Viable mouse gene ablations that robustly alter brain Aβ levels are rare
Toyn, Jeremy H, Lin, Xu-Alan, Thompson, Mark W, Guss, Valerie, Meredith, Jr, Jere E, Sankaranarayanan, Sethu, Barrezueta, Nestor, Corradi, John, Majumdar, Antara, Small, Daniel L, Hansard, Melissa, Lanthorn, Thomas, Westphal, Ryan S, Albright, Charles F
Published in BMC neuroscience (05.11.2010)
Published in BMC neuroscience (05.11.2010)
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The γ-Secretase Modulator, BMS-932481, Modulates Aβ Peptides in the Plasma and Cerebrospinal Fluid of Healthy Volunteers
Soares, Holly D, Gasior, Maciej, Toyn, Jeremy H, Wang, Jun-Sheng, Hong, Quan, Berisha, Flora, Furlong, Michael T, Raybon, Joseph, Lentz, Kimberley A, Sweeney, Francis, Zheng, Naiyu, Akinsanya, Billy, Berman, Robert M, Thompson, Lorin A, Olson, Richard E, Morrison, John, Drexler, Dieter M, Macor, John E, Albright, Charlie F, Ahlijanian, Michael K, AbuTarif, Malaz
Published in The Journal of pharmacology and experimental therapeutics (01.07.2016)
Published in The Journal of pharmacology and experimental therapeutics (01.07.2016)
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Journal Article
Synthesis of functionalized derivatives of the gamma-secretase modulator BMS-932481 and identification of its major metabolite
Zhang, Yunhui, Boy, Kenneth M., Wu, Yong-Jin, Ramirez, Antonio, Toyn, Jeremy H., Ahlijanian, Michael K., Albright, Charles F., Zhuo, Xiaoliang, Johnson, Benjamin M., Denton, R. Rex, Olson, Richard E., Thompson, Lorin A., Macor, John E.
Published in Bioorganic & medicinal chemistry letters (15.11.2020)
Published in Bioorganic & medicinal chemistry letters (15.11.2020)
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Journal Article
Discovery of S3-Truncated, C‑6 Heteroaryl Substituted Aminothiazine β‑Site APP Cleaving Enzyme‑1 (BACE1) Inhibitors
Wu, Yong-Jin, Guernon, Jason, Shi, Jianliang, Marcin, Lawrence, Higgins, Mendi, Rajamani, Ramkumar, Muckelbauer, Jodi, Lewis, Hal, Chang, ChiehYing, Camac, Dan, Toyn, Jeremy H, Ahlijanian, Michael K, Albright, Charles F, Macor, John E, Thompson, Lorin A
Published in Journal of medicinal chemistry (22.09.2016)
Published in Journal of medicinal chemistry (22.09.2016)
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Journal Article
Discovery of furo[2,3-d][1,3]thiazinamines as beta amyloid cleaving enzyme-1 (BACE1) inhibitors
Wu, Yong-Jin, Guernon, Jason, Rajamani, Ramkumar, Toyn, Jeremy H., Ahlijanian, Michael K., Albright, Charles F., Muckelbauer, Jodi, Chang, ChiehYing, Camac, Dan, Macor, John E., Thompson, Lorin A.
Published in Bioorganic & medicinal chemistry letters (01.12.2016)
Published in Bioorganic & medicinal chemistry letters (01.12.2016)
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Journal Article
Pharmacodynamics of selective inhibition of γ-secretase by avagacestat
Albright, Charles F, Dockens, Randy C, Meredith, Jr, Jere E, Olson, Richard E, Slemmon, Randy, Lentz, Kimberley A, Wang, Jun-Sheng, Denton, R Rex, Pilcher, Gary, Rhyne, Paul W, Raybon, Joseph J, Barten, Donna M, Burton, Catherine, Toyn, Jeremy H, Sankaranarayanan, Sethu, Polson, Craig, Guss, Valerie, White, Randy, Simutis, Frank, Sanderson, Thomas, Gillman, Kevin W, Starrett, Jr, John E, Bronson, Joanne, Sverdlov, Oleksandr, Huang, Shu-Pang, Castaneda, Lorna, Feldman, Howard, Coric, Vlad, Zaczek, Robert, Macor, John E, Houston, John, Berman, Robert M, Tong, Gary
Published in The Journal of pharmacology and experimental therapeutics (01.03.2013)
Published in The Journal of pharmacology and experimental therapeutics (01.03.2013)
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Journal Article
Robust Translation of γ-Secretase Modulator Pharmacology across Preclinical Species and Human Subjects
Toyn, Jeremy H, Boy, Kenneth M, Raybon, Joseph, Meredith, Jr, Jere E, Robertson, Alan S, Guss, Valerie, Hoque, Nina, Sweeney, Francis, Zhuo, Xiaoliang, Clarke, Wendy, Snow, Kimberly, Denton, R Rex, Zuev, Dmitry, Thompson, Lorin A, Morrison, John, Grace, James, Berisha, Flora, Furlong, Michael, Wang, Jun-Sheng, Lentz, Kimberly A, Padmanabha, Ramesh, Cook, Lynda, Wei, Cong, Drexler, Dieter M, Macor, John E, Albright, Charlie F, Gasior, Maciej, Olson, Richard E, Hong, Quan, Soares, Holly D, AbuTarif, Malaz, Ahlijanian, Michael K
Published in The Journal of pharmacology and experimental therapeutics (01.07.2016)
Published in The Journal of pharmacology and experimental therapeutics (01.07.2016)
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Journal Article
Synergistic inhibition of Aβ production by combinations of γ-secretase modulators
Robertson, Alan S., Iben, Lawrence G., Wei, Cong, Meredith, Jere E., Drexler, Dieter M., Banks, Martyn, Vite, Gregory D., Olson, Richard E., Thompson, Lorin A., Albright, Charles F., Ahlijanian, Michael K., Toyn, Jeremy H.
Published in European journal of pharmacology (05.10.2017)
Published in European journal of pharmacology (05.10.2017)
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Journal Article
Acyl Guanidine Inhibitors of β‑Secretase (BACE-1): Optimization of a Micromolar Hit to a Nanomolar Lead via Iterative Solid- and Solution-Phase Library Synthesis
Gerritz, Samuel W, Zhai, Weixu, Shi, Shuhao, Zhu, Shirong, Toyn, Jeremy H, Meredith, Jere E, Iben, Lawrence G, Burton, Catherine R, Albright, Charles F, Good, Andrew C, Tebben, Andrew J, Muckelbauer, Jodi K, Camac, Daniel M, Metzler, William, Cook, Lynda S, Padmanabha, Ramesh, Lentz, Kimberley A, Sofia, Michael J, Poss, Michael A, Macor, John E, Thompson, Lorin A
Published in Journal of medicinal chemistry (08.11.2012)
Published in Journal of medicinal chemistry (08.11.2012)
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Journal Article
Design and optimization of tricyclic gamma-secretase modulators
Shi, Jianliang, Zuev, Dmitry, Xu, Li, Lentz, Kimberley A., Grace, James E., Toyn, Jeremy H., Olson, Richard E., Macor, John E., Thompson, Lorin A.
Published in Bioorganic & medicinal chemistry letters (01.03.2016)
Published in Bioorganic & medicinal chemistry letters (01.03.2016)
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Journal Article
Discovery and Evaluation of BMS-708163, a Potent, Selective and Orally Bioavailable γ-Secretase Inhibitor
Gillman, Kevin W, Starrett, John E, Parker, Michael F, Xie, Kai, Bronson, Joanne J, Marcin, Lawrence R, McElhone, Kate E, Bergstrom, Carl P, Mate, Robert A, Williams, Richard, Meredith, Jere E, Burton, Catherine R, Barten, Donna M, Toyn, Jeremy H, Roberts, Susan B, Lentz, Kimberley A, Houston, John G, Zaczek, Robert, Albright, Charles F, Decicco, Carl P, Macor, John E, Olson, Richard E
Published in ACS medicinal chemistry letters (10.06.2010)
Published in ACS medicinal chemistry letters (10.06.2010)
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Journal Article
Targeting the BACE1 Active Site Flap Leads to a Potent Inhibitor That Elicits Robust Brain Aβ Reduction in Rodents
Wu, Yong-Jin, Guernon, Jason, Yang, Fukang, Snyder, Lawrence, Shi, Jianliang, Mcclure, Andrea, Rajamani, Ramkumar, Park, Hyunsoo, Ng, Alicia, Lewis, Hal, Chang, ChiehYing, Camac, Dan, Toyn, Jeremy H, Ahlijanian, Michael K, Albright, Charles F, Macor, John E, Thompson, Lorin A
Published in ACS medicinal chemistry letters (10.03.2016)
Published in ACS medicinal chemistry letters (10.03.2016)
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Journal Article
Macrocyclic prolinyl acyl guanidines as inhibitors of β-secretase (BACE)
Boy, Kenneth M., Guernon, Jason M., Wu, Yong-Jin, Zhang, Yunhui, Shi, Joe, Zhai, Weixu, Zhu, Shirong, Gerritz, Samuel W., Toyn, Jeremy H., Meredith, Jere E., Barten, Donna M., Burton, Catherine R., Albright, Charles F., Good, Andrew C., Grace, James E., Lentz, Kimberley A., Olson, Richard E., Macor, John E., Thompson, Lorin A.
Published in Bioorganic & medicinal chemistry letters (15.11.2015)
Published in Bioorganic & medicinal chemistry letters (15.11.2015)
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Journal Article
The Swi5 transcription factor of Saccharomyces cerevisiae has a role in exit from mitosis through induction of the cdk-inhibitor Sic1 in telophase
Toyn, J.H. (National Institute for Medical Research, London, UK.), Johnson, A.L, Donovan, J.D, Toone, W.M, Johnston, L.H
Published in Genetics (Austin) (01.01.1997)
Published in Genetics (Austin) (01.01.1997)
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Journal Article
Identification and Preclinical Evaluation of the Bicyclic Pyrimidine γ‑Secretase Modulator BMS-932481
Boy, Kenneth M, Guernon, Jason M, Zuev, Dmitry S, Xu, Li, Zhang, Yunhui, Shi, Jianliang, Marcin, Lawrence R, Higgins, Mendi A, Wu, Yong-Jin, Krishnananthan, Subramaniam, Li, Jianqing, Trehan, Ashok, Smith, Daniel, Toyn, Jeremy H, Meredith, Jere E, Burton, Catherine R, Kimura, S. Roy, Zvyaga, Tatyana, Zhuo, Xiaoliang, Lentz, Kimberley A, Grace, James E, Denton, Rex, Morrison, John S, Mathur, Arvind, Albright, Charles F, Ahlijanian, Michael K, Olson, Richard E, Thompson, Lorin A, Macor, John E
Published in ACS medicinal chemistry letters (14.03.2019)
Published in ACS medicinal chemistry letters (14.03.2019)
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Journal Article
Swi5 controls a novel wave of cyclin synthesis in late mitosis
Aerne, B L, Johnson, A L, Toyn, J H, Johnston, L H
Published in Molecular biology of the cell (01.04.1998)
Published in Molecular biology of the cell (01.04.1998)
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Journal Article
Bub2p-dependent spindle checkpoint pathway regulates the Dbf2p kinase in budding yeast
Fesquet, D, Fitzpatrick, P.J, Johnson, A.L, Kramer, K.M, Toyn, J.H, Johnston, L.H
Published in The EMBO journal (04.05.1999)
Published in The EMBO journal (04.05.1999)
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