C−H Bonds as Ubiquitous Functionality: A General Approach to Complex Arylated Imidazoles via Regioselective Sequential Arylation of All Three C−H Bonds and Regioselective N-Alkylation Enabled by SEM-Group Transposition
Joo, Jung Min, Touré, B. Barry, Sames, Dalibor
Published in Journal of organic chemistry (06.08.2010)
Published in Journal of organic chemistry (06.08.2010)
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A Three-Component Reaction for Diversity-Oriented Synthesis of Polysubstituted Piperidines: Solution and Solid-Phase Optimization of the First Tandem Aza[4+2]/Allylboration
Touré, Barry B., Hoveyda, Hamid R., Tailor, Jyoti, Ulaczyk-Lesanko, Agnieszka, Hall, Dennis G.
Published in Chemistry : a European journal (20.01.2003)
Published in Chemistry : a European journal (20.01.2003)
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Complementation of Biotransformations with Chemical C–H Oxidation: Copper-Catalyzed Oxidation of Tertiary Amines in Complex Pharmaceuticals
Genovino, Julien, Lütz, Stephan, Sames, Dalibor, Touré, B. Barry
Published in Journal of the American Chemical Society (21.08.2013)
Published in Journal of the American Chemical Society (21.08.2013)
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Toward the Validation of Maternal Embryonic Leucine Zipper Kinase: Discovery, Optimization of Highly Potent and Selective Inhibitors, and Preliminary Biology Insight
Touré, B. Barry, Giraldes, John, Smith, Troy, Sprague, Elizabeth R, Wang, Yaping, Mathieu, Simon, Chen, Zhuoliang, Mishina, Yuji, Feng, Yun, Yan-Neale, Yan, Shakya, Subarna, Chen, Dongshu, Meyer, Matthew, Puleo, David, Brazell, J. Tres, Straub, Christopher, Sage, David, Wright, Kirk, Yuan, Yanqiu, Chen, Xin, Duca, Jose, Kim, Sean, Tian, Li, Martin, Eric, Hurov, Kristen, Shao, Wenlin
Published in Journal of medicinal chemistry (26.05.2016)
Published in Journal of medicinal chemistry (26.05.2016)
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Identification of NVP-TNKS656: The Use of Structure–Efficiency Relationships To Generate a Highly Potent, Selective, and Orally Active Tankyrase Inhibitor
Shultz, Michael D, Cheung, Atwood K, Kirby, Christina A, Firestone, Brant, Fan, Jianmei, Chen, Christine Hiu-Tung, Chen, Zhouliang, Chin, Donovan N, DiPietro, Lucian, Fazal, Aleem, Feng, Yun, Fortin, Pascal D, Gould, Ty, Lagu, Bharat, Lei, Huangshu, Lenoir, Francois, Majumdar, Dyuti, Ochala, Etienne, Palermo, M. G, Pham, Ly, Pu, Minying, Smith, Troy, Stams, Travis, Tomlinson, Ronald C, Touré, B. Barry, Visser, Michael, Wang, Run Ming, Waters, Nigel J, Shao, Wenlin
Published in Journal of medicinal chemistry (22.08.2013)
Published in Journal of medicinal chemistry (22.08.2013)
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RLY-4008, the First Highly Selective FGFR2 Inhibitor with Activity across FGFR2 Alterations and Resistance Mutations
Subbiah, Vivek, Sahai, Vaibhav, Maglic, Dejan, Bruderek, Kamil, Touré, B Barry, Zhao, Songping, Valverde, Roberto, O'Hearn, Patrick J, Moustakas, Demetri T, Schönherr, Heike, Gerami-Moayed, Nastaran, Taylor, Alexander M, Hudson, Brandi M, Houde, Damian J, Pal, Debjani, Foster, Lindsey, Gunaydin, Hakan, Ayaz, Pelin, Sharon, Dina A, Goyal, Lipika, Schram, Alison M, Kamath, Suneel, Sherwin, Cori Ann, Schmidt-Kittler, Oleg, Jen, Kai Yu, Ricard, Fabien, Wolf, Beni B, Shaw, David E, Bergstrom, Donald A, Watters, James, Casaletto, Jessica B
Published in Cancer discovery (06.09.2023)
Published in Cancer discovery (06.09.2023)
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Allosteric Mutant IDH1 Inhibitors Reveal Mechanisms for IDH1 Mutant and Isoform Selectivity
Xie, Xiaoling, Baird, Daniel, Bowen, Kimberly, Capka, Vladimir, Chen, Jinyun, Chenail, Gregg, Cho, YoungShin, Dooley, Julia, Farsidjani, Ali, Fortin, Pascal, Kohls, Darcy, Kulathila, Raviraj, Lin, Fallon, McKay, Daniel, Rodrigues, Lindsey, Sage, David, Touré, B. Barry, van der Plas, Simon, Wright, Kirk, Xu, Ming, Yin, Hong, Levell, Julian, Pagliarini, Raymond A.
Published in Structure (London) (07.03.2017)
Published in Structure (London) (07.03.2017)
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Discovery of lirafugratinib (RLY-4008), a highly selective irreversible small-molecule inhibitor of FGFR2
Schönherr, Heike, Ayaz, Pelin, Taylor, Alexander M, Casaletto, Jessica B, Touré, B Barry, Moustakas, Demetri T, Hudson, Brandi M, Valverde, Roberto, Zhao, Songping, O'Hearn, Patrick J, Foster, Lindsey, Sharon, Dina A, Garfinkle, Sam, Giordanetto, Fabrizio, Lescarbeau, André, Kurukulasuriya, Ravi, Gerami-Moayed, Nastaran, Maglic, Dejan, Bruderek, Kamil, Naik, Gaauri, Gunaydin, Hakan, Mader, Mary M, Boezio, Alessandro A, McLean, Thomas H, Chen, Rongfeng, Wang, Yanxia, Shaw, David E, Watters, James, Bergstrom, Donald A
Published in Proceedings of the National Academy of Sciences - PNAS (06.02.2024)
Published in Proceedings of the National Academy of Sciences - PNAS (06.02.2024)
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“Addition” and “Subtraction”: Selectivity Design for Type II Maternal Embryonic Leucine Zipper Kinase Inhibitors
Chen, Xin, Giraldes, John, Sprague, Elizabeth R, Shakya, Subarna, Chen, Zhuoliang, Wang, Yaping, Joud, Carol, Mathieu, Simon, Chen, Christine Hiu-Tung, Straub, Christopher, Duca, Jose, Hurov, Kristen, Yuan, Yanqiu, Shao, Wenlin, Touré, B. Barry
Published in Journal of medicinal chemistry (09.03.2017)
Published in Journal of medicinal chemistry (09.03.2017)
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The Role of the Acidity of N‑Heteroaryl Sulfonamides as Inhibitors of Bcl‑2 Family Protein–Protein Interactions
Touré, B. Barry, Miller-Moslin, Karen, Yusuff, Naeem, Perez, Lawrence, Doré, Michael, Joud, Carol, Michael, Walter, DiPietro, Lucian, van der Plas, Simon, McEwan, Michael, Lenoir, Francois, Hoe, Madelene, Karki, Rajesh, Springer, Clayton, Sullivan, John, Levine, Kymberly, Fiorilla, Catherine, Xie, Xiaoling, Kulathila, Raviraj, Herlihy, Kara, Porter, Dale, Visser, Michael
Published in ACS medicinal chemistry letters (14.02.2013)
Published in ACS medicinal chemistry letters (14.02.2013)
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Optimization of 3‑Pyrimidin-4-yl-oxazolidin-2-ones as Allosteric and Mutant Specific Inhibitors of IDH1
Levell, Julian R., Caferro, Thomas, Chenail, Gregg, Dix, Ina, Dooley, Julia, Firestone, Brant, Fortin, Pascal D., Giraldes, John, Gould, Ty, Growney, Joseph D., Jones, Michael D., Kulathila, Raviraj, Lin, Fallon, Liu, Gang, Mueller, Arne, van der Plas, Simon, Slocum, Kelly, Smith, Troy, Terranova, Remi, Touré, B. Barry, Tyagi, Viraj, Wagner, Trixie, Xie, Xiaoling, Xu, Ming, Yang, Fan S., Zhou, Liping X., Pagliarini, Raymond, Cho, Young Shin
Published in ACS medicinal chemistry letters (09.02.2017)
Published in ACS medicinal chemistry letters (09.02.2017)
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Lipophilic Isosteres of a π–π Stacking Interaction: New Inhibitors of the Bcl-2-Bak Protein–Protein Interaction
Yusuff, Naeem, Doré, Michaël, Joud, Carol, Visser, Michael, Springer, Clayton, Xie, Xiaoling, Herlihy, Kara, Porter, Dale, Touré, B. Barry
Published in ACS medicinal chemistry letters (12.07.2012)
Published in ACS medicinal chemistry letters (12.07.2012)
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Mammalian Subtilisin/Kexin Isozyme SKI-1: A Widely Expressed Proprotein Convertase with a Unique Cleavage Specificity and Cellular Localization
Seidah, Nabil G., Mowla, Seyed J., Hamelin, Josee, Mamarbachi, Aida M., Benjannet, Suzanne, Toure, Barry B., Basak, Ajoy, Munzer, Jon Scott, Marcinkiewicz, Jadwiga, Zhong, Mei, Barale, Jean-Christophe, Lazure, Claude, Murphy, Richard A., Chretien, Michel, Marcinkiewicz, Mieczyslaw
Published in Proceedings of the National Academy of Sciences - PNAS (16.02.1999)
Published in Proceedings of the National Academy of Sciences - PNAS (16.02.1999)
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