Synthesis and biological evaluation of 4-morpholino-2-phenylquinazolines and related derivatives as novel PI3 kinase p110α inhibitors
Hayakawa, Masahiko, Kaizawa, Hiroyuki, Moritomo, Hiroyuki, Koizumi, Tomonobu, Ohishi, Takahide, Okada, Minoru, Ohta, Mitsuaki, Tsukamoto, Shin-ichi, Parker, Peter, Workman, Paul, Waterfield, Mike
Published in Bioorganic & medicinal chemistry (15.10.2006)
Published in Bioorganic & medicinal chemistry (15.10.2006)
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Atropisomeric 4-Phenyl-4 H -1,2,4-triazoles as Selective Glycine Transporter 1 Inhibitors
Sugane, Takashi, Tobe, Takahiko, Hamaguchi, Wataru, Shimada, Itsuro, Maeno, Kyoichi, Miyata, Junji, Suzuki, Takeshi, Kimizuka, Tetsuya, Sakamoto, Shuichi, Tsukamoto, Shin-ichi
Published in Journal of medicinal chemistry (25.07.2013)
Published in Journal of medicinal chemistry (25.07.2013)
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Synthesis and biological evaluation of pyrido[3′,2′:4,5]furo[3,2- d]pyrimidine derivatives as novel PI3 kinase p110α inhibitors
Hayakawa, Masahiko, Kaizawa, Hiroyuki, Moritomo, Hiroyuki, Koizumi, Tomonobu, Ohishi, Takahide, Yamano, Mayumi, Okada, Minoru, Ohta, Mitsuaki, Tsukamoto, Shin-ichi, Raynaud, Florence I., Workman, Paul, Waterfield, Michael D., Parker, Peter
Published in Bioorganic & medicinal chemistry letters (01.05.2007)
Published in Bioorganic & medicinal chemistry letters (01.05.2007)
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Journal Article
Synthesis and Biological Evaluation of 3-Biphenyl-4-yl-4-phenyl-4 H -1,2,4-triazoles as Novel Glycine Transporter 1 Inhibitors
Sugane, Takashi, Tobe, Takahiko, Hamaguchi, Wataru, Shimada, Itsuro, Maeno, Kyoichi, Miyata, Junji, Suzuki, Takeshi, Kimizuka, Tetsuya, Kohara, Atsuyuki, Morita, Takuma, Doihara, Hitoshi, Saita, Kyouko, Aota, Masaki, Furutani, Masako, Shimada, Yoshiaki, Hamada, Noritaka, Sakamoto, Shuichi, Tsukamoto, Shin-ichi
Published in Journal of medicinal chemistry (13.01.2011)
Published in Journal of medicinal chemistry (13.01.2011)
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Synthesis and biological evaluation of sulfonylhydrazone-substituted imidazo[1,2- a]pyridines as novel PI3 kinase p110α inhibitors
Hayakawa, Masahiko, Kawaguchi, Ken-ichi, Kaizawa, Hiroyuki, Koizumi, Tomonobu, Ohishi, Takahide, Yamano, Mayumi, Okada, Minoru, Ohta, Mitsuaki, Tsukamoto, Shin-ichi, Raynaud, Florence I., Parker, Peter, Workman, Paul, Waterfield, Michael D.
Published in Bioorganic & medicinal chemistry (01.09.2007)
Published in Bioorganic & medicinal chemistry (01.09.2007)
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Discovery of N-[2-Hydroxy-6-(4-methoxybenzamido)phenyl]-4- (4-methyl-1,4-diazepan-1-yl)benzamide (Darexaban, YM150) as a Potent and Orally Available Factor Xa Inhibitor
Hirayama, Fukushi, Koshio, Hiroyuki, Ishihara, Tsukasa, Hachiya, Shunichiro, Sugasawa, Keizo, Koga, Yuji, Seki, Norio, Shiraki, Ryouta, Shigenaga, Takeshi, Iwatsuki, Yoshiyuki, Moritani, Yumiko, Mori, Kenichi, Kadokura, Takeshi, Kawasaki, Tomihisa, Matsumoto, Yuzo, Sakamoto, Shuichi, Tsukamoto, Shin-ichi
Published in Journal of medicinal chemistry (08.12.2011)
Published in Journal of medicinal chemistry (08.12.2011)
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Journal Article
Synthesis and biological evaluation of imidazo[1,2- a]pyridine derivatives as novel PI3 kinase p110α inhibitors
Hayakawa, Masahiko, Kaizawa, Hiroyuki, Kawaguchi, Ken-ichi, Ishikawa, Noriko, Koizumi, Tomonobu, Ohishi, Takahide, Yamano, Mayumi, Okada, Minoru, Ohta, Mitsuaki, Tsukamoto, Shin-ichi, Raynaud, Florence I., Waterfield, Michael D., Parker, Peter, Workman, Paul
Published in Bioorganic & medicinal chemistry (2007)
Published in Bioorganic & medicinal chemistry (2007)
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Novel 7H-pyrrolo[2,3-d]pyrimidine derivatives as potent and orally active STAT6 inhibitors
Nagashima, Shinya, Hondo, Takeshi, Nagata, Hiroshi, Ogiyama, Takashi, Maeda, Jun, Hoshii, Hiroaki, Kontani, Toru, Kuromitsu, Sadao, Ohga, Keiko, Orita, Masaya, Ohno, Kazuki, Moritomo, Ayako, Shiozuka, Koichi, Furutani, Masako, Takeuchi, Makoto, Ohta, Mitsuaki, Tsukamoto, Shin-ichi
Published in Bioorganic & medicinal chemistry (01.10.2009)
Published in Bioorganic & medicinal chemistry (01.10.2009)
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Synthesis and pharmacological evaluation of 1-alkyl-N-[2-ethyl-2-(4-fluorophenyl)butyl]piperidine-4-carboxamide derivatives as novel antihypertensive agents
Watanuki, Susumu, Matsuura, Keisuke, Tomura, Yuichi, Okada, Minoru, Okazaki, Toshio, Ohta, Mitsuaki, Tsukamoto, Shin-ichi
Published in Bioorganic & medicinal chemistry (15.09.2011)
Published in Bioorganic & medicinal chemistry (15.09.2011)
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Journal Article
Practical and efficient synthesis of the (R)-atropisomer of a 4-phenyl 1,2,4-triazole derivative as a selective GlyT1 inhibitor
Sugane, Takashi, Hamada, Noritaka, Tobe, Takahiko, Hamaguchi, Wataru, Shimada, Itsuro, Maeno, Kyoichi, Miyata, Junji, Suzuki, Takeshi, Kimizuka, Tetsuya, Sakamoto, Shuichi, Tsukamoto, Shin-ichi
Published in Tetrahedron: asymmetry (15.12.2012)
Published in Tetrahedron: asymmetry (15.12.2012)
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Synthesis and Pharmacological Evaluation of 2-(1-Alkylpiperidin-4-yl)-N-[(1R)-1-(4-fluorophenyl)-2-methylpropyl]acetamide Derivatives as Novel Antihypertensive Agents
Watanuki, Susumu, Matsuura, Keisuke, Tomura, Yuichi, Okada, Minoru, Okazaki, Toshio, Ohta, Mitsuaki, Tsukamoto, Shin-ichi
Published in Chemical & pharmaceutical bulletin (2012)
Published in Chemical & pharmaceutical bulletin (2012)
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Synthesis and biological evaluation of (4H-1,2,4-triazol-4-yl)isoquinoline derivatives as selective glycine transporter 1 inhibitors
Sugane, Takashi, Tobe, Takahiko, Hamaguchi, Wataru, Shimada, Itsuro, Maeno, Kyoichi, Miyata, Junji, Suzuki, Takeshi, Kimizuka, Tetsuya, Morita, Takuma, Sakamoto, Shuichi, Tsukamoto, Shin-ichi
Published in Bioorganic & medicinal chemistry (01.01.2012)
Published in Bioorganic & medicinal chemistry (01.01.2012)
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Journal Article
Synthesis and evaluation of 2-{[2-(4-hydroxyphenyl)-ethyl]amino}pyrimidine-5-carboxamide derivatives as novel STAT6 inhibitors
Nagashima, Shinya, Yokota, Masaki, Nakai, Ei-ichi, Kuromitsu, Sadao, Ohga, Keiko, Takeuchi, Makoto, Tsukamoto, Shin-ichi, Ohta, Mitsuaki
Published in Bioorganic & medicinal chemistry (15.01.2007)
Published in Bioorganic & medicinal chemistry (15.01.2007)
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Pyrrolidinyl phenylurea derivatives as novel CCR3 antagonists
Nitta, Aiko, Iura, Yosuke, Inoue, Hideki, Sato, Ippei, Morihira, Koichiro, Kubota, Hirokazu, Morokata, Tatsuaki, Takeuchi, Makoto, Ohta, Mitsuaki, Tsukamoto, Shin-ichi, Imaoka, Takayuki, Takahashi, Toshiya
Published in Bioorganic & medicinal chemistry letters (15.11.2012)
Published in Bioorganic & medicinal chemistry letters (15.11.2012)
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Novel potent and selective calcium-release-activated calcium (CRAC) channel inhibitors. Part 2: Synthesis and inhibitory activity of aryl-3-trifluoromethylpyrazoles
Yonetoku, Yasuhiro, Kubota, Hirokazu, Okamoto, Yoshinori, Ishikawa, Jun, Takeuchi, Makoto, Ohta, Mitsuaki, Tsukamoto, Shin-ichi
Published in Bioorganic & medicinal chemistry (01.08.2006)
Published in Bioorganic & medicinal chemistry (01.08.2006)
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Journal Article
Synthesis and Pharmacological Evaluation of 1-Alkyl-N-[(1R)-1-(4-fluorophenyl)-2-methylpropyl]piperidine-4-carboxamide Derivatives as Novel Antihypertensive Agents
Watanuki, Susumu, Matsuura, Keisuke, Tomura, Yuichi, Okada, Minoru, Okazaki, Toshio, Ohta, Mitsuaki, Tsukamoto, Shin-ichi
Published in Chemical & Pharmaceutical Bulletin (2011)
Published in Chemical & Pharmaceutical Bulletin (2011)
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Journal Article
Discovery and structure–activity relationships of urea derivatives as potent and novel CCR3 antagonists
Nitta, Aiko, Iura, Yosuke, Tomioka, Hiroki, Sato, Ippei, Morihira, Koichiro, Kubota, Hirokazu, Morokata, Tatsuaki, Takeuchi, Makoto, Ohta, Mitsuaki, Tsukamoto, Shin-ichi, Imaoka, Takayuki, Takahashi, Toshiya
Published in Bioorganic & medicinal chemistry letters (01.08.2012)
Published in Bioorganic & medicinal chemistry letters (01.08.2012)
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Synthesis of 5-chloro-N-aryl-1H-indole-2-carboxamide derivatives as inhibitors of human liver glycogen phosphorylase a
ONDA, Kenichi, SUZUKI, Takayuki, TSUKAMOTO, Shin-Ichi, SHIRAKI, Ryota, YONETOKU, Yasuhiro, NEGORO, Kenji, MOMOSE, Kazuhiro, KATAYAMA, Naoko, ORITA, Masaya, YAMAGUCHI, Tomohiko, OHTA, Mitsuaki
Published in Bioorganic & medicinal chemistry (15.05.2008)
Published in Bioorganic & medicinal chemistry (15.05.2008)
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Journal Article
Synthesis and Pharmacological Evaluation of 1-Isopropyl-1,2,3,4-tetrahydroisoquinoline Derivatives as Novel Antihypertensive Agents
Watanuki, Susumu, Matsuura, Keisuke, Tomura, Yuichi, Okada, Minoru, Okazaki, Toshio, Ohta, Mitsuaki, Tsukamoto, Shin-ichi
Published in Chemical & Pharmaceutical Bulletin (2011)
Published in Chemical & Pharmaceutical Bulletin (2011)
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Journal Article
Synthesis and structure-activity relationships of a series of substituted 2-(1H-furo[2,3-g]indazol-1-yl)ethylamine derivatives as 5-HT2C receptor agonists
Shimada, Itsuro, Maeno, Kyoichi, Kazuta, Ken-ichi, Kubota, Hideki, Kimizuka, Tetsuya, Kimura, Yasuharu, Hatanaka, Ken-ichi, Naitou, Yuki, Wanibuchi, Fumikazu, Sakamoto, Shuichi, Tsukamoto, Shin-ichi
Published in Bioorganic & medicinal chemistry (15.02.2008)
Published in Bioorganic & medicinal chemistry (15.02.2008)
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