Ser38‐His93‐Asn91 triad confers resistance of JFH1 HCV NS5A‐Y93H variant to NS5A inhibitors
Lee, Wei‐Ping, Tsai, Keng‐Chang, Liao, Shi‐Xian, Huang, Yi‐Hsiang, Hou, Ming‐Chih, Lan, Keng‐Hsin
Published in The FEBS journal (01.03.2024)
Published in The FEBS journal (01.03.2024)
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Journal Article
The Blockade of Mitogen-Activated Protein Kinase 14 Activation by Marine Natural Product Crassolide Triggers ICD in Tumor Cells and Stimulates Anti-Tumor Immunity
Tsai, Keng-Chang, Chen, Chia-Sheng, Su, Jui-Hsin, Lee, Yu-Ching, Tseng, Yu-Hwei, Wei, Wen-Chi
Published in Marine drugs (31.03.2023)
Published in Marine drugs (31.03.2023)
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Journal Article
A traditional Chinese medicine formula NRICM101 to target COVID-19 through multiple pathways: A bedside-to-bench study
Tsai, Keng-Chang, Huang, Yi-Chia, Liaw, Chia-Ching, Tsai, Chia-I, Chiou, Chun-Tang, Lin, Chien-Jung, Wei, Wen-Chi, Lin, Sunny Jui-Shan, Tseng, Yu-Hwei, Yeh, Kuo-Ming, Lin, Yi-Ling, Jan, Jia-Tsrong, Liang, Jian-Jong, Liao, Chun-Che, Chiou, Wen-Fei, Kuo, Yao-Haur, Lee, Shen-Ming, Lee, Ming-Yung, Su, Yi-Chang
Published in Biomedicine & pharmacotherapy (01.01.2021)
Published in Biomedicine & pharmacotherapy (01.01.2021)
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Predicting Ligand Binding Sites on Protein Surfaces by 3-Dimensional Probability Density Distributions of Interacting Atoms
Jian, Jhih-Wei, Elumalai, Pavadai, Pitti, Thejkiran, Wu, Chih Yuan, Tsai, Keng-Chang, Chang, Jeng-Yih, Peng, Hung-Pin, Yang, An-Suei
Published in PloS one (11.08.2016)
Published in PloS one (11.08.2016)
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Journal Article
Pdia4 regulates β‐cell pathogenesis in diabetes: molecular mechanism and targeted therapy
Kuo, Tien‐Fen, Hsu, Shuo‐Wen, Huang, Shou‐Hsien, Chang, Cicero Lee‐Tian, Feng, Ching‐Shan, Huang, Ming‐Guang, Chen, Tzung‐Yan, Yang, Meng‐Ting, Jiang, Si‐Tse, Wen, Tuan‐Nan, Yang, Chun‐Yen, Huang, Chung‐Yu, Kao, Shu‐Huei, Tsai, Keng‐Chang, Yang, Greta, Yang, Wen‐Chin
Published in EMBO molecular medicine (07.10.2021)
Published in EMBO molecular medicine (07.10.2021)
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Development of anti-aflatoxin B1 nanobodies from a novel mutagenesis-derived synthetic library for traditional Chinese medicine and foods safety testing
Lee, Yu-Ching, Lai, Gar-Hwa, Lin, Tsai-Yu, Tseng, Tien-Sheng, Tsai, Tsung-Hsun, Chen, Wang-Chuan, Lee, Cheng-Chung, Tsai, Keng-Chang
Published in Journal of biological engineering (24.04.2023)
Published in Journal of biological engineering (24.04.2023)
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Journal Article
Characterizing the structure-activity relationships of natural products, tanshinones, reveals their mode of action in inhibiting spleen tyrosine kinase
Tung, Min-Che, Tsai, Keng-Chang, Fung, Kit-Man, Don, Ming-Jaw, Tseng, Tien-Sheng
Published in RSC advances (14.01.2021)
Published in RSC advances (14.01.2021)
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Journal Article
Synthesis of Tamiflu and its Phosphonate Congeners Possessing Potent Anti-Influenza Activity
Shie, Jiun-Jie, Fang, Jim-Min, Wang, Shi-Yun, Tsai, Keng-Chang, Cheng, Yih-Shyun E, Yang, An-Suei, Hsiao, Shih-Chia, Su, Ching-Yao, Wong, Chi-Huey
Published in Journal of the American Chemical Society (03.10.2007)
Published in Journal of the American Chemical Society (03.10.2007)
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Journal Article
Generation of avian-derived anti-B7-H4 antibodies exerts a blockade effect on the immunosuppressive response
Lin, Tsai-Yu, Tsai, Tsung-Hsun, Chen, Chih-Tien, Yang, Tz-Wen, Chang, Fu-Ling, Lo, Yan-Ni, Chung, Ting-Sheng, Cheng, Ming-Hui, Chen, Wang-Chuan, Tsai, Keng-Chang, Lee, Yu-Ching
Published in Experimental Animals (01.01.2021)
Published in Experimental Animals (01.01.2021)
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Sarkosyl-Induced Helical Structure of an Antimicrobial Peptide GW-Q6 Plays an Essential Role in the Binding of Surface Receptor OprI in Pseudomonas aeruginosa
Tseng, Tien-Sheng, Wang, Shih-Han, Chang, Ting-Wei, Wei, Hung-Mu, Wang, Yu-June, Tsai, Keng-Chang, Liao, You-Di, Chen, Chinpan
Published in PloS one (11.10.2016)
Published in PloS one (11.10.2016)
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Serendipitous Discovery of Short Peptides from Natural Products as Tyrosinase Inhibitors
Hsiao, Nai-Wan, Tseng, Tien-Sheng, Lee, Yu-Ching, Chen, Wang-Chuan, Lin, Hui-Hsiung, Chen, Yun-Ru, Wang, Yeng-Tseng, Hsu, Hung-Ju, Tsai, Keng-Chang
Published in Journal of chemical information and modeling (24.11.2014)
Published in Journal of chemical information and modeling (24.11.2014)
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Journal Article
Exploring the mode of action of inhibitors targeting the PhoP response regulator of Salmonella enterica through comprehensive pharmacophore approaches
Tsai, Keng-Chang, Hung, Po-Pin, Cheng, Ching-Feng, Chen, Chinpan, Tseng, Tien-Sheng
Published in RSC advances (01.01.2019)
Published in RSC advances (01.01.2019)
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Journal Article
Protein-DNA complex-guided discovery of the antibacterial lead E1 for restoring the susceptibility of Klebsiella Pneumoniae to polymyxin B by targeting the response regulator PmrA
Tseng, Tien-Sheng, Tu, I-Fan, Chen, Hsiao-Ting, Lin, Lie-Chwen, Tsai, Keng-Chang, Wu, Shih-Hsiung, Chen, Chinpan
Published in Chemical communications (Cambridge, England) (2018)
Published in Chemical communications (Cambridge, England) (2018)
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NRICM101 ameliorates SARS-CoV-2-S1-induced pulmonary injury in K18-hACE2 mice model
Wei, Wen-Chi, Tsai, Keng-Chang, Liaw, Chia-Ching, Chiou, Chun-Tang, Tseng, Yu-Hwei, Liao, Geng-You, Lin, Yu-Chi, Chiou, Wen-Fei, Liou, Kuo-Tong, Yu, I-Shing, Shen, Yuh-Chiang, Su, Yi-Chang
Published in Frontiers in pharmacology (21.06.2023)
Published in Frontiers in pharmacology (21.06.2023)
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Astragalus membranaceus–Derived Anti-Programmed Death-1 Monoclonal Antibodies with Immunomodulatory Therapeutic Effects against Tumors
Chen, Po-Hung, Yen, Yun, Pan, Shiow-Lin, Lee, Yu-Ching, Lu, Mei-Kuang, Chang, Jui-Hsien, Chen, Wang-Chuan, Lo, Yan-Ni, Yang, Tz-Wen, Lin, Tsai-Yu, Tsai, Keng-Chang, Chang, Fu-Ling, Chiou, Chun-Tang
Published in BioMed research international (2020)
Published in BioMed research international (2020)
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Inhibition of CYP1 by berberine, palmatine, and jatrorrhizine: Selectivity, kinetic characterization, and molecular modeling
Lo, Sheng-Nan, Chang, Yu-Ping, Tsai, Keng-Chang, Chang, Chia-Yu, Wu, Tian-Shung, Ueng, Yune-Fang
Published in Toxicology and applied pharmacology (01.11.2013)
Published in Toxicology and applied pharmacology (01.11.2013)
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Structure-guided identification and characterization of potent inhibitors targeting PhoP and MtrA to combat mycobacteria
Su, Han-Li, Lai, Shu-Jung, Tsai, Keng-Chang, Fung, Kit-Man, Lung, Tse-Lin, Hsu, Hsing-Mien, Wu, Yi-Chen, Liu, Ching-Hui, Lai, Hui-Xiang, Lin, Jiun-Han, Tseng, Tien-Sheng
Published in Computational and structural biotechnology journal (01.12.2024)
Published in Computational and structural biotechnology journal (01.12.2024)
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Peramivir analogues bearing hydrophilic side chains exhibit higher activities against H275Y mutant than wild-type influenza virus
Chiu, Din-Chi, Lin, Tzu-Chen, Huang, Wen-I, Cheng, Ting-Jen, Tsai, Keng-Chang, Fang, Jim-Min
Published in Organic & biomolecular chemistry (2017)
Published in Organic & biomolecular chemistry (2017)
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