New microtubulin inhibitor MT189 suppresses angiogenesis via the JNK-VEGF/VEGFR2 signaling axis
Xu, Lin, Wang, Wei, Meng, Tao, Ma, Lan-Ping, Tong, Lin-Jiang, Shen, Jing-Kang, Wang, Ying-Qing, Miao, Ze-Hong
Published in Cancer letters (01.03.2018)
Published in Cancer letters (01.03.2018)
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C11, a novel fibroblast growth factor receptor 1 (FGFR1) inhibitor, suppresses breast cancer metastasis and angiogenesis
Chen, Zhuo, Tong, Lin-jiang, Tang, Bai-you, Liu, Hong-yan, Wang, Xin, Zhang, Tao, Cao, Xian-wen, Chen, Yi, Li, Hong-lin, Qian, Xu-hong, Xu, Yu-fang, Xie, Hua, Ding, Jian
Published in Acta pharmacologica Sinica (01.06.2019)
Published in Acta pharmacologica Sinica (01.06.2019)
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Discovery and biological evaluation of N-(3-(7-((2-methoxy-4-(4-methylpiperazin-1-yl)phenyl)amino)-4-methyl-2-oxo-2H-pyrimido[4,5-d][1,3]oxazin-1(4H)-yl)phenyl)acrylamide as potent Bruton’s tyrosine kinase inhibitors
Lai, Meng-zhen, Song, Pei-ran, Dou, Dou, Diao, Yan-yan, Tong, Lin-jiang, Zhang, Tao, Xie, Hua, Li, Hong-lin, Ding, Jian
Published in Acta pharmacologica Sinica (01.03.2020)
Published in Acta pharmacologica Sinica (01.03.2020)
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Identification of compound D2923 as a novel anti-tumor agent targeting CSF1R
Liu, Ying-Qiang, Wang, Ya-Nan, Lu, Xiao-Yun, Tong, Lin-Jiang, Li, Yan, Zhang, Tao, Xun, Qiu-Ju, Feng, Fang, Chen, Yu-Zhe, Su, Yi, Shen, Yan-Yan, Chen, Yi, Geng, Mei-Yu, Ding, Ke, Li, Yan-Li, Xie, Hua, Ding, Jian
Published in Acta pharmacologica Sinica (01.11.2018)
Published in Acta pharmacologica Sinica (01.11.2018)
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Naturally Occurring Homoisoflavonoids Function as Potent Protein Tyrosine Kinase Inhibitors by c-Src-Based High-Throughput Screening
Lin, Li-Gen, Xie, Hua, Li, Hong-Lin, Tong, Lin-Jiang, Tang, Chun-Ping, Ke, Chang-Qiang, Liu, Qun-Fang, Lin, Li-Ping, Geng, Mei-Yu, Jiang, Hualiang, Zhao, Wei-Min, Ding, Jian, Ye, Yang
Published in Journal of medicinal chemistry (14.08.2008)
Published in Journal of medicinal chemistry (14.08.2008)
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DW10075, a novel selective and small-molecule inhibitor of VEGFR, exhibits antitumor activities both in vitro and in vivo
Li, Meng-yuan, Lv, Yong-cong, Tong, Lin-jiang, Peng, Ting, Qu, Rong, Zhang, Tao, Sun, Yi-ming, Chen, Yi, Wei, Li-xin, Geng, Mei-yu, Duan, Wen-hu, Xie, Hua, Ding, Jian
Published in Acta pharmacologica Sinica (01.03.2016)
Published in Acta pharmacologica Sinica (01.03.2016)
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Pseudolarix Acid B, a New Tubulin-Binding Agent, Inhibits Angiogenesis by Interacting with a Novel Binding Site on Tubulin
Tong, Yun-Guang, Zhang, Xiong-Wen, Geng, Mei-Yu, Yue, Jian-Ming, Xin, Xian-Liang, Tian, Fang, Shen, Xu, Tong, Lin-Jiang, Li, Mei-Hong, Zhang, Chao, Li, Wei-Hong, Lin, Li-Ping, Ding, Jian
Published in Molecular pharmacology (01.04.2006)
Published in Molecular pharmacology (01.04.2006)
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Increased accumulation of hypoxia-inducible factor-1α with reduced transcriptional activity mediates the antitumor effect of triptolide
Zhou, Zhao-Li, Luo, Zhi-Guo, Yu, Bing, Jiang, Yi, Chen, Yi, Feng, Jian-Ming, Dai, Mei, Tong, Lin-Jiang, Li, Zheng, Li, Yuan-Chao, Ding, Jian, Miao, Ze-Hong
Published in Molecular cancer (11.10.2010)
Published in Molecular cancer (11.10.2010)
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GA3, a new gambogic acid derivative, exhibits potent antitumor activities in vitro via apoptosis-involved mechanisms
Xie, Hua, Qin, Yu-xin, Zhou, Yun-long, Tong, Lin-jiang, Lin, Li-ping, Geng, Mei-yu, Duan, Wen-hu, Ding, Jian
Published in Acta pharmacologica Sinica (01.03.2009)
Published in Acta pharmacologica Sinica (01.03.2009)
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Naphthalimides Induce G2 Arrest Through the ATM-Activated Chk2-Executed Pathway in HCT116 Cells
Zhu, Hong, Miao, Ze-Hong, Huang, Min, Feng, Jian-Ming, Zhang, Zhi-Xiang, Lu, Jin-Jian, Cai, Yu-Jun, Tong, Lin-Jiang, Xu, Yu-Fang, Qian, Xu-Hong, Ding, Jian
Published in Neoplasia (New York, N.Y.) (01.11.2009)
Published in Neoplasia (New York, N.Y.) (01.11.2009)
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MFTZ‐1 reduces constitutive and inducible HIF‐1α accumulation and VEGF secretion independent of its topoisomerase II inhibition
Dai, Mei, Miao, Ze‐Hong, Ren, Xuan, Tong, Lin‐Jiang, Yang, Na, Li, Ting, Lin, Li‐Ping, Shen, Yue‐Mao, Ding, Jian
Published in Journal of cellular and molecular medicine (01.09.2010)
Published in Journal of cellular and molecular medicine (01.09.2010)
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Dihydroartemisinin induces apoptosis in HL-60 leukemia cells dependent of iron and p38 mitogen-activated protein kinase activation but independent of reactive oxygen species
Lu, Jin-Jian, Meng, Ling-Hua, Cai, Yu-Jun, Chen, Qin, Tong, Lin-Jiang, Lin, Li-Ping, Ding, Jian
Published in Cancer biology & therapy (01.07.2008)
Published in Cancer biology & therapy (01.07.2008)
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Nitidine chloride induces cardiac hypertrophy in mice by targeting autophagy-related 4B cysteine peptidase
Hong, Yang, Xu, Wan-qing, Feng, Jing, Lou, Han, Liu, Heng, Wang, Lei, Cui, Hao, Jiang, Lin-tong, Xu, Ran-chen, Xu, Heng-hui, Xie, Min-zhen, Li, Yang, Kopylov, Philipp, Wang, Qi, Zhang, Yong
Published in Acta pharmacologica Sinica (01.03.2023)
Published in Acta pharmacologica Sinica (01.03.2023)
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Establishment of platform for screening insulin-like growth factor-1 receptor inhibitors and evaluation of novel inhibitors
Tong, Lin-jiang, Xie, Hua, Peng, Ting, Liu, Xiao-feng, Xin, Xian-liang, Huang, Xun, Chen, Si-meng, Liu, Hong-yan, Li, Hong-lin, Geng, Mei-yu, Yin, Ming, Ding, Jian
Published in Acta pharmacologica Sinica (01.07.2011)
Published in Acta pharmacologica Sinica (01.07.2011)
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Topoisomerase II inhibitors from the roots of Stellera chamaejasme L
Liu, Li-Ping, Han, Kun, Chen, Wei, Zhang, Ying-Ying, Tong, Lin-Jiang, Peng, Ting, Xie, Hua, Ding, Jian, Wang, Hong-Bing
Published in Bioorganic & medicinal chemistry (01.08.2014)
Published in Bioorganic & medicinal chemistry (01.08.2014)
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Journal Article
MCL-1 degradation mediated by JNK activation via MEKK1/TAK1-MKK4 contributes to anticancer activity of new tubulin inhibitor MT189
Wang, Wei, Wang, Ying-Qing, Meng, Tao, Yi, Jun-Mei, Huan, Xia-Juan, Ma, Lan-Ping, Tong, Lin-Jiang, Chen, Yi, Ding, Jian, Shen, Jing-Kang, Miao, Ze-Hong
Published in Molecular cancer therapeutics (01.06.2014)
Published in Molecular cancer therapeutics (01.06.2014)
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Dihydroartemisinin accelerates c-MYC oncoprotein degradation and induces apoptosis in c-MYC-overexpressing tumor cells
Lu, Jin-Jian, Meng, Ling-Hua, Shankavaram, Uma T., Zhu, Cai-Hua, Tong, Lin-Jiang, Chen, Guang, Lin, Li-Ping, Weinstein, John N., Ding, Jian
Published in Biochemical pharmacology (01.07.2010)
Published in Biochemical pharmacology (01.07.2010)
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