Design and synthesis of a novel, orally active, brain penetrant, tri-substituted thiophene based JNK inhibitor
Bowers, Simeon, Truong, Anh P., Neitz, R. Jeffrey, Neitzel, Martin, Probst, Gary D., Hom, Roy K., Peterson, Brian, Galemmo, Robert A., Konradi, Andrei W., Sham, Hing L., Tóth, Gergley, Pan, Hu, Yao, Nanhua, Artis, Dean R., Brigham, Elizabeth F., Quinn, Kevin P., Sauer, John-Michael, Powell, Kyle, Ruslim, Lany, Ren, Zhao, Bard, Frédérique, Yednock, Ted A., Griswold-Prenner, Irene
Published in Bioorganic & medicinal chemistry letters (15.03.2011)
Published in Bioorganic & medicinal chemistry letters (15.03.2011)
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Journal Article
Design and synthesis of cell potent BACE-1 inhibitors: Structure–activity relationship of P1′ substituents
Sealy, Jennifer M., Truong, Anh P., Tso, Luke, Probst, Gary D., Aquino, Jose, Hom, Roy K., Jagodzinska, Barbara M., Dressen, Darren, Wone, David W.G., Brogley, Louis, John, Varghese, Tung, Jay S., Pleiss, Michael A., Tucker, John A., Konradi, Andrei W., Dappen, Michael S., Toth, Gergely, Pan, Hu, Ruslim, Lany, Miller, Jim, Bova, Michael P., Sinha, Sukanto, Quinn, Kevin P., Sauer, John-Michael
Published in Bioorganic & medicinal chemistry letters (15.11.2009)
Published in Bioorganic & medicinal chemistry letters (15.11.2009)
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Journal Article
Convergent Assembly of Highly Potent Analogues of Bryostatin 1 via Pyran Annulation: Bryostatin Look-Alikes That Mimic Phorbol Ester Function
Keck, Gary E, Kraft, Matthew B, Truong, Anh P, Li, Wei, Sanchez, Carina C, Kedei, Noemi, Lewin, Nancy E, Blumberg, Peter M
Published in Journal of the American Chemical Society (28.05.2008)
Published in Journal of the American Chemical Society (28.05.2008)
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Journal Article
Novel cinnoline-based inhibitors of LRRK2 kinase activity
Garofalo, Albert W., Adler, Marc, Aubele, Danielle L., Bowers, Simeon, Franzini, Maurizio, Goldbach, Erich, Lorentzen, Colin, Neitz, R. Jeffrey, Probst, Gary D., Quinn, Kevin P., Santiago, Pam, Sham, Hing L., Tam, Danny, Truong, Anh P., Ye, Xiaocong M., Ren, Zhao
Published in Bioorganic & medicinal chemistry letters (01.01.2013)
Published in Bioorganic & medicinal chemistry letters (01.01.2013)
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Journal Article
Discovery of 4-alkylamino-7-aryl-3-cyanoquinoline LRRK2 kinase inhibitors
Garofalo, Albert W., Adler, Marc, Aubele, Danielle L., Brigham, Elizabeth F., Chian, David, Franzini, Maurizio, Goldbach, Erich, Kwong, Grace T., Motter, Ruth, Probst, Gary D., Quinn, Kevin P., Ruslim, Lany, Sham, Hing L., Tam, Danny, Tanaka, Pearl, Truong, Anh P., Ye, Xiaocong M., Ren, Zhao
Published in Bioorganic & medicinal chemistry letters (01.04.2013)
Published in Bioorganic & medicinal chemistry letters (01.04.2013)
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Journal Article
Selective and Brain-Permeable Polo-like Kinase-2 (Plk-2) Inhibitors That Reduce -Synuclein Phosphorylation in Rat Brain
Aubele, Danielle L., Hom, Roy K., Adler, Marc, Galemmo, Robert A., Bowers, Simeon, Truong, Anh P., Pan, Hu, Beroza, Paul, Neitz, R. Jeffrey, Yao, Nanhua, Lin, May, Tonn, George, Zhang, Heather, Bova, Michael P., Ren, Zhao, Tam, Danny, Ruslim, Lany, Baker, Jeanne, Diep, Linnea, Fitzgerald, Kent, Hoffman, Jennifer, Motter, Ruth, Fauss, Donald, Tanaka, Pearl, Dappen, Michael, Jagodzinski, Jacek, Chan, Wayman, Konradi, Andrei W., Latimer, Lee, Zhu, Yong L., Sham, Hing L., Anderson, John P., Bergeron, Marcelle, Artis, Dean R.
Published in ChemMedChem (01.08.2013)
Published in ChemMedChem (01.08.2013)
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Journal Article
Substitution on the A-Ring Confers to Bryopyran Analogues the Unique Biological Activity Characteristic of Bryostatins and Distinct From That of the Phorbol Esters
Keck, Gary E, Poudel, Yam B, Welch, Dennie S, Kraft, Matthew B, Truong, Anh P, Stephens, Jeffrey C, Kedei, Noemi, Lewin, Nancy E, Blumberg, Peter M
Published in Organic letters (05.02.2009)
Published in Organic letters (05.02.2009)
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Journal Article
Selective and Brain-Permeable Polo-like Kinase-2 (Plk-2) Inhibitors That Reduce α-Synuclein Phosphorylation in Rat Brain
Aubele, Danielle L., Hom, Roy K., Adler, Marc, Galemmo Jr, Robert A., Bowers, Simeon, Truong, Anh P., Pan, Hu, Beroza, Paul, Neitz, R. Jeffrey, Yao, Nanhua, Lin, May, Tonn, George, Zhang, Heather, Bova, Michael P., Ren, Zhao, Tam, Danny, Ruslim, Lany, Baker, Jeanne, Diep, Linnea, Fitzgerald, Kent, Hoffman, Jennifer, Motter, Ruth, Fauss, Donald, Tanaka, Pearl, Dappen, Michael, Jagodzinski, Jacek, Chan, Wayman, Konradi, Andrei W., Latimer, Lee, Zhu, Yong L., Sham, Hing L., Anderson, John P., Bergeron, Marcelle, Artis, Dean R.
Published in ChemMedChem (01.08.2013)
Published in ChemMedChem (01.08.2013)
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Journal Article
Design and synthesis of highly selective, orally active Polo-like kinase-2 (Plk-2) inhibitors
Bowers, Simeon, Truong, Anh P., Ye, Michael, Aubele, Danielle L., Sealy, Jennifer M., Neitz, R. Jeffrey, Hom, Roy K., Chan, Wayman, Dappen, Michael S., Galemmo, Robert A., Konradi, Andrei W., Sham, Hing L., Zhu, Yong L., Beroza, Paul, Tonn, George, Zhang, Heather, Hoffman, Jennifer, Motter, Ruth, Fauss, Donald, Tanaka, Pearl, Bova, Michael P., Ren, Zhao, Tam, Danny, Ruslim, Lany, Baker, Jeanne, Pandya, Deepal, Diep, Linnea, Fitzgerald, Kent, Artis, Dean R., Anderson, John P., Bergeron, Marcelle
Published in Bioorganic & medicinal chemistry letters (01.05.2013)
Published in Bioorganic & medicinal chemistry letters (01.05.2013)
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Journal Article
Design and synthesis of brain penetrant selective JNK inhibitors with improved pharmacokinetic properties for the prevention of neurodegeneration
Bowers, Simeon, Truong, Anh P., Jeffrey Neitz, R., Hom, Roy K., Sealy, Jennifer M., Probst, Gary D., Quincy, David, Peterson, Brian, Chan, Wayman, Galemmo, Robert A., Konradi, Andrei W., Sham, Hing L., Tóth, Gergely, Pan, Hu, Lin, May, Yao, Nanhua, Artis, Dean R., Zhang, Heather, Chen, Linda, Dryer, Mark, Samant, Bhushan, Zmolek, Wes, Wong, Karina, Lorentzen, Colin, Goldbach, Erich, Tonn, George, Quinn, Kevin P., Sauer, John-Michael, Wright, Sarah, Powell, Kyle, Ruslim, Lany, Ren, Zhao, Bard, Frédérique, Yednock, Ted A., Griswold-Prenner, Irene
Published in Bioorganic & medicinal chemistry letters (15.09.2011)
Published in Bioorganic & medicinal chemistry letters (15.09.2011)
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Journal Article
Highly selective c-Jun N-terminal kinase (JNK) 2 and 3 inhibitors with in vitro CNS-like pharmacokinetic properties prevent neurodegeneration
Probst, Gary D., Bowers, Simeon, Sealy, Jennifer M., Truong, Anh P., Hom, Roy K., Galemmo, Robert A., Konradi, Andrei W., Sham, Hing L., Quincy, David A., Pan, Hu, Yao, Nanhua, Lin, May, Tóth, Gergley, Artis, Dean R., Zmolek, Wes, Wong, Karina, Qin, Ann, Lorentzen, Colin, Nakamura, David F., Quinn, Kevin P., Sauer, John-Michael, Powell, Kyle, Ruslim, Lany, Wright, Sarah, Chereau, David, Ren, Zhao, Anderson, John P., Bard, Frédérique, Yednock, Ted A., Griswold-Prenner, Irene
Published in Bioorganic & medicinal chemistry letters (01.01.2011)
Published in Bioorganic & medicinal chemistry letters (01.01.2011)
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Journal Article
Design, synthesis, and structure–activity relationship of novel orally efficacious pyrazole/sulfonamide based dihydroquinoline γ-secretase inhibitors
Truong, Anh P., Aubele, Danielle L., Probst, Gary D., Neitzel, Martin L., Semko, Chris M., Bowers, Simeon, Dressen, Darren, Hom, Roy K., Konradi, Andrei W., Sham, Hing L., Garofalo, Albert W., Keim, Pamela S., Wu, Jing, Dappen, Michael S., Wong, Karina, Goldbach, Erich, Quinn, Kevin P., Sauer, John-Michael, Brigham, Elizabeth F., Wallace, William, Nguyen, Lan, Hemphill, Susanna S., Bova, Michael P., Basi, Guriqbal
Published in Bioorganic & medicinal chemistry letters (01.09.2009)
Published in Bioorganic & medicinal chemistry letters (01.09.2009)
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Journal Article
Design and synthesis of disubstituted thiophene and thiazole based inhibitors of JNK
Hom, Roy K., Bowers, Simeon, Sealy, Jennifer M., Truong, Anh P., Probst, Gary D., Neitzel, Martin L., Neitz, R. Jeffrey, Fang, Larry, Brogley, Louis, Wu, Jing, Konradi, Andrei W., Sham, Hing L., Tóth, Gergely, Pan, Hu, Yao, Nanhua, Artis, Dean R., Quinn, Kevin, Sauer, John-Michael, Powell, Kyle, Ren, Zhao, Bard, Frédérique, Yednock, Ted A., Griswold-Prenner, Irene
Published in Bioorganic & medicinal chemistry letters (15.12.2010)
Published in Bioorganic & medicinal chemistry letters (15.12.2010)
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Journal Article
Improving the permeability of the hydroxyethylamine BACE-1 inhibitors: Structure–activity relationship of P2′ substituents
Truong, Anh P., Probst, Gary D., Aquino, Jose, Fang, Larry, Brogley, Louis, Sealy, Jennifer M., Hom, Roy K., Tucker, John A., John, Varghese, Tung, Jay S., Pleiss, Michael A., Konradi, Andrei W., Sham, Hing L., Dappen, Michael S., Tóth, Gergley, Yao, Nanhua, Brecht, Eric, Pan, Hu, Artis, Dean R., Ruslim, Lany, Bova, Michael P., Sinha, Sukanto, Yednock, Ted A., Zmolek, Wes, Quinn, Kevin P., Sauer, John-Michael
Published in Bioorganic & medicinal chemistry letters (15.08.2010)
Published in Bioorganic & medicinal chemistry letters (15.08.2010)
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Journal Article
Design and synthesis of hydroxyethylamine (HEA) BACE-1 inhibitors: Structure–activity relationship of the aryl region
Probst, Gary D., Bowers, Simeon, Sealy, Jennifer M., Stupi, Brian, Dressen, Darren, Jagodzinska, Barbara M., Aquino, Jose, Gailunas, Andrea, Truong, Anh P., Tso, Luke, Xu, Ying-Zi, Hom, Roy K., John, Varghese, Tung, Jay S., Pleiss, Michael A., Tucker, John A., Konradi, Andrei W., Sham, Hing L., Jagodzinski, Jacek, Toth, Gergely, Brecht, Eric, Yao, Nanhua, Pan, Hu, Lin, May, Artis, Dean R., Ruslim, Lany, Bova, Michael P., Sinha, Sukanto, Yednock, Ted A., Gauby, Shawn, Zmolek, Wes, Quinn, Kevin P., Sauer, John-Michael
Published in Bioorganic & medicinal chemistry letters (15.10.2010)
Published in Bioorganic & medicinal chemistry letters (15.10.2010)
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Journal Article
Design, synthesis and structure–activity relationship of novel [3.3.1] bicyclic sulfonamide-pyrazoles as potent γ-secretase inhibitors
Aubele, Danielle L., Truong, Anh P., Dressen, Darren B., Probst, Gary D., Bowers, Simeon, Mattson, Matthew N., Semko, Chris M., Sun, Minghua, Garofalo, Albert W., Konradi, Andrei W., Sham, Hing L., Zmolek, Wes, Wong, Karina, Goldbach, Erich, Quinn, Kevin P., Sauer, John-Michael, Brigham, Elizabeth F., Wallace, William, Nguyen, Lan, Bova, Michael P., Hemphill, Susanna S., Basi, Guriqbal
Published in Bioorganic & medicinal chemistry letters (01.10.2011)
Published in Bioorganic & medicinal chemistry letters (01.10.2011)
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Journal Article