Trisomy of human chromosome 21 enhances amyloid-β deposition independently of an extra copy of APP
Wiseman, Frances K, Pulford, Laura J, Barkus, Chris, Liao, Fan, Portelius, Erik, Webb, Robin, Chávez-Gutiérrez, Lucia, Cleverley, Karen, Noy, Sue, Sheppard, Olivia, Collins, Toby, Powell, Caroline, Sarell, Claire J, Rickman, Matthew, Choong, Xun, Tosh, Justin L, Siganporia, Carlos, Whittaker, Heather T, Stewart, Floy, Szaruga, Maria, Murphy, Michael P, Blennow, Kaj, de Strooper, Bart, Zetterberg, Henrik, Bannerman, David, Holtzman, David M, Tybulewicz, Victor L J, Fisher, Elizabeth M C
Published in Brain (London, England : 1878) (01.08.2018)
Published in Brain (London, England : 1878) (01.08.2018)
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Journal Article
Genetic dissection of down syndrome-associated alterations in APP/amyloid-β biology using mouse models
Tosh, Justin L, Rhymes, Elena R, Mumford, Paige, Whittaker, Heather T, Pulford, Laura J, Noy, Sue J, Cleverley, Karen, Walker, Matthew C, Tybulewicz, Victor L J, Wykes, Rob C, Fisher, Elizabeth M C, Wiseman, Frances K
Published in Scientific reports (11.03.2021)
Published in Scientific reports (11.03.2021)
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Journal Article
Dissecting Alzheimer disease in Down syndrome using mouse models
Choong, Xun Yu, Tosh, Justin L, Pulford, Laura J, Fisher, Elizabeth M C
Published in Frontiers in behavioral neuroscience (13.10.2015)
Published in Frontiers in behavioral neuroscience (13.10.2015)
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Journal Article
Gene expression dysregulation domains are not a specific feature of Down syndrome
Ahlfors, Helena, Anyanwu, Nneka, Pakanavicius, Edvinas, Dinischiotu, Natalia, Lana-Elola, Eva, Watson-Scales, Sheona, Tosh, Justin, Wiseman, Frances, Briscoe, James, Page, Karen, Fisher, Elizabeth M C, Tybulewicz, Victor L J
Published in Nature communications (06.06.2019)
Published in Nature communications (06.06.2019)
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Publisher Correction: Genetic dissection of down syndrome‑associated alterations in APP/amyloid‑β biology using mouse models
Tosh, Justin L, Rhymes, Elena R, Mumford, Paige, Whittaker, Heather T, Pulford, Laura J, Noy, Sue J, Cleverley, Karen, Walker, Matthew C, Tybulewicz, Victor L J, Wykes, Rob C, Fisher, Elizabeth M C, Wiseman, Frances K
Published in Scientific reports (16.07.2021)
Published in Scientific reports (16.07.2021)
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Comprehensive phenotypic analysis of the Dp1Tyb mouse strain reveals a broad range of Down syndrome-related phenotypes
Lana-Elola, Eva, Cater, Heather, Watson-Scales, Sheona, Greenaway, Simon, Müller-Winkler, Jennifer, Gibbins, Dorota, Nemes, Mihaela, Slender, Amy, Hough, Tertius, Keskivali-Bond, Piia, Scudamore, Cheryl L, Herbert, Eleanor, Banks, Gareth T, Mobbs, Helene, Canonica, Tara, Tosh, Justin, Noy, Suzanna, Llorian, Miriam, Nolan, Patrick M, Griffin, Julian L, Good, Mark, Simon, Michelle, Mallon, Ann-Marie, Wells, Sara, Fisher, Elizabeth M C, Tybulewicz, Victor L J
Published in Disease models & mechanisms (01.10.2021)
Published in Disease models & mechanisms (01.10.2021)
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Journal Article
The integration site of the APP transgene in the J20 mouse model of Alzheimer's disease
Tosh, Justin L, Rickman, Matthew, Rhymes, Ellie, Norona, Frances E, Clayton, Emma, Mucke, Lennart, Isaacs, Adrian M, Fisher, Elizabeth M C, Wiseman, Frances K
Published in Wellcome open research (2017)
Published in Wellcome open research (2017)
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Journal Article
The integration site of the APP transgene in the J20 mouse model of Alzheimer’s disease
Tosh, Justin L., Rickman, Matthew, Rhymes, Ellie, Norona, Frances E., Clayton, Emma, Mucke, Lennart, Isaacs, Adrian M., Fisher, Elizabeth M.C., Wiseman, Frances K.
Published in Wellcome open research (10.10.2018)
Published in Wellcome open research (10.10.2018)
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Mouse models of aneuploidy to understand chromosome disorders
Tosh, Justin, Tybulewicz, Victor, Fisher, Elizabeth M. C.
Published in Mammalian genome (01.03.2022)
Published in Mammalian genome (01.03.2022)
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Journal Article
Section on Cognitive Neuropsychology, Laboratory of Brain and Cognition, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892
Mumford, Paige, Tosh, Justin, Anderle, Silvia, Wikberg, Eleni Gkanatsiou, Lau, Gloria, Noy, Sue, Cleverley, Karen, Saito, Takashi, Saido, Takaomi C, Yu, Eugene, Brinkmalm, Gunnar, Portelius, Erik, Blennow, Kaj, Zetterberg, Henrik, Tybulewicz, Victor, Fisher, Elizabeth MC, Wiseman, Frances K
Published in The Journal of neuroscience (17.08.2022)
Published in The Journal of neuroscience (17.08.2022)
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Modelling of the development and response to amyloid‐β accumulation in the context of trisomy21 in the rodent brain
Farrell, Clíona, Mumford, Paige, Beament, Millie, Lau, Gloria, Wu, Yixing, Pellen, Marion, Baniowska, Monika Rataj, Tosh, Justin, Noy, Sue, Cleverley, Karen, HERAULT, Yann, Tybulewicz, Victor, Fisher, Elizabeth, Wiseman, Frances K
Published in Alzheimer's & dementia (01.12.2023)
Published in Alzheimer's & dementia (01.12.2023)
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Journal Article
Genetic Mapping of APP and Amyloid-β Biology Modulation by Trisomy 21
Mumford, Paige, Tosh, Justin, Anderle, Silvia, Gkanatsiou Wikberg, Eleni, Lau, Gloria, Noy, Sue, Cleverley, Karen, Saito, Takashi, Saido, Takaomi C, Yu, Eugene, Brinkmalm, Gunnar, Portelius, Erik, Blennow, Kaj, Zetterberg, Henrik, Tybulewicz, Victor, Fisher, Elizabeth M C, Wiseman, Frances K
Published in The Journal of neuroscience (17.08.2022)
Published in The Journal of neuroscience (17.08.2022)
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Journal Article
Genetic mapping of APP and amyloid‐β biology modulation by trisomy 21
Mumford, Paige, Tosh, Justin, Anderle, Silvia, Gkanatsiou, Eleni, Lau, Gloria, Noy, Sue, Cleverley, Karen, Saito, Takashi, Saido, Takaomi C., Yu, Eugene Y., Brinkmalm, Gunnar, Portelius, Erik, Blennow, Kaj, Zetterberg, Henrik, Tybulewicz, Victor, Fisher, Elizabeth, Wiseman, Frances K
Published in Alzheimer's & dementia (01.06.2023)
Published in Alzheimer's & dementia (01.06.2023)
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Journal Article
Downregulated Wnt/β-catenin signalling in the Down syndrome hippocampus
Granno, Simone, Nixon-Abell, Jonathon, Berwick, Daniel C, Tosh, Justin, Heaton, George, Almudimeegh, Sultan, Nagda, Zenisha, Rain, Jean-Christophe, Zanda, Manuela, Plagnol, Vincent, Tybulewicz, Victor L J, Cleverley, Karen, Wiseman, Frances K, Fisher, Elizabeth M C, Harvey, Kirsten
Published in Scientific reports (13.05.2019)
Published in Scientific reports (13.05.2019)
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Journal Article
TRISOMY 21 CAUSES A DEFICIT IN LYSOSOMAL CATHEPSINS AND ALTERS APP/Aβ PROCESSING, INDEPENDENTLY OF AN EXTRA COPY OF APP
Wiseman, Frances K., Pulford, Laura J., Barkus, Chris, Liao, Fan, Portelius, Erik, Webb, Robin, Chavez-Gutierrez, Lucia, Cleverley, Karen, Noy, Sue, Rickman, Matthew, Tosh, Justin, Whittaker, Heather, Stewart, Floy, Szaruga, Maria, Nizetic, Dean, Murphy, Paul, Blennow, Kaj, de Strooper, Bart, Zetterberg, Henrik, Bannerman, David, Holtzman, David M., Tybulewicz, Victor L., Fisher, Elizabeth
Published in Alzheimer's & dementia (01.07.2017)
Published in Alzheimer's & dementia (01.07.2017)
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Journal Article
Genetic mapping of APP and amyloid-β biology modulation by trisomy 21
Mumford, Paige, Tosh, Justin, Anderle, Silvia, Wikberg, Eleni Gkanatsiou, Lau, Gloria, Noy, Sue, Cleverley, Karen, Saito, Takashi, Saido, Takaomi C, Yu, Eugene Y, Brinkmalm, Gunnar, Portelius, Erik, Blennow, Kaj, Zetterberg, Henrik, Tybulewicz, Victor, Fisher, Elizabeth, Wiseman, Frances K
Published in bioRxiv (12.03.2022)
Published in bioRxiv (12.03.2022)
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Paper
Comprehensive phenotypic analysis of the Dp1Tyb mouse strain reveals a broad range of Down Syndrome-related phenotypes
Lana-Elola, Eva, Cater, Heather, Watson-Scales, Sheona, Greenaway, Simon, Müller-Winkler, Jennifer, Gibbins, Dorota, Nemes, Mihaela, Slender, Amy, Hough, Tertius, Keskivali-Bond, Piia, Scudamore, Cheryl L, Herbert, Eleanor, Banks, Gareth T, Mobbs, Helene, Canonica, Tara, Tosh, Justin, Noy, Suzanna, Llorian, Miriam, Nolan, Patrick M, Griffin, Julian L, Good, Mark, Simon, Michelle, Mallon, Ann-Marie, Wells, Sara, Fisher, Elizabeth M C, Tybulewicz, Victor L J
Published in bioRxiv (11.02.2021)
Published in bioRxiv (11.02.2021)
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Paper
Genetic dissection of Down syndrome-associated alterations in APP/amyloid-β biology using mouse models
Justin Lee Tosh, Rhymes, Ellie, Mumford, Paige, Whittaker, Heather T, Pulford, Laura J, Noy, Sue J, Cleverley, Karen, Walker, Matthew L, Tybulewicz, Victor Lj, Wykes, Rob C, Elizabeth Mc Fisher, Wiseman, Frances K
Published in bioRxiv (20.06.2020)
Published in bioRxiv (20.06.2020)
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