3D imaging of colorectal cancer organoids identifies responses to Tankyrase inhibitors
Badder, Luned M, Hollins, Andrew J, Herpers, Bram, Yan, Kuan, Ewan, Kenneth B, Thomas, Mairian, Shone, Jennifer R, Badder, Delyth A, Naven, Marc, Ashelford, Kevin E, Hargest, Rachel, Clarke, Alan R, Esdar, Christina, Buchstaller, Hans-Peter, Treherne, J. Mark, Boj, Sylvia, Ramezanpour, Bahar, Wienke, Dirk, Price, Leo S, Shaw, Paul H, Dale, Trevor C
Published in PloS one (18.08.2020)
Published in PloS one (18.08.2020)
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Predictive validity in drug discovery: what it is, why it matters and how to improve it
Scannell, Jack W., Bosley, James, Hickman, John A., Dawson, Gerard R., Truebel, Hubert, Ferreira, Guilherme S., Richards, Duncan, Treherne, J. Mark
Published in Nature reviews. Drug discovery (01.12.2022)
Published in Nature reviews. Drug discovery (01.12.2022)
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The N‑Methylated Peptide SEN304 Powerfully Inhibits Aβ(1–42) Toxicity by Perturbing Oligomer Formation
Amijee, Hozefa, Bate, Clive, Williams, Alun, Virdee, Jasmeet, Jeggo, Ross, Spanswick, David, Scopes, David I.C, Treherne, J. Mark, Mazzitelli, Sonia, Chawner, Ross, Eyers, Claire E, Doig, Andrew J
Published in Biochemistry (Easton) (23.10.2012)
Published in Biochemistry (Easton) (23.10.2012)
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Dose-dependent improvements in learning and memory deficits in APPPS1-21 transgenic mice treated with the orally active Aβ toxicity inhibitor SEN1500
Lo, Adrian C., Tesseur, Ina, Scopes, David I.C., Nerou, Edmund, Callaerts-Vegh, Zsuzsanna, Vermaercke, Ben, Treherne, J. Mark, De Strooper, Bart, D'Hooge, Rudi
Published in Neuropharmacology (01.12.2013)
Published in Neuropharmacology (01.12.2013)
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Orally bioavailable small molecule drug protects memory in Alzheimer's disease models
O'Hare, Eugene, Scopes, David I.C, Kim, Eun-Mee, Palmer, Philip, Jones, Martyn, Whyment, Andrew D, Spanswick, David, Amijee, Hozefa, Nerou, Edmund, McMahon, Bridgeen, Treherne, J. Mark, Jeggo, Ross
Published in Neurobiology of aging (01.04.2013)
Published in Neurobiology of aging (01.04.2013)
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Novel anti-inflammatory compound SEN1176 alleviates behavioral deficits induced following bilateral intrahippocampal injection of aggregated amyloid-β
O'Hare, Eugene, Scopes, David I C, Treherne, J Mark, Monaghan, John, Palmer, Philip M, Amijee, Hozefa, Kim, Eun-Mee
Published in Journal of Alzheimer's disease (2011)
Published in Journal of Alzheimer's disease (2011)
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Novel 5-aryloxypyrimidine SEN1576 as a candidate for the treatment of Alzheimer's disease
O'Hare, Eugene, Scopes, David I.C., Kim, Eun-Mee, Palmer, Philip, Spanswick, David, McMahon, Bridgeen, Amijee, Hozefa, Nerou, Edmund, Treherne, J. Mark, Jeggo, Ross
Published in The international journal of neuropsychopharmacology (01.01.2014)
Published in The international journal of neuropsychopharmacology (01.01.2014)
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RS-0406 Arrests Amyloid-β Oligomer-Induced Behavioural Deterioration In Vivo
O’Hare, Eugene, Scopes, David I.C., Treherne, J. Mark, Norwood, Kelly, Spanswick, David, Kim, Eun-Mee
Published in Behavioural brain research (26.06.2010)
Published in Behavioural brain research (26.06.2010)
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Restoration of Conduction and Growth of Axons through Injured Spinal Cord of Neonatal Opossum in Culture
Treherne, J. Mark, Sally K. A. Woodward, Varga, Zoltan M., Ritchie, J. Murdoch, Nicholls, John G.
Published in Proceedings of the National Academy of Sciences - PNAS (01.01.1992)
Published in Proceedings of the National Academy of Sciences - PNAS (01.01.1992)
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The application of high-throughput screening to novel lead discovery
Kenny, B A, Bushfield, M, Parry-Smith, D J, Fogarty, S, Treherne, J M
Published in Progress in drug research (1998)
Published in Progress in drug research (1998)
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Novel Anti-Inflammatory Compound SEN1176 Alleviates Behavioral Deficits Induced Following Bilateral Intrahippocampal Injection of Aggregated Amyloid-β1-42
O'Hare, Eugene, Scopes, David I.C., Treherne, J. Mark, Monaghan, John, Palmer, Philip M., Amijee, Hozefa, Kim, Eun-Mee
Published in Journal of Alzheimer's disease (01.07.2011)
Published in Journal of Alzheimer's disease (01.07.2011)
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The pharmacology of apoptosis
Kinloch, R A, Treherne, J M, Furness, L M, Hajimohamadreza, I
Published in Trends in pharmacological sciences (Regular ed.) (01.01.1999)
Published in Trends in pharmacological sciences (Regular ed.) (01.01.1999)
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P2-295: β-amyloid aggregation inhibitors for the treatment of Alzheimer's disease
Doig, Andrew J, Amijee, Hozefa, Scopes, David I.C, Treherne, J. Mark
Published in Alzheimer's & dementia (01.07.2008)
Published in Alzheimer's & dementia (01.07.2008)
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