Practical QSP application from the preclinical phase to enhance the probability of clinical success: Insights from case studies in oncology
Oishi, Masayo, Sayama, Hiroyuki, Toshimoto, Kota, Nakayama, Takeshi, Nagasaka, Yasuhisa
Published in Drug metabolism and pharmacokinetics (01.06.2024)
Published in Drug metabolism and pharmacokinetics (01.06.2024)
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Journal Article
Comparison of Methods for Estimating Unbound Intracellular-to-Medium Concentration Ratios in Rat and Human Hepatocytes Using Statins
Yoshikado, Takashi, Toshimoto, Kota, Nakada, Tomohisa, Ikejiri, Kazuaki, Kusuhara, Hiroyuki, Maeda, Kazuya, Sugiyama, Yuichi
Published in Drug metabolism and disposition (01.07.2017)
Published in Drug metabolism and disposition (01.07.2017)
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Journal Article
Physiologically Based Pharmacokinetic Modeling of Bosentan Identifies the Saturable Hepatic Uptake As a Major Contributor to Its Nonlinear Pharmacokinetics
Sato, Masanobu, Toshimoto, Kota, Tomaru, Atsuko, Yoshikado, Takashi, Tanaka, Yuta, Hisaka, Akihiro, Lee, Wooin, Sugiyama, Yuichi
Published in Drug metabolism and disposition (01.05.2018)
Published in Drug metabolism and disposition (01.05.2018)
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Journal Article
Evaluation of Alteration in Hepatic and Intestinal BCRP Function In Vivo from ABCG2 c.421C>A Polymorphism Based on PBPK Analysis of Rosuvastatin
Futatsugi, Azusa, Toshimoto, Kota, Yoshikado, Takashi, Sugiyama, Yuichi, Kato, Yukio
Published in Drug metabolism and disposition (01.05.2018)
Published in Drug metabolism and disposition (01.05.2018)
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Journal Article
Quantitative Analysis of Complex Drug-Drug Interactions between Cerivastatin and Metabolism/Transport Inhibitors Using Physiologically Based Pharmacokinetic Modeling
Yao, Yoshiaki, Toshimoto, Kota, Kim, Soo-Jin, Yoshikado, Takashi, Sugiyama, Yuichi
Published in Drug metabolism and disposition (01.07.2018)
Published in Drug metabolism and disposition (01.07.2018)
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Journal Article
Physiologically‐based pharmacokinetic modeling for investigating the effect of simeprevir on concomitant drugs and an endogenous biomarker of OATP1B
Nakayama, Shinji, Toshimoto, Kota, Yamazaki, Shinji, Snoeys, Jan, Sugiyama, Yuichi
Published in CPT: pharmacometrics and systems pharmacology (01.10.2023)
Published in CPT: pharmacometrics and systems pharmacology (01.10.2023)
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Journal Article
Cluster Gauss–Newton method
Aoki Yasunori, Hayami, Ken, Kota, Toshimoto, Sugiyama Yuichi
Published in Optimization and engineering (01.01.2022)
Published in Optimization and engineering (01.01.2022)
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Journal Article
PBPK Modeling of Coproporphyrin I as an Endogenous Biomarker for Drug Interactions Involving Inhibition of Hepatic OATP1B1 and OATP1B3
Yoshikado, Takashi, Toshimoto, Kota, Maeda, Kazuya, Kusuhara, Hiroyuki, Kimoto, Emi, Rodrigues, A. David, Chiba, Koji, Sugiyama, Yuichi
Published in CPT: pharmacometrics and systems pharmacology (01.11.2018)
Published in CPT: pharmacometrics and systems pharmacology (01.11.2018)
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Journal Article
Strategies to improve the prediction accuracy of hepatic intrinsic clearance of three antidiabetic drugs: Application of the extended clearance concept and consideration of the effect of albumin on CYP2C metabolism and OATP1B-mediated hepatic uptake
Fujino, Ryo, Hashizume, Kenta, Aoyama, Shinsuke, Maeda, Kazuya, Ito, Kiyomi, Toshimoto, Kota, Lee, Wooin, Ninomiya, Shin-ichi, Sugiyama, Yuichi
Published in European journal of pharmaceutical sciences (01.12.2018)
Published in European journal of pharmaceutical sciences (01.12.2018)
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Journal Article
A Clinical Quantitative Evaluation of Hepatobiliary Transport of [ 11 C]Dehydropravastatin in Humans Using Positron Emission Tomography
Kaneko, Ken-Ichi, Tanaka, Masaaki, Ishii, Akira, Katayama, Yumiko, Nakaoka, Takayoshi, Irie, Satsuki, Kawahata, Hideki, Yamanaga, Takashi, Wada, Yasuhiro, Miyake, Takeshi, Toshimoto, Kota, Maeda, Kazuya, Cui, Yilong, Enomoto, Masaru, Kawamura, Etsushi, Kawada, Norifumi, Kawabe, Joji, Shiomi, Susumu, Kusuhara, Hiroyuki, Sugiyama, Yuichi, Watanabe, Yasuyoshi
Published in Drug metabolism and disposition (01.05.2018)
Published in Drug metabolism and disposition (01.05.2018)
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Journal Article
Analysis of Nonlinear Pharmacokinetics of a Highly Albumin-Bound Compound: Contribution of Albumin-Mediated Hepatic Uptake Mechanism
Fukuchi, Yukina, Toshimoto, Kota, Mori, Takanori, Kakimoto, Keisuke, Tobe, Yoshifusa, Sawada, Takeshi, Asaumi, Ryuta, Iwata, Takeyuki, Hashimoto, Yoshitaka, Nunoya, Ken-ichi, Imawaka, Haruo, Miyauchi, Seiji, Sugiyam, Yuichi
Published in Journal of pharmaceutical sciences (01.09.2017)
Published in Journal of pharmaceutical sciences (01.09.2017)
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Journal Article
Physiologically‐Based Pharmacokinetic Modeling Analysis for Quantitative Prediction of Renal Transporter–Mediated Interactions Between Metformin and Cimetidine
Nishiyama, Kotaro, Toshimoto, Kota, Lee, Wooin, Ishiguro, Naoki, Bister, Bojan, Sugiyama, Yuichi
Published in CPT: pharmacometrics and systems pharmacology (01.06.2019)
Published in CPT: pharmacometrics and systems pharmacology (01.06.2019)
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Journal Article
Comprehensive PBPK Model of Rifampicin for Quantitative Prediction of Complex Drug‐Drug Interactions: CYP3A/2C9 Induction and OATP Inhibition Effects
Asaumi, Ryuta, Toshimoto, Kota, Tobe, Yoshifusa, Hashizume, Kenta, Nunoya, Ken‐ichi, Imawaka, Haruo, Lee, Wooin, Sugiyama, Yuichi
Published in CPT: pharmacometrics and systems pharmacology (01.03.2018)
Published in CPT: pharmacometrics and systems pharmacology (01.03.2018)
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Journal Article
In Silico Prediction of Major Clearance Pathways of Drugs among 9 Routes with Two-Step Support Vector Machines
Wakayama, Naomi, Toshimoto, Kota, Maeda, Kazuya, Hotta, Shun, Ishida, Takashi, Akiyama, Yutaka, Sugiyama, Yuichi
Published in Pharmaceutical research (01.10.2018)
Published in Pharmaceutical research (01.10.2018)
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Journal Article
Application of PBPK Modeling and Virtual Clinical Study Approaches to Predict the Outcomes of CYP2D6 Genotype‐Guided Dosing of Tamoxifen
Nakamura, Toshimichi, Toshimoto, Kota, Lee, Wooin, Imamura, Chiyo K., Tanigawara, Yusuke, Sugiyama, Yuichi
Published in CPT: pharmacometrics and systems pharmacology (01.07.2018)
Published in CPT: pharmacometrics and systems pharmacology (01.07.2018)
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Journal Article
Revisiting Nonlinear Bosentan Pharmacokinetics by Physiologically Based Pharmacokinetic Modeling: Target Binding, Albeit Not a Major Contributor to Nonlinearity, Can Offer Prediction of Target Occupancy
Koyama, Satoshi, Toshimoto, Kota, Lee, Wooin, Aoki, Yasunori, Sugiyama, Yuichi
Published in Drug metabolism and disposition (01.04.2021)
Published in Drug metabolism and disposition (01.04.2021)
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Journal Article