Search Results - "Tomoya KOTAKE" :: K.UTB vyhledávací portál | TBU Library Retrieval Portal

Validation of a New Methodology to Create Oral Drugs beyond the Rule of 5 for Intracellular Tough Targets

Validation of a New Methodology to Create Oral Drugs beyond the Rule of 5 for Intracellular Tough Targets

by Ohta, Atsushi, Tanada, Mikimasa, Shinohara, Shojiro, Morita, Yuya, Nakano, Kazuhiko, Yamagishi, Yusuke, Takano, Ryusuke, Kariyuki, Shiori, Iida, Takeo, Matsuo, Atsushi, Ozeki, Kazuhisa, Emura, Takashi, Sakurai, Yuuji, Takano, Koji, Higashida, Atsuko, Kojima, Miki, Muraoka, Terushige, Takeyama, Ryuuichi, Kato, Tatsuya, Kimura, Kaori, Ogawa, Kotaro, Ohara, Kazuhiro, Tanaka, Shota, Kikuchi, Yasufumi, Hisada, Nozomi, Hayashi, Ryuji, Nishimura, Yoshikazu, Nomura, Kenichi, Tachibana, Tatsuhiko, Irie, Machiko, Kawada, Hatsuo, Torizawa, Takuya, Murao, Naoaki, Kotake, Tomoya, Tanaka, Masahiko, Ishikawa, Shiho, Miyake, Taiji, Tamiya, Minoru, Arai, Masako, Chiyoda, Aya, Akai, Sho, Sase, Hitoshi, Kuramoto, Shino, Ito, Toshiya, Shiraishi, Takuya, Kojima, Tetsuo, Iikura, Hitoshi
Published in Journal of the American Chemical Society (08.11.2023)

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Journal Article

Asymmetric total synthesis of 9-methoxystrobilurin K

Asymmetric total synthesis of 9-methoxystrobilurin K

by Uchiro, Hiromi, Nagasawa, Koh, Aiba, Yasuyuki, Kotake, Tomoya, Hasegawa, Daiju, Kobayashi, Susumu
Published in Tetrahedron letters (02.07.2001)

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Journal Article

Lead Optimization and Avoidance of Reactive Metabolite Leading to PCO371, a Potent, Selective, and Orally Available Human Parathyroid Hormone Receptor 1 (hPTHR1) Agonist

Lead Optimization and Avoidance of Reactive Metabolite Leading to PCO371, a Potent, Selective, and Orally Available Human Parathyroid Hormone Receptor 1 (hPTHR1) Agonist

by Nishimura, Yoshikazu, Esaki, Toru, Isshiki, Yoshiaki, Furuta, Yoshiyuki, Mizutani, Akemi, Kotake, Tomoya, Emura, Takashi, Watanabe, Yoshiaki, Ohta, Masateru, Nakagawa, Toshito, Ogawa, Kotaro, Arai, Shinichi, Noda, Hiroshi, Kitamura, Hidetomo, Shimizu, Masaru, Tamura, Tatsuya, Sato, Haruhiko
Published in Journal of medicinal chemistry (28.05.2020)

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Journal Article

Structure-activity relationships of middle-size cyclic peptides, KRAS inhibitors derived from an mRNA display

Structure-activity relationships of middle-size cyclic peptides, KRAS inhibitors derived from an mRNA display

by Kage, Mirai, Hayashi, Ryuji, Matsuo, Atsushi, Tamiya, Minoru, Kuramoto, Shino, Ohara, Kazuhiro, Irie, Machiko, Chiyoda, Aya, Takano, Koji, Ito, Toshiya, Kotake, Tomoya, Takeyama, Ryuuichi, Ishikawa, Shiho, Nomura, Kenichi, Furuichi, Noriyuki, Morita, Yuya, Hashimoto, Satoshi, Kawada, Hatsuo, Nishimura, Yoshikazu, Nii, Keiji, Sase, Hitoshi, Ohta, Atsushi, Kojima, Tetsuo, Iikura, Hitoshi, Tanada, Mikimasa, Shiraishi, Takuya
Published in Bioorganic & medicinal chemistry (01.08.2024)

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Journal Article

Development of a Novel Human Parathyroid Hormone Receptor 1 (hPTHR1) Agonist (CH5447240), a Potent and Orally Available Small Molecule for Treatment of Hypoparathyroidism

Development of a Novel Human Parathyroid Hormone Receptor 1 (hPTHR1) Agonist (CH5447240), a Potent and Orally Available Small Molecule for Treatment of Hypoparathyroidism

by Nishimura, Yoshikazu, Esaki, Toru, Isshiki, Yoshiaki, Okamoto, Naoki, Furuta, Yoshiyuki, Kotake, Tomoya, Watanabe, Yoshiaki, Ohta, Masateru, Nakagawa, Toshito, Noda, Hiroshi, Shimizu, Masaru, Saito, Hitoshi, Tamura, Tatsuya, Sato, Haruhiko
Published in Journal of medicinal chemistry (26.07.2018)

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Journal Article

Development of Orally Bioavailable Peptides Targeting an Intracellular Protein: From a Hit to a Clinical KRAS Inhibitor

Development of Orally Bioavailable Peptides Targeting an Intracellular Protein: From a Hit to a Clinical KRAS Inhibitor

by Tanada, Mikimasa, Tamiya, Minoru, Matsuo, Atsushi, Chiyoda, Aya, Takano, Koji, Ito, Toshiya, Irie, Machiko, Kotake, Tomoya, Takeyama, Ryuuichi, Kawada, Hatsuo, Hayashi, Ryuji, Ishikawa, Shiho, Nomura, Kenichi, Furuichi, Noriyuki, Morita, Yuya, Kage, Mirai, Hashimoto, Satoshi, Nii, Keiji, Sase, Hitoshi, Ohara, Kazuhiro, Ohta, Atsushi, Kuramoto, Shino, Nishimura, Yoshikazu, Iikura, Hitoshi, Shiraishi, Takuya
Published in Journal of the American Chemical Society (02.08.2023)

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Journal Article

Design and synthesis of a new polymer-supported Evans-type oxazolidinone: an efficient chiral auxiliary in the solid-phase asymmetric alkylation reactions

Design and synthesis of a new polymer-supported Evans-type oxazolidinone: an efficient chiral auxiliary in the solid-phase asymmetric alkylation reactions

by Kotake, Tomoya, Hayashi, Yoshio, Rajesh, S., Mukai, Yoshie, Takiguchi, Yuka, Kimura, Tooru, Kiso, Yoshiaki
Published in Tetrahedron (11.04.2005)

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Journal Article

A new polymer-supported Evans-type chiral auxiliary derived from α-hydroxy-β-amino acid, phenylnorstatine: synthesis and application in solid-phase asymmetric alkylation reactions

A new polymer-supported Evans-type chiral auxiliary derived from α-hydroxy-β-amino acid, phenylnorstatine: synthesis and application in solid-phase asymmetric alkylation reactions

by Kotake, Tomoya, Rajesh, S, Hayashi, Yoshio, Mukai, Yoshie, Ueda, Mitsuhiro, Kimura, Tooru, Kiso, Yoshiaki
Published in Tetrahedron letters (26.04.2004)

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Journal Article

An expedient synthesis of N(alpha)-protected-L-tetrahydrofuranylglycine and its application in the synthesis of novel substrate based inhibitors of HIV-1 protease

An expedient synthesis of N(alpha)-protected-L-tetrahydrofuranylglycine and its application in the synthesis of novel substrate based inhibitors of HIV-1 protease

by Rajesh, S, Ami, Ei'ichi, Kotake, Tomoya, Kimura, Tooru, Hayashi, Yoshio, Kiso, Yoshiaki
Published in Bioorganic & medicinal chemistry letters (16.12.2002)

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Journal Article

CYCLIC COMPOUND HAVING SELECTIVE INHIBITORY ACTION ON KRAS OVER HRAS AND NRAS

CYCLIC COMPOUND HAVING SELECTIVE INHIBITORY ACTION ON KRAS OVER HRAS AND NRAS

by WAKAMIYA, Yuma, HAYASHI, Ryuji, HASHIMOTO, Satoshi, TAMIYA, Minoru, KAWADA, Hatsuo, TAKANO, Koji, KAGE, Mirai, KOTAKE, Tomoya, MORITA, Yuya
Year of Publication 16.05.2024

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Patent

CYCLIC COMPOUND HAVING INHIBITORY EFFECT SELECTIVE FOR KRAS BUT NOT FOR HRAS AND NRAS

CYCLIC COMPOUND HAVING INHIBITORY EFFECT SELECTIVE FOR KRAS BUT NOT FOR HRAS AND NRAS

by WAKAMIYA, Yuma, HAYASHI, Ryuji, HASHIMOTO, Satoshi, TAMIYA, Minoru, KAWADA, Hatsuo, TAKANO, Koji, KAGE, Mirai, KOTAKE, Tomoya, MORITA, Yuya
Year of Publication 24.01.2024

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Patent

CYCLIC COMPOUND HAVING INHIBITORY EFFECT SELECTIVE FOR KRAS BUT NOT FOR HRAS AND NRAS

CYCLIC COMPOUND HAVING INHIBITORY EFFECT SELECTIVE FOR KRAS BUT NOT FOR HRAS AND NRAS

by WAKAMIYA, Yuma, HAYASHI, Ryuji, HASHIMOTO, Satoshi, TAMIYA, Minoru, KAWADA, Hatsuo, TAKANO, Koji, KAGE, Mirai, KOTAKE, Tomoya, MORITA, Yuya
Year of Publication 21.12.2023

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Patent

Cyclic compound having selective inhibitory action on kras over hras and nras

Cyclic compound having selective inhibitory action on kras over hras and nras

by TAMIYA Minoru, MORITA Yuya, KOTAKE Tomoya, WAKAMIYA Yuma, TAKANO Koji, HASHIMOTO Satoshi, KAGE Mirai, KAWADA Hatsuo, HAYASHI Ryuji
Year of Publication 01.12.2023

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Patent

Reactor

Reactor

by Kotake, Tomoya, Nishiyama, Shuhei, Yoshio, Noriyuki, Matsuoka, Misato
Year of Publication 11.08.2020

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Patent

An expedient synthesis of Nα-protected- l-tetrahydrofuranylglycine and its application in the synthesis of novel substrate based inhibitors of HIV-1 protease

An expedient synthesis of Nα-protected- l-tetrahydrofuranylglycine and its application in the synthesis of novel substrate based inhibitors of HIV-1 protease

by Rajesh, S., Ami, Ei'ichi, Kotake, Tomoya, Kimura, Tooru, Hayashi, Yoshio, Kiso, Yoshiaki
Published in Bioorganic & medicinal chemistry letters (16.12.2002)

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Journal Article

CYCLIC COMPOUND HAVING SELECTIVE INHIBITORY ACTION ON KRAS OVER HRAS AND NRAS

CYCLIC COMPOUND HAVING SELECTIVE INHIBITORY ACTION ON KRAS OVER HRAS AND NRAS

by KAWADA, HATSUO, MORITA, YUYA, KOTAKE, TOMOYA, WAKAMIYA, YUMA, TAKANO, KOJI, KAGE, MIRAI, HASHIMOTO, SATOSHI, TAMIYA, MINORU, HAYASHI, RYUJI
Year of Publication 10.11.2022

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Patent

REACTOR

REACTOR

by YOSHIO, Noriyuki, NISHIYAMA, Shuhei, MATSUOKA, Misato, KOTAKE, Tomoya
Year of Publication 06.02.2020

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Patent

REACTOR

REACTOR

by YOSHIO, Noriyuki, NISHIYAMA, Shuhei, MATSUOKA, Misato, KOTAKE, Tomoya
Year of Publication 23.01.2020

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Patent

The first synthesis and antifungal activities of 9-methoxystrobilurin-type beta-substituted beta-methoxyacrylate

The first synthesis and antifungal activities of 9-methoxystrobilurin-type beta-substituted beta-methoxyacrylate

by Uchiro, H, Nagasawa, K, Kotake, T, Hasegawa, D, Tomita, A, Kobayashi, S
Published in Bioorganic & medicinal chemistry letters (21.10.2002)

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Journal Article

Remarkable influence of the aromatic substructure in 9-methoxystrobilurin derivatives on their antifungal activity

Remarkable influence of the aromatic substructure in 9-methoxystrobilurin derivatives on their antifungal activity

by Uchiro, Hiromi, Nagasawa, Koh, Sawa, Tomohiro, Hasegawa, Daiju, Kotake, Tomoya, Sugiura, Yoshitsugu, Kobayashi, Susumu, Otoguro, Kazuhiko, Ōmura, Satoshi
Published in Bioorganic & medicinal chemistry letters (07.10.2002)

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Journal Article