An on-demand, drop-on-drop method for studying enzyme catalysis by serial crystallography
Butryn, Agata, Simon, Philipp S., Aller, Pierre, Hinchliffe, Philip, Massad, Ramzi N., Leen, Gabriel, Tooke, Catherine L., Bogacz, Isabel, Kim, In-Sik, Bhowmick, Asmit, Brewster, Aaron S., Devenish, Nicholas E., Brem, Jürgen, Kamps, Jos J. A. G., Lang, Pauline A., Rabe, Patrick, Axford, Danny, Beale, John H., Davy, Bradley, Ebrahim, Ali, Orlans, Julien, Storm, Selina L. S., Zhou, Tiankun, Owada, Shigeki, Tanaka, Rie, Tono, Kensuke, Evans, Gwyndaf, Owen, Robin L., Houle, Frances A., Sauter, Nicholas K., Schofield, Christopher J., Spencer, James, Yachandra, Vittal K., Yano, Junko, Kern, Jan F., Orville, Allen M.
Published in Nature communications (22.07.2021)
Published in Nature communications (22.07.2021)
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Harvesting and amplifying gene cassettes confers cross-resistance to critically important antibiotics
Dulyayangkul, Punyawee, Beavis, Thomas, Lee, Winnie W Y, Ardagh, Robbie, Edwards, Frances, Hamilton, Fergus, Head, Ian, Heesom, Kate J, Mounsey, Oliver, Murarik, Marek, Pinweha, Peechanika, Reding, Carlos, Satapoomin, Naphat, Shaw, John M, Takebayashi, Yuiko, Tooke, Catherine L, Spencer, James, Williams, Philip B, Avison, Matthew B
Published in PLoS pathogens (01.06.2024)
Published in PLoS pathogens (01.06.2024)
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Allosteric communication in class A β-lactamases occurs via cooperative coupling of loop dynamics
Galdadas, Ioannis, Qu, Shen, Oliveira, Ana Sofia F, Olehnovics, Edgar, Mack, Andrew R, Mojica, Maria F, Agarwal, Pratul K, Tooke, Catherine L, Gervasio, Francesco Luigi, Spencer, James, Bonomo, Robert A, Mulholland, Adrian J, Haider, Shozeb
Published in eLife (23.03.2021)
Published in eLife (23.03.2021)
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Penicillanic Acid Sulfones Inactivate the Extended-Spectrum β-Lactamase CTX-M-15 through Formation of a Serine-Lysine Cross-Link: an Alternative Mechanism of β-Lactamase Inhibition
Hinchliffe, Philip, Tooke, Catherine L, Bethel, Christopher R, Wang, Benlian, Arthur, Christopher, Heesom, Kate J, Shapiro, Stuart, Schlatzer, Daniela M, Papp-Wallace, Krisztina M, Bonomo, Robert A, Spencer, James
Published in mBio (28.06.2022)
Published in mBio (28.06.2022)
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Short-term outcomes of very low-birthweight infants with intraventricular haemorrhage who received respiratory support in a middle-income country neonatal unit
Goolab, D, Tooke, L, Roux, S. le, Joolay, Y
Published in SAJCH : the South African journal of child health (01.09.2021)
Published in SAJCH : the South African journal of child health (01.09.2021)
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Studies on the Reactions of Biapenem with VIM Metallo β-Lactamases and the Serine β-Lactamase KPC-2
Lucic, Anka, Malla, Tika R, Calvopiña, Karina, Tooke, Catherine L, Brem, Jürgen, McDonough, Michael A, Spencer, James, Schofield, Christopher J
Published in Antibiotics (Basel) (16.03.2022)
Published in Antibiotics (Basel) (16.03.2022)
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Illness episodes in a cohort of preterm infants in their first year of life
Muller, SJ, Zar, HJ, Tooke, L
Published in SAJCH : the South African journal of child health (30.04.2021)
Published in SAJCH : the South African journal of child health (30.04.2021)
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Natural variants modify Klebsiella pneumoniae carbapenemase (KPC) acyl–enzyme conformational dynamics to extend antibiotic resistance
Tooke, Catherine L., Hinchliffe, Philip, Bonomo, Robert A., Schofield, Christopher J., Mulholland, Adrian J., Spencer, James
Published in The Journal of biological chemistry (01.01.2021)
Published in The Journal of biological chemistry (01.01.2021)
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Cross-class metallo-β-lactamase inhibition by bisthiazolidines reveals multiple binding modes
Hinchliffe, Philip, González, Mariano M., Mojica, Maria F., González, Javier M., Castillo, Valerie, Saiz, Cecilia, Kosmopoulou, Magda, Tooke, Catherine L., Llarrull, Leticia I., Mahler, Graciela, Bonomo, Robert A., Vila, Alejandro J., Spencer, James
Published in Proceedings of the National Academy of Sciences - PNAS (28.06.2016)
Published in Proceedings of the National Academy of Sciences - PNAS (28.06.2016)
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Tautomer-Specific Deacylation and Ω‑Loop Flexibility Explain the Carbapenem-Hydrolyzing Broad-Spectrum Activity of the KPC‑2 β‑Lactamase
Tooke, Catherine L., Hinchliffe, Philip, Beer, Michael, Zinovjev, Kirill, Colenso, Charlotte K., Schofield, Christopher J., Mulholland, Adrian J., Spencer, James
Published in Journal of the American Chemical Society (05.04.2023)
Published in Journal of the American Chemical Society (05.04.2023)
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