Autoantibodies targeting GPCRs and RAS-related molecules associate with COVID-19 severity
Cabral-Marques, Otavio, Halpert, Gilad, Schimke, Lena F., Ostrinski, Yuri, Vojdani, Aristo, Baiocchi, Gabriela Crispim, Freire, Paula Paccielli, Filgueiras, Igor Salerno, Zyskind, Israel, Lattin, Miriam T., Tran, Florian, Schreiber, Stefan, Marques, Alexandre H. C., Plaça, Desirée Rodrigues, Fonseca, Dennyson Leandro M., Humrich, Jens Y., Müller, Antje, Giil, Lasse M., Graßhoff, Hanna, Schumann, Anja, Hackel, Alexander, Junker, Juliane, Meyer, Carlotta, Ochs, Hans D., Lavi, Yael Bublil, Scheibenbogen, Carmen, Dechend, Ralf, Jurisica, Igor, Schulze-Forster, Kai, Silverberg, Jonathan I., Amital, Howard, Zimmerman, Jason, Heidecke, Harry, Rosenberg, Avi Z., Riemekasten, Gabriela, Shoenfeld, Yehuda
Published in Nature communications (09.03.2022)
Published in Nature communications (09.03.2022)
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ATG16L1 orchestrates interleukin-22 signaling in the intestinal epithelium via cGAS-STING
Aden, Konrad, Tran, Florian, Ito, Go, Sheibani-Tezerji, Raheleh, Lipinski, Simone, Kuiper, Jan W, Tschurtschenthaler, Markus, Saveljeva, Svetlana, Bhattacharyya, Joya, Häsler, Robert, Bartsch, Kareen, Luzius, Anne, Jentzsch, Marlene, Falk-Paulsen, Maren, Stengel, Stephanie T, Welz, Lina, Schwarzer, Robin, Rabe, Björn, Barchet, Winfried, Krautwald, Stefan, Hartmann, Gunther, Pasparakis, Manolis, Blumberg, Richard S, Schreiber, Stefan, Kaser, Arthur, Rosenstiel, Philip
Published in The Journal of experimental medicine (05.11.2018)
Published in The Journal of experimental medicine (05.11.2018)
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Activating Transcription Factor 6 Mediates Inflammatory Signals in Intestinal Epithelial Cells Upon Endoplasmic Reticulum Stress
Stengel, Stephanie T., Fazio, Antonella, Lipinski, Simone, Jahn, Martin T., Aden, Konrad, Ito, Go, Wottawa, Felix, Kuiper, Jan W.P., Coleman, Olivia I., Tran, Florian, Bordoni, Dora, Bernardes, Joana P., Jentzsch, Marlene, Luzius, Anne, Bierwirth, Sandra, Messner, Berith, Henning, Anna, Welz, Lina, Kakavand, Nassim, Falk-Paulsen, Maren, Imm, Simon, Hinrichsen, Finn, Zilbauer, Matthias, Schreiber, Stefan, Kaser, Arthur, Blumberg, Richard, Haller, Dirk, Rosenstiel, Philip
Published in Gastroenterology (New York, N.Y. 1943) (01.10.2020)
Published in Gastroenterology (New York, N.Y. 1943) (01.10.2020)
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Epithelial X-Box Binding Protein 1 Coordinates Tumor Protein p53-Driven DNA Damage Responses and Suppression of Intestinal Carcinogenesis
Welz, Lina, Kakavand, Nassim, Hang, Xiang, Laue, Georg, Ito, Go, Silva, Miguel Gomes, Plattner, Christina, Mishra, Neha, Tengen, Felicitas, Ogris, Christoph, Jesinghaus, Moritz, Wottawa, Felix, Arnold, Philipp, Kaikkonen, Leena, Stengel, Stefanie, Tran, Florian, Das, Saumya, Kaser, Arthur, Trajanoski, Zlatko, Blumberg, Richard, Roecken, Christoph, Saur, Dieter, Tschurtschenthaler, Markus, Schreiber, Stefan, Rosenstiel, Philip, Aden, Konrad
Published in Gastroenterology (New York, N.Y. 1943) (01.01.2022)
Published in Gastroenterology (New York, N.Y. 1943) (01.01.2022)
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Epithelial RNase H2 Maintains Genome Integrity and Prevents Intestinal Tumorigenesis in Mice
Aden, Konrad, Bartsch, Kareen, Dahl, Joseph, Reijns, Martin A.M., Esser, Daniela, Sheibani-Tezerji, Raheleh, Sinha, Anupam, Wottawa, Felix, Ito, Go, Mishra, Neha, Knittler, Katharina, Burkholder, Adam, Welz, Lina, van Es, Johan, Tran, Florian, Lipinski, Simone, Kakavand, Nassim, Boeger, Christine, Lucius, Ralph, von Schoenfels, Witigo, Schafmayer, Clemens, Lenk, Lennart, Chalaris, Athena, Clevers, Hans, Röcken, Christoph, Kaleta, Christoph, Rose-John, Stefan, Schreiber, Stefan, Kunkel, Thomas, Rabe, Björn, Rosenstiel, Philip
Published in Gastroenterology (New York, N.Y. 1943) (01.01.2019)
Published in Gastroenterology (New York, N.Y. 1943) (01.01.2019)
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Stem Cells and Organoid Technology in Precision Medicine in Inflammation: Are We There Yet?
Tran, Florian, Klein, Christine, Arlt, Alexander, Imm, Simon, Knappe, Evelyn, Simmons, Alison, Rosenstiel, Philip, Seibler, Philip
Published in Frontiers in immunology (21.12.2020)
Published in Frontiers in immunology (21.12.2020)
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Distinct Longitudinal Changes in Immunoglobulin G N-Glycosylation Associate with Therapy Response in Chronic Inflammatory Diseases
Štambuk, Jerko, Vučković, Frano, Habazin, Siniša, Hanić, Maja, Novokmet, Mislav, Nikolaus, Susanna, Tran, Florian, Schreiber, Stefan, Franke, Andre, Rosenstiel, Philip, Lauc, Gordan, Aden, Konrad, Pezer, Marija
Published in International journal of molecular sciences (01.08.2022)
Published in International journal of molecular sciences (01.08.2022)
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Dipeptidylpeptidase (DPP)-4 inhibitor therapy increases circulating levels of anti-inflammatory soluble frizzle receptor protein (sFRP)-5 which is decreased in severe COVID-19 disease
Brandes, Juliane, Zobel, Isabelle, Rohmann, Nathalie, Schlicht, Kristina, Geisler, Corinna, Hartmann, Katharina, Türk, Kathrin, von Schönfels, Witigo, Beckmann, Jan, Tran, Florian, Laudes, Matthias
Published in Scientific reports (02.09.2022)
Published in Scientific reports (02.09.2022)
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Dynamic changes in extracellular vesicle-associated miRNAs elicited by ultrasound in inflammatory bowel disease patients
Tran, Florian, Scharmacher, Alena, Baran, Nathan, Mishra, Neha, Wozny, Marek, Chavez, Samuel Pineda, Bhardwaj, Archana, Hinz, Sophia, Juzenas, Simonas, Bernardes, Joana P., Sievers, Laura Katharina, Lessing, Matthias, Aden, Konrad, Lassen, Arne, Bergfeld, Arne, Weber, Hauke Jann, Neas, Lennart, Vetrano, Stefania, Schreiber, Stefan, Rosenstiel, Philip
Published in Scientific reports (13.05.2024)
Published in Scientific reports (13.05.2024)
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FixNCut: single-cell genomics through reversible tissue fixation and dissociation
Jiménez-Gracia, Laura, Marchese, Domenica, Nieto, Juan C, Caratù, Ginevra, Melón-Ardanaz, Elisa, Gudiño, Victoria, Roth, Sara, Wise, Kellie, Ryan, Natalie K, Jensen, Kirk B, Hernando-Momblona, Xavier, Bernardes, Joana P, Tran, Florian, Sievers, Laura Katharina, Schreiber, Stefan, van den Berge, Maarten, Kole, Tessa, van der Velde, Petra L, Nawijn, Martijn C, Rosenstiel, Philip, Batlle, Eduard, Butler, Lisa M, Parish, Ian A, Plummer, Jasmine, Gut, Ivo, Salas, Azucena, Heyn, Holger, Martelotto, Luciano G
Published in Genome Biology (29.03.2024)
Published in Genome Biology (29.03.2024)
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Intelectin-1 binds and alters the localization of the mucus barrier-modifying bacterium Akkermansia muciniphila
Matute, Juan D, Duan, Jinzhi, Flak, Magdalena B, Griebel, Paul, Tascon-Arcila, Jose A, Doms, Shauni, Hanley, Thomas, Antanaviciute, Agne, Gundrum, Jennifer, Mark Welch, Jessica L, Sit, Brandon, Abtahi, Shabnam, Fuhler, Gwenny M, Grootjans, Joep, Tran, Florian, Stengel, Stephanie T, White, James R, Krupka, Niklas, Haller, Dirk, Clare, Simon, Lawley, Trevor D, Kaser, Arthur, Simmons, Alison, Glickman, Jonathan N, Bry, Lynn, Rosenstiel, Philip, Borisy, Gary, Waldor, Matthew K, Baines, John F, Turner, Jerrold R, Blumberg, Richard S
Published in The Journal of experimental medicine (02.01.2023)
Published in The Journal of experimental medicine (02.01.2023)
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DNA methyltransferase 3A controls intestinal epithelial barrier function and regeneration in the colon
Fazio, Antonella, Bordoni, Dora, Kuiper, Jan W. P., Weber-Stiehl, Saskia, Stengel, Stephanie T., Arnold, Philipp, Ellinghaus, David, Ito, Go, Tran, Florian, Messner, Berith, Henning, Anna, Bernardes, Joana P., Häsler, Robert, Luzius, Anne, Imm, Simon, Hinrichsen, Finn, Franke, Andre, Huber, Samuel, Nikolaus, Susanna, Aden, Konrad, Schreiber, Stefan, Sommer, Felix, Natoli, Gioacchino, Mishra, Neha, Rosenstiel, Philip
Published in Nature communications (21.10.2022)
Published in Nature communications (21.10.2022)
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Leptin induces TNFα-dependent inflammation in acquired generalized lipodystrophy and combined Crohn’s disease
Ziegler, Jörn F., Böttcher, Chotima, Letizia, Marilena, Yerinde, Cansu, Wu, Hao, Freise, Inka, Rodriguez-Sillke, Yasmina, Stoyanova, Ani K., Kreis, Martin E., Asbach, Patrick, Kunkel, Desiree, Priller, Josef, Anagnostopoulos, Ioannis, Kühl, Anja A., Miehle, Konstanze, Stumvoll, Michael, Tran, Florian, Fredrich, Broder, Forster, Michael, Franke, Andre, Bojarski, Christian, Glauben, Rainer, Löscher, Britt-Sabina, Siegmund, Britta, Weidinger, Carl
Published in Nature communications (10.12.2019)
Published in Nature communications (10.12.2019)
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Epithelial IL-23R Signaling Licenses Protective IL-22 Responses in Intestinal Inflammation
Aden, Konrad, Rehman, Ateequr, Falk-Paulsen, Maren, Secher, Thomas, Kuiper, Jan, Tran, Florian, Pfeuffer, Steffen, Sheibani-Tezerji, Raheleh, Breuer, Alexandra, Luzius, Anne, Jentzsch, Marlene, Häsler, Robert, Billmann-Born, Susanne, Will, Olga, Lipinski, Simone, Bharti, Richa, Adolph, Timon, Iovanna, Juan L., Kempster, Sarah L., Blumberg, Richard S., Schreiber, Stefan, Becher, Burkhard, Chamaillard, Mathias, Kaser, Arthur, Rosenstiel, Philip
Published in Cell reports (Cambridge) (23.08.2016)
Published in Cell reports (Cambridge) (23.08.2016)
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Brief Research Report: Serum clara cell 16 kDa protein levels are increased in patients hospitalized for severe SARS-CoV-2 or sepsis infection
Rohmann, Nathalie, Stürmer, Paula, Geisler, Corinna, Schlicht, Kristina, Hartmann, Katharina, Türk, Kathrin, Hollstein, Tim, Tran, Florian, Rosenstiel, Philip, Franke, Andre, Heyckendorf, Jan, Schreiber, Stefan, Schulte, Dominik M., Laudes, Matthias
Published in Frontiers in immunology (13.10.2022)
Published in Frontiers in immunology (13.10.2022)
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External Model Performance Evaluation of Twelve Infliximab Population Pharmacokinetic Models in Patients with Inflammatory Bowel Disease
Schräpel, Christina, Kovar, Lukas, Selzer, Dominik, Hofmann, Ute, Tran, Florian, Reinisch, Walter, Schwab, Matthias, Lehr, Thorsten
Published in Pharmaceutics (31.08.2021)
Published in Pharmaceutics (31.08.2021)
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Patient Reported Outcomes in Chronic Inflammatory Diseases: Current State, Limitations and Perspectives
Tran, Florian, Schirmer, Jan Henrik, Ratjen, Ilka, Lieb, Wolfgang, Helliwell, Philip, Burisch, Johan, Schulz, Juliane, Schrinner, Florian, Jaeckel, Charlot, Müller-Ladner, Ulf, Schreiber, Stefan, Hoyer, Bimba F
Published in Frontiers in immunology (18.03.2021)
Published in Frontiers in immunology (18.03.2021)
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Longitudinal multi-omics analysis identifies early blood-based predictors of anti-TNF therapy response in inflammatory bowel disease
Mishra, Neha, Aden, Konrad, Blase, Johanna I, Baran, Nathan, Bordoni, Dora, Tran, Florian, Conrad, Claudio, Avalos, Diana, Jaeckel, Charlot, Scherer, Michael, Sarensen, Signe B, Overgaard, Silja H, Schulte, Berenice, Nikolaus, Susanna, Rey, Guillaume, Gasparoni, Gilles, Lyons, Paul A, Schultze, Joachim L, Walter, Jörn, Andersen, Vibeke, Banos, Aggelos, Bertsias, George, Beyer, Marc, Boumpas, Dimitrios, Finckh, Axel, Franke, Andre, Georges, Michel, Gu, Wei, Häsler, Robert, Jawhara, Mohamad, Kenyon, Amy, Kratsch, Christina, Krause, Roland, Lauc, Gordan, Mangino, Massimo, Natoli, Gioacchino, Ostaszewski, Marek, Pezer, Marija, Raes, Jeroen, Rahmouni, Souad, Ramos-Pamplona, Marilou, Reiz, Benedikt, Rosati, Elisa, Sanoudou, Despina, Satagopam, Venkata, Schneider, Reinhard, Schulte-Schrepping, Jonas, Sidiropoulos, Prodromos, Smith, Kenneth G. C, Spector, Timothy, Vandeputte, Doris, Vieira-Silva, Sara, Vojta, Aleksandar, Warnat-Herresthal, Stefanie, ZoldoÅ¡, Vlatka
Published in Genome medicine (24.09.2022)
Published in Genome medicine (24.09.2022)
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Evolution of E. coli in a mouse model of inflammatory bowel disease leads to a disease-specific bacterial genotype and trade-offs with clinical relevance
Unni, Rahul, Andreani, Nadia Andrea, Vallier, Marie, Heinzmann, Silke S., Taubenheim, Jan, Guggeis, Martina A., Tran, Florian, Vogler, Olga, Künzel, Sven, Hövener, Jan-Bernd, Rosenstiel, Philip, Kaleta, Christoph, Dempfle, Astrid, Unterweger, Daniel, Baines, John F.
Published in Gut microbes (18.12.2023)
Published in Gut microbes (18.12.2023)
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