Phase-plate cryo-EM structure of a biased agonist-bound human GLP-1 receptor–Gs complex
Liang, Yi-Lynn, Khoshouei, Maryam, Glukhova, Alisa, Furness, Sebastian G. B., Zhao, Peishen, Clydesdale, Lachlan, Koole, Cassandra, Truong, Tin T., Thal, David M., Lei, Saifei, Radjainia, Mazdak, Danev, Radostin, Baumeister, Wolfgang, Wang, Ming-Wei, Miller, Laurence J., Christopoulos, Arthur, Sexton, Patrick M., Wootten, Denise
Published in Nature (London) (01.03.2018)
Published in Nature (London) (01.03.2018)
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Journal Article
Differential GLP-1R Binding and Activation by Peptide and Non-peptide Agonists
Zhang, Xin, Belousoff, Matthew J., Zhao, Peishen, Kooistra, Albert J., Truong, Tin T., Ang, Sheng Yu, Underwood, Christina Rye, Egebjerg, Thomas, Šenel, Petr, Stewart, Gregory D., Liang, Yi-Lynn, Glukhova, Alisa, Venugopal, Hari, Christopoulos, Arthur, Furness, Sebastian G.B., Miller, Laurence J., Reedtz-Runge, Steffen, Langmead, Christopher J., Gloriam, David E., Danev, Radostin, Sexton, Patrick M., Wootten, Denise
Published in Molecular cell (05.11.2020)
Published in Molecular cell (05.11.2020)
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Journal Article
Activation of the GLP-1 receptor by a non-peptidic agonist
Zhao, Peishen, Liang, Yi-Lynn, Belousoff, Matthew J., Deganutti, Giuseppe, Fletcher, Madeleine M., Willard, Francis S., Bell, Michael G., Christe, Michael E., Sloop, Kyle W., Inoue, Asuka, Truong, Tin T., Clydesdale, Lachlan, Furness, Sebastian G. B., Christopoulos, Arthur, Wang, Ming-Wei, Miller, Laurence J., Reynolds, Christopher A., Danev, Radostin, Sexton, Patrick M., Wootten, Denise
Published in Nature (London) (16.01.2020)
Published in Nature (London) (16.01.2020)
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Journal Article
Toward a Structural Understanding of Class B GPCR Peptide Binding and Activation
Liang, Yi-Lynn, Belousoff, Matthew J., Zhao, Peishen, Koole, Cassandra, Fletcher, Madeleine M., Truong, Tin T., Julita, Villy, Christopoulos, George, Xu, H. Eric, Zhang, Yan, Khoshouei, Maryam, Christopoulos, Arthur, Danev, Radostin, Sexton, Patrick M., Wootten, Denise
Published in Molecular cell (06.02.2020)
Published in Molecular cell (06.02.2020)
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Journal Article
Dynamics of GLP-1R peptide agonist engagement are correlated with kinetics of G protein activation
Deganutti, Giuseppe, Liang, Yi-Lynn, Zhang, Xin, Khoshouei, Maryam, Clydesdale, Lachlan, Belousoff, Matthew J., Venugopal, Hari, Truong, Tin T., Glukhova, Alisa, Keller, Andrew N., Gregory, Karen J., Leach, Katie, Christopoulos, Arthur, Danev, Radostin, Reynolds, Christopher A., Zhao, Peishen, Sexton, Patrick M., Wootten, Denise
Published in Nature communications (10.01.2022)
Published in Nature communications (10.01.2022)
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Journal Article
Dominant Negative G Proteins Enhance Formation and Purification of Agonist-GPCR‑G Protein Complexes for Structure Determination
Liang, Yi-Lynn, Zhao, Peishen, Draper-Joyce, Christopher, Baltos, Jo-Anne, Glukhova, Alisa, Truong, Tin T, May, Lauren T, Christopoulos, Arthur, Wootten, Denise, Sexton, Patrick M, Furness, Sebastian G. B
Published in ACS pharmacology & translational science (14.09.2018)
Published in ACS pharmacology & translational science (14.09.2018)
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Journal Article
Implications of ligand-receptor binding kinetics on GLP-1R signalling
Zhao, Peishen, Truong, Tin T., Merlin, Jon, Sexton, Patrick M., Wootten, Denise
Published in Biochemical pharmacology (01.05.2022)
Published in Biochemical pharmacology (01.05.2022)
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Journal Article
Structural and functional diversity among agonist-bound states of the GLP-1 receptor
Cary, Brian P., Deganutti, Giuseppe, Zhao, Peishen, Truong, Tin T., Piper, Sarah J., Liu, Xinyu, Belousoff, Matthew J., Danev, Radostin, Sexton, Patrick M., Wootten, Denise, Gellman, Samuel H.
Published in Nature chemical biology (01.03.2022)
Published in Nature chemical biology (01.03.2022)
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Journal Article
AM833 Is a Novel Agonist of Calcitonin Family G Protein-Coupled Receptors: Pharmacological Comparison with Six Selective and Nonselective Agonists
Fletcher, Madeleine M, Keov, Peter, Truong, Tin T, Mennen, Grace, Hick, Caroline A, Zhao, Peishen, Furness, Sebastian G B, Kruse, Thomas, Clausen, Trine R, Wootten, Denise, Sexton, Patrick M
Published in The Journal of pharmacology and experimental therapeutics (01.06.2021)
Published in The Journal of pharmacology and experimental therapeutics (01.06.2021)
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Journal Article
O‑GlcNAc Engineering of GPCR Peptide-Agonists Improves Their Stability and in Vivo Activity
Levine, Paul M, Balana, Aaron T, Sturchler, Emmanuel, Koole, Cassandra, Noda, Hiroshi, Zarzycka, Barbara, Daley, Eileen J, Truong, Tin T, Katritch, Vsevolod, Gardella, Thomas J, Wootten, Denise, Sexton, Patrick M, McDonald, Patricia, Pratt, Matthew R
Published in Journal of the American Chemical Society (11.09.2019)
Published in Journal of the American Chemical Society (11.09.2019)
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Journal Article
Phase-plate cryo-EM structure of a biased agonist-bound human GLP-1 receptorGs complex
Liang, Yi-Lynn, Khoshouei, Maryam, Glukhova, Alisa, Furness, Sebastian G. B, Zhao, Peishen, Clydesdale, Lachlan, Koole, Cassandra, Truong, Tin T, Thal, David M, Lei, Saifei, Radjainia, Mazdak, Danev, Radostin, Baumeister, Wolfgang, Wang, Ming-Wei, Miller, Laurence J, Christopoulos, Arthur, Sexton, Patrick M, Wootten, Denise
Published in Nature (London) (01.03.2018)
Published in Nature (London) (01.03.2018)
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Journal Article
Dynamics of GLP-1R peptide agonist engagement are correlated with kinetics of G protein activation
Deganutti, Giuseppe, Yi-Lynn, Liang, Zhang, Xin, Khoshouei, Maryam, Clydesdale, Lachlan, Belousoff, Matthew J, Venugopal, Hari, Truong, Tin T, Glukhova, Alisa, Keller, Andrew N, Gregory, Karen J, Leach, Katie, Christopoulos, Arthur, Danev, Radostin, Reynolds, Christopher A, Zhao, Peishen, Sexton, Patrick M, Wootten, Denise
Published in bioRxiv (11.03.2021)
Published in bioRxiv (11.03.2021)
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