Search Results - "Tran‐Dubé, Michelle" :: K.UTB vyhledávací portál | TBU Library Retrieval Portal

Structure Based Drug Design of Crizotinib (PF-02341066), a Potent and Selective Dual Inhibitor of Mesenchymal–Epithelial Transition Factor (c-MET) Kinase and Anaplastic Lymphoma Kinase (ALK)

Structure Based Drug Design of Crizotinib (PF-02341066), a Potent and Selective Dual Inhibitor of Mesenchymal–Epithelial Transition Factor (c-MET) Kinase and Anaplastic Lymphoma Kinase (ALK)

by Cui, J. Jean, Tran-Dubé, Michelle, Shen, Hong, Nambu, Mitchell, Kung, Pei-Pei, Pairish, Mason, Jia, Lei, Meng, Jerry, Funk, Lee, Botrous, Iriny, McTigue, Michele, Grodsky, Neil, Ryan, Kevin, Padrique, Ellen, Alton, Gordon, Timofeevski, Sergei, Yamazaki, Shinji, Li, Qiuhua, Zou, Helen, Christensen, James, Mroczkowski, Barbara, Bender, Steve, Kania, Robert S, Edwards, Martin P
Published in Journal of medicinal chemistry (22.09.2011)

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Rhodium(III)-Catalyzed C–H Activation: Ligand-Controlled Regioselective Synthesis of 4‑Methyl-Substituted Dihydroisoquinolones

Rhodium(III)-Catalyzed C–H Activation: Ligand-Controlled Regioselective Synthesis of 4‑Methyl-Substituted Dihydroisoquinolones

by Barber, Joyann S, Scales, Stephanie, Tran-Dubé, Michelle, Wang, Fen, Sach, Neal W, Bernier, Louise, Collins, Michael R, Zhu, JinJiang, McAlpine, Indrawan J, Patman, Ryan L
Published in Organic letters (19.07.2019)

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A Disconnection for Rapid Access to Heterocyclic Benzylic Amines with Fully Substituted α‑Carbons

A Disconnection for Rapid Access to Heterocyclic Benzylic Amines with Fully Substituted α‑Carbons

by Yang, Shouliang, Wang, Fen, Scales, Stephanie, Tran-Dubé, Michelle, Berry, Madeline, Xu, Haiwei, Tang, Feng, Xue, Liangliang, Ma, Zhongwei, Li, Bryan, McAlpine, Indrawan
Published in Journal of organic chemistry (15.03.2024)

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Copper-Catalyzed Chan–Lam Cyclopropylation of Phenols and Azaheterocycles

Copper-Catalyzed Chan–Lam Cyclopropylation of Phenols and Azaheterocycles

by Derosa, Joseph, O’Duill, Miriam L, Holcomb, Matthew, Boulous, Mark N, Patman, Ryan L, Wang, Fen, Tran-Dubé, Michelle, McAlpine, Indrawan, Engle, Keary M
Published in Journal of organic chemistry (06.04.2018)

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Anti-selective [3+2] (Hetero)annulation of non-conjugated alkenes via directed nucleopalladation

Anti-selective [3+2] (Hetero)annulation of non-conjugated alkenes via directed nucleopalladation

by Ni, Hui-Qi, Kevlishvili, Ilia, Bedekar, Pranali G, Barber, Joyann S, Yang, Shouliang, Tran-Dubé, Michelle, Romine, Andrew M, Lu, Hou-Xiang, McAlpine, Indrawan J, Liu, Peng, Engle, Keary M
Published in Nature communications (22.12.2020)

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Construction of Isoquinolone Scaffolds on DNA via Rhodium(III)-Catalyzed C–H Activation

Construction of Isoquinolone Scaffolds on DNA via Rhodium(III)-Catalyzed C–H Activation

by Ye, Yusong, Berry, Madeline, Bock, William J., Cheng, Kunpeng, Nair, Sajiv K., Park, Christiana S., Patman, Ryan L., Sakata, Sylvie, Tran-Dubé, Michelle, Donaldson, Joyann S., Yang, Guanyu, Liu, Guansai
Published in Organic letters (26.04.2024)

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Mapping Ambiphile Reactivity Trends in the Anti-(Hetero)annulation of Non-Conjugated Alkenes via Pd-II/Pd-IV Catalysis

Mapping Ambiphile Reactivity Trends in the Anti-(Hetero)annulation of Non-Conjugated Alkenes via Pd-II/Pd-IV Catalysis

by Ni, Hui-Qi, Cooper, Phillippa, Yang, Shouliang, Wang, Fen, Sach, Neal, Bedekar, Pranali G., Donaldson, Joyann S., Tran-Dube, Michelle, McAlpine, Indrawan J., Engle, Keary M.
Published in Angewandte Chemie International Edition (21.03.2022)

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Discovery of a Novel Class of Exquisitely Selective Mesenchymal-Epithelial Transition Factor (c-MET) Protein Kinase Inhibitors and Identification of the Clinical Candidate 2‑(4-(1-(Quinolin-6-ylmethyl)‑1H‑[1,2,3]triazolo[4,5‑b]pyrazin-6-yl)‑1H‑pyrazol-1-yl)ethanol (PF-04217903) for the Treatment of Cancer

Discovery of a Novel Class of Exquisitely Selective Mesenchymal-Epithelial Transition Factor (c-MET) Protein Kinase Inhibitors and Identification of the Clinical Candidate 2‑(4-(1-(Quinolin-6-ylmethyl)‑1H‑[1,2,3]triazolo[4,5‑b]pyrazin-6-yl)‑1H‑pyrazol-1-yl)ethanol (PF-04217903) for the Treatment of Cancer

by Cui, J. Jean, McTigue, Michele, Nambu, Mitchell, Tran-Dubé, Michelle, Pairish, Mason, Shen, Hong, Jia, Lei, Cheng, Hengmiao, Hoffman, Jacqui, Le, Phuong, Jalaie, Mehran, Goetz, Gilles H, Ryan, Kevin, Grodsky, Neil, Deng, Ya-li, Parker, Max, Timofeevski, Sergei, Murray, Brion W, Yamazaki, Shinji, Aguirre, Shirley, Li, Qiuhua, Zou, Helen, Christensen, James
Published in Journal of medicinal chemistry (27.09.2012)

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Synthesis of Small 3‑Fluoro- and 3,3-Difluoropyrrolidines Using Azomethine Ylide Chemistry

Synthesis of Small 3‑Fluoro- and 3,3-Difluoropyrrolidines Using Azomethine Ylide Chemistry

by McAlpine, Indrawan, Tran-Dubé, Michelle, Wang, Fen, Scales, Stephanie, Matthews, Jean, Collins, Michael R, Nair, Sajiv K, Nguyen, Mary, Bian, Jianwei, Alsina, Luis Martinez, Sun, Jianmin, Zhong, Jiaying, Warmus, Joseph S, O’Neill, Brian T
Published in Journal of organic chemistry (17.07.2015)

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Mapping Ambiphile Reactivity Trends in the Anti‐(Hetero)annulation of Non‐Conjugated Alkenes via PdII/PdIV Catalysis

Mapping Ambiphile Reactivity Trends in the Anti‐(Hetero)annulation of Non‐Conjugated Alkenes via PdII/PdIV Catalysis

by Ni, Hui‐Qi, Cooper, Phillippa, Yang, Shouliang, Wang, Fen, Sach, Neal, Bedekar, Pranali G., Donaldson, Joyann S., Tran‐Dubé, Michelle, McAlpine, Indrawan J., Engle, Keary M.
Published in Angewandte Chemie International Edition (21.03.2022)

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Development of a Late-Stage Diversification Strategy for the 4- and 5‑Positions of 4,5,6-Trisubstituted Indazoles

Development of a Late-Stage Diversification Strategy for the 4- and 5‑Positions of 4,5,6-Trisubstituted Indazoles

by Barber, Joyann S, Burtea, Alexander, Collins, Michael R, Tran-Dubé, Michelle, Patman, Ryan L, Scales, Stephanie, Smith, Graham, Spangler, Jillian E, Wang, Fen, Wang, Wei, Yang, Shouliang, Zhu, JinJiang, Montgomery, T. Patrick
Published in Organic letters (20.11.2020)

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Lessons from (S)‑6-(1-(6-(1-Methyl‑1H‑pyrazol-4-yl)-[1,2,4]triazolo[4,3‑b]pyridazin-3-yl)ethyl)quinoline (PF-04254644), an Inhibitor of Receptor Tyrosine Kinase c‑Met with High Protein Kinase Selectivity but Broad Phosphodiesterase Family Inhibition Leading to Myocardial Degeneration in Rats

Lessons from (S)‑6-(1-(6-(1-Methyl‑1H‑pyrazol-4-yl)-[1,2,4]triazolo[4,3‑b]pyridazin-3-yl)ethyl)quinoline (PF-04254644), an Inhibitor of Receptor Tyrosine Kinase c‑Met with High Protein Kinase Selectivity but Broad Phosphodiesterase Family Inhibition Leading to Myocardial Degeneration in Rats

by Cui, J. Jean, Shen, Hong, Tran-Dubé, Michelle, Nambu, Mitchell, McTigue, Michele, Grodsky, Neil, Ryan, Kevin, Yamazaki, Shinji, Aguirre, Shirley, Parker, Max, Li, Qiuhua, Zou, Helen, Christensen, James
Published in Journal of medicinal chemistry (12.09.2013)

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Synthesis of Aryl Ethers via a Sulfonyl Transfer Reaction

Synthesis of Aryl Ethers via a Sulfonyl Transfer Reaction

by Sach, Neal W, Richter, Daniel T, Cripps, Stephan, Tran-Dubé, Michelle, Zhu, Huichun, Huang, Buwen, Cui, Jean, Sutton, Scott C
Published in Organic letters (03.08.2012)

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A two-step, one-pot procedure using acid chlorides and propargyl amines to form tri-substituted oxazoles via gold-catalyzed cyclization

A two-step, one-pot procedure using acid chlorides and propargyl amines to form tri-substituted oxazoles via gold-catalyzed cyclization

by Tran-Dubé, Michelle, Johnson, Sarah, McAlpine, Indrawan
Published in Tetrahedron letters (16.01.2013)

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A simple and convenient two-step, one-pot synthesis of hetero-imidazoles from nitroaminoaryls catalyzed by Ytterbium triflate

A simple and convenient two-step, one-pot synthesis of hetero-imidazoles from nitroaminoaryls catalyzed by Ytterbium triflate

by Wang, Fen, Tran-Dubé, Michelle, Scales, Stephanie, Johnson, Sarah, McAlpine, Indrawan, Ninkovic, Sacha
Published in Tetrahedron letters (31.07.2013)

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Cu-Catalyzed Hydroboration of Benzylidenecyclopropanes: Reaction Optimization, (Hetero)Aryl Scope, and Origins of Pathway Selectivity

Cu-Catalyzed Hydroboration of Benzylidenecyclopropanes: Reaction Optimization, (Hetero)Aryl Scope, and Origins of Pathway Selectivity

by Medina, Jose M, Kang, Taeho, Erbay, Tuğçe G, Shao, Huiling, Gallego, Gary M, Yang, Shouliang, Tran-Dubé, Michelle, Richardson, Paul F, Derosa, Joseph, Helsel, Ryan T, Patman, Ryan L, Wang, Fen, Ashcroft, Christopher P, Braganza, John F, McAlpine, Indrawan, Liu, Peng, Engle, Keary M
Published in ACS catalysis (06.12.2019)

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Discovery of Potent, Selective, and Peripherally Restricted Pan-Trk Kinase Inhibitors for the Treatment of Pain

Discovery of Potent, Selective, and Peripherally Restricted Pan-Trk Kinase Inhibitors for the Treatment of Pain

by Bagal, Sharan K, Andrews, Mark, Bechle, Bruce M, Bian, Jianwei, Bilsland, James, Blakemore, David C, Braganza, John F, Bungay, Peter J, Corbett, Matthew S, Cronin, Ciaran N, Cui, Jingrong Jean, Dias, Rebecca, Flanagan, Neil J, Greasley, Samantha E, Grimley, Rachel, James, Kim, Johnson, Eric, Kitching, Linda, Kraus, Michelle L, McAlpine, Indrawan, Nagata, Asako, Ninkovic, Sacha, Omoto, Kiyoyuki, Scales, Stephanie, Skerratt, Sarah E, Sun, Jianmin, Tran-Dubé, Michelle, Waldron, Gareth J, Wang, Fen, Warmus, Joseph S
Published in Journal of medicinal chemistry (09.08.2018)

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Improved cyclization conditions to prepare 6-substituted pyrazolo[1,5-a]pyridines and pyrazolo[1,5-a]pyrazines using catalytic Ag(I) and Au(III) salts

Improved cyclization conditions to prepare 6-substituted pyrazolo[1,5-a]pyridines and pyrazolo[1,5-a]pyrazines using catalytic Ag(I) and Au(III) salts

by Braganza, John F., Bernier, Louise, Botrous, Iriny, Collins, Michael R., Li, Baohua, McAlpine, Indrawan, Ninkovic, Sacha, Ren, Shijian, Sach, Neal, Tran-Dubé, Michelle, Zeng, Qingbin, Zheng, Baojiang
Published in Tetrahedron letters (14.10.2015)

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The Synthesis of 3-pyrazinyl-pyrazolo [1,5-a] pyridines from an enol ether

The Synthesis of 3-pyrazinyl-pyrazolo [1,5-a] pyridines from an enol ether

by Tran-Dubé, Michelle, Sach, Neal, Ninkovic, Sacha, Braganza, John F., Huang, Qinhua, Johnson, Benjamin, Collins, Michael Raymond
Published in Tetrahedron letters (15.08.2012)

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A peptide-catalyzed asymmetric Stetter reaction

A peptide-catalyzed asymmetric Stetter reaction

by Mennen, SM, Blank, JT, Tran-Dube, MB, Imbriglio, JE, Miller, SJ
Published in Chemical communications (Cambridge, England) (14.01.2005)

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