Novel Carboxamide-Based Allosteric MEK Inhibitors: Discovery and Optimization Efforts toward XL518 (GDC-0973)
Rice, Kenneth D, Aay, Naing, Anand, Neel K, Blazey, Charles M, Bowles, Owen J, Bussenius, Joerg, Costanzo, Simona, Curtis, Jeffry K, Defina, Steven C, Dubenko, Larisa, Engst, Stefan, Joshi, Anagha A, Kennedy, Abigail R, Kim, Angie I, Koltun, Elena S, Lougheed, Julie C, Manalo, Jean-Claire L, Martini, Jean-Francois, Nuss, John M, Peto, Csaba J, Tsang, Tsze H, Yu, Peiwen, Johnston, Stuart
Published in ACS medicinal chemistry letters (10.05.2012)
Published in ACS medicinal chemistry letters (10.05.2012)
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Discovery of XL888: A novel tropane-derived small molecule inhibitor of HSP90
Bussenius, Joerg, Blazey, Charles M., Aay, Naing, Anand, Neel K., Arcalas, Arlyn, Baik, TaeGon, Bowles, Owen J., Buhr, Chris A., Costanzo, Simona, Curtis, Jeffrey K., DeFina, Steven C., Dubenko, Larisa, Heuer, Timothy S., Huang, Ping, Jaeger, Christopher, Joshi, Anagha, Kennedy, Abigail R., Kim, Angie I., Lara, Katherine, Lee, Jae, Li, Jonathan, Lougheed, Julie C., Ma, Sunghoon, Malek, Shiva, Manalo, Jean-Claire L., Martini, Jean-Francois, McGrath, Garth, Nicoll, Monique, Nuss, John M., Pack, Michael, Peto, Csaba J., Tsang, Tsze H., Wang, Longcheng, Womble, Scott W., Yakes, Michael, Zhang, Wentao, Rice, Kenneth D.
Published in Bioorganic & medicinal chemistry letters (01.09.2012)
Published in Bioorganic & medicinal chemistry letters (01.09.2012)
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Journal Article
Pyrazolopyrimidines as dual Akt/p70S6K inhibitors
Rice, Kenneth D., Kim, Moon H., Bussenius, Joerg, Anand, Neel K., Blazey, Charles M., Bowles, Owen J., Canne-Bannen, Lynne, Chan, Diva S.-M., Chen, Baili, Co, Erick W., Costanzo, Simona, DeFina, Steven C., Dubenko, Larisa, Engst, Stefan, Franzini, Maurizio, Huang, Ping, Jammalamadaka, Vasu, Khoury, Richard G., Klein, Rhett R., Laird, A.Douglas, Le, Donna T., Mac, Morrison B., Matthews, David J., Markby, David, Miller, Nicole, Nuss, John M., Parks, Jason J., Tsang, Tsze H., Tsuhako, Amy L., Wang, Yong, Xu, Wei
Published in Bioorganic & medicinal chemistry letters (15.04.2012)
Published in Bioorganic & medicinal chemistry letters (15.04.2012)
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Journal Article
Design and evaluation of a series of pyrazolopyrimidines as p70S6K inhibitors
Bussenius, Joerg, Anand, Neel K., Blazey, Charles M., Bowles, Owen J., Bannen, Lynne Canne, Chan, Diva S.-M., Chen, Baili, Co, Erick W., Costanzo, Simona, DeFina, Steven C., Dubenko, Larisa, Engst, Stefan, Franzini, Maurizio, Huang, Ping, Jammalamadaka, Vasu, Khoury, Richard G., Kim, Moon H., Klein, Rhett R., Laird, Douglas, Le, Donna T., Mac, Morrison B., Matthews, David J., Markby, David, Miller, Nicole, Nuss, John M., Parks, Jason J., Tsang, Tsze H., Tsuhako, Amy L., Wang, Yong, Xu, Wei, Rice, Kenneth D.
Published in Bioorganic & medicinal chemistry letters (15.03.2012)
Published in Bioorganic & medicinal chemistry letters (15.03.2012)
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MEK INHIBITORS AND METHOD FOR USING THE SAME
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Year of Publication 26.11.2020
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Year of Publication 26.11.2020
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MEK INHIBITOR AND APPLICATION METHOD THEREOF
DEFINA STEVEN CHARLES, KIM ANGIE INYOUNG, JOSHI ANAGHA ABHIJIT, BOWLES OWEN JOSEPH, AAY NAING, COSTANZO SIMONA, KENNEDY ABIGAIL R, KOLTUN ELENA, MANALO JEAN-CLAIRE LIMUN, ANAND NEEL KUMAR, LARISA DUBENKO, BUSSENIUS JOERG, TSANG TSZE H, BLAZEY CHARLES M, CURTIS JEFFRY KIMO, PETO CSABA J, RICE KENNETH D
Year of Publication 13.06.2019
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Year of Publication 13.06.2019
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MEK INHIBITOR AND APPLICATION METHOD THEREOF
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Year of Publication 12.04.2018
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Year of Publication 12.04.2018
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MEK INHIBITOR AND APPLICATION METHOD THEREOF
DEFINA STEVEN CHARLES, KIM ANGIE INYOUNG, JOSHI ANAGHA ABHIJIT, BOWLES OWEN JOSEPH, AAY NAING, COSTANZO SIMONA, KENNEDY ABIGAIL R, KOLTUN ELENA, MANALO JEAN-CLAIRE LIMUN, ANAND NEEL KUMAR, LARISA DUBENKO, BUSSENIUS JOERG, TSANG TSZE H, BLAZEY CHARLES M, CURTIS JEFFRY KIMO, PETO CSABA J, RICE KENNETH D
Year of Publication 08.06.2017
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Year of Publication 08.06.2017
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MEK INHIBITOR AND USE METHOD THEREOF
DEFINA STEVEN CHARLES, KIM ANGIE INYOUNG, JOSHI ANAGHA ABHIJIT, BOWLES OWEN JOSEPH, AAY NAING, COSTANZO SIMONA, KENNEDY ABIGAIL R, KOLTUN ELENA, MANALO JEAN-CLAIRE LIMUN, ANAND NEEL KUMAR, LARISA DUBENKO, BUSSENIUS JOERG, TSANG TSZE H, BLAZEY CHARLES M, CURTIS JEFFRY KIMO, PETO CSABA J, RICE KENNETH D
Year of Publication 24.12.2015
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Year of Publication 24.12.2015
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AZETIDINES AS MEK INHIBITORS FOR THE TREATMENT OF PROLIFERATIVE DISEASES
DEFINA STEVEN CHARLES, KIM ANGIE INYOUNG, JOSHI ANAGHA ABHIJIT, BOWLES OWEN JOSEPH, AAY NAING, COSTANZO SIMONA, KENNEDY ABIGAIL R, KOLTUN ELENA, MANALO JEAN CLAIRE LIMUN, ANAND NEEL KUMAR, BUSSENIUS JOERG, TSANG TSZE H, BLAZEY CHARLES M, CURTIS JEFFRY KIMO, PETO CSABA J, RICE KENNETH D, DUBENKO LARISA
Year of Publication 03.06.2013
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Year of Publication 03.06.2013
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BENZOXAZEPINES AS INHIBITORS OF PI3K/M TOR AND METHODS OF THEIR USE AND MANUFACTURE
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Year of Publication 07.08.2012
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BENZOXAZEPINES BASED P13K/MTOR INTHIBITORS AGAINST PROLIFERATIVE DISEASES
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Year of Publication 12.04.2012
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Year of Publication 12.04.2012
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TROPANE COMPOUNDS
DEFINA STEVEN CHARLES, KIM ANGIE INYOUNG, WANG LONGCHENG, BAIK, TAE GON, BOWLES OWEN JOSEPH, ARCALAS ARLYN, AAY NAING, COSTANZO SIMONA, KENNEDY ABIGAIL R, MANALO JEAN CLAIRE LIMUN, ANAND NEEL KUMAR, BUHR CHRIS A, BUSSENIUS JOERG, TSANG TSZE H, BLAZEY CHARLES M, LARA KATHERINE, RICE KENNETH D, CURTIS JEFFRY KIMO, PETO CSABA J, DUBENKO LARISA, MA, SUNG HOON
Year of Publication 17.08.2010
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Year of Publication 17.08.2010
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Forbindelser og farmasøytiske sammensetninger til behandling av proliferative sykdommer
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Year of Publication 15.05.2023
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Year of Publication 15.05.2023
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MEK inhibitors and methods of their use
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Year of Publication 07.03.2023
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Year of Publication 07.03.2023
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benzoxazepinas como inibidores de pi3k/mtor e métodos de seus usos e fabricação
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Year of Publication 24.09.2019
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Year of Publication 24.09.2019
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MEK Inhibitors and Methods of Their Use
Koltun, Elena S, Bussenius, Joerg, Tsang, Tsze H, Curtis, Jeffry Kimo, Kennedy, Abigail R, Blazey, Charles M, Peto, Csaba J, Anand, Neel Kumar, Aay, Naing, Kim, Angie Inyoung, Joshi, Anagha Abhijit, Bowles, Owen Joseph, Costanzo, Simona, Dubenko, Larisa, Rice, Kenneth D, DeFina, Steven Charles, Manalo, Jean-Claire Limun
Year of Publication 10.09.2020
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Year of Publication 10.09.2020
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RECEPTOR-TYPE KINASE MODULATORS AND METHODS OF USE
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Year of Publication 05.09.2018
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