A highly potent long-acting small-molecule HIV-1 capsid inhibitor with efficacy in a humanized mouse model
Yant, Stephen R., Mulato, Andrew, Hansen, Derek, Tse, Winston C., Niedziela-Majka, Anita, Zhang, Jennifer R., Stepan, George J., Jin, Debi, Wong, Melanie H., Perreira, Jill M., Singer, Eric, Papalia, Giuseppe A., Hu, Eric Y., Zheng, Jim, Lu, Bing, Schroeder, Scott D., Chou, Kevin, Ahmadyar, Shekeba, Liclican, Albert, Yu, Helen, Novikov, Nikolai, Paoli, Eric, Gonik, Daniel, Ram, Renee R., Hung, Magdeleine, McDougall, William M., Brass, Abraham L., Sundquist, Wesley I., Cihlar, Tomas, Link, John O.
Published in Nature medicine (01.09.2019)
Published in Nature medicine (01.09.2019)
Get full text
Journal Article
The Allyl Leaving Group Approach to Tricoordinate Silyl, Germyl, and Stannyl Cations
Lambert, Joseph B, Zhao, Yan, Wu, Hongwei, Tse, Winston C, Kuhlmann, Barbara
Published in Journal of the American Chemical Society (02.06.1999)
Published in Journal of the American Chemical Society (02.06.1999)
Get full text
Journal Article
Lenacapavir Exhibits Atropisomerism-Mechanistic Pharmacokinetics and Disposition Studies of Lenacapavir Reveal Intestinal Excretion as a Major Clearance Pathway
Zheng, Jim, Lu, Bing, Carr, Gavin, Mwangi, Judy, Wang, Kelly, Hao, Jia, Staiger, Kelly McLennan, Kozon, Nathan, Murray, Bernard P, Bashir, Mohammad, Gohdes, Mark A, Tse, Winston C, Schroeder, Scott, Graupe, Michael, Link, John O, Yoon, Jungjoo, Chiu, Anna, Rowe, William, Smith, Bill J, Subramanian, Raju
Published in The Journal of pharmacology and experimental therapeutics (18.09.2024)
Published in The Journal of pharmacology and experimental therapeutics (18.09.2024)
Get full text
Journal Article
Lenacapavir: A Novel, Potent, and Selective First-in-Class Inhibitor of HIV-1 Capsid Function Exhibits Optimal Pharmacokinetic Properties for a Long-Acting Injectable Antiretroviral Agent
Subramanian, Raju, Tang, Jennifer, Zheng, Jim, Lu, Bing, Wang, Kelly, Yant, Stephen R, Stepan, George J, Mulato, Andrew, Yu, Helen, Schroeder, Scott, Shaik, Naveed, Singh, Renu, Wolckenhauer, Scott, Chester, Anne, Tse, Winston C, Chiu, Anna, Rhee, Martin, Cihlar, Tomas, Rowe, William, Smith, Bill J
Published in Molecular pharmaceutics (04.12.2023)
Published in Molecular pharmaceutics (04.12.2023)
Get full text
Journal Article
539. GS-CA2: A Novel, Potent, and Selective First-In-class Inhibitor of HIV-1 Capsid Function Displays Nonclinical Pharmacokinetics Supporting Long-Acting Potential in Humans
Zheng, Jim, Yant, Stephen R, Ahmadyar, Shekeba, Chan, Tiffany Y, Chiu, Anna, Cihlar, Tomas, Link, John O, Lu, Bing, Mwangi, Judy, Rowe, William, Schroeder, Scott D, Stepan, George J, Wang, Kelly Wei, Subramanian, Raju, Tse, Winston C
Published in Open forum infectious diseases (26.11.2018)
Published in Open forum infectious diseases (26.11.2018)
Get full text
Journal Article
HIV 치료용 캡시드 저해제
KATO DARRYL, CHOU CHIENHUNG, SCHROEDER SCOTT D, TSE WINSTON C, ZHANG JENNIFER R, LAZERWITH SCOTT E
Year of Publication 27.02.2023
Get full text
Year of Publication 27.02.2023
Patent
HIV THERAPEUTIC COMPOUNDS USEFUL FOR THE PROPHYLACTIC OR THERAPEUTIC TREATMENT OF AN HIV VIRUS INFECTION
STEFANIDIS DIMITRIOS, ROWE CHARLES WILLIAM, SAITO ROLAND D, LINK JOHN O, SCHROEDER SCOTT D, HENRY STEVEN J, TSE WINSTON C, ZHANG JENNIFER R, GRAUPE MICHAEL
Year of Publication 21.05.2024
Get full text
Year of Publication 21.05.2024
Patent
HIV THERAPEUTIC COMPOUNDS USEFUL FOR THE PROPHYLACTIC OR THERAPEUTIC TREATMENT OF AN HIV VIRUS INFECTION
STEFANIDIS DIMITRIOS, ROWE CHARLES WILLIAM, SAITO ROLAND D, LINK JOHN O, SCHROEDER SCOTT D, HENRY STEVEN J, TSE WINSTON C, ZHANG JENNIFER R, GRAUPE MICHAEL
Year of Publication 20.01.2023
Get full text
Year of Publication 20.01.2023
Patent
HIV CAPSID INHIBITORS FOR THE TREATMENT OF HIV
STEFANIDIS DIMITRIOS, YANT STEPHEN R, MULATO ANDREW STEPHEN, LEVINE DANA J, ROWE CHARLES WILLIAM, SELLERS SCOTT P, BAUER LAURA ELIZABETH, CHIU ANNA, RHEE MARTIN SUNKWANG, TSE WINSTON C, GORMAN ERIC M
Year of Publication 10.10.2023
Get full text
Year of Publication 10.10.2023
Patent
PYRROLO [1,2-b] PYRIDAZINE DERIVATIVE
JEROMY J COTTELL, JOHN O LINK, JAMES G TAYLOR, JENNIFER R ZHANG, ELIZABETH M BACON, YANG ZHENG-YU, GEDIMINAS BRIZGYS, CHOU CHIENHUNG, NATHAN E WRIGHT, ELBERT CHIN, TSE WINSTON C, SHEILA M ZIPFEL
Year of Publication 19.07.2023
Get full text
Year of Publication 19.07.2023
Patent
HIV의 예방을 위한 캡시드 억제제
CIHLAR TOMAS, YANT STEPHEN R, LEVINE DANA J, CHIU ANNA, BEKERMAN ELENA, TSE WINSTON C, ZHENG JIM X, BLAIR WADE S
Year of Publication 28.07.2022
Get full text
Year of Publication 28.07.2022
Patent
METHODS AND INTERMEDIATES FOR PREPARING THERAPEUTIC COMPOUNDS USEFUL FOR TREATING RETROVIRIDAE VIRAL INFECTION
WANG XIANGHONG, SACHIN DHAR, WILLARD LEW, DIETRICH P STEINHUEBEL, AMANDA LYNN VANDEHEY, ALEX GOLDBERG, SHI BIN, GEDIMINAS BRIZGYS, LARS V HEUMANN, SHAHROKH KAZERANI, NGO VINH XUAN, HUANG ZILIN, KEVIN MCCORMACK ALLAN, NATHANIEL THOMAS KADUNCE, CHLOE YUY WONG, BRIAN MICHAEL O'KEEFE, TSE WINSTON C, BENJAMIN JAMES ROBERTS, ANNA MICHELLE WAGNER, SCOTT ALAN WOLCKENHAUER, IAN JAMES DOXSEE, JENNIFER R ZHANG, TREVOR JAMES RAINEY
Year of Publication 19.01.2024
Get full text
Year of Publication 19.01.2024
Patent
METHODS AND INTERMEDIATES FOR PREPARING A THERAPEUTIC COMPOUND USEFUL IN THE TREATMENT OF RETROVIRIDAE VIRAL INFECTION
WANG XIANGHONG, WONG CHLOE YUYI, BRIZGYS GEDIMINAS, GOLDBERG ALEX, STEINHUEBEL DIETRICH P, NGO VINH XUAN, HUANG ZILIN, TSE WINSTON C, HEUMANN LARS V, VANDEHEY AMANDA LYNN, LEW WILLARD, WOLCKENHAUER SCOTT ALAN, DHAR SACHIN, KAZERANI SHAHROKH, O'KEEFE BRIAN MICHAEL, ALLAN KEVIN MCCORMACK, ROBERTS BENJAMIN JAMES, DOXSEE IAN JAMES, SHI BING, KADUNCE NATHANIEL THOMAS, WAGNER ANNA MICHELLE, ZHANG JENNIFER R, RAINEY TREVOR JAMES
Year of Publication 17.10.2023
Get full text
Year of Publication 17.10.2023
Patent