, Tristan, Van Neste, Camille, Wilmes, Stephan, Tsutsumi, Naotaka, Trotman-Grant, Aaron Claudius, Gakovic, Milica, Andrews, Sarah, Gotlib, Jason, Darmanis, Spyros, Enge, Martin, Quake, Stephen, Hitchcock, Ian S, Piehler, Jacob, Garcia, K Christopher, Wernig, Gerlinde
Published in Proceedings of the National Academy of Sciences - PNAS (12.01.2021)
Published in Proceedings of the National Academy of Sciences - PNAS (12.01.2021)
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Journal Article
Structure and mechanism of oxalate transporter OxlT in an oxalate-degrading bacterium in the gut microbiota
Jaunet-Lahary, Titouan, Shimamura, Tatsuro, Hayashi, Masahiro, Nomura, Norimichi, Hirasawa, Kouta, Shimizu, Tetsuya, Yamashita, Masao, Tsutsumi, Naotaka, Suehiro, Yuta, Kojima, Keiichi, Sudo, Yuki, Tamura, Takashi, Iwanari, Hiroko, Hamakubo, Takao, Iwata, So, Okazaki, Kei-Ichi, Hirai, Teruhisa, Yamashita, Atsuko
Published in Nature communications (03.04.2023)
Published in Nature communications (03.04.2023)
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Journal Article
An innate interaction between IL-18 and the propeptide that inactivates its precursor form
Tsutsumi, Naotaka, Yokota, Ayumi, Kimura, Takeshi, Kato, Zenichiro, Fukao, Toshiyuki, Shirakawa, Masahiro, Ohnishi, Hidenori, Tochio, Hidehito
Published in Scientific reports (16.04.2019)
Published in Scientific reports (16.04.2019)
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Journal Article
Intramolecular interaction suggests an autosuppression mechanism for the innate immune adaptor protein MyD88
Uno, Masatoshi, Watanabe-Nakayama, Takahiro, Konno, Hiroki, Akagi, Ken-Ichi, Tsutsumi, Naotaka, Fukao, Toshiyuki, Shirakawa, Masahiro, Ohnishi, Hidenori, Tochio, Hidehito
Published in Chemical communications (Cambridge, England) (30.10.2018)
Published in Chemical communications (Cambridge, England) (30.10.2018)
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Journal Article
S252: MODULATING HEMATOPOIESIS: ENGINEERING TPO VARIANTS WITH DISTINCT HEMATOPOIETIC FUNCTION
Masoumi, Zahra, Moss, Lucie, Tucker, Julie, James, Sophie, Picton, Lora, Tsutsumi, Naotaka, Grey, William, Garcia, Chris, Hitchcock, Ian
Published in HemaSphere (08.08.2023)
Published in HemaSphere (08.08.2023)
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Journal Article
Molecular analysis of the binding mode of Toll/interleukin-1 receptor (TIR) domain proteins during TLR2 signaling
Nada, Masatoshi, Ohnishi, Hidenori, Tochio, Hidehito, Kato, Zenichiro, Kimura, Takeshi, Kubota, Kazuo, Yamamoto, Takahiro, Kamatari, Yuji O., Tsutsumi, Naotaka, Shirakawa, Masahiro, Kondo, Naomi
Published in Molecular immunology (01.10.2012)
Published in Molecular immunology (01.10.2012)
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Journal Article
Purification, crystallization and preliminary X-ray crystallographic analysis of human IL-18 and its extracellular complexes
Kimura, Takeshi, Tsutsumi, Naotaka, Arita, Kyohei, Ariyoshi, Mariko, Ohnishi, Hidenori, Kondo, Naomi, Shirakawa, Masahiro, Kato, Zenichiro, Tochio, Hidehito
Published in Acta crystallographica. Section F, Structural biology communications (01.10.2014)
Published in Acta crystallographica. Section F, Structural biology communications (01.10.2014)
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Journal Article