6‑Cyano Analogues of Bedaquiline as Less Lipophilic and Potentially Safer Diarylquinolines for Tuberculosis
Tong, Amy S. T, Choi, Peter J, Blaser, Adrian, Sutherland, Hamish S, Tsang, Sophia K. Y, Guillemont, Jerome, Motte, Magali, Cooper, Christopher B, Andries, Koen, Van den Broeck, Walter, Franzblau, Scott G, Upton, Anna M, Denny, William A, Palmer, Brian D, Conole, Daniel
Published in ACS medicinal chemistry letters (12.10.2017)
Published in ACS medicinal chemistry letters (12.10.2017)
Get full text
Journal Article
Synthesis and Structure–Activity Relationships for the Anti-Mycobacterial Activity of 3-Phenyl-N-(Pyridin-2-ylmethyl)Pyrazolo[1,5-a]Pyrimidin-7-Amines
Sutherland, Hamish S., Choi, Peter J., Lu, Guo-Liang, Giddens, Anna C., Tong, Amy S. T., Franzblau, Scott G., Cooper, Christopher B., Palmer, Brian D., Denny, William A.
Published in Pharmaceuticals (Basel, Switzerland) (08.09.2022)
Published in Pharmaceuticals (Basel, Switzerland) (08.09.2022)
Get full text
Journal Article
Synthetic Studies to Help Elucidate the Metabolism of the Preclinical Candidate TBAJ-876-A Less Toxic and More Potent Analogue of Bedaquiline
Choi, Peter J, Conole, Daniel, Sutherland, Hamish S, Blaser, Adrian, Tong, Amy S T, Cooper, Christopher B, Upton, Anna M, Palmer, Brian D, Denny, William A
Published in Molecules (Basel, Switzerland) (20.03.2020)
Published in Molecules (Basel, Switzerland) (20.03.2020)
Get full text
Journal Article
3,5-Dialkoxypyridine analogues of bedaquiline are potent antituberculosis agents with minimal inhibition of the hERG channel
Sutherland, Hamish S., Tong, Amy S.T., Choi, Peter J., Blaser, Adrian, Conole, Daniel, Franzblau, Scott G., Lotlikar, Manisha U., Cooper, Christopher B., Upton, Anna M., Denny, William A., Palmer, Brian D.
Published in Bioorganic & medicinal chemistry (01.04.2019)
Published in Bioorganic & medicinal chemistry (01.04.2019)
Get full text
Journal Article
Structure-activity relationships for analogs of the tuberculosis drug bedaquiline with the naphthalene unit replaced by bicyclic heterocycles
Sutherland, Hamish S., Tong, Amy S.T., Choi, Peter J., Conole, Daniel, Blaser, Adrian, Franzblau, Scott G., Cooper, Christopher B., Upton, Anna M., Lotlikar, Manisha U., Denny, William A., Palmer, Brian D.
Published in Bioorganic & medicinal chemistry (01.05.2018)
Published in Bioorganic & medicinal chemistry (01.05.2018)
Get full text
Journal Article
Structure-activity relationships for unit C pyridyl analogues of the tuberculosis drug bedaquiline
Blaser, Adrian, Sutherland, Hamish S., Tong, Amy S.T., Choi, Peter J., Conole, Daniel, Franzblau, Scott G., Cooper, Christopher B., Upton, Anna M., Lotlikar, Manisha, Denny, William A., Palmer, Brian D.
Published in Bioorganic & medicinal chemistry (01.04.2019)
Published in Bioorganic & medicinal chemistry (01.04.2019)
Get full text
Journal Article
Variations in the C-unit of bedaquiline provides analogues with improved biology and pharmacology
Sutherland, Hamish S., Tong, Amy S.T., Choi, Peter J., Blaser, Adrian, Franzblau, Scott G., Cooper, Christopher B., Upton, Anna M., Lotlikar, Manisha, Denny, William A., Palmer, Brian D.
Published in Bioorganic & medicinal chemistry (01.01.2020)
Published in Bioorganic & medicinal chemistry (01.01.2020)
Get full text
Journal Article
Synthesis and evaluation of analogues of the tuberculosis drug bedaquiline containing heterocyclic B-ring units
Choi, Peter J., Sutherland, Hamish S., Tong, Amy S.T., Blaser, Adrian, Franzblau, Scott G., Cooper, Christopher B., Lotlikar, Manisha U., Upton, Anna M., Guillemont, Jerome, Motte, Magali, Queguiner, Laurence, Andries, Koen, Van den Broeck, Walter, Denny, William A., Palmer, Brian D.
Published in Bioorganic & medicinal chemistry letters (01.12.2017)
Published in Bioorganic & medicinal chemistry letters (01.12.2017)
Get full text
Journal Article
Synthesis and structure-activity relationships for tetrahydroisoquinoline-based inhibitors of Mycobacterium tuberculosis
Lu, Guo-Liang, Tong, Amy S.T., Conole, Daniel, Sutherland, Hamish S., Choi, Peter J., Franzblau, Scott G., Upton, Anna M., Lotlikar, Manisha U., Cooper, Christopher B., Denny, William A., Palmer, Brian D.
Published in Bioorganic & medicinal chemistry (15.11.2020)
Published in Bioorganic & medicinal chemistry (15.11.2020)
Get full text
Journal Article
Synthesis and structure-activity relationships for a new class of tetrahydronaphthalene amide inhibitors of Mycobacterium tuberculosis
Sutherland, Hamish S., Lu, Guo-Liang, Tong, Amy S.T., Conole, Daniel, Franzblau, Scott G., Upton, Anna M., Lotlikar, Manisha U., Cooper, Christopher B., Palmer, Brian D., Choi, Peter J., Denny, William A.
Published in European journal of medicinal chemistry (05.02.2022)
Published in European journal of medicinal chemistry (05.02.2022)
Get full text
Journal Article
Synthesis and Structure–Activity Relationships for the Anti-Mycobacterial Activity of 3-Phenyl-IN/I-Pyrazolo[1,5-Ia/I]Pyrimidin-7-Amines
Sutherland, Hamish S, Choi, Peter J, Lu, Guo-Liang, Giddens, Anna C, Tong, Amy S. T, Franzblau, Scott G, Cooper, Christopher B, Palmer, Brian D, Denny, William A
Published in Pharmaceuticals (Basel, Switzerland) (01.09.2022)
Published in Pharmaceuticals (Basel, Switzerland) (01.09.2022)
Get full text
Journal Article