Search Results - "Tsou Hwei-Ru" :: K.UTB vyhledávací portál | TBU Library Retrieval Portal

Antitumor activity of HKI-272, an orally active, irreversible inhibitor of the HER-2 tyrosine kinase

Antitumor activity of HKI-272, an orally active, irreversible inhibitor of the HER-2 tyrosine kinase

by RABINDRAN, Sridhar K, DISCAFANI, Carolyn M, REICH, Marvin F, RU SHEN, XIAOQING SHI, TSOU, Hwei-Ru, WANG, Yu-Fen, WISSNER, Allan, ROSFJORD, Edward C, BAXTER, Michelle, FLOYD, M. Brawner, GOLAS, Jonathan, HALLETT, William A, JOHNSON, Bernard D, NILAKANTAN, Ramaswamy, OVERBEEK, Elsebe
Published in Cancer research (Chicago, Ill.) (01.06.2004)

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Journal Article

Optimization of 6,7-Disubstituted-4-(arylamino)quinoline-3-carbonitriles as Orally Active, Irreversible Inhibitors of Human Epidermal Growth Factor Receptor-2 Kinase Activity

Optimization of 6,7-Disubstituted-4-(arylamino)quinoline-3-carbonitriles as Orally Active, Irreversible Inhibitors of Human Epidermal Growth Factor Receptor-2 Kinase Activity

by Tsou, Hwei-Ru, Overbeek-Klumpers, Elsebe G, Hallett, William A, Reich, Marvin F, Floyd, M. Brawner, Johnson, Bernard D, Michalak, Ronald S, Nilakantan, Ramaswamy, Discafani, Carolyn, Golas, Jonathan, Rabindran, Sridhar K, Shen, Ru, Shi, Xiaoqing, Wang, Yu-Fen, Upeslacis, Janis, Wissner, Allan
Published in Journal of medicinal chemistry (24.02.2005)

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Journal Article

Gemtuzumab Ozogamicin, A Potent and Selective Anti-CD33 Antibody−Calicheamicin Conjugate for Treatment of Acute Myeloid Leukemia

Gemtuzumab Ozogamicin, A Potent and Selective Anti-CD33 Antibody−Calicheamicin Conjugate for Treatment of Acute Myeloid Leukemia

by Hamann, Philip R, Hinman, Lois M, Hollander, Irwin, Beyer, Carl F, Lindh, Delores, Holcomb, Ryan, Hallett, William, Tsou, Hwei-Ru, Upeslacis, Janis, Shochat, Dan, Mountain, Andrew, Flowers, David A, Bernstein, Irwin
Published in Bioconjugate chemistry (01.01.2002)

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Journal Article

Synthesis and Structure−Activity Relationships of 6,7-Disubstituted 4-Anilinoquinoline-3-carbonitriles. The Design of an Orally Active, Irreversible Inhibitor of the Tyrosine Kinase Activity of the Epidermal Growth Factor Receptor (EGFR) and the Human Epidermal Growth Factor Receptor-2 (HER-2)

Synthesis and Structure−Activity Relationships of 6,7-Disubstituted 4-Anilinoquinoline-3-carbonitriles. The Design of an Orally Active, Irreversible Inhibitor of the Tyrosine Kinase Activity of the Epidermal Growth Factor Receptor (EGFR) and the Human Epidermal Growth Factor Receptor-2 (HER-2)

by Wissner, Allan, Overbeek, Elsebe, Reich, Marvin F, Floyd, M. Brawner, Johnson, Bernard D, Mamuya, Nellie, Rosfjord, Edward C, Discafani, Carolyn, Davis, Rachel, Shi, Xiaoqing, Rabindran, Sridhar K, Gruber, Brian C, Ye, Fei, Hallett, William A, Nilakantan, Ramaswamy, Shen, Ru, Wang, Yu-Fen, Greenberger, Lee M, Tsou, Hwei-Ru
Published in Journal of medicinal chemistry (02.01.2003)

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Journal Article

Palladium-catalyzed arylation of N, N-dialkylhydrazines and the subsequent conversion to anilines

Palladium-catalyzed arylation of N, N-dialkylhydrazines and the subsequent conversion to anilines

by Liu, Xiaoxiang, Barry, Michael, Tsou, Hwei-Ru
Published in Tetrahedron letters (26.11.2007)

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Journal Article

4-(Phenylaminomethylene)isoquinoline-1,3(2H,4H)-diones as Potent and Selective Inhibitors of the Cyclin-Dependent Kinase 4 (CDK4)

4-(Phenylaminomethylene)isoquinoline-1,3(2H,4H)-diones as Potent and Selective Inhibitors of the Cyclin-Dependent Kinase 4 (CDK4)

by Tsou, Hwei-Ru, Otteng, Mercy, Tran, Tritin, Floyd, M. Brawner, Reich, Marvin, Birnberg, Gary, Kutterer, Kristina, Ayral-Kaloustian, Semiramis, Ravi, Malini, Nilakantan, Ramaswamy, Grillo, Mary, McGinnis, John P, Rabindran, Sridhar K
Published in Journal of medicinal chemistry (26.06.2008)

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Journal Article

4-Substituted-7-azaindoles bearing a ureidobenzofuranone moiety as potent and selective, ATP-competitive inhibitors of the mammalian target of rapamycin (mTOR)

4-Substituted-7-azaindoles bearing a ureidobenzofuranone moiety as potent and selective, ATP-competitive inhibitors of the mammalian target of rapamycin (mTOR)

by Tsou, Hwei-Ru, MacEwan, Gloria, Birnberg, Gary, Zhang, Nan, Brooijmans, Natasja, Toral-Barza, Lourdes, Hollander, Irwin, Ayral-Kaloustian, Semiramis, Yu, Ker
Published in Bioorganic & medicinal chemistry letters (01.04.2010)

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Journal Article

Lead identification to generate isoquinolinedione inhibitors of insulin-like growth factor receptor (IGF-1R) for potential use in cancer treatment

Lead identification to generate isoquinolinedione inhibitors of insulin-like growth factor receptor (IGF-1R) for potential use in cancer treatment

by Mayer, Scott C., Banker, Annette L., Boschelli, Frank, Di, Li, Johnson, Mark, Kenny, Cynthia Hess, Krishnamurthy, Girija, Kutterer, Kristina, Moy, Franklin, Petusky, Susan, Ravi, Malini, Tkach, Diane, Tsou, Hwei-Ru, Xu, Weixin
Published in Bioorganic & medicinal chemistry letters (15.06.2008)

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Journal Article

Discovery and optimization of 2-(4-substituted-pyrrolo[2,3- b]pyridin-3-yl)methylene-4-hydroxybenzofuran-3(2 H)-ones as potent and selective ATP-competitive inhibitors of the mammalian target of rapamycin (mTOR)

Discovery and optimization of 2-(4-substituted-pyrrolo[2,3- b]pyridin-3-yl)methylene-4-hydroxybenzofuran-3(2 H)-ones as potent and selective ATP-competitive inhibitors of the mammalian target of rapamycin (mTOR)

by Tsou, Hwei-Ru, MacEwan, Gloria, Birnberg, Gary, Grosu, George, Bursavich, Matthew G., Bard, Joel, Brooijmans, Natasja, Toral-Barza, Lourdes, Hollander, Irwin, Mansour, Tarek S., Ayral-Kaloustian, Semiramis, Yu, Ker
Published in Bioorganic & medicinal chemistry letters (01.04.2010)

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Journal Article

Pyrazolo[1,5- a]pyrimidin-7-yl phenyl amides as novel anti-proliferative agents: parallel synthesis for lead optimization of amide region

Pyrazolo[1,5- a]pyrimidin-7-yl phenyl amides as novel anti-proliferative agents: parallel synthesis for lead optimization of amide region

by Gopalsamy, Ariamala, Yang, Hui, Ellingboe, John W., Tsou, Hwei-Ru, Zhang, Nan, Honores, Erick, Powell, Dennis, Miranda, Miriam, McGinnis, John P., Rabindran, Sridhar K.
Published in Bioorganic & medicinal chemistry letters (15.03.2005)

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Journal Article

Syntheses and EGFR and HER-2 kinase inhibitory activities of 4-anilinoquinoline-3-carbonitriles: Analogues of three important 4-anilinoquinazolines currently undergoing clinical evaluation as therapeutic antitumor agents

Syntheses and EGFR and HER-2 kinase inhibitory activities of 4-anilinoquinoline-3-carbonitriles: Analogues of three important 4-anilinoquinazolines currently undergoing clinical evaluation as therapeutic antitumor agents

by WISSNER, Allan, FLOYD, M. Brawner, RABINDRAN, Sridhar K, NILAKANTAN, Ramaswamy, GREENBERGER, Lee M, RU SHEN, WANG, Yu-Fen, TSOU, Hwei-Ru
Published in Bioorganic & medicinal chemistry letters (21.10.2002)

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Journal Article

SUBSTITUTED QUINAZOLINE DERIVATIVES AND THEIR USE AS TYROSINE KINASE INHIBITORS

SUBSTITUTED QUINAZOLINE DERIVATIVES AND THEIR USE AS TYROSINE KINASE INHIBITORS

by TSOU HWEI-RU, HAMANN PHILIP ROSS, JOHNSON BERNARD DEAN, WISSNER ALLAN, ZHANG NAN
Year of Publication 06.11.2014

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Patent

THE UTILIZATION OF MOLECULAR OXYGEN DURING THE BIOSYNTHESIS OF MADURAMICIN

THE UTILIZATION OF MOLECULAR OXYGEN DURING THE BIOSYNTHESIS OF MADURAMICIN

by TSOU, HWEI-RU, RAJAN, SRINIVASAN, CHANG, TED T., FIALA, RUTH R., STOCKTON, GERALD W., BULLOCK, MILON W.
Published in Journal of antibiotics (01.01.1987)

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Journal Article

Discovery of 4-(Benzylaminomethylene)isoquinoline-1,3-(2H,4H)-diones and 4-[(Pyridylmethyl)aminomethylene]isoquinoline-1,3-(2H,4H)-diones as Potent and Selective Inhibitors of the Cyclin-Dependent Kinase 4

Discovery of 4-(Benzylaminomethylene)isoquinoline-1,3-(2H,4H)-diones and 4-[(Pyridylmethyl)aminomethylene]isoquinoline-1,3-(2H,4H)-diones as Potent and Selective Inhibitors of the Cyclin-Dependent Kinase 4

by Tsou, Hwei-Ru, Liu, Xiaoxiang, Birnberg, Gary, Kaplan, Joshua, Otteng, Mercy, Tran, Tritin, Kutterer, Kristina, Tang, Zhilian, Suayan, Ron, Zask, Arie, Ravi, Malini, Bretz, Angela, Grillo, Mary, McGinnis, John P, Rabindran, Sridhar K, Ayral-Kaloustian, Semiramis, Mansour, Tarek S
Published in Journal of medicinal chemistry (23.04.2009)

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Journal Article

ChemInform Abstract: Palladium-Catalyzed Arylation of N,N-Dialkylhydrazines and the Subsequent Conversion to Anilines

ChemInform Abstract: Palladium-Catalyzed Arylation of N,N-Dialkylhydrazines and the Subsequent Conversion to Anilines

by Liu, Xiaoxiang, Barry, Michael, Tsou, Hwei-Ru
Published in ChemInform (11.03.2008)

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Journal Article

Natural abundance two-dimensional double-quantum 13C NMR spectroscopy of maduramicin, a polyether ionophore antibiotic and coccidiostat

Natural abundance two-dimensional double-quantum 13C NMR spectroscopy of maduramicin, a polyether ionophore antibiotic and coccidiostat

by SRINIVASAN RAJAN, HWEI-RU TSOU, MOWERY, P. C, BULLOCK, M. W, STOCKTON, G. W
Published in Journal of antibiotics (1984)

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Journal Article

6-Substituted-4-(3-bromophenylamino)quinazolines as Putative Irreversible Inhibitors of the Epidermal Growth Factor Receptor (EGFR) and Human Epidermal Growth Factor Receptor (HER-2) Tyrosine Kinases with Enhanced Antitumor Activity

6-Substituted-4-(3-bromophenylamino)quinazolines as Putative Irreversible Inhibitors of the Epidermal Growth Factor Receptor (EGFR) and Human Epidermal Growth Factor Receptor (HER-2) Tyrosine Kinases with Enhanced Antitumor Activity

by Tsou, Hwei-Ru, Mamuya, Nellie, Johnson, Bernard D, Reich, Marvin F, Gruber, Brian C, Ye, Fei, Nilakantan, Ramaswamy, Shen, Ru, Discafani, Carolyn, DeBlanc, Ronald, Davis, Rachel, Koehn, Frank E, Greenberger, Lee M, Wang, Yu-Fen, Wissner, Allan
Published in Journal of medicinal chemistry (16.08.2001)

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Journal Article

4-Anilino-6,7-dialkoxyquinoline-3-carbonitrile Inhibitors of Epidermal Growth Factor Receptor Kinase and Their Bioisosteric Relationship to the 4-Anilino-6,7-dialkoxyquinazoline Inhibitors

4-Anilino-6,7-dialkoxyquinoline-3-carbonitrile Inhibitors of Epidermal Growth Factor Receptor Kinase and Their Bioisosteric Relationship to the 4-Anilino-6,7-dialkoxyquinazoline Inhibitors

by Wissner, Allan, Berger, Dan M, Boschelli, Diane H, Floyd, M. Brawner, Greenberger, Lee M, Gruber, Brian C, Johnson, Bernard D, Mamuya, Nellie, Nilakantan, Ramaswamy, Reich, Marvin F, Shen, Ru, Tsou, Hwei-Ru, Upeslacis, Erik, Wang, Yu Fen, Wu, Biqi, Ye, Fei, Zhang, Nan
Published in Journal of medicinal chemistry (24.08.2000)

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Journal Article

Procedure for diethoxymethylation of ketones

Procedure for diethoxymethylation of ketones

by Mock, William L, Tsou, Hwei-Ru
Published in Journal of organic chemistry (01.06.1981)

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Journal Article

Pyrazolo[1,5-a]pyrimidin-7-yl Phenyl Amides as Novel Antiproliferative Agents: Parallel Synthesis for Lead Optimization of Amide Region

Pyrazolo[1,5-a]pyrimidin-7-yl Phenyl Amides as Novel Antiproliferative Agents: Parallel Synthesis for Lead Optimization of Amide Region

by Gopalsamy, Ariamala, Yang, Hui, Ellingboe, John W., Tsou, Hwei-Ru, Zhang, Nan, Honores, Erick, Powell, Dennis, Miranda, Miriam, McGinnis, John P., Rabindran, Sridhar K.
Published in ChemInform (19.07.2005)

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