Targeting MLL1 H3K4 Methyltransferase Activity in Mixed-Lineage Leukemia
Cao, Fang, Townsend, Elizabeth C., Karatas, Hacer, Xu, Jing, Li, Li, Lee, Shirley, Liu, Liu, Chen, Yong, Ouillette, Peter, Zhu, Jidong, Hess, Jay L., Atadja, Peter, Lei, Ming, Qin, Zhaohui S., Malek, Sami, Wang, Shaomeng, Dou, Yali
Published in Molecular cell (23.01.2014)
Published in Molecular cell (23.01.2014)
Get full text
Journal Article
High-Affinity, Small-Molecule Peptidomimetic Inhibitors of MLL1/WDR5 Protein–Protein Interaction
Karatas, Hacer, Townsend, Elizabeth C, Cao, Fang, Chen, Yong, Bernard, Denzil, Liu, Liu, Lei, Ming, Dou, Yali, Wang, Shaomeng
Published in Journal of the American Chemical Society (16.01.2013)
Published in Journal of the American Chemical Society (16.01.2013)
Get full text
Journal Article
Discovery of a Highly Potent, Cell-Permeable Macrocyclic Peptidomimetic (MM-589) Targeting the WD Repeat Domain 5 Protein (WDR5)–Mixed Lineage Leukemia (MLL) Protein–Protein Interaction
Karatas, Hacer, Li, Yangbing, Liu, Liu, Ji, Jiao, Lee, Shirley, Chen, Yong, Yang, Jiuling, Huang, Liyue, Bernard, Denzil, Xu, Jing, Townsend, Elizabeth C, Cao, Fang, Ran, Xu, Li, Xiaoqin, Wen, Bo, Sun, Duxin, Stuckey, Jeanne A, Lei, Ming, Dou, Yali, Wang, Shaomeng
Published in Journal of medicinal chemistry (22.06.2017)
Published in Journal of medicinal chemistry (22.06.2017)
Get full text
Journal Article
Key aspects of papillomavirus infection influence the host cervicovaginal microbiome in a preclinical murine papillomavirus (MmuPV1) infection model
Spurgeon, Megan E, Townsend, Elizabeth C, Blaine-Sauer, Simon, McGregor, Stephanie M, Horswill, Mark, den Boon, Johan A, Ahlquist, Paul, Kalan, Lindsay, Lambert, Paul F
Published in mBio (14.05.2024)
Published in mBio (14.05.2024)
Get full text
Journal Article
Longitudinal multi-omics analyses of the gut-liver axis reveals metabolic dysregulation in hepatitis C infection and cirrhosis
Ali, Rabab O, Quinn, Gabriella M, Umarova, Regina, Haddad, James A, Zhang, Grace Y, Townsend, Elizabeth C, Scheuing, Lisa, Hill, Kareen L, Gewirtz, Meital, Rampertaap, Shakuntala, Rosenzweig, Sergio D, Remaley, Alan T, Han, Jung Min, Periwal, Vipul, Cai, Hongyi, Walter, Peter J, Koh, Christopher, Levy, Elliot B, Kleiner, David E, Etzion, Ohad, Heller, Theo
Published in Nature microbiology (01.01.2023)
Published in Nature microbiology (01.01.2023)
Get full text
Journal Article
Discovery of a Novel Simian Pegivirus in Common Marmosets (Callithrix jacchus) with Lymphocytic Enterocolitis
Heffron, Anna S., Lauck, Michael, Somsen, Elizabeth D., Townsend, Elizabeth C., Bailey, Adam L., Sosa, Megan, Eickhoff, Jens, Capuano III, Saverio, Newman, Christina M., Kuhn, Jens H., Mejia, Andres, Simmons, Heather A., O’Connor, David H.
Published in Microorganisms (Basel) (30.09.2020)
Published in Microorganisms (Basel) (30.09.2020)
Get full text
Journal Article
Molecular basis of USP7 inhibition by selective small-molecule inhibitors
Turnbull, Andrew P, Ioannidis, Stephanos, Krajewski, Wojciech W, Pinto-Fernandez, Adan, Heride, Claire, Martin, Agnes C L, Tonkin, Louise M, Townsend, Elizabeth C, Buker, Shane M, Lancia, David R, Caravella, Justin A, Toms, Angela V, Charlton, Thomas M, Lahdenranta, Johanna, Wilker, Erik, Follows, Bruce C, Evans, Nicola J, Stead, Lucy, Alli, Cristina, Zarayskiy, Vladislav V, Talbot, Adam C, Buckmelter, Alexandre J, Wang, Minghua, McKinnon, Crystal L, Saab, Fabienne, McGouran, Joanna F, Century, Hannah, Gersch, Malte, Pittman, Marc S, Marshall, C Gary, Raynham, Tony M, Simcox, Mary, Stewart, Lorna M D, McLoughlin, Sheila B, Escobedo, Jaime A, Bair, Kenneth W, Dinsmore, Christopher J, Hammonds, Tim R, Kim, Sunkyu, Urbé, Sylvie, Clague, Michael J, Kessler, Benedikt M, Komander, David
Published in Nature (London) (26.10.2017)
Published in Nature (London) (26.10.2017)
Get full text
Journal Article
Analysis of the Binding of Mixed Lineage Leukemia 1 (MLL1) and Histone 3 Peptides to WD Repeat Domain 5 (WDR5) for the Design of Inhibitors of the MLL1−WDR5 Interaction
Karatas, Hacer, Townsend, Elizabeth C, Bernard, Denzil, Dou, Yali, Wang, Shaomeng
Published in Journal of medicinal chemistry (22.07.2010)
Published in Journal of medicinal chemistry (22.07.2010)
Get full text
Journal Article
What is slough? Defining the proteomic and microbial composition of slough and its implications for wound healing
Townsend, Elizabeth C, Cheong, J Z Alex, Radzietza, Michael, Fritz, Blaine, Malone, Matthew, Bjarnsholt, Thomas, Ousey, Karen, Swanson, Terry, Schultz, Gregory, Gibson, Angela L F, Kalan, Lindsay R
Published in Wound repair and regeneration (01.04.2024)
Published in Wound repair and regeneration (01.04.2024)
Get full text
Journal Article
The porcine skin microbiome exhibits broad fungal antagonism
De La Cruz, Karinda F., Townsend, Elizabeth C., Alex Cheong, J.Z., Salamzade, Rauf, Liu, Aiping, Sandstrom, Shelby, Davila, Evelin, Huang, Lynda, Xu, Kayla H., Wu, Sherrie Y., Meudt, Jennifer J., Shanmuganayagam, Dhanansayan, Gibson, Angela L.F., Kalan, Lindsay R.
Published in Fungal genetics and biology (01.08.2024)
Published in Fungal genetics and biology (01.08.2024)
Get full text
Journal Article
Triplication of a 21q22 region contributes to B cell transformation through HMGN1 overexpression and loss of histone H3 Lys27 trimethylation
Lane, Andrew A, Chapuy, Bjoern, Lin, Charles Y, Tivey, Trevor, Li, Hubo, Townsend, Elizabeth C, van Bodegom, Diederik, Day, Tovah A, Wu, Shuo-Chieh, Liu, Huiyun, Yoda, Akinori, Alexe, Gabriela, Schinzel, Anna C, Sullivan, Timothy J, Malinge, Sébastien, Taylor, Jordan E, Stegmaier, Kimberly, Jaffe, Jacob D, Bustin, Michael, te Kronnie, Geertruy, Izraeli, Shai, Harris, Marian H, Stevenson, Kristen E, Neuberg, Donna, Silverman, Lewis B, Sallan, Stephen E, Bradner, James E, Hahn, William C, Crispino, John D, Pellman, David, Weinstock, David M
Published in Nature genetics (01.06.2014)
Published in Nature genetics (01.06.2014)
Get full text
Journal Article
The balance of type 1 and type 2 immune responses in the contexts of hepatitis B infection and hepatitis D infection
Townsend, Elizabeth C, Zhang, Grace Y, Ali, Rabab, Firke, Marian, Moon, Mi Sun, Han, Ma Ai Thanda, Fram, Benjamin, Glenn, Jeffrey S, Kleiner, David E, Koh, Christopher, Heller, Theo
Published in Journal of gastroenterology and hepatology (01.04.2019)
Published in Journal of gastroenterology and hepatology (01.04.2019)
Get full text
Journal Article
Co-activation of AMPK and mTORC1 Induces Cytotoxicity in Acute Myeloid Leukemia
Sujobert, Pierre, Poulain, Laury, Paubelle, Etienne, Zylbersztejn, Florence, Grenier, Adrien, Lambert, Mireille, Townsend, Elizabeth C., Brusq, Jean-Marie, Nicodeme, Edwige, Decrooqc, Justine, Nepstad, Ina, Green, Alexa S., Mondesir, Johanna, Hospital, Marie-Anne, Jacque, Nathalie, Christodoulou, Alexandra, Desouza, Tiffany A., Hermine, Olivier, Foretz, Marc, Viollet, Benoit, Lacombe, Catherine, Mayeux, Patrick, Weinstock, David M., Moura, Ivan C., Bouscary, Didier, Tamburini, Jerome
Published in Cell reports (Cambridge) (09.06.2015)
Published in Cell reports (Cambridge) (09.06.2015)
Get full text
Journal Article
Exploring the Link Between Platelet Numbers and Vascular Homeostasis Across Early and Late Stages of Fibrosis in Hepatitis C
Ali, Rabab O., Moon, Mi Sun, Townsend, Elizabeth C., Hill, Kareen, Zhang, Grace Y., Bradshaw, Alyson, Guan, Hannah, Hamilton, Destanee, Kleiner, David E., Auh, Sungyoung, Koh, Christopher, Heller, Theo
Published in Digestive diseases and sciences (01.02.2020)
Published in Digestive diseases and sciences (01.02.2020)
Get full text
Journal Article
Microbial Translocation in the Context of Hepatitis B Infection and Hepatitis D Infection
Townsend, Elizabeth C, Zhang, Grace Y, Ali, Rabab, Surana, Pallavi, Firke, Marian, Moon, Mi Sun, Han, Ma Ai Thanda, Gewirtz, Meital, Haddad, James A, Kleiner, David E, Koh, Christopher, Heller, Theo
Published in Open forum infectious diseases (01.11.2021)
Published in Open forum infectious diseases (01.11.2021)
Get full text
Journal Article
Pim kinases modulate resistance to FLT3 tyrosine kinase inhibitors in FLT3-ITD acute myeloid leukemia
Green, Alexa S, Maciel, Thiago T, Hospital, Marie-Anne, Yin, Chae, Mazed, Fetta, Townsend, Elizabeth C, Pilorge, Sylvain, Lambert, Mireille, Paubelle, Etienne, Jacquel, Arnaud, Zylbersztejn, Florence, Decroocq, Justine, Poulain, Laury, Sujobert, Pierre, Jacque, Nathalie, Adam, Kevin, So, Jason C C, Kosmider, Olivier, Auberger, Patrick, Hermine, Olivier, Weinstock, David M, Lacombe, Catherine, Mayeux, Patrick, Vanasse, Gary J, Leung, Anskar Y, Moura, Ivan C, Bouscary, Didier, Tamburini, Jerome
Published in Science advances (01.09.2015)
Published in Science advances (01.09.2015)
Get full text
Journal Article
Bacterial Translocation and Host Immune Activation in Chronic Hepatitis C Infection
Moon, Mi Sun, Quinn, Gabriella, Townsend, Elizabeth C, Ali, Rabab O, Zhang, Grace Y, Bradshaw, Alyson, Hill, Kareen, Guan, Hannah, Hamilton, Destanee, Kleiner, David E, Koh, Christopher, Heller, Theo
Published in Open forum infectious diseases (01.07.2019)
Published in Open forum infectious diseases (01.07.2019)
Get full text
Journal Article
The MDM2 Inhibitor NVP-CGM097 Is Highly Active in a Randomized Preclinical Trial of B-Cell Acute Lymphoblastic Leukemia Patient Derived Xenografts
Townsend, Elizabeth C, DeSouza, Tiffany, Murakami, Mark A., Montero, Joan, Stevenson, Kristen, Christie, Amanda L, Christodolou, Alexandra N, Vojinovic, Una, Kopp, Nadja, Barzaghi-Rinaudo, Patrizia, Murakami, Masato, Letai, Anthony, Jeay, Sebastien, Wuerthner, Jens, Halilovic, Ensar, Weinstock, David M.
Published in Blood (03.12.2015)
Published in Blood (03.12.2015)
Get full text
Journal Article