Induction of synthetic lethality in IDH1-mutated gliomas through inhibition of Bcl-xL
Karpel-Massler, Georg, Ishida, Chiaki Tsuge, Bianchetti, Elena, Zhang, Yiru, Shu, Chang, Tsujiuchi, Takashi, Banu, Matei A., Garcia, Franklin, Roth, Kevin A., Bruce, Jeffrey N., Canoll, Peter, Siegelin, Markus D.
Published in Nature communications (20.10.2017)
Published in Nature communications (20.10.2017)
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Journal Article
Spatial mapping of gemcitabine and its pharmacologically active metabolites in tissues using MALDI mass spectrometry imaging
Phulara, Nav Raj, Ishida, Chiaki Tsuge, Espenshade, Peter, Seneviratne, Herana Kamal
Published in Drug metabolism and pharmacokinetics (01.04.2024)
Published in Drug metabolism and pharmacokinetics (01.04.2024)
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Journal Article
Structure of the trypanosome cyanide-insensitive alternative oxidase
Shiba, Tomoo, Kido, Yasutoshi, Sakamoto, Kimitoshi, Inaoka, Daniel Ken, Tsuge, Chiaki, Tatsumi, Ryoko, Takahashi, Gen, Balogun, Emmanuel Oluwadare, Nara, Takeshi, Aoki, Takashi, Honma, Teruki, Tanaka, Akiko, Inoue, Masayuki, Matsuoka, Shigeru, Saimoto, Hiroyuki, Moore, Anthony L., Harada, Shigeharu, Kita, Kiyoshi
Published in Proceedings of the National Academy of Sciences - PNAS (19.03.2013)
Published in Proceedings of the National Academy of Sciences - PNAS (19.03.2013)
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Journal Article
Inhibition of Mitochondrial Matrix Chaperones and Antiapoptotic Bcl-2 Family Proteins Empower Antitumor Therapeutic Responses
Karpel-Massler, Georg, Ishida, Chiaki Tsuge, Bianchetti, Elena, Shu, Chang, Perez-Lorenzo, Rolando, Horst, Basil, Banu, Matei, Roth, Kevin A, Bruce, Jeffrey N, Canoll, Peter, Altieri, Dario C, Siegelin, Markus D
Published in Cancer research (Chicago, Ill.) (01.07.2017)
Published in Cancer research (Chicago, Ill.) (01.07.2017)
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Journal Article
Activation of LXRβ inhibits tumor respiration and is synthetically lethal with Bcl‐xL inhibition
Nguyen, Trang Thi Thu, Ishida, Chiaki Tsuge, Shang, Enyuan, Shu, Chang, Torrini, Consuelo, Zhang, Yiru, Bianchetti, Elena, Sanchez‐Quintero, Maria J, Kleiner, Giulio, Quinzii, Catarina M, Westhoff, Mike‐Andrew, Karpel‐Massler, Georg, Canoll, Peter, Siegelin, Markus D
Published in EMBO molecular medicine (01.10.2019)
Published in EMBO molecular medicine (01.10.2019)
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Journal Article
BH3-mimetics and BET-inhibitors elicit enhanced lethality in malignant glioma
Ishida, Chiaki Tsuge, Bianchetti, Elena, Shu, Chang, Halatsch, Marc-Eric, Westhoff, M Andrew, Karpel-Massler, Georg, Siegelin, Markus D
Published in Oncotarget (02.05.2017)
Published in Oncotarget (02.05.2017)
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Journal Article
Dual Inhibition of Bcl-2/Bcl-xL and XPO1 is synthetically lethal in glioblastoma model systems
Shang, Enyuan, Zhang, Yiru, Shu, Chang, Ishida, Chiaki Tsuge, Bianchetti, Elena, Westhoff, Mike-Andrew, Karpel-Massler, Georg, Siegelin, Markus D.
Published in Scientific reports (18.10.2018)
Published in Scientific reports (18.10.2018)
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Journal Article
Mitochondrial matrix chaperone and c-myc inhibition causes enhanced lethality in glioblastoma
Ishida, Chiaki Tsuge, Shu, Chang, Halatsch, Marc-Eric, Westhoff, Mike-Andrew, Altieri, Dario C, Karpel-Massler, Georg, Siegelin, Markus David
Published in Oncotarget (06.06.2017)
Published in Oncotarget (06.06.2017)
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Journal Article
Inhibition of Bcl-2/Bcl-xL and c-MET causes synthetic lethality in model systems of glioblastoma
Zhang, Yiru, Ishida, Chiaki Tsuge, Shu, Chang, Kleiner, Giulio, Sanchez-Quintero, Maria J., Bianchetti, Elena, Quinzii, Catarina M., Westhoff, Mike-Andrew, Karpel-Massler, Georg, Siegelin, Markus D.
Published in Scientific reports (09.05.2018)
Published in Scientific reports (09.05.2018)
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Journal Article
Molecular basis for the reverse reaction of African human trypanosomes glycerol kinase
Balogun, Emmanuel Oluwadare, Inaoka, Daniel Ken, Shiba, Tomoo, Kido, Yasutoshi, Tsuge, Chiaki, Nara, Takeshi, Aoki, Takashi, Honma, Teruki, Tanaka, Akiko, Inoue, Masayuki, Matsuoka, Shigeru, Michels, Paul A. M., Kita, Kiyoshi, Harada, Shigeharu
Published in Molecular microbiology (01.12.2014)
Published in Molecular microbiology (01.12.2014)
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Journal Article
Cytosolic 5'-Nucleotidase III and Nucleoside Triphosphate Diphosphohydrolase 1 Dephosphorylate the Pharmacologically Active Metabolites of Gemcitabine and Emtricitabine
Phulara, Nav Raj, Ishida, Chiaki Tsuge, Espenshade, Peter J, Seneviratne, Herana Kamal
Published in Drug metabolism and disposition (01.04.2024)
Published in Drug metabolism and disposition (01.04.2024)
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Journal Article
Metabolic Reprogramming by Dual AKT/ERK Inhibition Through Imipridones Elicits Unique Vulnerabilities in Glioblastoma
Ishida, Chiaki Tsuge, Zhang, Yiru, Bianchetti, Elena, Shu, Chang, Nguyen, Trang Tt, Kleiner, Giulio, Sanchez-Quintero, Maria, Quinzii, Catarina M, Westhoff, Mike-Andrew, Karpel-Massler, Georg, Prabhu, Varun Vijay, Allen, Joshua E, Siegelin, Markus D
Published in Clinical cancer research (01.11.2018)
Published in Clinical cancer research (01.11.2018)
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Journal Article
Combined HDAC and Bromodomain Protein Inhibition Reprograms Tumor Cell Metabolism and Elicits Synthetic Lethality in Glioblastoma
Zhang, Yiru, Ishida, Chiaki Tsuge, Ishida, Wataru, Lo, Sheng-Fu L, Zhao, Junfei, Shu, Chang, Bianchetti, Elena, Kleiner, Giulio, Sanchez-Quintero, Maria J, Quinzii, Catarina M, Westhoff, Mike-Andrew, Karpel-Massler, Georg, Canoll, Peter, Siegelin, Markus D
Published in Clinical cancer research (15.08.2018)
Published in Clinical cancer research (15.08.2018)
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Journal Article
Insights into the ubiquinol/dioxygen binding and proton relay pathways of the alternative oxidase
Shiba, Tomoo, Inaoka, Daniel Ken, Takahashi, Gen, Tsuge, Chiaki, Kido, Yasutoshi, Young, Luke, Ueda, Satoshi, Balogun, Emmanuel Oluwadare, Nara, Takeshi, Honma, Teruki, Tanaka, Akiko, Inoue, Masayuki, Saimoto, Hiroyuki, Harada, Shigeharu, Moore, Anthony L., Kita, Kiyoshi
Published in Biochimica et biophysica acta. Bioenergetics (01.05.2019)
Published in Biochimica et biophysica acta. Bioenergetics (01.05.2019)
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Journal Article
Discovery of trypanocidal coumarins with dual inhibition of both the glycerol kinase and alternative oxidase of Trypanosoma brucei brucei
Balogun, Emmanuel Oluwadare, Inaoka, Daniel Ken, Shiba, Tomoo, Tsuge, Chiaki, May, Benjamin, Sato, Tomohiro, Kido, Yasutoshi, Nara, Takeshi, Aoki, Takashi, Honma, Teruki, Tanaka, Akiko, Inoue, Masayuki, Matsuoka, Shigeru, Michels, Paul A M, Watanabe, Yoh-Ichi, Moore, Anthony L, Harada, Shigeharu, Kita, Kiyoshi
Published in The FASEB journal (01.11.2019)
Published in The FASEB journal (01.11.2019)
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Journal Article
Targeting intrinsic apoptosis and other forms of cell death by BH3-mimetics in glioblastoma
Karpel-Massler, Georg, Ishida, Chiaki Tsuge, Zhang, Yiru, Halatsch, Marc-Eric, Westhoff, M-Andrew, Siegelin, Markus D
Published in Expert opinion on drug discovery (03.10.2017)
Published in Expert opinion on drug discovery (03.10.2017)
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Journal Article
IDH1 R132H predicts sensitivity to Bcl-xL inhibition-mediated programmed cell death
Karpel-Massler, Georg, Ishida, Chiaki Tsuge, Siegelin, Markus D
Published in Oncotarget (02.01.2018)
Published in Oncotarget (02.01.2018)
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Journal Article
Targeting the alternative oxidase for antitrypanosomal drug development
Inaoka, Daniel Ken, Shiba, Tomoo, Chiaki, Tsuge, Kido, Yasutoshi, Balogun, Emmanuel Oluwadare, Young, Luke, Moore, Anthony, Saimoto, Hiroyuki, Harada, Shigeharu, Kita, Kiyoshi
Published in Biochimica et biophysica acta. Bioenergetics (01.09.2018)
Published in Biochimica et biophysica acta. Bioenergetics (01.09.2018)
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Journal Article
BET-inhibitors as sensitizers for BH3-mimetics
Ishida, Chiaki Tsuge, Karpel-Massler, Georg, Siegelin, Markus D
Published in Aging (Albany, NY.) (26.06.2017)
Published in Aging (Albany, NY.) (26.06.2017)
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Journal Article