Prioritizing Parkinson's disease genes using population-scale transcriptomic data
Li, Yang I, Wong, Garrett, Humphrey, Jack, Raj, Towfique
Published in Nature communications (01.03.2019)
Published in Nature communications (01.03.2019)
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Integrating whole-genome sequencing with multi-omic data reveals the impact of structural variants on gene regulation in the human brain
Vialle, Ricardo A, de Paiva Lopes, Katia, Bennett, David A, Crary, John F, Raj, Towfique
Published in Nature neuroscience (01.04.2022)
Published in Nature neuroscience (01.04.2022)
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Journal Article
Alzheimer's disease: early alterations in brain DNA methylation at ANK1, BIN1, RHBDF2 and other loci
De Jager, Philip L, Srivastava, Gyan, Lunnon, Katie, Burgess, Jeremy, Schalkwyk, Leonard C, Yu, Lei, Eaton, Matthew L, Keenan, Brendan T, Ernst, Jason, McCabe, Cristin, Tang, Anna, Raj, Towfique, Replogle, Joseph, Brodeur, Wendy, Gabriel, Stacey, Chai, High S, Younkin, Curtis, Younkin, Steven G, Zou, Fanggeng, Szyf, Moshe, Epstein, Charles B, Schneider, Julie A, Bernstein, Bradley E, Meissner, Alex, Ertekin-Taner, Nilufer, Chibnik, Lori B, Kellis, Manolis, Mill, Jonathan, Bennett, David A
Published in Nature neuroscience (01.09.2014)
Published in Nature neuroscience (01.09.2014)
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Transcriptomic analysis of frontotemporal lobar degeneration with TDP-43 pathology reveals cellular alterations across multiple brain regions
Hasan, Rahat, Humphrey, Jack, Bettencourt, Conceição, Newcombe, Jia, Lashley, Tammaryn, Fratta, Pietro, Raj, Towfique
Published in Acta neuropathologica (01.03.2022)
Published in Acta neuropathologica (01.03.2022)
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Journal Article
Genetic analysis of the human microglial transcriptome across brain regions, aging and disease pathologies
Lopes, Katia de Paiva, Snijders, Gijsje J L, Humphrey, Jack, Allan, Amanda, Sneeboer, Marjolein A M, Navarro, Elisa, Schilder, Brian M, Vialle, Ricardo A, Parks, Madison, Missall, Roy, van Zuiden, Welmoed, Gigase, Frederieke A J, Kübler, Raphael, van Berlekom, Amber Berdenis, Hicks, Emily M, Bӧttcher, Chotima, Priller, Josef, Kahn, René S, de Witte, Lot D, Raj, Towfique
Published in Nature genetics (01.01.2022)
Published in Nature genetics (01.01.2022)
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Journal Article
Intersection of population variation and autoimmunity genetics in human T cell activation
Ye, Chun Jimmie, Feng, Ting, Kwon, Ho-Keun, Raj, Towfique, Wilson, Michael, Asinovski, Natasha, McCabe, Cristin, Lee, Michelle H., Frohlich, Irene, Paik, Hyun-il, Zaitlen, Noah, Hacohen, Nir, Stranger, Barbara, De Jager, Philip, Mathis, Diane, Regev, Aviv, Benoist, Christophe
Published in Science (American Association for the Advancement of Science) (12.09.2014)
Published in Science (American Association for the Advancement of Science) (12.09.2014)
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Human HLA-G+ extravillous trophoblasts: Immune-activating cells that interact with decidual leukocytes
Tilburgs, Tamara, Crespo, Ângela C., van der Zwan, Anita, Rybalov, Basya, Raj, Towfique, Stranger, Barbara, Gardner, Lucy, Moffett, Ashley, Strominger, Jack L.
Published in Proceedings of the National Academy of Sciences - PNAS (09.06.2015)
Published in Proceedings of the National Academy of Sciences - PNAS (09.06.2015)
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Journal Article
Polarization of the Effects of Autoimmune and Neurodegenerative Risk Alleles in Leukocytes
Raj, Towfique, Rothamel, Katie, Mostafavi, Sara, Ye, Chun, Lee, Mark N., Replogle, Joseph M., Feng, Ting, Lee, Michelle, Asinovski, Natasha, Frohlich, Irene, Imboywa, Selina, Von Korff, Alina, Okada, Yukinori, Patsopoulos, Nikolaos A., Davis, Scott, McCabe, Cristin, Paik, Hyun-il, Srivastava, Gyan P., Raychaudhuri, Soumya, Hafler, David A., Koller, Daphne, Regev, Aviv, Hacohen, Nir, Mathis, Diane, Benoist, Christophe, Stranger, Barbara E., De Jager, Philip L.
Published in Science (American Association for the Advancement of Science) (02.05.2014)
Published in Science (American Association for the Advancement of Science) (02.05.2014)
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Journal Article
CD33 Alzheimer's disease locus: altered monocyte function and amyloid biology
Bradshaw, Elizabeth M, Chibnik, Lori B, Keenan, Brendan T, Ottoboni, Linda, Raj, Towfique, Tang, Anna, Rosenkrantz, Laura L, Imboywa, Selina, Lee, Michelle, Von Korff, Alina, Morris, Martha C, Evans, Denis A, Johnson, Keith, Sperling, Reisa A, Schneider, Julie A, Bennett, David A, De Jager, Philip L
Published in Nature neuroscience (01.07.2013)
Published in Nature neuroscience (01.07.2013)
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Journal Article
Genetics of the human microglia regulome refines Alzheimer's disease risk loci
Kosoy, Roman, Fullard, John F, Zeng, Biao, Bendl, Jaroslav, Dong, Pengfei, Rahman, Samir, Kleopoulos, Steven P, Shao, Zhiping, Girdhar, Kiran, Humphrey, Jack, de Paiva Lopes, Katia, Charney, Alexander W, Kopell, Brian H, Raj, Towfique, Bennett, David, Kellner, Christopher P, Haroutunian, Vahram, Hoffman, Gabriel E, Roussos, Panos
Published in Nature genetics (01.08.2022)
Published in Nature genetics (01.08.2022)
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Journal Article
Common Genetic Variants Modulate Pathogen-Sensing Responses in Human Dendritic Cells
Lee, Mark N., Ye, Chun, Villani, Alexandra-Chloé, Raj, Towfique, Li, Weibo, Eisenhaure, Thomas M., Imboywa, Selina H., Chipendo, Portia I., Ran, F. Ann, Slowikowski, Kamil, Ward, Lucas D., Raddassi, Khadir, McCabe, Cristin, Lee, Michelle H., Frohlich, Irene Y., Hafler, David A., Kellis, Manolis, Raychaudhuri, Soumya, Zhang, Feng, Stranger, Barbara E., Benoist, Christophe O., De Jager, Philip L., Regev, Aviv, Hacohen, Nir
Published in Science (American Association for the Advancement of Science) (07.03.2014)
Published in Science (American Association for the Advancement of Science) (07.03.2014)
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Journal Article
Parsing the Interferon Transcriptional Network and Its Disease Associations
Mostafavi, Sara, Yoshida, Hideyuki, Moodley, Devapregasan, LeBoité, Hugo, Rothamel, Katherine, Raj, Towfique, Ye, Chun Jimmie, Chevrier, Nicolas, Zhang, Shen-Ying, Feng, Ting, Lee, Mark, Casanova, Jean-Laurent, Clark, James D., Hegen, Martin, Telliez, Jean-Baptiste, Hacohen, Nir, De Jager, Philip L., Regev, Aviv, Mathis, Diane, Benoist, Christophe
Published in Cell (28.01.2016)
Published in Cell (28.01.2016)
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HnRNP K mislocalisation is a novel protein pathology of frontotemporal lobar degeneration and ageing and leads to cryptic splicing
Bampton, Alexander, Gatt, Ariana, Humphrey, Jack, Cappelli, Sara, Bhattacharya, Dipanjan, Foti, Sandrine, Brown, Anna-Leigh, Asi, Yasmine, Low, Yi Hua, Foiani, Marco, Raj, Towfique, Buratti, Emanuele, Fratta, Pietro, Lashley, Tammaryn
Published in Acta neuropathologica (01.10.2021)
Published in Acta neuropathologica (01.10.2021)
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Journal Article
Patterns of cis regulatory variation in diverse human populations
Stranger, Barbara E, Montgomery, Stephen B, Dimas, Antigone S, Parts, Leopold, Stegle, Oliver, Ingle, Catherine E, Sekowska, Magda, Smith, George Davey, Evans, David, Gutierrez-Arcelus, Maria, Price, Alkes, Raj, Towfique, Nisbett, James, Nica, Alexandra C, Beazley, Claude, Durbin, Richard, Deloukas, Panos, Dermitzakis, Emmanouil T
Published in PLoS genetics (01.04.2012)
Published in PLoS genetics (01.04.2012)
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Distinct non-inflammatory signature of microglia in post-mortem brain tissue of patients with major depressive disorder
Snijders, Gijsje J L J, Sneeboer, Marjolein A M, Fernández-Andreu, Alba, Udine, Evan, Boks, Marco P, Ormel, Paul R, van Berlekom, Amber Berdenis, van Mierlo, Hans C, Bӧttcher, Chotima, Priller, Josef, Raj, Towfique, Hol, Elly M, Kahn, René S, de Witte, Lot D
Published in Molecular psychiatry (01.07.2021)
Published in Molecular psychiatry (01.07.2021)
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Dysregulated coordination of MAPT exon 2 and exon 10 splicing underlies different tau pathologies in PSP and AD
Bowles, Kathryn R., Pugh, Derian A., Oja, Laura-Maria, Jadow, Benjamin M., Farrell, Kurt, Whitney, Kristen, Sharma, Abhijeet, Cherry, Jonathan D., Raj, Towfique, Pereira, Ana C., Crary, John F., Goate, Alison M.
Published in Acta neuropathologica (01.02.2022)
Published in Acta neuropathologica (01.02.2022)
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Journal Article
High-resolution temporal and regional mapping of MAPT expression and splicing in human brain development
Hefti, Marco M, Farrell, Kurt, Kim, SoongHo, Bowles, Kathryn R, Fowkes, Mary E, Raj, Towfique, Crary, John F
Published in PloS one (10.04.2018)
Published in PloS one (10.04.2018)
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Journal Article
Interindividual variation in human T regulatory cells
Ferraro, Alessandra, D'Alise, Anna Morena, Raj, Towfique, Asinovski, Natasha, Phillips, Roxanne, Ergun, Ayla, Replogle, Joseph M., Bernier, Angelina, Laffel, Lori, Stranger, Barbara E., De Jager, Philip L., Mathis, Diane, Benoist, Christophe
Published in Proceedings of the National Academy of Sciences - PNAS (25.03.2014)
Published in Proceedings of the National Academy of Sciences - PNAS (25.03.2014)
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