Discovery of N-(1-(3-(4-phenoxyphenyl)-1,2,4-oxadiazol-5-yl)ethyl)acetamides as novel acetyl-CoA carboxylase 2 (ACC2) inhibitors with peroxisome proliferator-activated receptor α/δ (PPARα/δ) dual agonistic activity
Okazaki, Shogo, Noguchi-Yachide, Tomomi, Sakai, Taki, Ishikawa, Minoru, Makishima, Makoto, Hashimoto, Yuichi, Yamaguchi, Takao
Published in Bioorganic & medicinal chemistry (01.11.2016)
Published in Bioorganic & medicinal chemistry (01.11.2016)
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Mono- and Dihydroxylated Metabolites of Thalidomide
Nakamura, Takanori, Noguchi, Tomomi, Kobayashi, Hisayoshi, Miyachi, Hiroyuki, Hashimoto, Yuichi
Published in Chemical & pharmaceutical bulletin (01.12.2006)
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Published in Chemical & pharmaceutical bulletin (01.12.2006)
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Structure–activity relationship studies of non-carboxylic acid peroxisome proliferator-activated receptor α/δ (PPARα/δ) dual agonists
Okazaki, Shogo, Shioi, Ryuta, Noguchi-Yachide, Tomomi, Ishikawa, Minoru, Makishima, Makoto, Hashimoto, Yuichi, Yamaguchi, Takao
Published in Bioorganic & medicinal chemistry (01.11.2016)
Published in Bioorganic & medicinal chemistry (01.11.2016)
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Switching subtype-selectivity: Fragment replacement strategy affords novel class of peroxisome proliferator-activated receptor α/δ (PPARα/δ) dual agonists
Shioi, Ryuta, Okazaki, Shogo, Noguchi-Yachide, Tomomi, Ishikawa, Minoru, Makishima, Makoto, Hashimoto, Yuichi, Yamaguchi, Takao
Published in Bioorganic & medicinal chemistry letters (15.07.2017)
Published in Bioorganic & medicinal chemistry letters (15.07.2017)
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Design and synthesis of estrogen receptor ligands with a 4-heterocycle-4-phenylheptane skeleton
Eto, Ryo, Misawa, Takashi, Noguchi-Yachide, Tomomi, Ohoka, Nobumichi, Kurihara, Masaaki, Naito, Mikihiko, Tanaka, Masakazu, Demizu, Yosuke
Published in Bioorganic & medicinal chemistry (01.05.2018)
Published in Bioorganic & medicinal chemistry (01.05.2018)
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Design, Synthesis, and Biological Evaluation of Novel Transrepression-Selective Liver X Receptor (LXR) Ligands with 5,11-Dihydro-5-methyl-11-methylene‑6H‑dibenz[b,e]azepin-6-one Skeleton
Aoyama, Atsushi, Endo-Umeda, Kaori, Kishida, Kenji, Ohgane, Kenji, Noguchi-Yachide, Tomomi, Aoyama, Hiroshi, Ishikawa, Minoru, Miyachi, Hiroyuki, Makishima, Makoto, Hashimoto, Yuichi
Published in Journal of medicinal chemistry (13.09.2012)
Published in Journal of medicinal chemistry (13.09.2012)
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DEVELOPMENT OF N-6-(HETEROARYLCARBONYL)ADENINES AS BRD4 INHIBITORS
Amemiya, Seika, Yamaguchi, Takao, Hashimoto, Yuichi, Noguchi-Yachide, Tomomi
Published in Heterocycles (01.06.2017)
Published in Heterocycles (01.06.2017)
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Design, Synthesis, and Biological Evaluation of Novel Transrepression-Selective Liver X Receptor (LXR) Ligands with 5,11-Dihydro-5-methyl-11-methylene-6 H -dibenz[ b , e ]azepin-6-one Skeleton
Aoyama, Atsushi, Endo-Umeda, Kaori, Kishida, Kenji, Ohgane, Kenji, Noguchi-Yachide, Tomomi, Aoyama, Hiroshi, Ishikawa, Minoru, Miyachi, Hiroyuki, Makishima, Makoto, Hashimoto, Yuichi
Published in Journal of medicinal chemistry (13.09.2012)
Published in Journal of medicinal chemistry (13.09.2012)
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Phenylhomophthalimide-type NOS inhibitors derived from thalidomide
Noguchi, Tomomi, Sano, Hiroko, Shimazawa, Rumiko, Tanatani, Aya, Miyachi, Hiroyuki, Hashimoto, Yuichi
Published in Bioorganic & medicinal chemistry letters (16.08.2004)
Published in Bioorganic & medicinal chemistry letters (16.08.2004)
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Structure-Activity Relationship Study of N-6-Benzoyladenine-Type BRD4 Inhibitors and Their Effects on Cell Differentiation and TNF-alpha Production
Amemiya, Seika, Yamaguchi, Takao, Sakai, Taki, Hashimoto, Yuichi, Noguchi-Yachide, Tomomi
Published in Chemical & pharmaceutical bulletin (01.09.2016)
Published in Chemical & pharmaceutical bulletin (01.09.2016)
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Structure–activity relationship of benzodiazepine derivatives as LXXLL peptide mimetics that inhibit the interaction of vitamin D receptor with coactivators
Mita, Yusuke, Dodo, Kosuke, Noguchi-Yachide, Tomomi, Hashimoto, Yuichi, Ishikawa, Minoru
Published in Bioorganic & medicinal chemistry (15.02.2013)
Published in Bioorganic & medicinal chemistry (15.02.2013)
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5HPP-33, a Novel Tubulin-Polymerization Inhibitor Derived from Thalidomide, Directly Inhibits Proliferation and Induces Apoptosis of Human Multiple Myeloma Cells
Iguchi, Toyotaka, Oda-Nakazato, Sawako, Noguchi, Tomomi, Hashimoto, Yuichi, Hattori, Yutaka, Yamada, Taketo, Ikeda, Yasuo, Kizaki, Masahiro
Published in Blood (16.11.2005)
Published in Blood (16.11.2005)
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Separation of α-glucosidase-inhibitory and liver X receptor-antagonistic activities of phenethylphenyl phthalimide analogs and generation of LXRα-selective antagonists
Motoshima, Kazunori, Noguchi-Yachide, Tomomi, Sugita, Kazuyuki, Hashimoto, Yuichi, Ishikawa, Minoru
Published in Bioorganic & medicinal chemistry (15.07.2009)
Published in Bioorganic & medicinal chemistry (15.07.2009)
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UNEXPECTED EMERGENCE OF LUCIFERASE-INHIBITORY ACTIVITY DURING STRUCTURAL DEVELOPMENT STUDY OF PHENYLOXADIAZOLE-BASED PPAR LIGANDS
Shioi, Ryuta, Toyota, Yosuke, Noguchi-Yachide, Tomomi, Ishikawa, Minoru, Yamaguchi, Takao, Makishima, Makoto, Hashimoto, Yuichi, Ohgane, Kenji
Published in Heterocycles (01.09.2018)
Published in Heterocycles (01.09.2018)
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Cell differentiation inducers derived from thalidomide
Noguchi, Tomomi, Miyachi, Hiroyuki, Katayama, Ryohei, Naito, Mikihiko, Hashimoto, Yuichi
Published in Bioorganic & medicinal chemistry letters (01.07.2005)
Published in Bioorganic & medicinal chemistry letters (01.07.2005)
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β-Naphthoflavone analogs as potent and soluble aryl hydrocarbon receptor agonists: Improvement of solubility by disruption of molecular planarity
Fujita, Yuji, Yonehara, Mitsuhiro, Tetsuhashi, Masashi, Noguchi-Yachide, Tomomi, Hashimoto, Yuichi, Ishikawa, Minoru
Published in Bioorganic & medicinal chemistry (01.02.2010)
Published in Bioorganic & medicinal chemistry (01.02.2010)
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N-Phenylphthalimide-Type Cyclooxygenase (COX) Inhibitors Derived from Thalidomide
Sano, Hiroko, Noguchi, Tomomi, Tanatani, Aya, Miyachi, Hiroyuki, Hashimoto, Yuichi
Published in Chemical & pharmaceutical bulletin (01.08.2004)
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Published in Chemical & pharmaceutical bulletin (01.08.2004)
Journal Article
LXXLL peptide mimetics as inhibitors of the interaction of vitamin D receptor with coactivators
Mita, Yusuke, Dodo, Kosuke, Noguchi-Yachide, Tomomi, Miyachi, Hiroyuki, Makishima, Makoto, Hashimoto, Yuichi, Ishikawa, Minoru
Published in Bioorganic & medicinal chemistry letters (01.03.2010)
Published in Bioorganic & medicinal chemistry letters (01.03.2010)
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