A direct role for SNX9 in the biogenesis of filopodia
Jarsch, Iris K, Gadsby, Jonathan R, Nuccitelli, Annalisa, Mason, Julia, Shimo, Hanae, Pilloux, Ludovic, Marzook, Bishara, Mulvey, Claire M, Dobramysl, Ulrich, Bradshaw, Charles R, Lilley, Kathryn S, Hayward, Richard D, Vaughan, Tristan J, Dobson, Claire L, Gallop, Jennifer L
Published in The Journal of cell biology (06.04.2020)
Published in The Journal of cell biology (06.04.2020)
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Journal Article
Discovery and characterisation of an antibody that selectively modulates the inhibitory activity of plasminogen activator inhibitor-1
Vousden, Katherine A, Lundqvist, Tomas, Popovic, Bojana, Naiman, Brian, Carruthers, Alan M, Newton, Philip, Johnson, Daniel J D, Pomowski, Anja, Wilkinson, Trevor, Dufner, Patrick, de Mendez, Isabelle, Mallinder, Philip R, Murray, Clare, Strain, Martin, Connor, Jane, Murray, Lynne A, Sleeman, Matthew A, Lowe, David C, Huntington, James A, Vaughan, Tristan J
Published in Scientific reports (07.02.2019)
Published in Scientific reports (07.02.2019)
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Journal Article
Structure and characterization of a high affinity C5a monoclonal antibody that blocks binding to C5aR1 and C5aR2 receptors
Colley, Caroline S, Popovic, Bojana, Sridharan, Sudharsan, Debreczeni, Judit E, Hargeaves, David, Fung, Michael, An, Ling-Ling, Edwards, Bryan, Arnold, Joanne, England, Elizabeth, Eghobamien, Laura, Sivars, Ulf, Flavell, Liz, Renshaw, Jonathan, Wickson, Kate, Warrener, Paul, Zha, Jingying, Bonnell, Jessica, Woods, Rob, Wilkinson, Trevor, Dobson, Claire, Vaughan, Tristan J
Published in mAbs (01.01.2018)
Published in mAbs (01.01.2018)
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Journal Article
Interactions Between the Gravitostat and the Fibroblast Growth Factor System for the Regulation of Body Weight
Palsdottir, Vilborg, Windahl, Sara H, Hägg, Daniel A, Keantar, Hanna, Bellman, Jakob, Buchanan, Andrew, Vaughan, Tristan J, Lindén, Daniel, Jansson, John-Olov, Ohlsson, Claes
Published in Endocrinology (Philadelphia) (01.05.2019)
Published in Endocrinology (Philadelphia) (01.05.2019)
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Journal Article
Isolation of high-affinity, neutralizing anti-idiotype antibodies by phage and ribosome display for application in immunogenicity and pharmacokinetic analyses
Chin, Stacey E., Ferraro, Franco, Groves, Maria, Liang, Meina, Vaughan, Tristan J., Dobson, Claire L.
Published in Journal of immunological methods (01.01.2015)
Published in Journal of immunological methods (01.01.2015)
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Journal Article
A CD80-Biased CTLA4-Ig Fusion Protein with Superior In Vivo Efficacy by Simultaneous Engineering of Affinity, Selectivity, Stability, and FcRn Binding
Douthwaite, Julie, Moisan, Jacques, Privezentzev, Cyril, Soskic, Blagoje, Sabbah, Shereen, Cohen, Suzanne, Collinson, Andie, England, Elizabeth, Huntington, Catherine, Kemp, Ben, Zhuang, Li, Hudak, Suzanne, Rees, D Gareth, Goldberg, Debbie, Barton, Chris, Chang, Linda, Vainshtein, Inna, Liang, Meina, Iciek, Laurie, Ambery, Philip, Peakman, Mark, Vaughan, Tristan J, Tree, Tim I M, Sansom, David M, Bowen, Michael A, Minter, Ralph R, Jermutus, Lutz
Published in The Journal of immunology (1950) (01.01.2017)
Published in The Journal of immunology (1950) (01.01.2017)
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Journal Article
Structure of the trypanosome transferrin receptor reveals mechanisms of ligand recognition and immune evasion
Trevor, Camilla E, Gonzalez-Munoz, Andrea L, Macleod, Olivia J S, Woodcock, Peter G, Rust, Steven, Vaughan, Tristan J, Garman, Elspeth F, Minter, Ralph, Carrington, Mark, Higgins, Matthew K
Published in Nature microbiology (01.12.2019)
Published in Nature microbiology (01.12.2019)
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Journal Article
Phage display and hybridoma generation of antibodies to human CXCR2 yields antibodies with distinct mechanisms and epitopes
Rossant, Christine J, Carroll, Danielle, Huang, Ling, Elvin, John, Neal, Frances, Walker, Edward, Benschop, Joris J, Kim, Eldar E, Barry, Simon T, Vaughan, Tristan J
Published in mAbs (01.11.2014)
Published in mAbs (01.11.2014)
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Journal Article
Affinity maturation of a novel antagonistic human monoclonal antibody with a long VH CDR3 targeting the Class A GPCR formyl-peptide receptor 1
Douthwaite, Julie A, Sridharan, Sudharsan, Huntington, Catherine, Hammersley, Jayne, Marwood, Rose, Hakulinen, Jonna K, Ek, Margareta, Sjögren, Tove, Rider, David, Privezentzev, Cyril, Seaman, Jonathan C, Cariuk, Peter, Knights, Vikki, Young, Joyce, Wilkinson, Trevor, Sleeman, Matthew, Finch, Donna K, Lowe, David C, Vaughan, Tristan J
Published in mAbs (01.01.2015)
Published in mAbs (01.01.2015)
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Journal Article
Affinity maturation of a novel antagonistic human monoclonal antibody with a long V H CDR3 targeting the Class A GPCR formyl-peptide receptor 1
Douthwaite, Julie A, Sridharan, Sudharsan, Huntington, Catherine, Hammersley, Jayne, Marwood, Rose, Hakulinen, Jonna K, Ek, Margareta, Sjögren, Tove, Rider, David, Privezentzev, Cyril, Seaman, Jonathan C, Cariuk, Peter, Knights, Vikki, Young, Joyce, Wilkinson, Trevor, Sleeman, Matthew, Finch, Donna K, Lowe, David C, Vaughan, Tristan J
Published in mAbs (02.01.2015)
Published in mAbs (02.01.2015)
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Journal Article
Correction: A CD80-Biased CTLA4-Ig Fusion Protein with Superior In Vivo Efficacy by Simultaneous Engineering of Affinity, Selectivity, Stability, and FcRn Binding
Douthwaite, Julie, Moisan, Jacques, Privezentzev, Cyril, Soskic, Blagoje, Sabbah, Shereen, Cohen, Suzanne, Collinson, Andie, England, Elizabeth, Huntington, Catherine, Kemp, Ben, Zhuang, Li, Hudak, Suzanne, Rees, D Gareth, Goldberg, Debbie, Barton, Chris, Chang, Linda, Vainshtein, Inna, Liang, Meina, Iciek, Laurie, Ambery, Philip, Peakman, Mark, Vaughan, Tristan J, Tree, Tim I M, Sansom, David M, Bowen, Michael A, Minter, Ralph R, Jermutus, Lutz
Published in The Journal of immunology (1950) (01.09.2017)
Published in The Journal of immunology (1950) (01.09.2017)
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Journal Article
Isolation of Potent CGRP Neutralizing Antibodies Using Four Simple Assays
Neal, Frances, Arnold, Joanne, Rossant, Christine J, Podichetty, Sadhana, Lowne, David, Dobson, Claire, Wilkinson, Trevor, Colley, Caroline, Howes, Rob, Vaughan, Tristan J
Published in Journal of biomolecular screening (01.01.2016)
Published in Journal of biomolecular screening (01.01.2016)
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Journal Article
Engineering a High-Affinity Anti-IL-15 Antibody: Crystal Structure Reveals an α-Helix in VH CDR3 as Key Component of Paratope
Lowe, David C., Gerhardt, Stefan, Ward, Alison, Hargreaves, David, Anderson, Malcolm, Ferraro, Franco, Pauptit, Richard A., Pattison, Debbie V., Buchanan, Catriona, Popovic, Bojana, Finch, Donna K., Wilkinson, Trevor, Sleeman, Matthew, Vaughan, Tristan J., Mallinder, Philip R.
Published in Journal of molecular biology (11.02.2011)
Published in Journal of molecular biology (11.02.2011)
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Journal Article
Feasibility of implementing cell-based pathway reporter assays in early high-throughput screening assay cascades for antibody drug discovery
Smith, Alison J, Hancock, Michael K, Bi, Kun, Andrews, John, Harrison, Paula, Vaughan, Tristan J
Published in Journal of biomolecular screening (01.07.2012)
Published in Journal of biomolecular screening (01.07.2012)
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Journal Article
Antibody VH and VL recombination using phage and ribosome display technologies reveals distinct structural routes to affinity improvements with VH-VL interface residues providing important structural diversity
Groves, Maria AT, Amanuel, Lily, Campbell, Jamie I, Rees, D Gareth, Sridharan, Sudharsan, Finch, Donna K, Lowe, David C, Vaughan, Tristan J
Published in mAbs (01.01.2014)
Published in mAbs (01.01.2014)
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Journal Article
Generation of potent mouse monoclonal antibodies to self-proteins using T-cell epitope "tags"
Percival-Alwyn, Jennifer L, England, Elizabeth, Kemp, Benjamin, Rapley, Laura, Davis, Nicola H E, McCarthy, Grant R, Majithiya, Jayesh B, Corkill, Dominic J, Welsted, Sarah, Minton, Kevin, Cohen, E Suzanne, Robinson, Matthew J, Dobson, Claire, Wilkinson, Trevor C I, Vaughan, Tristan J, Groves, Maria A T, Tigue, Natalie J
Published in mAbs (01.01.2015)
Published in mAbs (01.01.2015)
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Journal Article
Human Antibodies with Sub-nanomolar Affinities Isolated from a Large Non-immunized Phage Display Library
Vaughan, Tristan J, Williams, Andrew J, Pritchard, Kevin, Osbourn, Jane K, Pope, Anthony R, Earnshaw, John C, McCafferty, John, Hodits, Regina A, Wilton, Jane, Johnson, Kevin S
Published in Nature biotechnology (01.03.1996)
Published in Nature biotechnology (01.03.1996)
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Journal Article
The Remarkable Flexibility of the Human Antibody Repertoire; Isolation of Over One Thousand Different Antibodies to a Single Protein, BLyS
Edwards, Bryan M., Barash, Steven C., Main, Sarah H., Choi, Gil H., Minter, Ralph, Ullrich, Stephen, Williams, Elizabeth, Du Fou, Leila, Wilton, Jane, Albert, Vivian R., Ruben, Steve M., Vaughan, Tristan J.
Published in Journal of molecular biology (14.11.2003)
Published in Journal of molecular biology (14.11.2003)
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Journal Article
Development of a homogeneous high-throughput screening assay for biological inhibitors of human rhinovirus infection
Newton, Philip, O'Shea, Desmond, Wells, Edward, Moakes, Kerry, Dunmore, Rebecca, Butler, Robin J, Wilkinson, Trevor, Ward, Alison, Casson, Nigel, Strain, Martin, Vousden, Katherine, Lowe, David C, Pattison, Debbie V, Carruthers, Alan M, Sleeman, Matthew A, Vaughan, Tristan J, Harrison, Paula
Published in Journal of biomolecular screening (01.03.2013)
Published in Journal of biomolecular screening (01.03.2013)
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Journal Article
Human antibodies by design
Vaughan, Tristan J, Osbourn, Jane K, Tempest, Philip R
Published in Nature biotechnology (01.06.1998)
Published in Nature biotechnology (01.06.1998)
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Journal Article