Sphingosine kinase type 2 inhibition elevates circulating sphingosine 1-phosphate
Kharel, Yugesh, Raje, Mithun, Gao, Ming, Gellett, Amanda M, Tomsig, Jose L, Lynch, Kevin R, Santos, Webster L
Published in Biochemical journal (01.10.2012)
Published in Biochemical journal (01.10.2012)
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Journal Article
Structure−Activity Relationship Studies and in Vivo Activity of Guanidine-Based Sphingosine Kinase Inhibitors: Discovery of SphK1- and SphK2-Selective Inhibitors
Patwardhan, Neeraj N, Morris, Emily A, Kharel, Yugesh, Raje, Mithun R, Gao, Ming, Tomsig, Jose L, Lynch, Kevin R, Santos, Webster L
Published in Journal of medicinal chemistry (26.02.2015)
Published in Journal of medicinal chemistry (26.02.2015)
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Journal Article
Metabolic vulnerabilities in endometrial cancer
Byrne, Frances L, Poon, Ivan K H, Modesitt, Susan C, Tomsig, Jose L, Chow, Jenny D Y, Healy, Marin E, Baker, William D, Atkins, Kristen A, Lancaster, Johnathan M, Marchion, Douglas C, Moley, Kelle H, Ravichandran, Kodi S, Slack-Davis, Jill K, Hoehn, Kyle L
Published in Cancer research (Chicago, Ill.) (15.10.2014)
Published in Cancer research (Chicago, Ill.) (15.10.2014)
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Journal Article
Lipid phosphate phosphohydrolase type 1 (LPP1) degrades extracellular lysophosphatidic acid in vivo
Tomsig, Jose L, Snyder, Ashley H, Berdyshev, Evgeny V, Skobeleva, Anastasia, Mataya, Chifundo, Natarajan, Viswanathan, Brindley, David N, Lynch, Kevin R
Published in Biochemical journal (01.05.2009)
Published in Biochemical journal (01.05.2009)
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Journal Article
Sphingosine kinase type 1 inhibition reveals rapid turnover of circulating sphingosine 1-phosphate
Kharel, Yugesh, Mathews, Thomas P, Gellett, Amanda M, Tomsig, Jose L, Kennedy, Perry C, Moyer, Morgan L, Macdonald, Timothy L, Lynch, Kevin R
Published in Biochemical journal (15.12.2011)
Published in Biochemical journal (15.12.2011)
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Journal Article
Genetic inhibition of hepatic acetyl-CoA carboxylase activity increases liver fat and alters global protein acetylation
Chow, Jenny D.Y, Lawrence, Robert T, Healy, Marin E, Dominy, John E, Liao, Jason A, Breen, David S, Byrne, Frances L, Kenwood, Brandon M, Lackner, Carolin, Okutsu, Saeko, Mas, Valeria R, Caldwell, Stephen H, Tomsig, Jose L, Cooney, Gregory J, Puigserver, Pere B, Turner, Nigel, James, David E, Villén, Judit, Hoehn, Kyle L
Published in Molecular metabolism (Germany) (01.07.2014)
Published in Molecular metabolism (Germany) (01.07.2014)
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Journal Article
Inhibition of autotaxin production or activity blocks lysophosphatidylcholine-induced migration of human breast cancer and melanoma cells
Gaetano, Cristoforo G., Samadi, Nasser, Tomsig, Jose L., Macdonald, Timothy L., Lynch, Kevin R., Brindley, David N.
Published in Molecular carcinogenesis (01.09.2009)
Published in Molecular carcinogenesis (01.09.2009)
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Journal Article
Lysophosphatidic acid counteracts glucagon-induced hepatocyte glucose production via STAT3
Taddeo, Evan P., Hargett, Stefan R., Lahiri, Sujoy, Nelson, Marin E., Liao, Jason A., Li, Chien, Slack-Davis, Jill K., Tomsig, Jose L., Lynch, Kevin R., Yan, Zhen, Harris, Thurl E., Hoehn, Kyle L.
Published in Scientific reports (09.03.2017)
Published in Scientific reports (09.03.2017)
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Journal Article
Characterization of a sphingosine 1-phosphate receptor antagonist prodrug
Kennedy, Perry C, Zhu, Ran, Huang, Tao, Tomsig, Jose L, Mathews, Thomas P, David, Marion, Peyruchaud, Olivier, Macdonald, Timothy L, Lynch, Kevin R
Published in The Journal of pharmacology and experimental therapeutics (01.09.2011)
Published in The Journal of pharmacology and experimental therapeutics (01.09.2011)
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Journal Article
Synthesis and biological evaluation of phosphonate derivatives as autotaxin (ATX) inhibitors
Cui, Peng, Tomsig, Jose L., McCalmont, William F., Lee, Sangderk, Becker, Christopher J., Lynch, Kevin R., Macdonald, Timothy L.
Published in Bioorganic & medicinal chemistry letters (15.03.2007)
Published in Bioorganic & medicinal chemistry letters (15.03.2007)
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Journal Article
Sphingosine Kinase 2 Inhibition and Blood Sphingosine 1-Phosphate Levels
Kharel, Yugesh, Morris, Emily A, Congdon, Molly D, Thorpe, Steven B, Tomsig, Jose L, Santos, Webster L, Lynch, Kevin R
Published in The Journal of pharmacology and experimental therapeutics (01.10.2015)
Published in The Journal of pharmacology and experimental therapeutics (01.10.2015)
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Journal Article
Segment boundaries of the adult rat epididymis limit interstitial signaling by potential paracrine factors and segments lose differential gene expression after efferent duct ligation
Turner, Terry T., Johnston, Daniel S., Jelinsky, Scott A., Tomsig, Jose L., Finger, Joshua N.
Published in Asian journal of andrology (01.07.2007)
Published in Asian journal of andrology (01.07.2007)
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Journal Article
Identification of a novel mitochondrial uncoupler that does not depolarize the plasma membrane
Kenwood, Brandon M, Weaver, Janelle L, Bajwa, Amandeep, Poon, Ivan K, Byrne, Frances L, Murrow, Beverley A, Calderone, Joseph A, Huang, Liping, Divakaruni, Ajit S, Tomsig, Jose L, Okabe, Kohki, Lo, Ryan H, Cameron Coleman, G, Columbus, Linda, Yan, Zhen, Saucerman, Jeffrey J, Smith, Jeffrey S, Holmes, Jeffrey W, Lynch, Kevin R, Ravichandran, Kodi S, Uchiyama, Seiichi, Santos, Webster L, Rogers, George W, Okusa, Mark D, Bayliss, Douglas A, Hoehn, Kyle L
Published in Molecular metabolism (Germany) (01.04.2014)
Published in Molecular metabolism (Germany) (01.04.2014)
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Journal Article
α- and β-Substituted phosphonate analogs of LPA as autotaxin inhibitors
Cui, Peng, McCalmont, William F., Tomsig, Jose L., Lynch, Kevin R., Macdonald, Timothy L.
Published in Bioorganic & medicinal chemistry (01.03.2008)
Published in Bioorganic & medicinal chemistry (01.03.2008)
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Journal Article
Synthesis and structure–activity relationships of tyrosine-based inhibitors of autotaxin (ATX)
East, James E., Kennedy, Andrew J., Tomsig, Jose L., De Leon, Alexandra R., Lynch, Kevin R., Macdonald, Timothy L.
Published in Bioorganic & medicinal chemistry letters (01.12.2010)
Published in Bioorganic & medicinal chemistry letters (01.12.2010)
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Journal Article
The Copines, a Novel Class of C2 Domain-containing, Calciumdependent, Phospholipid-binding Proteins Conserved from Paramecium to Humans
Creutz, Carl E., Tomsig, Jose L., Snyder, Sandra L., Gautier, Marie-Christine, Skouri, Feriel, Beisson, Janine, Cohen, Jean
Published in The Journal of biological chemistry (16.01.1998)
Published in The Journal of biological chemistry (16.01.1998)
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