Search Results - "Tomohiro Kaku" :: K.UTB vyhledávací portál | TBU Library Retrieval Portal

Strictly regulated agonist-dependent activation of AMPA-R is the key characteristic of TAK-653 for robust synaptic responses and cognitive improvement

Strictly regulated agonist-dependent activation of AMPA-R is the key characteristic of TAK-653 for robust synaptic responses and cognitive improvement

by Suzuki, Atsushi, Kunugi, Akiyoshi, Tajima, Yasukazu, Suzuki, Noriko, Suzuki, Motohisa, Toyofuku, Masashi, Kuno, Haruhiko, Sogabe, Satoshi, Kosugi, Yohei, Awasaki, Yasuyuki, Kaku, Tomohiro, Kimura, Haruhide
Published in Scientific reports (15.07.2021)

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Author Correction: Strictly regulated agonist-dependent activation of AMPA-R is the key characteristic of TAK-653 for robust synaptic responses and cognitive improvement

Author Correction: Strictly regulated agonist-dependent activation of AMPA-R is the key characteristic of TAK-653 for robust synaptic responses and cognitive improvement

by Suzuki, Atsushi, Kunugi, Akiyoshi, Tajima, Yasukazu, Suzuki, Noriko, Suzuki, Motohisa, Toyofuku, Masashi, Kuno, Haruhiko, Sogabe, Satoshi, Kosugi, Yohei, Awasaki, Yasuyuki, Kaku, Tomohiro, Kimura, Haruhide
Published in Scientific reports (21.07.2021)

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Design, synthesis, and biological evaluation of 4-arylmethyl-1-phenylpyrazole and 4-aryloxy-1-phenylpyrazole derivatives as novel androgen receptor antagonists

Design, synthesis, and biological evaluation of 4-arylmethyl-1-phenylpyrazole and 4-aryloxy-1-phenylpyrazole derivatives as novel androgen receptor antagonists

by Yamamoto, Satoshi, Tomita, Naoki, Suzuki, Yuri, Suzaki, Tomohiko, Kaku, Tomohiro, Hara, Takahito, Yamaoka, Masuo, Kanzaki, Naoyuki, Hasuoka, Atsushi, Baba, Atsuo, Ito, Mitsuhiro
Published in Bioorganic & medicinal chemistry (01.04.2012)

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Different effects of eNOS and nNOS inhibition on transient forebrain ischemia

Different effects of eNOS and nNOS inhibition on transient forebrain ischemia

by Jiang, Min Hai, Kaku, Tomohiro, Hada, Junichi, Hayashi, Yasumasa
Published in Brain research (09.08.2002)

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C17,20-Lyase inhibitors I. Structure-based de novo design and SAR study of C17,20-lyase inhibitors

C17,20-Lyase inhibitors I. Structure-based de novo design and SAR study of C17,20-lyase inhibitors

by MATSUNAGA, Nobuyuki, KAKU, Tomohiro, TASAKA, Akihiro, ITOH, Fumio, TANAKA, Toshimasa, HARA, Takahito, MIKI, Hiroshi, IWASAKI, Masahiko, AONO, Tetsuya, YAMAOKA, Masuo, KUSAKA, Masami
Published in Bioorganic & medicinal chemistry (01.05.2004)

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Discovery of orteronel (TAK-700), a naphthylmethylimidazole derivative, as a highly selective 17,20-lyase inhibitor with potential utility in the treatment of prostate cancer

Discovery of orteronel (TAK-700), a naphthylmethylimidazole derivative, as a highly selective 17,20-lyase inhibitor with potential utility in the treatment of prostate cancer

by Kaku, Tomohiro, Hitaka, Takenori, Ojida, Akio, Matsunaga, Nobuyuki, Adachi, Mari, Tanaka, Toshimasa, Hara, Takahito, Yamaoka, Masuo, Kusaka, Masami, Okuda, Teruaki, Asahi, Satoru, Furuya, Shuichi, Tasaka, Akihiro
Published in Bioorganic & medicinal chemistry (01.11.2011)

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O2F-3-4 Inhibition of androgen synthesis by TAK-700, a 17, 20-lyase inhibitor

O2F-3-4 Inhibition of androgen synthesis by TAK-700, a 17, 20-lyase inhibitor

by Masuo Yamaoka, Takahito Hara, Hiromi Shinohara, Tsuneo Masaki, Hideo Araki, Yumiko Akinaga, Takenori Hitaka, Nobuyuki Matsunaga, Tomohiro Kaku, Akihiro Tasaka, Masami Kusaka, Shuichi Furuya
Published in Journal of Pharmacological Sciences (2009)

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TAK-137, an AMPA-R potentiator with little agonistic effect, has a wide therapeutic window

TAK-137, an AMPA-R potentiator with little agonistic effect, has a wide therapeutic window

by Kunugi, Akiyoshi, Tanaka, Maiko, Suzuki, Atsushi, Tajima, Yasukazu, Suzuki, Noriko, Suzuki, Motohisa, Nakamura, Shinji, Kuno, Haruhiko, Yokota, Akihiro, Sogabe, Satoshi, Kosugi, Yohei, Awasaki, Yasuyuki, Kaku, Tomohiro, Kimura, Haruhide
Published in Neuropsychopharmacology (New York, N.Y.) (01.04.2019)

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Effect of a novel 17,20-lyase inhibitor, orteronel (TAK-700), on androgen synthesis in male rats

Effect of a novel 17,20-lyase inhibitor, orteronel (TAK-700), on androgen synthesis in male rats

by Hara, Takahito, Kouno, Jin, Kaku, Tomohiro, Takeuchi, Toshiyuki, Kusaka, Masami, Tasaka, Akihiro, Yamaoka, Masuo
Published in The Journal of steroid biochemistry and molecular biology (01.03.2013)

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Orteronel (TAK-700), a novel non-steroidal 17,20-lyase inhibitor: Effects on steroid synthesis in human and monkey adrenal cells and serum steroid levels in cynomolgus monkeys

Orteronel (TAK-700), a novel non-steroidal 17,20-lyase inhibitor: Effects on steroid synthesis in human and monkey adrenal cells and serum steroid levels in cynomolgus monkeys

by Yamaoka, Masuo, Hara, Takahito, Hitaka, Takenori, Kaku, Tomohiro, Takeuchi, Toshiyuki, Takahashi, Junzo, Asahi, Satoru, Miki, Hiroshi, Tasaka, Akihiro, Kusaka, Masami
Published in The Journal of steroid biochemistry and molecular biology (01.04.2012)

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Effect of an investigational CYP17A1 inhibitor, orteronel (TAK-700), on estrogen- and corticoid-synthesis pathways in hypophysectomized female rats and on the serum estradiol levels in female cynomolgus monkeys

Effect of an investigational CYP17A1 inhibitor, orteronel (TAK-700), on estrogen- and corticoid-synthesis pathways in hypophysectomized female rats and on the serum estradiol levels in female cynomolgus monkeys

by Yamaoka, Masuo, Hara, Takahito, Araki, Hideo, Kaku, Tomohiro, Hitaka, Takenori, Tasaka, Akihiro, Kusaka, Masami
Published in The Journal of steroid biochemistry and molecular biology (01.11.2013)

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Design, synthesis, and biological evaluation of 3-aryl-3-hydroxy-1-phenylpyrrolidine derivatives as novel androgen receptor antagonists

Design, synthesis, and biological evaluation of 3-aryl-3-hydroxy-1-phenylpyrrolidine derivatives as novel androgen receptor antagonists

by Yamamoto, Satoshi, Kobayashi, Hiromi, Kaku, Tomohiro, Aikawa, Katsuji, Hara, Takahito, Yamaoka, Masuo, Kanzaki, Naoyuki, Hasuoka, Atsushi, Baba, Atsuo, Ito, Mitsuhiro
Published in Bioorganic & medicinal chemistry (01.01.2013)

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17,20-Lyase inhibitors. Part 4: Design, synthesis and structure–activity relationships of naphthylmethylimidazole derivatives as novel 17,20-lyase inhibitors

17,20-Lyase inhibitors. Part 4: Design, synthesis and structure–activity relationships of naphthylmethylimidazole derivatives as novel 17,20-lyase inhibitors

by Kaku, Tomohiro, Matsunaga, Nobuyuki, Ojida, Akio, Tanaka, Toshimasa, Hara, Takahito, Yamaoka, Masuo, Kusaka, Masami, Tasaka, Akihiro
Published in Bioorganic & medicinal chemistry (01.03.2011)

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17,20-Lyase inhibitors. Part 3: Design, synthesis, and structure–activity relationships of biphenylylmethylimidazole derivatives as novel 17,20-lyase inhibitors

17,20-Lyase inhibitors. Part 3: Design, synthesis, and structure–activity relationships of biphenylylmethylimidazole derivatives as novel 17,20-lyase inhibitors

by Kaku, Tomohiro, Tsujimoto, Saori, Matsunaga, Nobuyuki, Tanaka, Toshimasa, Hara, Takahito, Yamaoka, Masuo, Kusaka, Masami, Tasaka, Akihiro
Published in Bioorganic & medicinal chemistry (01.04.2011)

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C17,20-lyase inhibitors. Part 2: Design, synthesis and structure-activity relationships of (2-naphthylmethyl)-1H-imidazoles as novel C17,20-lyase inhibitors

C17,20-lyase inhibitors. Part 2: Design, synthesis and structure-activity relationships of (2-naphthylmethyl)-1H-imidazoles as novel C17,20-lyase inhibitors

by MATSUNAGA, Nobuyuki, KAKU, Tomohiro, OJIDA, Akio, TANAKA, Toshimasa, HARA, Takahito, YAMAOKA, Masuo, KUSAKA, Masami, TASAKA, Akihiro
Published in Bioorganic & medicinal chemistry (15.08.2004)

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Abstract DD01-03: TAK-700, an inhibitor of 17,20-lyase

Abstract DD01-03: TAK-700, an inhibitor of 17,20-lyase

by Yamaoka, Masuo, Hara, Takahito, Miki, Hiroshi, Hitaka, Takenori, Kaku, Tomohiro, Kawaguchi, Naohiro, Yamasaki, Hitomi, Takeuchi, Toshiyuki, Tasaka, Akihiro, Kusaka, Masami
Published in Cancer research (Chicago, Ill.) (15.04.2010)

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Synthetic studies on (1S)-1-(6,7-dimethoxy-2-naphthyl)-1-(1H-imidazol-4-yl)-2-methylpropan-1-ol as a selective C17,20-lyase inhibitor

Synthetic studies on (1S)-1-(6,7-dimethoxy-2-naphthyl)-1-(1H-imidazol-4-yl)-2-methylpropan-1-ol as a selective C17,20-lyase inhibitor

by Matsunaga, Nobuyuki, Kaku, Tomohiro, Ojida, Akio, Tasaka, Akihiro
Published in Tetrahedron: asymmetry (05.07.2004)

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Stereocontrolled synthesis of (1S)-1-(1H-imidazol-4-yl)-1-(6-methoxy-2-naphthyl)-2-methylpropan-1-ol as a potent C17,20-lyase inhibitor

Stereocontrolled synthesis of (1S)-1-(1H-imidazol-4-yl)-1-(6-methoxy-2-naphthyl)-2-methylpropan-1-ol as a potent C17,20-lyase inhibitor

by Ojida, Akio, Matsunaga, Nobuyuki, Kaku, Tomohiro, Tasaka, Akihiro
Published in Tetrahedron: asymmetry (24.05.2004)

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Stereocontrolled synthesis of (1 S)-1-(1 H-imidazol-4-yl)-1-(6-methoxy-2-naphthyl)-2-methylpropan-1-ol as a potent C 17,20-lyase inhibitor

Stereocontrolled synthesis of (1 S)-1-(1 H-imidazol-4-yl)-1-(6-methoxy-2-naphthyl)-2-methylpropan-1-ol as a potent C 17,20-lyase inhibitor

by Ojida, Akio, Matsunaga, Nobuyuki, Kaku, Tomohiro, Tasaka, Akihiro
Published in Tetrahedron: asymmetry (2004)

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Synthetic studies on (1 S)-1-(6,7-dimethoxy-2-naphthyl)-1-(1 H-imidazol-4-yl)-2-methylpropan-1-ol as a selective C 17,20-lyase inhibitor

Synthetic studies on (1 S)-1-(6,7-dimethoxy-2-naphthyl)-1-(1 H-imidazol-4-yl)-2-methylpropan-1-ol as a selective C 17,20-lyase inhibitor

by Matsunaga, Nobuyuki, Kaku, Tomohiro, Ojida, Akio, Tasaka, Akihiro
Published in Tetrahedron: asymmetry (2004)

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