An Integrated Approach for Identification and Target Validation of Antifungal Compounds Active against Erg11p
HOEPFNER, Dominic, KARKARE, Shantanu, REINKER, Stefan, FREDERIKSEN, Mathias, RAO MOVVA, N, PORTER, Jeffrey A, RYDER, Neil S, PARKER, Christian N, HELLIWELL, Stephen B, PFEIFER, Martin, TRUNZER, Markus, DE BONNECHOSE, Sophie, ZIMMERLIN, Alfred, TAO, Jianshi, RICHIE, Daryl, HOFMANN, Andreas
Published in Antimicrobial Agents and Chemotherapy (01.08.2012)
Published in Antimicrobial Agents and Chemotherapy (01.08.2012)
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Journal Article
CYP3A Time-Dependent Inhibition Risk Assessment Validated with 400 Reference Drugs
ZIMMERLIN, Alfred, TRUNZER, Markus, FALLER, Bernard
Published in Drug metabolism and disposition (01.06.2011)
Published in Drug metabolism and disposition (01.06.2011)
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Journal Article
Improving In Vitro-In Vivo Extrapolation (IVIVE) of Clearance Using Rat Liver Microsomes for Highly Plasma Protein Bound Molecules
Trunzer, Markus, Teigão, Joana, Huth, Felix, Poller, Birk, Desrayaud, Sandrine, Rodríguez-Pérez, Raquel, Faller, Bernard
Published in Drug metabolism and disposition (01.05.2024)
Published in Drug metabolism and disposition (01.05.2024)
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Journal Article
Design of a Supersoft Topical JAK Inhibitor, Which Is Effective in Human Skin but Rapidly Deactivated in Blood
Thoma, Gebhard, Decoret, Odile, Vangrevelinghe, Eric, Trunzer, Markus, Decker, Andrea, Orjuela Leon, Anette, Beerli, Christian, Bruno, Sandro, Hauchard, Alice, Paulat, Guido, Zerwes, Hans-Guenter, Hacini-Rachinel, Feriel
Published in Journal of medicinal chemistry (09.11.2023)
Published in Journal of medicinal chemistry (09.11.2023)
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Journal Article
Discovery of NP3-253, a Potent Brain Penetrant Inhibitor of the NLRP3 Inflammasome
Mackay, Angela, Velcicky, Juraj, Gommermann, Nina, Mattes, Henri, Janser, Philipp, Wright, Michael, Dubois, Celine, Brenneisen, Silke, Ilic, Slavica, Vangrevelinghe, Eric, Stiefl, Nikolaus, Boettcher, Andreas, Schoenboerner, Michel, Vogelsanger, Melanie, Muller-Bentz, Sophie, Kamke, Marion, Rubert, Joelle, Kauffmann, Muriel, Desrayaud, Sandrine, Trunzer, Markus, Srinivas, Honnappa, Hinniger, Alexandra, von Burg, Nicole, Beltz, Karen, Dekker, Carien, Farady, Christopher J
Published in Journal of medicinal chemistry (22.11.2024)
Published in Journal of medicinal chemistry (22.11.2024)
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Journal Article
NIBR-LTSi is a selective LATS kinase inhibitor activating YAP signaling and expanding tissue stem cells in vitro and in vivo
Namoto, Kenji, Baader, Clara, Orsini, Vanessa, Landshammer, Alexandro, Breuer, Eva, Dinh, Kieu Trinh, Ungricht, Rosemarie, Pikiolek, Monika, Laurent, Stephane, Lu, Bo, Aebi, Alexandra, Schönberger, Katharina, Vangrevelinghe, Eric, Evrova, Olivera, Sun, Tianliang, Annunziato, Stefano, Lachal, Julie, Redmond, Emily, Wang, Louis, Wetzel, Kristie, Capodieci, Paola, Turner, Jonathan, Schutzius, Gabi, Unterreiner, Vincent, Trunzer, Markus, Buschmann, Nicole, Behnke, Dirk, Machauer, Rainer, Scheufler, Clemens, Parker, Christian N., Ferro, Magali, Grevot, Armelle, Beyerbach, Armin, Lu, Wei-Yu, Forbes, Stuart J., Wagner, Jürgen, Bouwmeester, Tewis, Liu, Jun, Sohal, Bindi, Sahambi, Sukhdeep, Greenbaum, Linda E., Lohmann, Felix, Hoppe, Philipp, Cong, Feng, Sailer, Andreas W., Ruffner, Heinz, Glatthar, Ralf, Humar, Bostjan, Clavien, Pierre-Alain, Dill, Michael T., George, Elizabeth, Maibaum, Jürgen, Liberali, Prisca, Tchorz, Jan S.
Published in Cell stem cell (04.04.2024)
Published in Cell stem cell (04.04.2024)
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Journal Article
Evaluation of relative MS response factors of drug metabolites for semi‐quantitative assessment of chemical liabilities in drug discovery
Blanz, Joachim, Williams, Gareth, Dayer, Jerôme, Délémonté, Thierry, Gertsch, Werner, Ramstein, Philippe, Aichholz, Reiner, Trunzer, Markus, Pearson, David
Published in Journal of mass spectrometry. (01.04.2017)
Published in Journal of mass spectrometry. (01.04.2017)
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Journal Article
Comparison of a two-dimensional liquid chromatography/mass spectrometry approach with a chip-based nanoelectrospray device for structural elucidation of metabolites in a human ADME study using a quadrupole time-of-flight mass spectrometer
Trunzer, Markus, Graf, Daniel, Kiffe, Michael
Published in Rapid communications in mass spectrometry (01.01.2007)
Published in Rapid communications in mass spectrometry (01.01.2007)
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Journal Article
Cytostar-T plates—A valid alternative for microplate scintillation counting of low radioactivity in combination with high-performance liquid chromatography in drug metabolism studies?
Kiffe, Michael, Nufer, Robert, Trunzer, Markus, Graf, Daniel
Published in Journal of Chromatography A (20.07.2007)
Published in Journal of Chromatography A (20.07.2007)
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Journal Article
Photodegradation analysis as additional tool to verify phototoxicity
Struwe, Melanie, Trunzer, Markus, Bauer, Daniel, Kiffe, Michael, Plappert-Helbig, Ulla, Suter, Willi
Published in Toxicology (Amsterdam) (01.09.2006)
Published in Toxicology (Amsterdam) (01.09.2006)
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