Exosomal delivery of doxorubicin enables rapid cell entry and enhanced in vitro potency
Schindler, Christina, Collinson, Andie, Matthews, Carl, Pointon, Amy, Jenkinson, Lesley, Minter, Ralph R, Vaughan, Tristan J, Tigue, Natalie J
Published in PloS one (29.03.2019)
Published in PloS one (29.03.2019)
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Oxidation of the alarmin IL-33 regulates ST2-dependent inflammation
Cohen, E Suzanne, Scott, Ian C, Majithiya, Jayesh B, Rapley, Laura, Kemp, Benjamin P, England, Elizabeth, Rees, D Gareth, Overed-Sayer, Catherine L, Woods, Joanne, Bond, Nicholas J, Veyssier, Christel Séguy, Embrey, Kevin J, Sims, Dorothy A, Snaith, Michael R, Vousden, Katherine A, Strain, Martin D, Chan, Denice T Y, Carmen, Sara, Huntington, Catherine E, Flavell, Liz, Xu, Jianqing, Popovic, Bojana, Brightling, Christopher E, Vaughan, Tristan J, Butler, Robin, Lowe, David C, Higazi, Daniel R, Corkill, Dominic J, May, Richard D, Sleeman, Matthew A, Mustelin, Tomas
Published in Nature communications (14.09.2015)
Published in Nature communications (14.09.2015)
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Overcoming the Refractory Expression of Secreted Recombinant Proteins in Mammalian Cells through Modification of the Signal Peptide and Adjacent Amino Acids
Güler-Gane, Gülin, Kidd, Sara, Sridharan, Sudharsan, Vaughan, Tristan J, Wilkinson, Trevor C I, Tigue, Natalie J
Published in PloS one (19.05.2016)
Published in PloS one (19.05.2016)
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Tozorakimab (MEDI3506): an anti-IL-33 antibody that inhibits IL-33 signalling via ST2 and RAGE/EGFR to reduce inflammation and epithelial dysfunction
England, Elizabeth, Rees, D Gareth, Scott, Ian Christopher, Carmen, Sara, Chan, Denice T Y, Chaillan Huntington, Catherine E, Houslay, Kirsty F, Erngren, Teodor, Penney, Mark, Majithiya, Jayesh B, Rapley, Laura, Sims, Dorothy A, Hollins, Claire, Hinchy, Elizabeth C, Strain, Martin D, Kemp, Benjamin P, Corkill, Dominic J, May, Richard D, Vousden, Katherine A, Butler, Robin J, Mustelin, Tomas, Vaughan, Tristan J, Lowe, David C, Colley, Caroline, Cohen, E Suzanne
Published in Scientific reports (17.06.2023)
Published in Scientific reports (17.06.2023)
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Computational Design of Epitope-Specific Functional Antibodies
Nimrod, Guy, Fischman, Sharon, Austin, Mark, Herman, Asael, Keyes, Feenagh, Leiderman, Olga, Hargreaves, David, Strajbl, Marek, Breed, Jason, Klompus, Shelley, Minton, Kevin, Spooner, Jennifer, Buchanan, Andrew, Vaughan, Tristan J., Ofran, Yanay
Published in Cell reports (Cambridge) (20.11.2018)
Published in Cell reports (Cambridge) (20.11.2018)
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Antibodies binding the head domain of P2X4 inhibit channel function and reverse neuropathic pain
Williams, Wendy A, Linley, John E, Jones, Clare A, Shibata, Yoko, Snijder, Arjan, Button, James, Hatcher, Jon P, Huang, Ling, Taddese, Bruck, Thornton, Peter, Schofield, Darren J, Thom, George, Popovic, Bojana, Dosanjh, Bhupinder, Wilkinson, Trevor, Hughes, Jane, Dobson, Claire L, Groves, Maria A, Webster, Carl I, Billinton, Andy, Vaughan, Tristan J, Chessell, Iain
Published in Pain (Amsterdam) (01.09.2019)
Published in Pain (Amsterdam) (01.09.2019)
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Experimentally guided computational antibody affinity maturation with de novo docking, modelling and rational design
Cannon, Daniel A, Shan, Lu, Du, Qun, Shirinian, Lena, Rickert, Keith W, Rosenthal, Kim L, Korade, 3rd, Martin, van Vlerken-Ysla, Lilian E, Buchanan, Andrew, Vaughan, Tristan J, Damschroder, Melissa M, Popovic, Bojana
Published in PLoS computational biology (01.05.2019)
Published in PLoS computational biology (01.05.2019)
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A receptor for the complement regulator factor H increases transmission of trypanosomes to tsetse flies
Macleod, Olivia J S, Bart, Jean-Mathieu, MacGregor, Paula, Peacock, Lori, Savill, Nicholas J, Hester, Svenja, Ravel, Sophie, Sunter, Jack D, Trevor, Camilla, Rust, Steven, Vaughan, Tristan J, Minter, Ralph, Mohammed, Shabaz, Gibson, Wendy, Taylor, Martin C, Higgins, Matthew K, Carrington, Mark
Published in Nature communications (12.03.2020)
Published in Nature communications (12.03.2020)
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A single dose of antibody-drug conjugate cures a stage 1 model of African trypanosomiasis
MacGregor, Paula, Gonzalez-Munoz, Andrea L, Jobe, Fatoumatta, Taylor, Martin C, Rust, Steven, Sandercock, Alan M, Macleod, Olivia J S, Van Bocxlaer, Katrien, Francisco, Amanda F, D'Hooge, Francois, Tiberghien, Arnaud, Barry, Conor S, Howard, Philip, Higgins, Matthew K, Vaughan, Tristan J, Minter, Ralph, Carrington, Mark
Published in PLoS neglected tropical diseases (01.05.2019)
Published in PLoS neglected tropical diseases (01.05.2019)
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Structural and functional characterization of C0021158, a high-affinity monoclonal antibody that inhibits Arginase 2 function via a novel non-competitive mechanism of action
Austin, Mark, Burschowsky, Daniel, Chan, Denice T Y, Jenkinson, Lesley, Haynes, Stuart, Diamandakis, Agata, Seewooruthun, Chitra, Addyman, Alexandra, Fiedler, Sebastian, Ryman, Stephanie, Whitehouse, Jessica, Slater, Louise H, Hadjinicolaou, Andreas V, Gileadi, Uzi, Gowans, Ellen, Shibata, Yoko, Barnard, Michelle, Kaserer, Teresa, Sharma, Pooja, Luheshi, Nadia M, Wilkinson, Robert W, Vaughan, Tristan J, Holt, Sarah V, Cerundolo, Vincenzo, Carr, Mark D, Groves, Maria A T
Published in mAbs (01.01.2020)
Published in mAbs (01.01.2020)
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A novel IgE-neutralizing antibody for the treatment of severe uncontrolled asthma
Cohen, E Suzanne, Dobson, Claire L, Käck, Helena, Wang, Bing, Sims, Dorothy A, Lloyd, Christopher O, England, Elizabeth, Rees, D Gareth, Guo, Hongwei, Karagiannis, Sophia N, O'Brien, Siobhan, Persdotter, Sofia, Ekdahl, Helena, Butler, Robin, Keyes, Feenagh, Oakley, Sarah, Carlsson, Mats, Briend, Emmanuel, Wilkinson, Trevor, Anderson, Ian K, Monk, Phillip D, von Wachenfeldt, Karin, Eriksson, Per-Olof F, Gould, Hannah J, Vaughan, Tristan J, May, Richard D
Published in mAbs (01.05.2014)
Published in mAbs (01.05.2014)
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Machine learning designs new GCGR/GLP-1R dual agonists with enhanced biological potency
Puszkarska, Anna M, Taddese, Bruck, Revell, Jefferson, Davies, Graeme, Field, Joss, Hornigold, David C, Buchanan, Andrew, Vaughan, Tristan J, Colwell, Lucy J
Published in Nature chemistry (01.09.2024)
Published in Nature chemistry (01.09.2024)
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Human monomeric antibody fragments to TRAIL-R1 and TRAIL-R2 that display potent in vitro agonism
Dobson, Claire L., Main, Sarah, Newton, Philip, Chodorge, Matthieu, Cadwallader, Karen, Humphreys, Robin C., Albert, Vivian, Vaughan, Tristan J., Minter, Ralph R., Edwards, Bryan M.
Published in mAbs (01.11.2009)
Published in mAbs (01.11.2009)
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A Potent Human Anti-Eotaxin1 Antibody, CAT-213: Isolation by Phage Display and in Vitro and in Vivo Efficacy
Main, Sarah, Handy, Rachel, Wilton, Jane, Smith, Stephen, Williams, Liz, Fou, Leila Du, Andrews, John, Conroy, Louise A, May, Richard, Anderson, Ian, Vaughan, Tristan J
Published in The Journal of pharmacology and experimental therapeutics (01.12.2006)
Published in The Journal of pharmacology and experimental therapeutics (01.12.2006)
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Journal Article
Rate of Asparagine Deamidation in a Monoclonal Antibody Correlating with Hydrogen Exchange Rate at Adjacent Downstream Residues
Phillips, Jonathan J, Buchanan, Andrew, Andrews, John, Chodorge, Matthieu, Sridharan, Sudharsan, Mitchell, Laura, Burmeister, Nicole, Kippen, Alistair D, Vaughan, Tristan J, Higazi, Daniel R, Lowe, David
Published in Analytical chemistry (Washington) (21.02.2017)
Published in Analytical chemistry (Washington) (21.02.2017)
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Engineering the surface properties of a human monoclonal antibody prevents self-association and rapid clearance in vivo
Dobson, Claire L, Devine, Paul W A, Phillips, Jonathan J, Higazi, Daniel R, Lloyd, Christopher, Popovic, Bojana, Arnold, Joanne, Buchanan, Andrew, Lewis, Arthur, Goodman, Joanne, van der Walle, Christopher F, Thornton, Peter, Vinall, Lisa, Lowne, David, Aagaard, Anna, Olsson, Lise-Lotte, Ridderstad Wollberg, Anna, Welsh, Fraser, Karamanos, Theodoros K, Pashley, Clare L, Iadanza, Matthew G, Ranson, Neil A, Ashcroft, Alison E, Kippen, Alistair D, Vaughan, Tristan J, Radford, Sheena E, Lowe, David C
Published in Scientific reports (20.12.2016)
Published in Scientific reports (20.12.2016)
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MEDI1814 selectively reduces free Aβ42 in cerebrospinal fluid of non-clinical species and Alzheimer's disease patients
Lloyd, Christopher, Freskgård, Per-Ola, Newton, Philip, Lowne, David, Nickson, Adrian, Bogstedt, Anna, Eketjäll, Susanna, Höglund, Kina, Gustavsson, Susanne, Welsh, Fraser, Chessell, Tharani, McFarlane, Mary, Bhat, Ratan V, Turner, Richard, Perkinton, Michael S, Santisteban Valencia, Zulma, Lindqvist, Eva, Pomfret, Michael, Dudley, Amanda D, Vaughan, Tristan J, Groves, Maria T, Natanegara, Fanni, Feng, Yingdong, Sims, John R, Proctor, Nicholas Kyle, Dage, Jeffrey L, Shering, Craig, Tan, Keith, Ostenfeld, Thor, Billinton, Andy, Chessell, Iain P
Published in Alzheimer's & dementia (25.09.2024)
Published in Alzheimer's & dementia (25.09.2024)
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Extensive sequence and structural evolution of Arginase 2 inhibitory antibodies enabled by an unbiased approach to affinity maturation
Chan, Denice T. Y., Jenkinson, Lesley, Haynes, Stuart W., Austin, Mark, Diamandakis, Agata, Burschowsky, Daniel, Seewooruthun, Chitra, Addyman, Alexandra, Fiedler, Sebastian, Ryman, Stephanie, Whitehouse, Jessica, Slater, Louise H., Gowans, Ellen, Shibata, Yoko, Barnard, Michelle, Wilkinson, Robert W., Vaughan, Tristan J., Holt, Sarah V., Cerundolo, Vincenzo, Carr, Mark D., Groves, Maria A. T.
Published in Proceedings of the National Academy of Sciences - PNAS (21.07.2020)
Published in Proceedings of the National Academy of Sciences - PNAS (21.07.2020)
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