Identification of LY3522348: A Highly Selective and Orally Efficacious Ketohexokinase Inhibitor
Durham, Timothy B., Hao, Junliang, Spinazze, Patrick, Stack, Douglas R., Toth, James L., Massey, Steven, Mbofana, Curren T., Johnston, Richard D., Lineswala, Jayana P., Wrobleski, Aaron, Mínguez, Jose Miguel, Perez, Carlos, Smith, Daryl L., Lamar, Jason, Leon, Rebecca, Corkins, Christopher, Durbin, Jim, Tung, Frances, Guo, Sherry, Linder, Ryan J., Yumibe, Nathan, Wang, Wei, MacKrell, James, Antonellis, Meghan, Mascaro, Bethany
Published in Journal of medicinal chemistry (14.12.2023)
Published in Journal of medicinal chemistry (14.12.2023)
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Discovery of N‑(6-Fluoro-1-oxo-1,2-dihydroisoquinolin-7-yl)-5-[(3R)‑3-hydroxypyrrolidin-1-yl]thiophene-2-sulfonamide (LSN 3213128), a Potent and Selective Nonclassical Antifolate Aminoimidazole-4-carboxamide Ribonucleotide Formyltransferase (AICARFT) Inhibitor Effective at Tumor Suppression in a Cancer Xenograft Model
Fales, Kevin R., Njoroge, F. George, Brooks, Harold B., Thibodeaux, Stefan, Torrado, Alicia, Si, Chong, Toth, James L., Mc Cowan, Jefferson R., Roth, Kenneth D., Thrasher, Kenneth J., Frimpong, Kwame, Lee, Matthew R., Dally, Robert D., Shepherd, Timothy A., Durham, Timothy B., Margolis, Brandon J., Wu, Zhipei, Wang, Yong, Atwell, Shane, Wang, Jing, Hui, Yu-Hua, Meier, Timothy I., Konicek, Susan A., Geeganage, Sandaruwan
Published in Journal of medicinal chemistry (14.12.2017)
Published in Journal of medicinal chemistry (14.12.2017)
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Journal Article
Dual Exosite-binding Inhibitors of Insulin-degrading Enzyme Challenge Its Role as the Primary Mediator of Insulin Clearance in Vivo
Durham, Timothy B., Toth, James L., Klimkowski, Valentine J., Cao, Julia X.C., Siesky, Angela M., Alexander-Chacko, Jesline, Wu, Ginger Y., Dixon, Jeffrey T., McGee, James E., Wang, Yong, Guo, Sherry Y., Cavitt, Rachel Nicole, Schindler, John, Thibodeaux, Stefan J., Calvert, Nathan A., Coghlan, Michael J., Sindelar, Dana K., Christe, Michael, Kiselyov, Vladislav V., Michael, M. Dodson, Sloop, Kyle W.
Published in The Journal of biological chemistry (14.08.2015)
Published in The Journal of biological chemistry (14.08.2015)
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A Highly Selective Hydantoin Inhibitor of Aggrecanase‑1 and Aggrecanase‑2 with a Low Projected Human Dose
Durham, Timothy B, Marimuthu, Jothirajah, Toth, James L, Liu, Chin, Adams, Lisa, Mudra, Daniel R, Swearingen, Craig, Lin, Chaohua, Chambers, Mark G, Thirunavukkarasu, Kannan, Wiley, Michael R
Published in Journal of medicinal chemistry (13.07.2017)
Published in Journal of medicinal chemistry (13.07.2017)
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Characterization of a novel AICARFT inhibitor which potently elevates ZMP and has anti-tumor activity in murine models
Brooks, Harold B, Meier, Timothy I, Geeganage, Sandaruwan, Fales, Kevin R, Thrasher, Kenneth J, Konicek, Susan A, Spencer, Charles D, Thibodeaux, Stefan, Foreman, Robert T, Hui, Yu-Hua, Roth, Kenneth D, Qian, Yue-Wei, Wang, Tao, Luo, Shuang, Torrado, Alicia, Si, Chong, Toth, James L, Mc Cowan, Jefferson R, Frimpong, Kwame, Lee, Matthew R, Dally, Robert D, Shepherd, Timothy A, Durham, Timothy B, Wang, Yong, Wu, Zhipei, Iversen, Philip W, Njoroge, F George
Published in Scientific reports (18.10.2018)
Published in Scientific reports (18.10.2018)
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Use of Osmotic Pumps to Establish the Pharmacokinetic–Pharmacodynamic Relationship and Define Desirable Human Performance Characteristics for Aggrecanase Inhibitors
Wiley, Michael R, Durham, Timothy B, Adams, Lisa A, Chambers, Mark G, Lin, Chaohua, Liu, Chin, Marimuthu, Jothirajah, Mitchell, Peter G, Mudra, Daniel R, Swearingen, Craig A, Toth, James L, Weller, Jennifer M, Thirunavukkarasu, Kannan
Published in Journal of medicinal chemistry (23.06.2016)
Published in Journal of medicinal chemistry (23.06.2016)
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Identification of Potent and Selective Hydantoin Inhibitors of Aggrecanase‑1 and Aggrecanase‑2 That Are Efficacious in Both Chemical and Surgical Models of Osteoarthritis
Durham, Timothy B, Klimkowski, Valentine J, Rito, Christopher J, Marimuthu, Jothirajah, Toth, James L, Liu, Chin, Durbin, Jim D, Stout, Stephanie L, Adams, Lisa, Swearingen, Craig, Lin, Chaohua, Chambers, Mark G, Thirunavukkarasu, Kannan, Wiley, Michael R
Published in Journal of medicinal chemistry (26.12.2014)
Published in Journal of medicinal chemistry (26.12.2014)
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A novel achiral seco-amino-cyclopropylindoline (CI) analog of CC-1065 and the duocarmycins: design, synthesis and biological studies
Toth, James L, Trzupek, John D, Flores, Lloyd V, Kiakos, Konstantinos, Hartley, John A, Pennington, William T, Lee, Moses
Published in Medicinal chemistry (Shp-sariqah, United Arab Emirates) (01.01.2005)
Published in Medicinal chemistry (Shp-sariqah, United Arab Emirates) (01.01.2005)
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Sequence selective recognition of DNA by hairpin conjugates of a racemic seco-cyclopropaneindoline-2-benzofurancarboxamide and polyamides
Toth, James L, Price, Carly A, Madsen, Erik C, Handl, Heather L, Hudson, Stephen J, Hubbard, III, Richard B, Bowen, J.Phillip, Kiakos, Konstantinos, Hartley, John A, Lee, Moses
Published in Bioorganic & medicinal chemistry letters (19.08.2002)
Published in Bioorganic & medicinal chemistry letters (19.08.2002)
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Identification of antimicrobial compounds active against intracellular Staphylococcus aureus
Malouin, François, Brouillette, Eric, Martinez, Alejandro, Boyll, Bobbi J., Toth, James L., Gage, Jennifer L., Allen, Norris E.
Published in FEMS immunology and medical microbiology (01.08.2005)
Published in FEMS immunology and medical microbiology (01.08.2005)
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EFFICIENT SYNTHESIS OF (±)-seco-CYCLOPROPANEINDOLINE ANALOGS OF CC-1065
Jennings, Sharon A., Toth, James L., Roller, Shane G., Brooks, Natalie, O'Hare, Caroline, Kiakos, Konstantinos, Hartley, John A., Burke, Philip J., Lee, Moses
Published in Heterocyclic communications (2001)
Published in Heterocyclic communications (2001)
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