Thrombomodulin alfa prevents oxaliplatin-induced neuropathic symptoms through activation of thrombin-activatable fibrinolysis inhibitor and protein C without affecting anti-tumor activity
Minami, Tatsuro, Takeda, Mineko, Sata, Minako, Kato, Hiroki, Yano, Kazuo, Sakai, Takumi, Tsujita, Ryuichi, Kawasaki, Koh, Ito, Akitoshi
Published in European journal of pharmacology (05.08.2020)
Published in European journal of pharmacology (05.08.2020)
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Thrombomodulin induces anti-inflammatory effects by inhibiting the rolling adhesion of leukocytes in vivo
Nishizawa, Shino, Kikuta, Junichi, Seno, Shigeto, Kajiki, Masahiro, Tsujita, Ryuichi, Mizuno, Hiroki, Sudo, Takao, Ao, Tomoka, Matsuda, Hideo, Ishii, Masaru
Published in Journal of pharmacological sciences (01.05.2020)
Published in Journal of pharmacological sciences (01.05.2020)
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Human soluble thrombomodulin-induced blockade of peripheral HMGB1-dependent allodynia in mice requires both the lectin-like and EGF-like domains
Hayashi, Yusuke, Tsujita, Ryuichi, Tsubota, Maho, Saeki, Haruka, Sekiguchi, Fumiko, Honda, Goichi, Kawabata, Atsufumi
Published in Biochemical and biophysical research communications (01.01.2018)
Published in Biochemical and biophysical research communications (01.01.2018)
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Role of Thrombin in Soluble Thrombomodulin-Induced Suppression of Peripheral HMGB1-Mediated Allodynia in Mice
Tsujita, Ryuichi, Tsubota, Maho, Hayashi, Yusuke, Saeki, Haruka, Sekiguchi, Fumiko, Kawabata, Atsufumi
Published in Journal of neuroimmune pharmacology (01.06.2018)
Published in Journal of neuroimmune pharmacology (01.06.2018)
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The effects of AP521, a novel anxiolytic drug, in three anxiety models and on serotonergic neural transmission in rats
Kasahara, Ken-ichi, Hashimoto, Shinji, Hattori, Tsuyoshi, Kawasaki, Koh, Tsujita, Ryuichi, Nakazono, Osamu, Takao, Katsuyuki, Kawakubo, Hiromu, Nagatani, Tadashi
Published in Journal of pharmacological sciences (01.01.2015)
Published in Journal of pharmacological sciences (01.01.2015)
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Synthesis of derivatives of (1 S,2 R)-1-phenyl-2-[( S)-1-aminopropyl] -N,N-diethylcyclopropanecarboxamide (PPDC) modified at the 1-aromatic moiety as novel NMDA receptor antagonists: the aromatic group is essential for the activity
Kazuta, Yuji, Tsujita, Ryuichi, Yamashita, Kanako, Uchino, Shigeo, Kohsaka, Shinichi, Matsuda, Akira, Shuto, Satoshi
Published in Bioorganic & medicinal chemistry (01.12.2002)
Published in Bioorganic & medicinal chemistry (01.12.2002)
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Molecular mechanisms for the recombinant soluble thrombomodulin-induced suppression of HMGB1-dependent allodynia in mice: Roles of the N-terminal domains of thrombomodulin
Hayashi, Yusuke, Tsubota, Maho, Tsujita, Ryuichi, Honda, Goichi, Kawabata, Atsufumi
Published in Proceedings for Annual Meeting of The Japanese Pharmacological Society (2018)
Published in Proceedings for Annual Meeting of The Japanese Pharmacological Society (2018)
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Discovery of selective PDE4B inhibitors
NAGANUMA, Kenji, OMURA, Akifumi, NAKAMURA, Junji, TSUJITA, Ryuichi, KAWASAKI, Koh, YOKOI, Hirotsugu, KAWANISHI, Masashi, MAEKAWARA, Naomi, SAITOH, Masahiro, OHKAWA, Naoto, KUBOTA, Takashi, NAGUMO, Hiromitsu, KODAMA, Toshiyuki, TAKEMURA, Masayoshi, OHTSUKA, Yuji
Published in Bioorganic & medicinal chemistry letters (15.06.2009)
Published in Bioorganic & medicinal chemistry letters (15.06.2009)
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Synthesis of (1S,2R)-1-phenyl-2-[(S)-1-aminoalkyl]-N,N-diethylcyclopropanecarboxamides as novel NMDA receptor antagonists having a unique NMDA receptor subtype selectivity
Kazuta, Y, Tsujita, R, Uchino, S, Kamiyama, N, Mochizuki, D, Yamashita, K, Ohmori, Y, Yamashita, A, Yamamoto, T, Kohsaka, S, Matsuda, A, Shuto, S
Published in Perkin 1 : an international journal of organic and bio-organic chemistry (26.04.2002)
Published in Perkin 1 : an international journal of organic and bio-organic chemistry (26.04.2002)
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Neurochemical and behavioural characterization of milnacipran, a serotonin and noradrenaline reuptake inhibitor in rats
MOCHIZUKI, Daisuke, TSUJITA, Ryuichi, YAMADA, Shinji, KAWASAKI, Koh, OTSUKA, Yuji, HASHIMOTO, Shinji, HATTORI, Tsuyoshi, KITAMURA, Yoshihisa, MIKI, Naomasa
Published in Psychopharmacologia (01.07.2002)
Published in Psychopharmacologia (01.07.2002)
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Post-marketing surveillance data of thrombomodulin alfa: sub-analysis in patients with sepsis-induced disseminated intravascular coagulation
Eguchi, Yutaka, Gando, Satoshi, Ishikura, Hiroyasu, Saitoh, Daizoh, Mimuro, Jun, Takahashi, Hoyu, Kitajima, Isao, Tsuji, Hajime, Matsushita, Tadashi, Tsujita, Ryuichi, Nagao, Osamu, Sakata, Yoichi
Published in Journal of intensive care (30.04.2014)
Published in Journal of intensive care (30.04.2014)
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Identification of Structurally Diverse Growth Hormone Secretagogue Agonists by Virtual Screening and Structure−Activity Relationship Analysis of 2-Formylaminoacetamide Derivatives
Shoda, Miyuki, Harada, Takeo, Kogami, Yuji, Tsujita, Ryuichi, Akashi, Hirotada, Kouji, Hiroyuki, Stahura, Florence L, Xue, Ling, Bajorath, Jürgen
Published in Journal of medicinal chemistry (12.08.2004)
Published in Journal of medicinal chemistry (12.08.2004)
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A Method for Designing Conformationally Restricted Analogues Based on Allylic Strain: Synthesis of a Novel Class of Noncompetitive NMDA Receptor Antagonists Having the Acrylamide Structure
Ohmori, Yutaka, Yamashita, Akitake, Tsujita, Ryuichi, Yamamoto, Tamotsu, Taniuchi, Kaku, Matsuda, Akira, Shuto, Satoshi
Published in Journal of medicinal chemistry (04.12.2003)
Published in Journal of medicinal chemistry (04.12.2003)
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Synthesis of (1 S,2 R)-1-Phenyl-2-[( S)-1-aminopropyl] -N,N-diethylcyclopropanecarboxamide (PPDC) Derivatives Modified at the Carbamoyl Moiety As a New Class of NMDA Receptor Antagonists
Kazuta, Yuji, Tsujita, Ryuichi, Ogawa, Kiyoshi, Hokonohara, Tadami, Yamashita, Kanako, Morino, Kiyoko, Matsuda, Akira, Shuto, Satoshi
Published in Bioorganic & medicinal chemistry (01.06.2002)
Published in Bioorganic & medicinal chemistry (01.06.2002)
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(.+-.)-(Z)-2-(Aminomethyl)-1-phenylcyclopropanecarboxamide Derivatives as a New Prototype of NMDA Receptor Antagonists
Shuto, Satoshi, Takada, Hironao, Mochizuki, Daisuke, Tsujita, Ryuichi, Hase, Yukako, Ono, Shizuka, Shibuya, Nobuko, Matsuda, Akira
Published in Journal of medicinal chemistry (21.07.1995)
Published in Journal of medicinal chemistry (21.07.1995)
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Journal Article
NOVEL AZEPINE DERIVATIVE, PRODUCTION THEREOF, AND USE THEREOF
MOCHIZUKI, DAISUKE, YASO, MASAO, TAKAHASHI, NOBUYUKI, KOMAKI, HISAYUKI, TSUJITA, RYUICHI, SUZUKI, YUKIO
Year of Publication 10.06.1993
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Year of Publication 10.06.1993
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