An engineered PET depolymerase to break down and recycle plastic bottles
Tournier, V., Topham, C. M., Gilles, A., David, B., Folgoas, C., Moya-Leclair, E., Kamionka, E., Desrousseaux, M.-L., Texier, H., Gavalda, S., Cot, M., Guémard, E., Dalibey, M., Nomme, J., Cioci, G., Barbe, S., Chateau, M., André, I., Duquesne, S., Marty, A.
Published in Nature (London) (01.04.2020)
Published in Nature (London) (01.04.2020)
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Molecular modelling of the ORL1 receptor and its complex with nociceptin
Topham, C M, Moulédous, L, Poda, G, Maigret, B, Meunier, J C
Published in Protein engineering (01.12.1998)
Published in Protein engineering (01.12.1998)
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The nociceptin (ORL1) receptor: molecular cloning and functional architecture
Meunier, Jean-Claude, Mouledous, Lionel, Topham, Christopher M
Published in Peptides (New York, N.Y. : 1980) (01.07.2000)
Published in Peptides (New York, N.Y. : 1980) (01.07.2000)
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Fragment Ranking in Modelling of Protein Structure: Conformationally Constrained Environmental Amino Acid Substitution Tables
Topham, Christopher M., McLeod, Alasdair, Eisenmenger, Frank, Overington, John P., Johnson, Mark S., Blundell, Tom L.
Published in Journal of molecular biology (05.01.1993)
Published in Journal of molecular biology (05.01.1993)
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Ionization characteristics of the Cys-25/His-159 interactive system and of the modulatory group of papain : resolution of ambiguity by electronic perturbation of the quasi-2-mercaptopyridine leaving group in a new pyrimidyl disulphide reactivity probe
MELLOR, G. W, THOMAS, E. W, TOPHAM, C. M, BROCKLEHURST, K
Published in Biochemical journal (15.02.1993)
Published in Biochemical journal (15.02.1993)
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Structure of chymopapain M the late-eluted chymopapain deduced by comparative modelling techniques and active-centre characteristics determined by pH-dependent kinetics of catalysis and reactions with time-dependent inhibitors : the Cys-25/His-159 ion-pair is insufficient for catalytic competence in both chymopapain M and papain
THOMAS, M. P, TOPHAM, C. M, KOWLESSUR, D, MELLOR, G. W, THOMAS, E. W, WHITFORD, D, BROCKLEHURST, K
Published in Biochemical journal (15.06.1994)
Published in Biochemical journal (15.06.1994)
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A polyclonal antibody preparation with Michaelian catalytic properties
GALLACHER, G, JACKSON, C. S, SEARCEY, M, BADMAN, G. T, GOEL, R, TOPHAM, C. M, MELLOR, G. W, BROCKLEHURST, K
Published in Biochemical journal (01.11.1991)
Published in Biochemical journal (01.11.1991)
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Structure-function relationships in the cysteine proteinases actinidin, papain and papaya proteinase Ω : three-dimensional structure of papaya proteinase Ω deduced by knowledge-based modelling and active-centre characteristics determined by two-hydronic-state reactivity probe kinetics and kinetics of catalysis
TOPHAM, C. M, SALIH, E, FRAZAO, C, KOWLESSUR, D, OVERINGTON, J. P, THOMAS, M, BROCKLEHURST, S. M, PATEL, M, THOMAS, E. W, BROCKLEHURST, K
Published in Biochemical journal (15.11.1991)
Published in Biochemical journal (15.11.1991)
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The interplay of electrostatic fields and binding interactions determining catalytic-site reactivity in actinidin. A possible origin of differences in the behaviour of actinidin and papain
Kowlessur, D, O'Driscoll, M, Topham, C M, Templeton, W, Thomas, E W, Brocklehurst, K
Published in Biochemical journal (15.04.1989)
Published in Biochemical journal (15.04.1989)
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Identification of signalling and non-signalling binding contributions to enzyme reactivity. Alternative combinations of binding interactions provide for change in transition-state geometry in reactions of papain
Kowlessur, D, Topham, C M, Thomas, E W, O'Driscoll, M, Templeton, W, Brocklehurst, K
Published in Biochemical journal (15.03.1989)
Published in Biochemical journal (15.03.1989)
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