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Published in Journal of medicinal chemistry (27.02.2020)
Published in Journal of medicinal chemistry (27.02.2020)
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Yun, Cai-Hong, Mengwasser, Kristen E, Toms, Angela V, Woo, Michele S, Greulich, Heidi, Wong, Kwok-Kin, Meyerson, Matthew, Eck, Michael J
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Distinct USP25 and USP28 Oligomerization States Regulate Deubiquitinating Activity
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Published in Cell reports (Cambridge) (01.03.2013)
Published in Cell reports (Cambridge) (01.03.2013)
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Leit, Silvana, Greenwood, Jeremy, Carriero, Samantha, Mondal, Sayan, Abel, Robert, Ashwell, Mark, Blanchette, Heather, Boyles, Nicholas A., Cartwright, Mark, Collis, Alan, Feng, Shulu, Ghanakota, Phani, Harriman, Geraldine C., Hosagrahara, Vinayak, Kaila, Neelu, Kapeller, Rosanna, Rafi, Salma B., Romero, Donna L., Tarantino, Paul M., Timaniya, Jignesh, Toms, Angela V., Wester, Ronald T., Westlin, William, Srivastava, Bhaskar, Miao, Wenyan, Tummino, Peter, McElwee, Joshua J., Edmondson, Scott D., Masse, Craig E.
Published in Journal of medicinal chemistry (10.08.2023)
Published in Journal of medicinal chemistry (10.08.2023)
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Potent and selective TYK2-JH1 inhibitors highly efficacious in rodent model of psoriasis
Leit, Silvana, Greenwood, Jeremy R., Mondal, Sayan, Carriero, Samantha, Dahlgren, Markus, Harriman, Geraldine C., Kennedy-Smith, Joshua J., Kapeller, Rosana, Lawson, Jon P., Romero, Donna L., Toms, Angela V., Shelley, Mee, Wester, Ronald T., Westlin, William, McElwee, Joshua J., Miao, Wenyan, Edmondson, Scott D., Masse, Craig E.
Published in Bioorganic & medicinal chemistry letters (01.10.2022)
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Structure and function of the interacting domains of Spire and Fmn-family formins
Vizcarra, Christina L, Kreutz, Barry, Rodal, Avital A, Toms, Angela V, Lu, Jun, Zheng, Wei, Quinlan, Margot E, Eck, Michael J
Published in Proceedings of the National Academy of Sciences - PNAS (19.07.2011)
Published in Proceedings of the National Academy of Sciences - PNAS (19.07.2011)
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Crystal structure of a coiled-coil domain from human ROCK I
Tu, Daqi, Li, Yiqun, Song, Hyun Kyu, Toms, Angela V, Gould, Christopher J, Ficarro, Scott B, Marto, Jarrod A, Goode, Bruce L, Eck, Michael J
Published in PloS one (21.03.2011)
Published in PloS one (21.03.2011)
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Structural basis for isoform-specific inhibition of human CTPS1
Lynch, Eric M, DiMattia, Michael A, Albanese, Steven, van Zundert, Gydo C P, Hansen, Jesse M, Quispe, Joel D, Kennedy, Madison A, Verras, Andreas, Borrelli, Kenneth, Toms, Angela V, Kaila, Neelu, Kreutter, Kevin D, McElwee, Joshua J, Kollman, Justin M
Published in Proceedings of the National Academy of Sciences - PNAS (05.10.2021)
Published in Proceedings of the National Academy of Sciences - PNAS (05.10.2021)
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Structure of a pseudokinase-domain switch that controls oncogenic activation of Jak kinases
Toms, Angela V, Deshpande, Anagha, McNally, Randall, Jeong, Youngjee, Rogers, Julia M, Kim, Chae Un, Gruner, Sol M, Ficarro, Scott B, Marto, Jarrod A, Sattler, Martin, Griffin, James D, Eck, Michael J
Published in Nature structural & molecular biology (01.10.2013)
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Discovery and Optimization of Quinolinone Derivatives as Potent, Selective, and Orally Bioavailable Mutant Isocitrate Dehydrogenase 1 (mIDH1) Inhibitors
Lin, Jian, Lu, Wei, Caravella, Justin A, Campbell, Ann Marie, Diebold, R. Bruce, Ericsson, Anna, Fritzen, Edward, Gustafson, Gary R, Lancia, David R, Shelekhin, Tatiana, Wang, Zhongguo, Castro, Jennifer, Clarke, Andrea, Gotur, Deepali, Josephine, Helen R, Katz, Marie, Diep, Hien, Kershaw, Mark, Yao, Lili, Kauffman, Goss, Hubbs, Stephen E, Luke, George P, Toms, Angela V, Wang, Liann, Bair, Kenneth W, Barr, Kenneth J, Dinsmore, Christopher, Walker, Duncan, Ashwell, Susan
Published in Journal of medicinal chemistry (25.07.2019)
Published in Journal of medicinal chemistry (25.07.2019)
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Genetic resistance to JAK2 enzymatic inhibitors is overcome by HSP90 inhibition
Weigert, Oliver, Lane, Andrew A, Bird, Liat, Kopp, Nadja, Chapuy, Bjoern, van Bodegom, Diederik, Toms, Angela V, Marubayashi, Sachie, Christie, Amanda L, McKeown, Michael, Paranal, Ronald M, Bradner, James E, Yoda, Akinori, Gaul, Christoph, Vangrevelinghe, Eric, Romanet, Vincent, Murakami, Masato, Tiedt, Ralph, Ebel, Nicolas, Evrot, Emeline, De Pover, Alain, Régnier, Catherine H, Erdmann, Dirk, Hofmann, Francesco, Eck, Michael J, Sallan, Stephen E, Levine, Ross L, Kung, Andrew L, Baffert, Fabienne, Radimerski, Thomas, Weinstock, David M
Published in The Journal of experimental medicine (13.02.2012)
Published in The Journal of experimental medicine (13.02.2012)
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Discovery and optimization of novel piperazines as potent inhibitors of fatty acid synthase (FASN)
Martin, Matthew W., Lancia, David R., Li, Hongbin, Schiller, Shawn E.R., Toms, Angela V., Wang, Zhongguo, Bair, Kenneth W., Castro, Jennifer, Fessler, Shawn, Gotur, Deepali, Hubbs, Stephen E., Kauffman, Goss S., Kershaw, Mark, Luke, George P., McKinnon, Crystal, Yao, Lili, Lu, Wei, Millan, David S.
Published in Bioorganic & medicinal chemistry letters (15.04.2019)
Published in Bioorganic & medicinal chemistry letters (15.04.2019)
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Molecular basis of USP7 inhibition by selective small-molecule inhibitors
Turnbull, Andrew P, Ioannidis, Stephanos, Krajewski, Wojciech W, Pinto-Fernandez, Adan, Heride, Claire, Martin, Agnes C L, Tonkin, Louise M, Townsend, Elizabeth C, Buker, Shane M, Lancia, David R, Caravella, Justin A, Toms, Angela V, Charlton, Thomas M, Lahdenranta, Johanna, Wilker, Erik, Follows, Bruce C, Evans, Nicola J, Stead, Lucy, Alli, Cristina, Zarayskiy, Vladislav V, Talbot, Adam C, Buckmelter, Alexandre J, Wang, Minghua, McKinnon, Crystal L, Saab, Fabienne, McGouran, Joanna F, Century, Hannah, Gersch, Malte, Pittman, Marc S, Marshall, C Gary, Raynham, Tony M, Simcox, Mary, Stewart, Lorna M D, McLoughlin, Sheila B, Escobedo, Jaime A, Bair, Kenneth W, Dinsmore, Christopher J, Hammonds, Tim R, Kim, Sunkyu, Urbé, Sylvie, Clague, Michael J, Kessler, Benedikt M, Komander, David
Published in Nature (London) (26.10.2017)
Published in Nature (London) (26.10.2017)
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McElwee, Joshua J, Kaila, Neelu, Carreiro, Samantha, Kumar, Sheetal, Toms, Angela V, Phadke, Avinash, Jacques, Suzanne, Caravella, Justin A, Kreutter, Kevin, Campos, Sebastien, Verras, Andreas, Albanese, Steven K, Demarco, Kevin R, DiMattia, Michael A, Lynch, Eric, Kollman, Justin, Tummino, Peter
Published in The Journal of immunology (1950) (01.05.2023)
Published in The Journal of immunology (1950) (01.05.2023)
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