Exploitation of Elevated Extracellular ATP to Specifically Direct Antibody to Tumor Microenvironment
Mimoto, Futa, Tatsumi, Kanako, Shimizu, Shun, Kadono, Shojiro, Haraya, Kenta, Nagayasu, Miho, Suzuki, Yuki, Fujii, Etsuko, Kamimura, Masaki, Hayasaka, Akira, Kawauchi, Hiroki, Ohara, Kazuhiro, Matsushita, Masayuki, Baba, Takeshi, Susumu, Hiroaki, Sakashita, Takuya, Muraoka, Terushige, Aso, Kosuke, Katada, Hitoshi, Tanaka, Eriko, Nakagawa, Kenji, Hasegawa, Masami, Ayabe, Miho, Yamamoto, Tessai, Tanba, Shigero, Ishiguro, Takahiro, Kamikawa, Takayuki, Nambu, Takeru, Kibayashi, Tatsuya, Azuma, Yumiko, Tomii, Yasushi, Kato, Atsuhiko, Ozeki, Kazuhisa, Murao, Naoaki, Endo, Mika, Kikuta, Junichi, Kamata-Sakurai, Mika, Ishii, Masaru, Hattori, Kunihiro, Igawa, Tomoyuki
Published in Cell reports (Cambridge) (22.12.2020)
Published in Cell reports (Cambridge) (22.12.2020)
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Journal Article
Fluorine Scanning by Nonselective Fluorination: Enhancing Raf/MEK Inhibition while Keeping Physicochemical Properties
Hyohdoh, Ikumi, Furuichi, Noriyuki, Aoki, Toshihiro, Itezono, Yoshiko, Shirai, Haruyoshi, Ozawa, Sawako, Watanabe, Fumio, Matsushita, Masayuki, Sakaitani, Masahiro, Ho, Pil-Su, Takanashi, Kenji, Harada, Naoki, Tomii, Yasushi, Yoshinari, Kiyoshi, Ori, Kazutomo, Tabo, Mitsuyasu, Aoki, Yuko, Shimma, Nobuo, Iikura, Hitoshi
Published in ACS medicinal chemistry letters (14.11.2013)
Published in ACS medicinal chemistry letters (14.11.2013)
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Journal Article
Optimizing the Physicochemical Properties of Raf/MEK Inhibitors by Nitrogen Scanning
Aoki, Toshihiro, Hyohdoh, Ikumi, Furuichi, Noriyuki, Ozawa, Sawako, Watanabe, Fumio, Matsushita, Masayuki, Sakaitani, Masahiro, Morikami, Kenji, Takanashi, Kenji, Harada, Naoki, Tomii, Yasushi, Shiraki, Koji, Furumoto, Kentaro, Tabo, Mitsuyasu, Yoshinari, Kiyoshi, Ori, Kazutomo, Aoki, Yuko, Shimma, Nobuo, Iikura, Hitoshi
Published in ACS medicinal chemistry letters (10.04.2014)
Published in ACS medicinal chemistry letters (10.04.2014)
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Journal Article
Antibody to CD137 Activated by Extracellular Adenosine Triphosphate Is Tumor Selective and Broadly Effective In Vivo without Systemic Immune Activation
Kamata-Sakurai, Mika, Narita, Yoshinori, Hori, Yuji, Nemoto, Takayuki, Uchikawa, Ryo, Honda, Masaki, Hironiwa, Naoka, Taniguchi, Kenji, Shida-Kawazoe, Meiri, Metsugi, Shoichi, Miyazaki, Taro, Wada, Naoko A, Ohte, Yuki, Shimizu, Shun, Mikami, Hirofumi, Tachibana, Tatsuhiko, Ono, Natsuki, Adachi, Kenji, Sakiyama, Tetsushi, Matsushita, Tomochika, Kadono, Shojiro, Komatsu, Shun-Ichiro, Sakamoto, Akihisa, Horikawa, Sayuri, Hirako, Ayano, Hamada, Koki, Naoi, Sotaro, Savory, Nasa, Satoh, Yasuko, Sato, Motohiko, Noguchi, Yuki, Shinozuka, Junko, Kuroi, Haruka, Ito, Ami, Wakabayashi, Tetsuya, Kamimura, Masaki, Isomura, Fumihisa, Tomii, Yasushi, Sawada, Noriaki, Kato, Atsuhiko, Ueda, Otoya, Nakanishi, Yoshito, Endo, Mika, Jishage, Kou-Ichi, Kawabe, Yoshiki, Kitazawa, Takehisa, Igawa, Tomoyuki
Published in Cancer discovery (01.01.2021)
Published in Cancer discovery (01.01.2021)
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Journal Article
Enhanced Inhibition of ERK Signaling by a Novel Allosteric MEK Inhibitor, CH5126766, That Suppresses Feedback Reactivation of RAF Activity
ISHII, Nobuya, HARADA, Naoki, AOKI, Toshihiro, SHIMMA, Nobuo, ARISAWA, Mikio, SOWA, Yoshihiro, POULIKAKOS, Poulikos I, ROSEN, Neal, AOKI, Yuko, SAKAI, Toshiyuki, JOSEPH, Eric W, OHARA, Kazuhiro, MIURA, Takaaki, SAKAMOTO, Hiroshi, MATSUDA, Yutaka, TOMII, Yasushi, TACHIBANA-KONDO, Yukako, LIKURA, Hitoshi
Published in Cancer research (Chicago, Ill.) (01.07.2013)
Published in Cancer research (Chicago, Ill.) (01.07.2013)
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Journal Article
The sulfamide moiety affords higher inhibitory activity and oral bioavailability to a series of coumarin dual selective RAF/MEK inhibitors
Aoki, Toshihiro, Hyohdoh, Ikumi, Furuichi, Noriyuki, Ozawa, Sawako, Watanabe, Fumio, Matsushita, Masayuki, Sakaitani, Masahiro, Ori, Kazutomo, Takanashi, Kenji, Harada, Naoki, Tomii, Yasushi, Tabo, Mitsuyasu, Yoshinari, Kiyoshi, Aoki, Yuko, Shimma, Nobuo, Iikura, Hitoshi
Published in Bioorganic & medicinal chemistry letters (01.12.2013)
Published in Bioorganic & medicinal chemistry letters (01.12.2013)
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Abstract 2789: Discovery of a novel specific MEK and Raf inhibitor, CH5126766 (RO5126766), hit to lead study of a unique scaffold for kinase inhibitor to a clinical compound
Iikura, Hitoshi, Aoki, Toshihiro, Hyoudoh, Ikumi, Furuichi, Noriyuki, Watanabe, Fumio, Ozawa, Sawako, Sakaidani, Masahiro, Matsushita, Masayuki, Shimma, Nobuo, Harada, Naoki, Tomii, Yasushi, Aoki, Yuko, Takanashi, Kenji
Published in Cancer research (Chicago, Ill.) (15.04.2011)
Published in Cancer research (Chicago, Ill.) (15.04.2011)
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Abstract 3606: CH5126766 is a novel allosteric inhibitor of MEK that prevents its phosphorylation by RAF
Ishii, Nobuya, Harada, Naoki, Sakamoto, Hiroshi, Matsuda, Yutaka, Tomii, Yasushi, Tachibana-Kondo, Yukako, Miura, Takaaki, Ohara, Kazuhiro, Iikura, Hitoshi, Aoki, Toshihiro, Shimma, Nobuo, Arisawa, Mikio, Joseph, Eric, Poulikakos, Poulikos, Sowa, Yoshihiro, Rosen, Neal, Aoki, Yuko, Sakai, Toshiyuki
Published in Cancer research (Chicago, Ill.) (15.04.2011)
Published in Cancer research (Chicago, Ill.) (15.04.2011)
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Cell binding isoforms of vascular endothelial growth factor-A (VEGF189) contribute to blood flow-distant metastasis of pulmonary adenocarcinoma
Nishi, Masatake, Abe, Yoshiyuki, Tomii, Yasushi, Tsukamoto, Hideo, Kijima, Hiroshi, Yamazaki, Hitoshi, Ohnishi, Yasuyuki, Iwasaki, Masayuki, Inoue, Hiroshi, Ueyama, Yoshito, Nakamura, Masato
Published in International journal of oncology (01.06.2005)
Published in International journal of oncology (01.06.2005)
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The modifier subunit of glutamate cysteine ligase (GCLM) is a molecular target for amelioration of cisplatin resistance in lung cancer
Inoue, Yoshimasa, Tomisawa, Masashi, Yamazaki, Hitoshi, Abe, Yoshiyuki, Suemizu, Hiroshi, Tsukamoto, Hideo, Tomii, Yasushi, Kawamura, Masafumi, Kijima, Hiroshi, Hatanaka, Hiroyuki, Ueyama, Yoshito, Nakamura, Masato, Kobayashi, Koichi
Published in International journal of oncology (01.11.2003)
Published in International journal of oncology (01.11.2003)
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Human thrombospondin 2 inhibits proliferation of microvascular endothelial cells
Tomii, Yasushi, Kamochi, Junichiro, Yamazaki, Hitoshi, Sawa, Nobuko, Tokunaga, Tetsuji, Ohnishi, Yasuyuki, Kijima, Hiroshi, Ueyama, Yoshito, Tamaoki, Norikazu, Nakamura, Masato
Published in International journal of oncology (01.02.2002)
Published in International journal of oncology (01.02.2002)
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IIKURA HITOSHI, FURUICHI NORIYUKI, WATANABE FUMIO, SAKAITANI MASAHIRO, OZAWA SAWAKO, MATSUSHITA MASAYUKI, HYOUDOH IKUMI, TAKANASHI KENJI, HO, PIL SU, TOMII YASUSHI, SAKAI TOSHIYUKI, AOKI TOSHIHIRO, HARADA NAOKI
Year of Publication 26.04.2010
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Year of Publication 26.04.2010
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p27 PROTEIN INDUCER
TAKANASHI, KENJI, OZAWA, SAWAKO, SAKAI, TOSHIYUKI, HYOUDOH, IKUMI, FURUICHI, NORIYUKI, IIKURA, HITOSHI, TOMII, YASUSHI, HARADA, NAOKI, WATANABE, FUMIO, SAKAITANI, MASAHIRO, AOKI, TOSHIHIRO, MATSUSHITA, MASAYUKI, HO, PIL-SU
Year of Publication 29.01.2009
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Year of Publication 29.01.2009
Patent
Overexpression of the thrombospondin 2 (TSP2) gene modulated by the matrix metalloproteinase family expression and production in human colon carcinoma cell line
Kamochi, Junichiro, Tokunaga, Tetsuji, Tomii, Yasushi, Abe, Yoshiyuki, Hatanaka, Hiroyuki, Kijima, Hiroshi, Yamazaki, Hitoshi, Watanabe, Norihito, Matsuzaki, Shohei, Ueyama, Yoshito, Nakamura, Masato
Published in Oncology reports (01.07.2003)
Published in Oncology reports (01.07.2003)
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Ribozyme mediated suppression of vascular endothelial growth factor gene expression enhances matrix metalloproteinase 1 expression in a human hepatocellular carcinoma cell line
Kamochi, Junichiro, Tokunaga, Tetsuji, Morino, Fumitoshi, Nagata, Junko, Tomii, Yasushi, Abe, Yoshiyuki, Hatanaka, Hiroyuki, Kijima, Hiroshi, Yamazaki, Hitoshi, Watanabe, Norihito, Matsuzaki, Shohei, Ueyama, Yoshito, Nakamura, Masato
Published in International journal of oncology (01.07.2002)
Published in International journal of oncology (01.07.2002)
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NOVEL COUMARIN DERIVATIVE HAVING ANTITUMOR ACTIVITY
TOMII, YASUSHI, TAKANASHI, KENJI, HARADA, NAOKI, OZAWA, SAWAKO, WATANABE, FUMIO, SAKAITANI, MASAHIRO, HYOUDOH, IKUMI, FURUICHI, NORIYUKI, IIKURA, HITOSHI, AOKI, TOSHIHIRO, MATSUSHITA, MASAYUKI, HO, PIL-SU
Year of Publication 16.08.2007
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Year of Publication 16.08.2007
Patent
Unique properties of 189 amino acid isoform of vascular endothelial growth factor in tumorigenesis
Tomii, Yasushi, Yamazaki, Hitoshi, Sawa, Nobuko, Ohnishi, Yasuyuki, Kamochi, Junichiro, Tokunaga, Tetsuji, Osamura, Yoshiyuki, Sadahiro, Sotaro, Kijima, Hiroshi, Abe, Yoshiyuki, Ueyama, Yoshito, Tamaoki, Norikazu, Nakamura, Masato
Published in International journal of oncology (01.12.2002)
Published in International journal of oncology (01.12.2002)
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Interleukin 10 expression is correlated with thrombospondin expression and decreased vascular involvement in colon cancer
Kawakami, T, Tokunaga, T, Hatanaka, H, Tsuchida, T, Tomii, Y, Osada, H, Onoda, N, Morino, F, Nagata, J, Kijima, H, Yamazaki, H, Abe, Y, Osamura, Y, Ueyama, Y, Nakamura, M
Published in International journal of oncology (01.03.2001)
Published in International journal of oncology (01.03.2001)
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Nye kumarinderivater med antitumoraktivitet
Sakaitani, Masahiro, Furuichi, Noriyuki, Hyoudoh, Ikumi, Iikura, Hitoshi, Matsushita, Masayuki, Harada, Naoki, Tomii, Yasushi, Takanashi, Kenji, Watanabe, Fumio, Ozawa, Sawako, Aoki, Toshihiro, Ho, Pil-Su
Year of Publication 13.11.2017
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Year of Publication 13.11.2017
Patent